LOCUS       NM_001393494            1613 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interleukin 34 (IL34), transcript variant 5, mRNA.
ACCESSION   NM_001393494
VERSION     NM_001393494.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Nian,Z., Dou,Y., Shen,Y., Liu,J., Du,X., Jiang,Y., Zhou,Y., Fu,B.,
            Sun,R., Zheng,X., Tian,Z. and Wei,H.
  TITLE     Interleukin-34-orchestrated tumor-associated macrophage
            reprogramming is required for tumor immune escape driven by p53
            inactivation
  JOURNAL   Immunity 57 (10), 2344-2361 (2024)
   PUBMED   39321806
  REMARK    GeneRIF: Interleukin-34-orchestrated tumor-associated macrophage
            reprogramming is required for tumor immune escape driven by p53
            inactivation.
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Zhang,L., Wang,W., Chen,T., Cui,J., Li,X., Liu,A., Liu,R., Fang,L.,
            Jiang,J., Yang,L., Wu,D. and Ying,S.
  TITLE     SAMHD1 dysfunction induces IL-34 expression via NF-kappaB p65 in
            neuronal SH-SY5Y cells
  JOURNAL   Mol Immunol 168, 1-9 (2024)
   PUBMED   38367301
  REMARK    GeneRIF: SAMHD1 dysfunction induces IL-34 expression via NF-kappaB
            p65 in neuronal SH-SY5Y cells.
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Tang,F., Hou,X.F., Cheng,Y., Liu,Y., Sun,J., Liu,H.Y., Lv,L.P. and
            Fu,L.
  TITLE     Longitudinal associations between serum IL-34 with severity and
            prognosis in community-acquired pneumonia patients
  JOURNAL   Respir Investig 62 (2), 223-230 (2024)
   PUBMED   38218098
  REMARK    GeneRIF: Longitudinal associations between serum IL-34 with
            severity and prognosis in community-acquired pneumonia patients.
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Honsawek,S., Bovornsethanant,N., Woraruthai,T., Vejchapipat,P.,
            Udomsinprasert,W. and Poovorawan,Y.
  TITLE     Elevated serum IL-34 is correlated with disease severity in
            patients with biliary atresia following Kasai portoenterostomy
  JOURNAL   Int Immunopharmacol 127, 111356 (2024)
   PUBMED   38103407
  REMARK    GeneRIF: Elevated serum IL-34 is correlated with disease severity
            in patients with biliary atresia following Kasai portoenterostomy.
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Karasu,M. and Bolayir,H.A.
  TITLE     Cut-off value for interleukin-34 as an additional potential
            inflammatory biomarker for estimation of slow coronary flow risk
  JOURNAL   BMC Cardiovasc Disord 24 (1), 2 (2024)
   PUBMED   38166811
  REMARK    GeneRIF: Cut-off value for interleukin-34 as an additional
            potential inflammatory biomarker for estimation of slow coronary
            flow risk.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Hwang,S.J., Choi,B., Kang,S.S., Chang,J.H., Kim,Y.G., Chung,Y.H.,
            Sohn,D.H., So,M.W., Lee,C.K., Robinson,W.H. and Chang,E.J.
  TITLE     Interleukin-34 produced by human fibroblast-like synovial cells in
            rheumatoid arthritis supports osteoclastogenesis
  JOURNAL   Arthritis Res Ther 14 (1), R14 (2012)
   PUBMED   22264405
  REMARK    GeneRIF: Data suggest a discrete role of IL-34 in inflammatory
            rheumatoid arthritis (RA) diseases.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   Chemel,M., Le Goff,B., Brion,R., Cozic,C., Berreur,M., Amiaud,J.,
            Bougras,G., Touchais,S., Blanchard,F., Heymann,M.F.,
            Berthelot,J.M., Verrecchia,F. and Heymann,D.
  TITLE     Interleukin 34 expression is associated with synovitis severity in
            rheumatoid arthritis patients
  JOURNAL   Ann Rheum Dis 71 (1), 150-154 (2012)
   PUBMED   22039170
  REMARK    GeneRIF: study identifies IL-34 expression in the synovial tissue
            of patients with arthritis; this cytokine, as a downstream effector
            of TNFalpha and IL-1beta, may contribute to inflammation and bone
            erosions in rheumatoid arthritis
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   Wei,S., Nandi,S., Chitu,V., Yeung,Y.G., Yu,W., Huang,M.,
            Williams,L.T., Lin,H. and Stanley,E.R.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
  REMARK    GeneRIF: Discovered IL-34 and its receptor CSF1 by functional
            screening of the extracellular proteome.
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020763.6.
            
            Summary: Interleukin-34 is a cytokine that promotes the
            differentiation and viability of monocytes and macrophages through
            the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin
            et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029804.1, AK172744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288098.7/ ENSP00000288098.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AC020763.6         126724-127140       c
            418-551             AC020763.6         119028-119161       c
            552-629             AC020763.6         117020-117097       c
            630-791             AC020763.6         116578-116739       c
            792-927             AC020763.6         113946-114081       c
            928-1613            AC020763.6         113017-113702       c
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1613
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="interleukin 34"
                     /db_xref="GeneID:146433"
                     /db_xref="HGNC:HGNC:28529"
                     /db_xref="MIM:612081"
     exon            1..417
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1118
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 5"
                     /codon_start=1
                     /product="interleukin-34 isoform 1 precursor"
                     /protein_id="NP_001380423.1"
                     /db_xref="CCDS:CCDS10895.1"
                     /db_xref="GeneID:146433"
                     /db_xref="HGNC:HGNC:28529"
                     /db_xref="MIM:612081"
                     /translation="MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDK
                     LQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSAT
                     ESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVR
                     PKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPW
                     SPSSPPHSTGSVRPVRAQGEGLLP"
     exon            418..551
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            552..629
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            630..791
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            792..927
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1613
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1591..1596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="hexamer: ATTAAA"
     polyA_site      1613
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="major polyA site"
ORIGIN      
        1 acactgagca gctgcagtcg gagaaatcag agaaagcgtc acccagcccc agattccgag
       61 gggcctgcca gggactctct cctcctgctc cttggaaagg aagaccccga aagaccccca
      121 agccaccggc tcagacctgc ttctgggctg ccatgggact tgcggccacc gccccccggc
      181 tgtcctccac gctgccgggc agataagggc agctgctgcc cttggggcac ctgctcactc
      241 ccgcagccca gccactcctc cagggccagc ccttccctga ctgagtgacc acctctgctg
      301 ccccgaggcc atgtaggccg tgcttaggcc tctgtggaca cactgctggg gacggcgcct
      361 gagctctcag ggggacgagg aacaccacca tgccccgggg cttcacctgg ctgcgctatc
      421 ttgggatctt ccttggcgtg gccttgggga atgagccttt ggagatgtgg cccttgacgc
      481 agaatgagga gtgcactgtc acgggttttc tgcgggacaa gctgcagtac aggagccgac
      541 ttcagtacat gaaacactac ttccccatca actacaagat cagtgtgcct tacgaggggg
      601 tgttcagaat cgccaacgtc accaggctgc agagggccca ggtgagcgag cgggagctgc
      661 ggtatctgtg ggtcttggtg agcctcagtg ccactgagtc ggtgcaggac gtgctgctcg
      721 agggccaccc atcctggaag tacctgcagg aggtggagac gctgctgctg aatgtccagc
      781 agggcctcac ggatgtggag gtcagcccca aggtggaatc cgtgttgtcc ctcttgaatg
      841 ccccagggcc aaacctgaag ctggtgcggc ccaaagccct gctggacaac tgcttccggg
      901 tcatggagct gctgtactgc tcctgctgta aacaaagctc cgtcctaaac tggcaggact
      961 gtgaggtgcc aagtcctcag tcttgcagcc cagagccctc attgcagtat gcggccaccc
     1021 agctgtaccc tccgcccccg tggtccccca gctccccgcc tcactccacg ggctcggtga
     1081 ggccggtcag ggcacagggc gagggcctct tgccctgagc accctggatg gtgactgcgg
     1141 ataggggcag ccagaccagc tcccacagga gttcaactgg gtctgagact tcaaggggtg
     1201 gtggtgggag ccccccttgg gagaggaccc ctgggaaggg tgtttttcct ttgaggggga
     1261 ttctgtgcca cagcagggct cagcttcctg ccttccatag ctgtcatggc ctcacctgga
     1321 gcggagggga cctggggacc tgaaggtgga tggggacaca gctcctggct tctcctggtg
     1381 ctgccctcac tgtccccccg cctaaagggg gtactgagcc tcctgtggcc cgcagcagtg
     1441 agggcacagc tgtgggttgc aggggagaca gccagcacgg cgtggccatt ctatgacccc
     1501 ccagcctggc agactgggga gctgggggca gagggcggtg ccaagtgcca catcttgcca
     1561 tagtggatgc tcttccagtt tcttttttct attaaacacc ccacttcctt tgg
//
