LOCUS       NM_033439               2685 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 33 (IL33), transcript variant 1, mRNA.
ACCESSION   NM_033439
VERSION     NM_033439.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Alashkar Alhamwe,B., Ponath,V., Alhamdan,F., Dorsam,B.,
            Landwehr,C., Linder,M., Pauck,K., Miethe,S., Garn,H.,
            Finkernagel,F., Brichkina,A., Lauth,M., Tiwari,D.K., Buchholz,M.,
            Bachurski,D., Elmshauser,S., Nist,A., Stiewe,T., Pogge von
            Strandmann,L., Szymanski,W., Beutgen,V., Graumann,J.,
            Teply-Szymanski,J., Keber,C., Denkert,C., Jacob,R., Preusser,C. and
            Pogge von Strandmann,E.
  TITLE     BAG6 restricts pancreatic cancer progression by suppressing the
            release of IL33-presenting extracellular vesicles and the
            activation of mast cells
  JOURNAL   Cell Mol Immunol 21 (8), 918-931 (2024)
   PUBMED   38942797
  REMARK    GeneRIF: BAG6 restricts pancreatic cancer progression by
            suppressing the release of IL33-presenting extracellular vesicles
            and the activation of mast cells.
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Ruan,J., Tian,Q., Li,S., Zhou,X., Sun,Q., Wang,Y., Xiao,Y., Li,M.,
            Chang,K. and Yi,X.
  TITLE     The IL-33-ST2 axis plays a vital role in endometriosis via
            promoting epithelial-mesenchymal transition by phosphorylating
            beta-catenin
  JOURNAL   Cell Commun Signal 22 (1), 318 (2024)
   PUBMED   38858740
  REMARK    GeneRIF: The IL-33-ST2 axis plays a vital role in endometriosis via
            promoting epithelial-mesenchymal transition by phosphorylating
            beta-catenin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Wei,L., He,P., Tan,Z., Lin,C. and Wei,Z.
  TITLE     Comprehensively analysis of IL33 in hepatocellular carcinoma
            prognosis, immune microenvironment and biological role
  JOURNAL   J Cell Mol Med 28 (12), e18468 (2024)
   PUBMED   38923705
  REMARK    GeneRIF: Comprehensively analysis of IL33 in hepatocellular
            carcinoma prognosis, immune microenvironment and biological role.
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Perri,G., Vilas Boas,V.G., Nogueira,M.R.S., Mello Junior,E.J.F.,
            Coelho,A.L., Posadas,E.M., Hogaboam,C., Cavassani,K.A. and
            Campanelli,A.P.
  TITLE     Interleukin 33 supports squamous cell carcinoma growth via a dual
            effect on tumour proliferation, migration and invasion, and T cell
            activation
  JOURNAL   Cancer Immunol Immunother 73 (6), 110 (2024)
   PUBMED   38662248
  REMARK    GeneRIF: Interleukin 33 supports squamous cell carcinoma growth via
            a dual effect on tumour proliferation, migration and invasion, and
            T cell activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Liu,K., Huang,H., Xiong,M., Wang,Q., Chen,X., Feng,Y., Ma,H.,
            Chen,W., Li,X. and Ye,X.
  TITLE     IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis
            Mediated Autolysosomal Degradation of GKN1
  JOURNAL   Int J Biol Sci 20 (6), 2323-2338 (2024)
   PUBMED   38617533
  REMARK    GeneRIF: IL-33 Accelerates Chronic Atrophic Gastritis through
            AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2685)
  AUTHORS   Lock,F.E., Babaian,A., Zhang,Y., Gagnier,L., Kuah,S., Weberling,A.,
            Karimi,M.M. and Mager,D.L.
  TITLE     A novel isoform of IL-33 revealed by screening for transposable
            element promoted genes in human colorectal cancer
  JOURNAL   PLoS One 12 (7), e0180659 (2017)
   PUBMED   28715472
  REMARK    GeneRIF: LTR-IL-33 expression is required for optimal CRC cell line
            growth
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2685)
  AUTHORS   Schmitz,J., Owyang,A., Oldham,E., Song,Y., Murphy,E.,
            McClanahan,T.K., Zurawski,G., Moshrefi,M., Qin,J., Li,X.,
            Gorman,D.M., Bazan,J.F. and Kastelein,R.A.
  TITLE     IL-33, an interleukin-1-like cytokine that signals via the IL-1
            receptor-related protein ST2 and induces T helper type 2-associated
            cytokines
  JOURNAL   Immunity 23 (5), 479-490 (2005)
   PUBMED   16286016
  REMARK    GeneRIF: IL-33, which mediates its biological effects via IL-1
            receptor ST 2, activates NF-kappaB and MAP kinases, and drives
            production of T(H)2-associated cytokines from in vitro polarized
            T(H)2 cells
REFERENCE   8  (bases 1 to 2685)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 2685)
  AUTHORS   Baekkevold,E.S., Roussigne,M., Yamanaka,T., Johansen,F.E.,
            Jahnsen,F.L., Amalric,F., Brandtzaeg,P., Erard,M., Haraldsen,G. and
            Girard,J.P.
  TITLE     Molecular characterization of NF-HEV, a nuclear factor
            preferentially expressed in human high endothelial venules
  JOURNAL   Am J Pathol 163 (1), 69-79 (2003)
   PUBMED   12819012
  REMARK    GeneRIF: Results suggest that NF-HEV may be one of the key nuclear
            factors that controls the specialized phenotype of the lymphatic
            venule endothelium.
REFERENCE   10 (bases 1 to 2685)
  AUTHORS   Onda,H., Kasuya,H., Takakura,K., Hori,T., Imaizumi,T., Takeuchi,T.,
            Inoue,I. and Takeda,J.
  TITLE     Identification of genes differentially expressed in canine
            vasospastic cerebral arteries after subarachnoid hemorrhage
  JOURNAL   J Cereb Blood Flow Metab 19 (11), 1279-1288 (1999)
   PUBMED   10566975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB477860.1, BC047085.1,
            AB024518.1 and AI610794.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_033439.3.
            
            Summary: The protein encoded by this gene is a cytokine that binds
            to the IL1RL1/ST2 receptor. The encoded protein is involved in the
            maturation of Th2 cells and the activation of mast cells,
            basophils, eosinophils and natural killer cells. Several transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as 1).
            Variants 1, 4, and 5 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.30793.1,
                                           SRR1660809.94310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682010.1/ ENSP00000507310.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB477860.1         22-23
            3-1230              BC047085.1         1-1228
            1231-2251           AB024518.1         1191-2211
            2252-2664           AB024518.1         2213-2625
            2665-2685           AI610794.1         13-33               c
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..2685
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="interleukin 33"
                     /db_xref="GeneID:90865"
                     /db_xref="HGNC:HGNC:16028"
                     /db_xref="MIM:608678"
     exon            1..46
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            47..148
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..870
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; DVS27-related protein; nuclear factor for high
                     endothelial venules; nuclear factor from high endothelial
                     venules; interleukin-1 family member 11"
                     /codon_start=1
                     /product="interleukin-33 isoform a precursor"
                     /protein_id="NP_254274.1"
                     /db_xref="CCDS:CCDS6468.1"
                     /db_xref="GeneID:90865"
                     /db_xref="HGNC:HGNC:16028"
                     /db_xref="MIM:608678"
                     /translation="MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYF
                     MKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQ
                     KYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVL
                     LSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFF
                     VLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET"
     exon            149..274
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            275..400
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            401..526
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            527..577
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            578..669
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            670..2685
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2662..2667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="major polyA site"
ORIGIN      
        1 acagagctgc agctcttcag ggaagaaatc aaaacaagat cacaagaata ctgaaaaatg
       61 aagcctaaaa tgaagtattc aaccaacaaa atttccacag caaagtggaa gaacacagca
      121 agcaaagcct tgtgtttcaa gctgggaaaa tcccaacaga aggccaaaga agtttgcccc
      181 atgtacttta tgaagctccg ctctggcctt atgataaaaa aggaggcctg ttactttagg
      241 agagaaacca ccaaaaggcc ttcactgaaa acaggtagaa agcacaaaag acatctggta
      301 ctcgctgcct gtcaacagca gtctactgtg gagtgctttg cctttggtat atcaggggtc
      361 cagaaatata ctagagcact tcatgattca agtatcacag gaatttcacc tattacagag
      421 tatcttgctt ctctaagcac atacaatgat caatccatta cttttgcttt ggaggatgaa
      481 agttatgaga tatatgttga agacttgaaa aaagatgaaa agaaagataa ggtgttactg
      541 agttactatg agtctcaaca cccctcaaat gaatcaggtg acggtgttga tggtaagatg
      601 ttaatggtaa ccctgagtcc tacaaaagac ttctggttgc atgccaacaa caaggaacac
      661 tctgtggagc tccataagtg tgaaaaacca ctgccagacc aggccttctt tgtccttcat
      721 aatatgcact ccaactgtgt ttcatttgaa tgcaagactg atcctggagt gtttataggt
      781 gtaaaggata atcatcttgc tctgattaaa gtagactctt ctgagaattt gtgtactgaa
      841 aatatcttgt ttaagctctc tgaaacttag ttgatggaaa cctgtgagtc ttgggttgag
      901 tacccaaatg ctaccactgg agaaggaatg agagataaag aaagagacag gtgacatcta
      961 agggaaatga agagtgctta gcatgtgtgg aatgttttcc atattatgta taaaaatatt
     1021 ttttctaatc ctccagttat tcttttattt ccctctgtat aactgcatct tcaatacaag
     1081 tatcagtata ttaaataggg tattggtaaa gaaacggtca acattctaaa gagatacagt
     1141 ctgaccttta cttttctcta gtttcagtcc agaaagaact tcatatttag agctaaggcc
     1201 actgaggaaa gagccatagc ttaagtctct atgtagacag ggatccattt taaagagcta
     1261 cttagagaaa taattttcca cagttccaaa cgataggctc aaacactaga gctgctagta
     1321 aaaagaagac cagatgcttc acagaattat cattttttca actggaataa aacaccaggt
     1381 ttgtttgtag atgtcttagg caacactcag agcagatctc ccttactgtc aggggatatg
     1441 gaacttcaaa ggcccacatg gcaagccagg taacataaat gtgtgaaaaa gtaaagataa
     1501 ctaaaaaatt tagaaaaata aatccagtat ttgtaaagtg aataacttca tttctaattg
     1561 tttaattttt aaaattctga tttttatata ttgagtttaa gcaaggcatt cttacacgag
     1621 gaagtgaagt aaattttagt tcagacataa aatttcactt attaggaata tgtaacatgc
     1681 taaaactttt ttttttttaa agagtactga gtcacaacat gttttagagc atccaagtac
     1741 catataatcc aactatcatg gtaaggccag aaatcttcta acctaccaga gcctagatga
     1801 gacaccgaat taacattaaa atttcagtaa ctgactgtcc ctcatgtcca tggcctacca
     1861 tcccttctga ccctggcttc cagggaccta tgtcttttaa tactcactgt cacattgggc
     1921 aaagttgctt ctaatcctta tttcccatgt gcacaagtct ttttgtattc cagcttcctg
     1981 ataacactgc ttactgtgga atattcattt gacatctgtc tcttttcatt tcttttaact
     2041 accatgccct tgatatatct tttgcacctg ctgaacttca tttctgtatc acctgacctc
     2101 tggatgccaa aacgtttatt ctgctttgtc tgttgtagaa ttttagataa agctattaat
     2161 ggcaatattt ttttgctaaa cgtttttgtt ttttactgtc actagggcaa taaaatttat
     2221 actcaaccat ataataacat tttttaacta ctaaaggagt agtttttatt ttaaagtctt
     2281 agcaatttct attacaactt ttcttagact taacacttat gataaatgac taacatagta
     2341 acagaatctt tatgaaatat gaccttttct gaaaatacat acttttacat ttctacttta
     2401 ttgagaccta ttagatgtaa gtgctagtag aatataagat aaaagaggct gagaattacc
     2461 atacaagggt attacaactg taaaacaatt tatctttgtt tcattgttct gtcaataatt
     2521 gttaccaaag agataaaaat aaaagcagaa tgtatatcat cccatctgaa aaacactaat
     2581 tattgacatg tgcatctgta caataaactt aaaatgatta ttaaataatc aaatatatct
     2641 actacattgt ttatattatt gaataaagta tattttccaa atgta
//
