LOCUS       NM_001172772            1762 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interleukin 34 (IL34), transcript variant 3, mRNA.
ACCESSION   NM_001172772
VERSION     NM_001172772.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Nian,Z., Dou,Y., Shen,Y., Liu,J., Du,X., Jiang,Y., Zhou,Y., Fu,B.,
            Sun,R., Zheng,X., Tian,Z. and Wei,H.
  TITLE     Interleukin-34-orchestrated tumor-associated macrophage
            reprogramming is required for tumor immune escape driven by p53
            inactivation
  JOURNAL   Immunity 57 (10), 2344-2361 (2024)
   PUBMED   39321806
  REMARK    GeneRIF: Interleukin-34-orchestrated tumor-associated macrophage
            reprogramming is required for tumor immune escape driven by p53
            inactivation.
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Zhang,L., Wang,W., Chen,T., Cui,J., Li,X., Liu,A., Liu,R., Fang,L.,
            Jiang,J., Yang,L., Wu,D. and Ying,S.
  TITLE     SAMHD1 dysfunction induces IL-34 expression via NF-kappaB p65 in
            neuronal SH-SY5Y cells
  JOURNAL   Mol Immunol 168, 1-9 (2024)
   PUBMED   38367301
  REMARK    GeneRIF: SAMHD1 dysfunction induces IL-34 expression via NF-kappaB
            p65 in neuronal SH-SY5Y cells.
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Tang,F., Hou,X.F., Cheng,Y., Liu,Y., Sun,J., Liu,H.Y., Lv,L.P. and
            Fu,L.
  TITLE     Longitudinal associations between serum IL-34 with severity and
            prognosis in community-acquired pneumonia patients
  JOURNAL   Respir Investig 62 (2), 223-230 (2024)
   PUBMED   38218098
  REMARK    GeneRIF: Longitudinal associations between serum IL-34 with
            severity and prognosis in community-acquired pneumonia patients.
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Honsawek,S., Bovornsethanant,N., Woraruthai,T., Vejchapipat,P.,
            Udomsinprasert,W. and Poovorawan,Y.
  TITLE     Elevated serum IL-34 is correlated with disease severity in
            patients with biliary atresia following Kasai portoenterostomy
  JOURNAL   Int Immunopharmacol 127, 111356 (2024)
   PUBMED   38103407
  REMARK    GeneRIF: Elevated serum IL-34 is correlated with disease severity
            in patients with biliary atresia following Kasai portoenterostomy.
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Karasu,M. and Bolayir,H.A.
  TITLE     Cut-off value for interleukin-34 as an additional potential
            inflammatory biomarker for estimation of slow coronary flow risk
  JOURNAL   BMC Cardiovasc Disord 24 (1), 2 (2024)
   PUBMED   38166811
  REMARK    GeneRIF: Cut-off value for interleukin-34 as an additional
            potential inflammatory biomarker for estimation of slow coronary
            flow risk.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Hwang,S.J., Choi,B., Kang,S.S., Chang,J.H., Kim,Y.G., Chung,Y.H.,
            Sohn,D.H., So,M.W., Lee,C.K., Robinson,W.H. and Chang,E.J.
  TITLE     Interleukin-34 produced by human fibroblast-like synovial cells in
            rheumatoid arthritis supports osteoclastogenesis
  JOURNAL   Arthritis Res Ther 14 (1), R14 (2012)
   PUBMED   22264405
  REMARK    GeneRIF: Data suggest a discrete role of IL-34 in inflammatory
            rheumatoid arthritis (RA) diseases.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1762)
  AUTHORS   Chemel,M., Le Goff,B., Brion,R., Cozic,C., Berreur,M., Amiaud,J.,
            Bougras,G., Touchais,S., Blanchard,F., Heymann,M.F.,
            Berthelot,J.M., Verrecchia,F. and Heymann,D.
  TITLE     Interleukin 34 expression is associated with synovitis severity in
            rheumatoid arthritis patients
  JOURNAL   Ann Rheum Dis 71 (1), 150-154 (2012)
   PUBMED   22039170
  REMARK    GeneRIF: study identifies IL-34 expression in the synovial tissue
            of patients with arthritis; this cytokine, as a downstream effector
            of TNFalpha and IL-1beta, may contribute to inflammation and bone
            erosions in rheumatoid arthritis
REFERENCE   8  (bases 1 to 1762)
  AUTHORS   Wei,S., Nandi,S., Chitu,V., Yeung,Y.G., Yu,W., Huang,M.,
            Williams,L.T., Lin,H. and Stanley,E.R.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (bases 1 to 1762)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
  REMARK    GeneRIF: Discovered IL-34 and its receptor CSF1 by functional
            screening of the extracellular proteome.
REFERENCE   10 (bases 1 to 1762)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020763.6, CD248375.1, AK172744.1 and AW292500.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001172772.1.
            
            Summary: Interleukin-34 is a cytokine that promotes the
            differentiation and viability of monocytes and macrophages through
            the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin
            et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.140191.1,
                                           SRR14038192.3427797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2153031
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC020763.6         149591-149707       c
            118-468             CD248375.1         36-386
            469-1759            AK172744.1         1-1291
            1760-1762           AW292500.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1762
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="interleukin 34"
                     /db_xref="GeneID:146433"
                     /db_xref="HGNC:HGNC:28529"
                     /db_xref="MIM:612081"
     exon            1..138
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            139..566
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     CDS             539..1267
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3"
                     /codon_start=1
                     /product="interleukin-34 isoform 1 precursor"
                     /protein_id="NP_001166243.1"
                     /db_xref="CCDS:CCDS10895.1"
                     /db_xref="GeneID:146433"
                     /db_xref="HGNC:HGNC:28529"
                     /db_xref="MIM:612081"
                     /translation="MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDK
                     LQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSAT
                     ESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVR
                     PKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPW
                     SPSSPPHSTGSVRPVRAQGEGLLP"
     exon            567..700
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            701..778
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            779..940
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1076
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1762
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="hexamer: ATTAAA"
     polyA_site      1762
                     /gene="IL34"
                     /gene_synonym="C16orf77; IL-34"
                     /note="major polyA site"
ORIGIN      
        1 ctcgaagctc ggcgtctgtg atggtctacg gggctttcga ggtgatcagg cagcgtcagt
       61 cttcagccgc taagccgaga aggagtcagt cagagagcct tgggccagag ttccaggggc
      121 tctgggagtg gctgccagag ccagatttca cactgagcag ctgcagtcgg agaaatcaga
      181 gaaagcgtca cccagcccca gattccgagg ggcctgccag ggactctctc ctcctgctcc
      241 ttggaaagga agaccccgaa agacccccaa gccaccggct cagacctgct tctgggctgc
      301 catgggactt gcggccaccg ccccccggct gtcctccacg ctgccgggca gataagggca
      361 gctgctgccc ttggggcacc tgctcactcc cgcagcccag ccactcctcc agggccagcc
      421 cttccctgac tgagtgacca cctctgctgc cccgaggcca tgtaggccgt gcttaggcct
      481 ctgtggacac actgctgggg acggcgcctg agctctcagg gggacgagga acaccaccat
      541 gccccggggc ttcacctggc tgcgctatct tgggatcttc cttggcgtgg ccttggggaa
      601 tgagcctttg gagatgtggc ccttgacgca gaatgaggag tgcactgtca cgggttttct
      661 gcgggacaag ctgcagtaca ggagccgact tcagtacatg aaacactact tccccatcaa
      721 ctacaagatc agtgtgcctt acgagggggt gttcagaatc gccaacgtca ccaggctgca
      781 gagggcccag gtgagcgagc gggagctgcg gtatctgtgg gtcttggtga gcctcagtgc
      841 cactgagtcg gtgcaggacg tgctgctcga gggccaccca tcctggaagt acctgcagga
      901 ggtggagacg ctgctgctga atgtccagca gggcctcacg gatgtggagg tcagccccaa
      961 ggtggaatcc gtgttgtccc tcttgaatgc cccagggcca aacctgaagc tggtgcggcc
     1021 caaagccctg ctggacaact gcttccgggt catggagctg ctgtactgct cctgctgtaa
     1081 acaaagctcc gtcctaaact ggcaggactg tgaggtgcca agtcctcagt cttgcagccc
     1141 agagccctca ttgcagtatg cggccaccca gctgtaccct ccgcccccgt ggtcccccag
     1201 ctccccgcct cactccacgg gctcggtgag gccggtcagg gcacagggcg agggcctctt
     1261 gccctgagca ccctggatgg tgactgcgga taggggcagc cagaccagct cccacaggag
     1321 ttcaactggg tctgagactt caaggggtgg tggtgggagc cccccttggg agaggacccc
     1381 tgggaagggt gtttttcctt tgagggggat tctgtgccac agcagggctc agcttcctgc
     1441 cttccatagc tgtcatggcc tcacctggag cggaggggac ctggggacct gaaggtggat
     1501 ggggacacag ctcctggctt ctcctggtgc tgccctcact gtccccccgc ctaaaggggg
     1561 tactgagcct cctgtggccc gcagcagtga gggcacagct gtgggttgca ggggagacag
     1621 ccagcacggc gtggccattc tatgaccccc cagcctggca gactggggag ctgggggcag
     1681 agggcggtgc caagtgccac atcttgccat agtggatgct cttccagttt cttttttcta
     1741 ttaaacaccc cacttccttt gg
//
