LOCUS       NM_001314045            2701 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 33 (IL33), transcript variant 5, mRNA.
ACCESSION   NM_001314045 XM_005251626
VERSION     NM_001314045.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Alashkar Alhamwe,B., Ponath,V., Alhamdan,F., Dorsam,B.,
            Landwehr,C., Linder,M., Pauck,K., Miethe,S., Garn,H.,
            Finkernagel,F., Brichkina,A., Lauth,M., Tiwari,D.K., Buchholz,M.,
            Bachurski,D., Elmshauser,S., Nist,A., Stiewe,T., Pogge von
            Strandmann,L., Szymanski,W., Beutgen,V., Graumann,J.,
            Teply-Szymanski,J., Keber,C., Denkert,C., Jacob,R., Preusser,C. and
            Pogge von Strandmann,E.
  TITLE     BAG6 restricts pancreatic cancer progression by suppressing the
            release of IL33-presenting extracellular vesicles and the
            activation of mast cells
  JOURNAL   Cell Mol Immunol 21 (8), 918-931 (2024)
   PUBMED   38942797
  REMARK    GeneRIF: BAG6 restricts pancreatic cancer progression by
            suppressing the release of IL33-presenting extracellular vesicles
            and the activation of mast cells.
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Ruan,J., Tian,Q., Li,S., Zhou,X., Sun,Q., Wang,Y., Xiao,Y., Li,M.,
            Chang,K. and Yi,X.
  TITLE     The IL-33-ST2 axis plays a vital role in endometriosis via
            promoting epithelial-mesenchymal transition by phosphorylating
            beta-catenin
  JOURNAL   Cell Commun Signal 22 (1), 318 (2024)
   PUBMED   38858740
  REMARK    GeneRIF: The IL-33-ST2 axis plays a vital role in endometriosis via
            promoting epithelial-mesenchymal transition by phosphorylating
            beta-catenin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Wei,L., He,P., Tan,Z., Lin,C. and Wei,Z.
  TITLE     Comprehensively analysis of IL33 in hepatocellular carcinoma
            prognosis, immune microenvironment and biological role
  JOURNAL   J Cell Mol Med 28 (12), e18468 (2024)
   PUBMED   38923705
  REMARK    GeneRIF: Comprehensively analysis of IL33 in hepatocellular
            carcinoma prognosis, immune microenvironment and biological role.
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Perri,G., Vilas Boas,V.G., Nogueira,M.R.S., Mello Junior,E.J.F.,
            Coelho,A.L., Posadas,E.M., Hogaboam,C., Cavassani,K.A. and
            Campanelli,A.P.
  TITLE     Interleukin 33 supports squamous cell carcinoma growth via a dual
            effect on tumour proliferation, migration and invasion, and T cell
            activation
  JOURNAL   Cancer Immunol Immunother 73 (6), 110 (2024)
   PUBMED   38662248
  REMARK    GeneRIF: Interleukin 33 supports squamous cell carcinoma growth via
            a dual effect on tumour proliferation, migration and invasion, and
            T cell activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Liu,K., Huang,H., Xiong,M., Wang,Q., Chen,X., Feng,Y., Ma,H.,
            Chen,W., Li,X. and Ye,X.
  TITLE     IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis
            Mediated Autolysosomal Degradation of GKN1
  JOURNAL   Int J Biol Sci 20 (6), 2323-2338 (2024)
   PUBMED   38617533
  REMARK    GeneRIF: IL-33 Accelerates Chronic Atrophic Gastritis through
            AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Lock,F.E., Babaian,A., Zhang,Y., Gagnier,L., Kuah,S., Weberling,A.,
            Karimi,M.M. and Mager,D.L.
  TITLE     A novel isoform of IL-33 revealed by screening for transposable
            element promoted genes in human colorectal cancer
  JOURNAL   PLoS One 12 (7), e0180659 (2017)
   PUBMED   28715472
  REMARK    GeneRIF: LTR-IL-33 expression is required for optimal CRC cell line
            growth
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2701)
  AUTHORS   Schmitz,J., Owyang,A., Oldham,E., Song,Y., Murphy,E.,
            McClanahan,T.K., Zurawski,G., Moshrefi,M., Qin,J., Li,X.,
            Gorman,D.M., Bazan,J.F. and Kastelein,R.A.
  TITLE     IL-33, an interleukin-1-like cytokine that signals via the IL-1
            receptor-related protein ST2 and induces T helper type 2-associated
            cytokines
  JOURNAL   Immunity 23 (5), 479-490 (2005)
   PUBMED   16286016
  REMARK    GeneRIF: IL-33, which mediates its biological effects via IL-1
            receptor ST 2, activates NF-kappaB and MAP kinases, and drives
            production of T(H)2-associated cytokines from in vitro polarized
            T(H)2 cells
REFERENCE   8  (bases 1 to 2701)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 2701)
  AUTHORS   Baekkevold,E.S., Roussigne,M., Yamanaka,T., Johansen,F.E.,
            Jahnsen,F.L., Amalric,F., Brandtzaeg,P., Erard,M., Haraldsen,G. and
            Girard,J.P.
  TITLE     Molecular characterization of NF-HEV, a nuclear factor
            preferentially expressed in human high endothelial venules
  JOURNAL   Am J Pathol 163 (1), 69-79 (2003)
   PUBMED   12819012
  REMARK    GeneRIF: Results suggest that NF-HEV may be one of the key nuclear
            factors that controls the specialized phenotype of the lymphatic
            venule endothelium.
REFERENCE   10 (bases 1 to 2701)
  AUTHORS   Onda,H., Kasuya,H., Takakura,K., Hori,T., Imaizumi,T., Takeuchi,T.,
            Inoue,I. and Takeda,J.
  TITLE     Identification of genes differentially expressed in canine
            vasospastic cerebral arteries after subarachnoid hemorrhage
  JOURNAL   J Cereb Blood Flow Metab 19 (11), 1279-1288 (1999)
   PUBMED   10566975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA439244.1, AB024518.1 and
            AI610794.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001314045.1.
            
            Summary: The protein encoded by this gene is a cytokine that binds
            to the IL1RL1/ST2 receptor. The encoded protein is involved in the
            maturation of Th2 cells and the activation of mast cells,
            basophils, eosinophils and natural killer cells. Several transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.231646.1,
                                           SRR1803617.235861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               DA439244.1         1-555
            556-2267            AB024518.1         500-2211
            2268-2661           AB024518.1         2213-2606
            2662-2701           AI610794.1         13-52               c
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..2701
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="interleukin 33"
                     /db_xref="GeneID:90865"
                     /db_xref="HGNC:HGNC:16028"
                     /db_xref="MIM:608678"
     exon            1..62
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            63..164
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..886
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="isoform a precursor is encoded by transcript
                     variant 5; DVS27-related protein; nuclear factor for high
                     endothelial venules; nuclear factor from high endothelial
                     venules; interleukin-1 family member 11"
                     /codon_start=1
                     /product="interleukin-33 isoform a precursor"
                     /protein_id="NP_001300974.1"
                     /db_xref="CCDS:CCDS6468.1"
                     /db_xref="GeneID:90865"
                     /db_xref="HGNC:HGNC:16028"
                     /db_xref="MIM:608678"
                     /translation="MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYF
                     MKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQ
                     KYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVL
                     LSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFF
                     VLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET"
     exon            165..290
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            291..416
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            417..542
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            543..593
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            594..685
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2701
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="hexamer: AATAAA"
     polyA_site      2701
                     /gene="IL33"
                     /gene_synonym="C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV"
                     /note="major polyA site"
ORIGIN      
        1 aaatactaca attgctgact acaggaaacc tcatcatctg agaccagcac tttataaatt
       61 agaatactga aaaatgaagc ctaaaatgaa gtattcaacc aacaaaattt ccacagcaaa
      121 gtggaagaac acagcaagca aagccttgtg tttcaagctg ggaaaatccc aacagaaggc
      181 caaagaagtt tgccccatgt actttatgaa gctccgctct ggccttatga taaaaaagga
      241 ggcctgttac tttaggagag aaaccaccaa aaggccttca ctgaaaacag gtagaaagca
      301 caaaagacat ctggtactcg ctgcctgtca acagcagtct actgtggagt gctttgcctt
      361 tggtatatca ggggtccaga aatatactag agcacttcat gattcaagta tcacaggaat
      421 ttcacctatt acagagtatc ttgcttctct aagcacatac aatgatcaat ccattacttt
      481 tgctttggag gatgaaagtt atgagatata tgttgaagac ttgaaaaaag atgaaaagaa
      541 agataaggtg ttactgagtt actatgagtc tcaacacccc tcaaatgaat caggtgacgg
      601 tgttgatggt aagatgttaa tggtaaccct gagtcctaca aaagacttct ggttgcatgc
      661 caacaacaag gaacactctg tggagctcca taagtgtgaa aaaccactgc cagaccaggc
      721 cttctttgtc cttcataata tgcactccaa ctgtgtttca tttgaatgca agactgatcc
      781 tggagtgttt ataggtgtaa aggataatca tcttgctctg attaaagtag actcttctga
      841 gaatttgtgt actgaaaata tcttgtttaa gctctctgaa acttagttga tggaaacctg
      901 tgagtcttgg gttgagtacc caaatgctac cactggagaa ggaatgagag ataaagaaag
      961 agacaggtga catctaaggg aaatgaagag tgcttagcat gtgtggaatg ttttccatat
     1021 tatgtataaa aatatttttt ctaatcctcc agttattctt ttatttccct ctgtataact
     1081 gcatcttcaa tacaagtatc agtatattaa atagggtatt ggtaaagaaa cggtcaacat
     1141 tctaaagaga tacagtctga cctttacttt tctctagttt cagtccagaa agaacttcat
     1201 atttagagct aaggccactg aggaaagagc catagcttaa gtctctatgt agacagggat
     1261 ccattttaaa gagctactta gagaaataat tttccacagt tccaaacgat aggctcaaac
     1321 actagagctg ctagtaaaaa gaagaccaga tgcttcacag aattatcatt ttttcaactg
     1381 gaataaaaca ccaggtttgt ttgtagatgt cttaggcaac actcagagca gatctccctt
     1441 actgtcaggg gatatggaac ttcaaaggcc cacatggcaa gccaggtaac ataaatgtgt
     1501 gaaaaagtaa agataactaa aaaatttaga aaaataaatc cagtatttgt aaagtgaata
     1561 acttcatttc taattgttta atttttaaaa ttctgatttt tatatattga gtttaagcaa
     1621 ggcattctta cacgaggaag tgaagtaaat tttagttcag acataaaatt tcacttatta
     1681 ggaatatgta acatgctaaa actttttttt ttttaaagag tactgagtca caacatgttt
     1741 tagagcatcc aagtaccata taatccaact atcatggtaa ggccagaaat cttctaacct
     1801 accagagcct agatgagaca ccgaattaac attaaaattt cagtaactga ctgtccctca
     1861 tgtccatggc ctaccatccc ttctgaccct ggcttccagg gacctatgtc ttttaatact
     1921 cactgtcaca ttgggcaaag ttgcttctaa tccttatttc ccatgtgcac aagtcttttt
     1981 gtattccagc ttcctgataa cactgcttac tgtggaatat tcatttgaca tctgtctctt
     2041 ttcatttctt ttaactacca tgcccttgat atatcttttg cacctgctga acttcatttc
     2101 tgtatcacct gacctctgga tgccaaaacg tttattctgc tttgtctgtt gtagaatttt
     2161 agataaagct attaatggca atattttttt gctaaacgtt tttgtttttt actgtcacta
     2221 gggcaataaa atttatactc aaccatataa taacattttt taactactaa aggagtagtt
     2281 tttattttaa agtcttagca atttctatta caacttttct tagacttaac acttatgata
     2341 aatgactaac atagtaacag aatctttatg aaatatgacc ttttctgaaa atacatactt
     2401 ttacatttct actttattga gacctattag atgtaagtgc tagtagaata taagataaaa
     2461 gaggctgaga attaccatac aagggtatta caactgtaaa acaatttatc tttgtttcat
     2521 tgttctgtca ataattgtta ccaaagagat aaaaataaaa gcagaatgta tatcatccca
     2581 tctgaaaaac actaattatt gacatgtgca tctgtacaat aaacttaaaa tgattattaa
     2641 ataatcaaat atatctacta cattgtttat attattgaat aaagtatatt ttccaaatgt
     2701 a
//
