LOCUS       NM_139017               8239 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 31 receptor A (IL31RA), transcript variant
            1, mRNA.
ACCESSION   NM_139017
VERSION     NM_139017.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8239)
  AUTHORS   Akkenepally,S.V., Yombo,D.J.K., Yerubandi,S., Reddy,G.B.,
            Deshpande,D.A., McCormack,F.X. and Madala,S.K.
  TITLE     Interleukin 31 receptor alpha promotes smooth muscle cell
            contraction and airway hyperresponsiveness in asthma
  JOURNAL   Nat Commun 14 (1), 8207 (2023)
   PUBMED   38081868
  REMARK    GeneRIF: Interleukin 31 receptor alpha promotes smooth muscle cell
            contraction and airway hyperresponsiveness in asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8239)
  AUTHORS   Okuno,S., Hashimoto,T., Yamazaki,Y., Okuzawa,M. and Satoh,T.
  TITLE     IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more
            than just itch?
  JOURNAL   J Dermatol 50 (7), 927-930 (2023)
   PUBMED   36651089
  REMARK    GeneRIF: IL-31 and IL-31 receptor alpha in pemphigus: Contributors
            to more than just itch?
REFERENCE   3  (bases 1 to 8239)
  AUTHORS   Kuzumi,A., Yoshizaki,A., Matsuda,K.M., Kotani,H., Norimatsu,Y.,
            Fukayama,M., Ebata,S., Fukasawa,T., Yoshizaki-Ogawa,A., Asano,Y.,
            Morikawa,K., Kazoe,Y., Mawatari,K., Kitamori,T. and Sato,S.
  TITLE     Interleukin-31 promotes fibrosis and T helper 2 polarization in
            systemic sclerosis
  JOURNAL   Nat Commun 12 (1), 5947 (2021)
   PUBMED   34642338
  REMARK    GeneRIF: Interleukin-31 promotes fibrosis and T helper 2
            polarization in systemic sclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8239)
  AUTHORS   Medina-Cucurella,A.V., Bammert,G.F., Dunkle,W., Javens,C., Zhu,Y.,
            Mutchler,V.T., Teel,J.T., Stein,C.A., Dunham,S.A. and
            Whitehead,T.A.
  TITLE     Feline Interleukin-31 Shares Overlapping Epitopes with the
            Oncostatin M Receptor and IL-31RA
  JOURNAL   Biochemistry 59 (23), 2171-2181 (2020)
   PUBMED   32459958
  REMARK    GeneRIF: Feline Interleukin-31 Shares Overlapping Epitopes with the
            Oncostatin M Receptor and IL-31RA.
REFERENCE   5  (bases 1 to 8239)
  AUTHORS   Ferretti,E., Corcione,A. and Pistoia,V.
  TITLE     The IL-31/IL-31 receptor axis: general features and role in tumor
            microenvironment
  JOURNAL   J Leukoc Biol 102 (3), 711-717 (2017)
   PUBMED   28408397
  REMARK    GeneRIF: The first demonstration of the involvement of the
            IL-31/IL-31R axis in cancer came from studies in patients with
            mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T
            cell lymphoma. Tumor cells were shown to produce IL-31, whose serum
            levels correlated with pruritus intensity.
            Review article
REFERENCE   6  (bases 1 to 8239)
  AUTHORS   Dreuw,A., Radtke,S., Pflanz,S., Lippok,B.E., Heinrich,P.C. and
            Hermanns,H.M.
  TITLE     Characterization of the signaling capacities of the novel
            gp130-like cytokine receptor
  JOURNAL   J Biol Chem 279 (34), 36112-36120 (2004)
   PUBMED   15194700
  REMARK    GeneRIF: the molecular mechanisms underlying GPL-mediated signal
            transduction
REFERENCE   7  (bases 1 to 8239)
  AUTHORS   Dillon,S.R., Sprecher,C., Hammond,A., Bilsborough,J.,
            Rosenfeld-Franklin,M., Presnell,S.R., Haugen,H.S., Maurer,M.,
            Harder,B., Johnston,J., Bort,S., Mudri,S., Kuijper,J.L.,
            Bukowski,T., Shea,P., Dong,D.L., Dasovich,M., Grant,F.J.,
            Lockwood,L., Levin,S.D., LeCiel,C., Waggie,K., Day,H., Topouzis,S.,
            Kramer,J., Kuestner,R., Chen,Z., Foster,D., Parrish-Novak,J. and
            Gross,J.A.
  TITLE     Interleukin 31, a cytokine produced by activated T cells, induces
            dermatitis in mice
  JOURNAL   Nat Immunol 5 (7), 752-760 (2004)
   PUBMED   15184896
  REMARK    Erratum:[Nat Immunol. 2005 Jan;6(1):114]
REFERENCE   8  (bases 1 to 8239)
  AUTHORS   Diveu,C., Lelievre,E., Perret,D., Lak-Hal,A.H., Froger,J.,
            Guillet,C., Chevalier,S., Rousseau,F., Wesa,A., Preisser,L.,
            Chabbert,M., Gauchat,J.F., Galy,A., Gascan,H. and Morel,A.
  TITLE     GPL, a novel cytokine receptor related to GP130 and leukemia
            inhibitory factor receptor
  JOURNAL   J Biol Chem 278 (50), 49850-49859 (2003)
   PUBMED   14504285
  REMARK    GeneRIF: GPL is a novel cytokine receptor related to GP130 and
            leukemia inhibitory factor receptor
REFERENCE   9  (bases 1 to 8239)
  AUTHORS   Ghilardi,N., Li,J., Hongo,J.A., Yi,S., Gurney,A. and de
            Sauvage,F.J.
  TITLE     A novel type I cytokine receptor is expressed on monocytes, signals
            proliferation, and activates STAT-3 and STAT-5
  JOURNAL   J Biol Chem 277 (19), 16831-16836 (2002)
   PUBMED   11877449
  REMARK    GeneRIF: A novel type I cytokine receptor is expressed on
            monocytes, signals proliferation, and activates STAT-3 and STAT-5.
REFERENCE   10 (bases 1 to 8239)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008914.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 23, 2020 this sequence version replaced NM_139017.6.
            
            Summary: The protein encoded by this gene belongs to the type I
            cytokine receptor family. This receptor, with homology to gp130, is
            expressed on monocytes, and is involved in IL-31 signaling via
            activation of STAT-3 and STAT-5. It functions either as a monomer,
            or as part of a receptor complex with oncostatin M receptor (OSMR).
            Several alternatively spliced transcript variants encoding
            different isoforms have been noted for this gene.[provided by
            RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.739763.1,
                                           SRR14038197.1485099.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652347.2/ ENSP00000498630.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC008914.7         50222-50498
            278-368             AC008914.7         58374-58464
            369-486             AC008914.7         67656-67773
            487-668             AC008914.7         71135-71316
            669-820             AC008914.7         81909-82060
            821-986             AC008914.7         88835-89000
            987-1066            AC008914.7         95215-95294
            1067-1283           AC008914.7         98781-98997
            1284-1466           AC008914.7         104971-105153
            1467-1568           AC008914.7         106224-106325
            1569-1715           AC008914.7         107130-107276
            1716-1856           AC008914.7         109397-109537
            1857-1950           AC008914.7         112342-112435
            1951-2032           AC008914.7         113712-113793
            2033-8239           AC008914.7         115509-121715
FEATURES             Location/Qualifiers
     source          1..8239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..8239
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /note="interleukin 31 receptor A"
                     /db_xref="GeneID:133396"
                     /db_xref="HGNC:HGNC:18969"
                     /db_xref="MIM:609510"
     exon            1..277
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2509
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gp130-like monocyte receptor; soluble type I cytokine
                     receptor CRL3; class I cytokine receptor; IL-31R subunit
                     alpha; cytokine receptor-like 3; IL-31 receptor subunit
                     alpha"
                     /codon_start=1
                     /product="interleukin-31 receptor subunit alpha isoform 1"
                     /protein_id="NP_620586.3"
                     /db_xref="CCDS:CCDS3970.2"
                     /db_xref="GeneID:133396"
                     /db_xref="HGNC:HGNC:18969"
                     /db_xref="MIM:609510"
                     /translation="MCIRQLKFFTTACVCECPQNILSPQPSCVNLGMMWTWALWMLPS
                     LCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTT
                     NSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIF
                     RVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTY
                     NLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGR
                     RPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSM
                     ISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWF
                     PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKE
                     GVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSI
                     LQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLIL
                     IILTVAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRI
                     LKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPL
                     GKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEGAPNPY
                     LKNSVTAREFLVSEKLPEHTKGEV"
     exon            278..368
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            369..486
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            487..668
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            669..820
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            821..986
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1066
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1283
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1466
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1568
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1715
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1856
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1950
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2032
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..8239
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7815..7820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /note="hexamer: AATATA"
     polyA_site      7839
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
     regulatory      8220..8225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /note="hexamer: ATTAAA"
     polyA_site      8239
                     /gene="IL31RA"
                     /gene_synonym="CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R;
                     IL-31RA; PLCA2; PRO21384; zcytoR17"
                     /note="major polyA site"
ORIGIN      
        1 acagcctcct tctgcttagg aacaccagac agcactccag cactctgctt ggggggcatt
       61 cgaaacagca aaatcactca taaaaggcaa aaaattgcaa aaaaaaatag taataaccag
      121 catggcacta aatagaccat gaaaagacat gtgtgtgcag tatgaaaatt gagacaggaa
      181 ggcagagtgt cagcttgttc cacctcagct gggaatgtgc atcaggcaac tcaagttttt
      241 caccacggca tgtgtctgtg aatgtccgca aaacattctc tctccccagc cttcatgtgt
      301 taacctgggg atgatgtgga cctgggcact gtggatgctc ccctcactct gcaaattcag
      361 cctggcagct ctgccagcta agcctgagaa catttcctgt gtctactact ataggaaaaa
      421 tttaacctgc acttggagtc caggaaagga aaccagttat acccagtaca cagttaagag
      481 aacttacgct tttggagaaa aacatgataa ttgtacaacc aatagttcta caagtgaaaa
      541 tcgtgcttcg tgctcttttt tccttccaag aataacgatc ccagataatt ataccattga
      601 ggtggaagct gaaaatggag atggtgtaat taaatctcat atgacatact ggagattaga
      661 gaacatagcg aaaactgaac cacctaagat tttccgtgtg aaaccagttt tgggcatcaa
      721 acgaatgatt caaattgaat ggataaagcc tgagttggcg cctgtttcat ctgatttaaa
      781 atacacactt cgattcagga cagtcaacag taccagctgg atggaagtca acttcgctaa
      841 gaaccgtaag gataaaaacc aaacgtacaa cctcacgggg ctgcagcctt ttacagaata
      901 tgtcatagct ctgcgatgtg cggtcaagga gtcaaagttc tggagtgact ggagccaaga
      961 aaaaatggga atgactgagg aagaagctcc atgtggcctg gaactgtgga gagtcctgaa
     1021 accagctgag gcggatggaa gaaggccagt gcggttgtta tggaagaagg caagaggagc
     1081 cccagtccta gagaaaacac ttggctacaa catatggtac tatccagaaa gcaacactaa
     1141 cctcacagaa acaatgaaca ctactaacca gcagcttgaa ctgcatctgg gaggcgagag
     1201 cttttgggtg tctatgattt cttataattc tcttgggaag tctccagtgg ccaccctgag
     1261 gattccagct attcaagaaa aatcatttca gtgcattgag gtcatgcagg cctgcgttgc
     1321 tgaggaccag ctagtggtga agtggcaaag ctctgctcta gacgtgaaca cttggatgat
     1381 tgaatggttt ccggatgtgg actcagagcc caccaccctt tcctgggaat ctgtgtctca
     1441 ggccacgaac tggacgatcc agcaagataa attaaaacct ttctggtgct ataacatctc
     1501 tgtgtatcca atgttgcatg acaaagttgg cgagccatat tccatccagg cttatgccaa
     1561 agaaggcgtt ccatcagaag gtcctgagac caaggtggag aacattggcg tgaagacggt
     1621 cacgatcaca tggaaagaga ttcccaagag tgagagaaag ggtatcatct gcaactacac
     1681 catcttttac caagctgaag gtggaaaagg attctccaag acagtcaatt ccagcatctt
     1741 gcagtacggc ctggagtccc tgaaacgaaa gacctcttac attgttcagg tcatggccag
     1801 caccagtgct gggggaacca acgggaccag cataaatttc aagacattgt cattcagtgt
     1861 ctttgagatt atcctcataa cttctctgat tggtggaggc cttcttattc tcattatcct
     1921 gacagtggca tatggtctca aaaaacccaa caaattgact catctgtgtt ggcccaccgt
     1981 tcccaaccct gctgaaagta gtatagccac atggcatgga gatgatttca aggataagct
     2041 aaacctgaag gagtctgatg actctgtgaa cacagaagac aggatcttaa aaccatgttc
     2101 cacccccagt gacaagttgg tgattgacaa gttggtggtg aactttggga atgttctgca
     2161 agaaattttc acagatgaag ccagaacggg tcaggaaaac aatttaggag gggaaaagaa
     2221 tgggtatgtg acctgcccct tcaggcctga ttgtcccctg gggaaaagtt ttgaggagct
     2281 cccagtttca cctgagattc cgcccagaaa atcccaatac ctacgttcga ggatgccaga
     2341 ggggacccgc ccagaagcca aagagcagct tctcttttct ggtcaaagtt tagtaccaga
     2401 tcatctgtgt gaggaaggag ccccaaatcc atatttgaaa aattcagtga cagccaggga
     2461 atttcttgtg tctgaaaaac ttccagagca caccaaggga gaagtctaaa tgcgaccata
     2521 gcatgagacc ctcggggcct cagtgtggat ggcccttgcc agagaagatg tcaagactcg
     2581 gcacgcagcg cttgcttggc cctgccacat cctgcctagg ttaaagtttc ccctgcccct
     2641 tgagctgcca gttgaacttg gtcggcaaag atgcgacctt gtactgggaa gaagggatgg
     2701 tgataagccc gagttttgta aaggaacagc agtctctttt cgtttgttca gataccaagc
     2761 tctcaccgag gcctcctgac agattgactt tgaaggaagg gcccaggttc tgagcccaaa
     2821 ggacccccag ggtggacata tctggcctcc caggaattgg gtcatggtcc cagcctttgc
     2881 tggggctgag cctcagagtt ccagaaggcc tttccctgct gccagaggac agttgttttg
     2941 ttggctcttg ggtggtctgg tgggagcctg ggctctggtc ttcccctaca aggtagccct
     3001 gaagccttcc tctctcccca tagttggggc tggaggtgga gtggaccttc ctaaggggtt
     3061 gtctgaggct cctcacatcc tcttagatct caagtgcctg tagcaacacc gcacctgaga
     3121 atcctcaccc ccaatttaga ctgcattgac tactaaaaaa tcaaggaatg gggagggccc
     3181 tggggaatgt atgctgccgg gcgcagctct gtccagtctc cagggggcca cttcccagct
     3241 gctgctgccc ttctattcag cacccagcct gggagcagaa aggcacctga cattgcagtg
     3301 gttgtcatat agggacgctg gcccctcaca ctggttcaga gcccaggaat gcttacttaa
     3361 aaggcctctt cccggaagca gcagggcagg gcctgggaac atgcaatgcc tagcaaattt
     3421 gcagccccaa caggaggact tctgctcctt ttctctagct gagcacagag cttgtgacag
     3481 ttagtggagc ctttcacgaa agtgtggatt gctggcttca gcactgagat agtactgggc
     3541 tcctcctgta actatagtga cagagtcagc tgtgactccc ttgacctttg tgggaggcca
     3601 ctaggaggct ggtgagatca gggcaggcga ggcaatgagt gagtggccca aggtgcagtg
     3661 aacccagcac ttgccagcca ggaaggctga tggtattttt tctaggagag tttgaggaat
     3721 cagtactagg attgcaggca tgaacttcgc aagccaccca ctcaggtgtg caaaacatca
     3781 ctttactttc ctaaaactaa aattaattgc cagcctgaga cctgacactt caaagtaacc
     3841 tcagcccagt atgatgattt ctgagttgcc gtaggtttgt gactcagtca catttggggt
     3901 tttgccctcc cctgtcctgc ctgggactgg ctctgagtgc cgaggatgtt caatggcgca
     3961 gcgtgcatgg ggcagagttg gtcactcagt ggcatcctct gggtcatgta tttgtccggc
     4021 cgtgtttttg tctctggcct cgtgtgttta ctatggtccc tcctgtccct gttgggtcac
     4081 ctaccactta ccttagccaa ttgctgcctc gttactgtgg gcacaggaag gtgtggctgc
     4141 tctctcaaag ctctgtcctc ctaacatctc cagcggctgc agccaccccc ccaccaccca
     4201 cccaggactc agtactcctg gtttacggaa cagtgacttc tggtacacca aggaatgagg
     4261 gaggcccgag gcagggcact ggggaataag actctagggc aatgcccctg tcccgttgtc
     4321 ctgcactcaa gtccaggtgt aggaagggac caaacaaaag agatgcgtcc aattctcatg
     4381 ccgcccctga tgtctgctct ccctgctctc cctgttctcc accccttcta tggtgtgggc
     4441 tcttctgtga gcccactgtc cccagagttc cagatggggc ctttggcaac cccaccttca
     4501 gattcatgaa catatgggga gattctagcc ttgcctcctg tcttggcccg aggatggggg
     4561 agggcacggg tacccccaca gctgttcttt caaccctcct gcccacctgt agttggggga
     4621 attttctcaa attctgtggg aggtgggtga gaggagagcc tggaacaagt tctcccaaac
     4681 ttgtctgtct cacacctgga tgtagatgaa gcttctgaac ctaaaatcta agaatttgat
     4741 gggagagaaa atggatcccc aatggctcct gtgagtggat tccagagata aggatgttgc
     4801 cctctggccc ctgctccttc atcatcaaag ctggaagcgt cttttgctgg acaatttgca
     4861 aatccccacc cagcccttcc tgtttcattt cttctttcct ttctctcctc ttgcccctat
     4921 cttgtgcttt gttttccccc actgccagag cttctcatct tttaacactt gctattgttt
     4981 tcttgtttct tttcattcct ttctcccctt ccatcagcct cctttgatca ttttccatgg
     5041 ttttattacc tttgaggggt gggaagatgg tggctctgtt tctttctagg tgagaggagc
     5101 tgtttctatg agtccccaaa aggcactggt gggccacacc ttagctctcc tgagcaggtt
     5161 cacaggatgt gagcctcaga gttcagggcg caggtgactt cctctcctgg atcgagtcac
     5221 caactgtccc cgctctgggc accagggact gcctctgtgg ctggagaagg ccatctgtgt
     5281 tttccctgtt tactgtcaga gacattgtga ggacacaaac aggaagactt gtgttttagc
     5341 aaggttatta aaaatggata aaccagtttt ctgagaccct gggatccatg cagacagcta
     5401 ggttagtggc ctttctttaa cagtaagagc agaaaatttt taaagaatga cagagaaacc
     5461 agtctgtggc ttaaataaaa agaccacaag ttccttctgg tgtcttggga ggcagcggtg
     5521 tgaaaacacc acgcaagggt ctggaggagg caggagatgg ggagagatga aaaaggagag
     5581 gcccacagta tggatgcctc cggctgctct gctgatgctc tgtgtgcgag gaaagcctgt
     5641 gctggcctgt ccaccccagt ctgattctgt ccccatttcc agcacgcccc tagttactcc
     5701 tgctgcagca ggcaccctgc cacccagggc agtggcccac gggccaaatc caggccctgt
     5761 ttttgtaggt tcatgaacta aaagctataa tgacctattt aatggttgaa aacaaaaaga
     5821 ataacatttt gtgacaagaa aagtccaaga aattcacgta gtgttgacaa agtgtaattg
     5881 gaacacagcc atgcccatcg ttgacctatt ccctatggcg gcttgcccct acaaaggcag
     5941 agttgagtag tttcaacaca gagtttttcc cacaaagcag aaaacgttta ctctctgacc
     6001 ctttgcagaa aaaatttgtg gacgcctacc ataacccaca gacatgaaac tcagactgcc
     6061 actatgtttc aactttgaat tagctgcaaa ttaaaaagaa atcaggatat gtcattctga
     6121 atttctgacc aaataaggac tgccctcttt gaagggtgca cacacactta ctggttcccc
     6181 accagccctc ctaaattcct gtccccttcc catagctaag gtcgagagtt ggtggcttac
     6241 accagtggtc tttcaacagg agtgattttg acccccagcc tccaaacctc agacatttgg
     6301 tgatgcctgg agatattttt gattgtcacg actgggaagg tgctactggc atctagtggg
     6361 tagaggccgg caatgctgga aattatctta taatgcgcag aacagccctc acaacaaaga
     6421 attatctggc agaaaatgtc agcagtgctg aggctgagaa gtcgtggcct gaactaccct
     6481 ctgccttcta gatccacaca cagtgttcac atgggtgaga ctcccctcta ggtgtcccct
     6541 cttttttcta atttaaaatt tgttttaaat tcaactttac agcagtaatc ccaagagttt
     6601 taaatagcaa ttatttgtca tgcttaatta actcctaaca tgatctgtgt gcacctgtac
     6661 acatttttca gctaattgca aatcatactg aatacattat gttctcccat atataaaaat
     6721 tcatgcatga gcaaagcatt ttgaacatcc atgaaaaacc ccatggcggg cctgcatggt
     6781 gtggtttgct aaggcatccc ttggttgata ggattcgttt aaaggtcctc ctagtataga
     6841 gtgcaatgcg ataaacattt atcttttctt acctttgtcc tgtctctttg gggctgtttt
     6901 caaaagtgga attgctggtc agaattttat ggttgtcaca ttttgcgtga ctgtgtccca
     6961 tcaaaggtta tgctgattta cagtatcacc agacatgtct gacggatcct ttgtcctttt
     7021 ccactgagaa tcagctgtct accactgtga gcttgatttt gtcaatttat cgggaatagt
     7081 taatgaaact ttatagttat ttgtgttgct ttaatccttg tgaagccaaa cttttctttt
     7141 tttattgttg ccatgtccct gtgttgacat tacagaatgt tctctgcctc cgtgctcctg
     7201 gggacattga cagaccagct gagttgctag aaataagagg gactcagtag gcccttagca
     7261 cagcgggtgg actttgccat ttggttgact atttaaaata cttgtttttg tagggcatct
     7321 gaaaaagaaa tttcacactg gtgtattttg ttaattgttt ctacgtaaat gttgattatt
     7381 gacaagccta cttgtaatca aaatgtgtag tgtggtcagt gtcttgcact cttatgttgt
     7441 ggcggggggg gggggcggtt cctgaagagt ggagtgtgac taaggataac agcagtcctc
     7501 atttcctttg gacactgggg tcagtgggga gagagtttgc tccgaagcac aaacagctcc
     7561 aatccatgct ggaagagacc ccaggccaca atagcccttg acacagagct ctatgcaggg
     7621 ctgtgctgcc caagacgctt gtcgtgtgct gatgaaaagg gctggggaga agcaaggggc
     7681 aggggagggg cagaactcca caagagggca aaacctgctg tcagcaatgc tctcgtggct
     7741 gttcaaggga agtgagatac ttgtactatg catttcattt ttaggactag aattctgtct
     7801 tcctgcccaa cttcaatata agtgtggact aaaatgcgag aaaggtgtcc tgtggtctat
     7861 gcaaattaga aaggacatgc agagttttcc aactaggaag actgaatctg tggccccaag
     7921 agaaccatct ctgaagactg ggtatgtggt cttttccaca catggaccac ctacggatgc
     7981 aatctgtaat gcatgtgcat gagaagtctg ttattaagta gagtgtgaaa acatggttat
     8041 ggtaatagga acagctttta aaatgctttt gtatttgggc ctttcataca aaaaagccat
     8101 aataccattt tcatgtaatg ctatacttct atactatttt catgtaatac tatacttcta
     8161 tactattttc atgtaatact atacttctat actattttca tgtaatacta tacttctata
     8221 ttaaagtttt acccactca
//
