LOCUS       NM_001014336             927 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens interleukin 31 (IL31), mRNA.
ACCESSION   NM_001014336
VERSION     NM_001014336.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Lashin,S.E., Shaker,O.G., El-Tahlawi,S.M., Yousef,E.H. and
            Yaseen,S.M.
  TITLE     Interleukin 31 in vitiligo patients with and without pruritus
  JOURNAL   Acta Dermatovenerol Alp Pannonica Adriat 33 (3), 111-116 (2024)
   PUBMED   39324348
  REMARK    GeneRIF: Interleukin 31 in vitiligo patients with and without
            pruritus.
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Du,K., Zhang,M., Yao,S., Luo,T., Yu,H. and Lou,H.
  TITLE     The IL-31/CysLT2R axis is associated with itching in patients with
            allergic rhinitis
  JOURNAL   Int Forum Allergy Rhinol 14 (6), 1070-1078 (2024)
   PUBMED   38088514
  REMARK    GeneRIF: The IL-31/CysLT2R axis is associated with itching in
            patients with allergic rhinitis.
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Lee,S.G., Kim,S.E., Jeong,I.H. and Lee,S.E.
  TITLE     Mechanism underlying pruritus in recessive dystrophic epidermolysis
            bullosa: Role of interleukin-31 from mast cells and macrophages
  JOURNAL   J Eur Acad Dermatol Venereol 38 (5), 895-903 (2024)
   PUBMED   38084871
  REMARK    GeneRIF: Mechanism underlying pruritus in recessive dystrophic
            epidermolysis bullosa: Role of interleukin-31 from mast cells and
            macrophages.
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Wongjirattikarn,R., Chaisuriya,N., Chaowattanapanit,S.,
            Ungarreevittaya,P., Poosekeaw,P., Winaikosol,K., Choonhakarn,C.,
            Julanon,N., Utchariyaprasit,E. and Sawanyawisuth,K.
  TITLE     Increased tissue expression of IL-31 in patients with psoriasis
  JOURNAL   Cytokine 176, 156531 (2024)
   PUBMED   38301356
  REMARK    GeneRIF: Increased tissue expression of IL-31 in patients with
            psoriasis.
REFERENCE   5  (bases 1 to 927)
  AUTHORS   Metz,M.
  TITLE     Targeting Interleukin-31 in Prurigo
  JOURNAL   N Engl J Med 389 (17), 1619-1620 (2023)
   PUBMED   37888922
  REMARK    GeneRIF: Targeting Interleukin-31 in Prurigo.
REFERENCE   6  (bases 1 to 927)
  AUTHORS   Neis,M.M., Peters,B., Dreuw,A., Wenzel,J., Bieber,T., Mauch,C.,
            Krieg,T., Stanzel,S., Heinrich,P.C., Merk,H.F., Bosio,A.,
            Baron,J.M. and Hermanns,H.M.
  TITLE     Enhanced expression levels of IL-31 correlate with IL-4 and IL-13
            in atopic and allergic contact dermatitis
  JOURNAL   J Allergy Clin Immunol 118 (4), 930-937 (2006)
   PUBMED   17030248
REFERENCE   7  (bases 1 to 927)
  AUTHORS   Bilsborough,J., Leung,D.Y., Maurer,M., Howell,M., Boguniewicz,M.,
            Yao,L., Storey,H., LeCiel,C., Harder,B. and Gross,J.A.
  TITLE     IL-31 is associated with cutaneous lymphocyte antigen-positive skin
            homing T cells in patients with atopic dermatitis
  JOURNAL   J Allergy Clin Immunol 117 (2), 418-425 (2006)
   PUBMED   16461143
  REMARK    GeneRIF: IL-31 expression is associated with CLA(+) T cells and
            might contribute to the development of atopic dermatitis-induced
            skin inflammation and pruritus
            Erratum:[J Allergy Clin Immunol. 2006 May;117(5):1124. Boguniewcz,
            Mark [corrected to Boguniewicz, Mark]]
REFERENCE   8  (bases 1 to 927)
  AUTHORS   Sonkoly,E., Muller,A., Lauerma,A.I., Pivarcsi,A., Soto,H.,
            Kemeny,L., Alenius,H., Dieu-Nosjean,M.C., Meller,S., Rieker,J.,
            Steinhoff,M., Hoffmann,T.K., Ruzicka,T., Zlotnik,A. and Homey,B.
  TITLE     IL-31: a new link between T cells and pruritus in atopic skin
            inflammation
  JOURNAL   J Allergy Clin Immunol 117 (2), 411-417 (2006)
   PUBMED   16461142
  REMARK    GeneRIF: Significantly upregulated in pruritic atopic dermatitis.
            These findings provide a new link among staphylococcal
            colonization, subsequent T-cell recruitment/activation, and
            pruritus induction in patients with atopic dermatitis.
REFERENCE   9  (bases 1 to 927)
  AUTHORS   Takaoka,A., Arai,I., Sugimoto,M., Yamaguchi,A., Tanaka,M. and
            Nakaike,S.
  TITLE     Expression of IL-31 gene transcripts in NC/Nga mice with atopic
            dermatitis
  JOURNAL   Eur J Pharmacol 516 (2), 180-181 (2005)
   PUBMED   15925362
  REMARK    GeneRIF: Findings suggest that IL-31 may participate in the cause
            of itch sensation and promote scratching behavior in NC/Nga mice
            with atopic dermatitis.
REFERENCE   10 (bases 1 to 927)
  AUTHORS   Dillon,S.R., Sprecher,C., Hammond,A., Bilsborough,J.,
            Rosenfeld-Franklin,M., Presnell,S.R., Haugen,H.S., Maurer,M.,
            Harder,B., Johnston,J., Bort,S., Mudri,S., Kuijper,J.L.,
            Bukowski,T., Shea,P., Dong,D.L., Dasovich,M., Grant,F.J.,
            Lockwood,L., Levin,S.D., LeCiel,C., Waggie,K., Day,H., Topouzis,S.,
            Kramer,J., Kuestner,R., Chen,Z., Foster,D., Parrish-Novak,J. and
            Gross,J.A.
  TITLE     Interleukin 31, a cytokine produced by activated T cells, induces
            dermatitis in mice
  JOURNAL   Nat Immunol 5 (7), 752-760 (2004)
   PUBMED   15184896
  REMARK    Erratum:[Nat Immunol. 2005 Jan;6(1):114]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC048338.29 and AY499343.1.
            
            On May 17, 2019 this sequence version replaced NM_001014336.1.
            
            Summary: IL31, which is made principally by activated Th2-type T
            cells, interacts with a heterodimeric receptor consisting of IL31RA
            (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed
            on epithelial cells and keratinocytes. IL31 may be involved in the
            promotion of allergic skin disorders and in regulating other
            allergic diseases, such as asthma (Dillon et al., 2004 [PubMed
            15184896]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY499343.1, BC132998.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2148093,
                                           SAMEA2148874 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377035.2/ ENSP00000366234.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC048338.29        156311-156332
            23-926              AY499343.1         1-904
            927-927             AC048338.29        158503-158503
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..927
                     /gene="IL31"
                     /gene_synonym="IL-31"
                     /note="interleukin 31"
                     /db_xref="GeneID:386653"
                     /db_xref="HGNC:HGNC:19372"
                     /db_xref="MIM:609509"
     exon            1..65
                     /gene="IL31"
                     /gene_synonym="IL-31"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..544
                     /gene="IL31"
                     /gene_synonym="IL-31"
                     /codon_start=1
                     /product="interleukin-31 precursor"
                     /protein_id="NP_001014358.1"
                     /db_xref="CCDS:CCDS31919.1"
                     /db_xref="GeneID:386653"
                     /db_xref="HGNC:HGNC:19372"
                     /db_xref="MIM:609509"
                     /translation="MASHSGPSTSVLFLFCCLGGWLASHTLPVRLLRPSDDVQKIVEE
                     LQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKS
                     VIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQ
                     QATT"
     exon            66..214
                     /gene="IL31"
                     /gene_synonym="IL-31"
                     /inference="alignment:Splign:2.1.0"
     exon            215..927
                     /gene="IL31"
                     /gene_synonym="IL-31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catctggctc cagaagcccc cactgaagct ggccttgctc tctctcgcca tggcctctca
       61 ctcaggcccc tcgacgtctg tgctctttct gttctgctgc ctgggaggct ggctggcctc
      121 ccacacgttg cccgtccgtt tactacgacc aagtgatgat gtacagaaaa tagtcgagga
      181 attacagtcc ctctcgaaga tgcttttgaa agatgtggag gaagagaagg gcgtgctcgt
      241 gtcccagaat tacacgctgc cgtgtctcag ccctgacgcc cagccgccaa acaacatcca
      301 cagcccagcc atccgggcat atctcaagac aatcagacag ctagacaaca aatctgttat
      361 tgatgagatc atagagcacc tcgacaaact catatttcaa gatgcaccag aaacaaacat
      421 ttctgtgcca acagacaccc atgaatgtaa acgcttcatc ctgactattt ctcaacagtt
      481 ttcagagtgc atggacctcg cactaaaatc attgacctct ggagcccaac aggccaccac
      541 ttaaggccat ctcttccttt cggattggca ggaacttaag gagccttaaa aagatgaccg
      601 acagctaagt gtgggaactc tgccgtgatt ccttaagtac atttttccaa tgaataatct
      661 cagggacccc tcatatgggc tagtcccggg agggctgaga tgtgaatttg tgaattacct
      721 tgaaaaacat taggttattg ttattagtct tggtatttat ggaatgcttt tcttctgcag
      781 gcttaagtct tacttattat accctcgtga gggtgggagg tggcagctat gttaatttat
      841 tgatatttat tgtactaaga gttgtcaatg ctccctgggg gagccctcgg aatctattta
      901 ataaattata ttgaattttt ctcataa
//
