LOCUS       NM_000588                924 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens interleukin 3 (IL3), mRNA.
ACCESSION   NM_000588
VERSION     NM_000588.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Xu,W., Tian,F., Tai,X., Song,G., Liu,Y., Fan,L., Weng,X., Yang,E.,
            Wang,M., Bornhauser,M., Zhang,C., Lock,R.B., Wong,J.W.H., Wang,J.,
            Jing,D. and Mi,J.Q.
  TITLE     ETV6::ACSL6 translocation-driven super-enhancer activation leads to
            eosinophilia in acute lymphoblastic leukemia through IL-3
            overexpression
  JOURNAL   Haematologica 109 (8), 2445-2458 (2024)
   PUBMED   38356460
  REMARK    GeneRIF: ETV6::ACSL6 translocation-driven super-enhancer activation
            leads to eosinophilia in acute lymphoblastic leukemia through IL-3
            overexpression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Panwar,R., Shekhawat,R.S., Shukla,K.K., Rao,M., Rathore,M. and
            Kanchan,T.
  TITLE     Quantitative estimation of TNF-alpha and IL-3 by using ELISA from
            human lung tissue in fatal asphyxial deaths
  JOURNAL   J Forensic Leg Med 98, 102559 (2023)
   PUBMED   37453342
  REMARK    GeneRIF: Quantitative estimation of TNF-alpha and IL-3 by using
            ELISA from human lung tissue in fatal asphyxial deaths.
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Kiss,M.G., Mindur,J.E., Yates,A.G., Lee,D., Fullard,J.F., Anzai,A.,
            Poller,W.C., Christie,K.A., Iwamoto,Y., Roudko,V., Downey,J.,
            Chan,C.T., Huynh,P., Janssen,H., Ntranos,A., Hoffmann,J.D.,
            Jacob,W., Goswami,S., Singh,S., Leppert,D., Kuhle,J.,
            Kim-Schulze,S., Nahrendorf,M., Kleinstiver,B.P., Probert,F.,
            Roussos,P., Swirski,F.K. and McAlpine,C.S.
  TITLE     Interleukin-3 coordinates glial-peripheral immune crosstalk to
            incite multiple sclerosis
  JOURNAL   Immunity 56 (7), 1502-1514 (2023)
   PUBMED   37160117
  REMARK    GeneRIF: Interleukin-3 coordinates glial-peripheral immune
            crosstalk to incite multiple sclerosis.
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Fogha,J., de Brevern,A.G. and Diharce,J.
  TITLE     Conformational and binding mode assessment of the human IL-3
            recognition by its alpha receptor
  JOURNAL   Proteins 91 (7), 904-919 (2023)
   PUBMED   36729088
  REMARK    GeneRIF: Conformational and binding mode assessment of the human
            IL-3 recognition by its alpha receptor.
REFERENCE   5  (bases 1 to 924)
  AUTHORS   Benard,A., Hansen,F.J., Uhle,F., Klosch,B., Czubayko,F.,
            Mittelstadt,A., Jacobsen,A., David,P., Podolska,M.J., Anthuber,A.,
            Swierzy,I., Schaack,D., Muhl-Zurbes,P., Steinkasserer,A.,
            Weyand,M., Weigand,M.A., Brenner,T., Krautz,C., Grutzmann,R. and
            Weber,G.F.
  TITLE     Interleukin-3 protects against viral pneumonia in sepsis by
            enhancing plasmacytoid dendritic cell recruitment into the lungs
            and T cell priming
  JOURNAL   Front Immunol 14, 1140630 (2023)
   PUBMED   36911737
  REMARK    GeneRIF: Interleukin-3 protects against viral pneumonia in sepsis
            by enhancing plasmacytoid dendritic cell recruitment into the lungs
            and T cell priming.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 924)
  AUTHORS   Kitamura,T., Sato,N., Arai,K. and Miyajima,A.
  TITLE     Expression cloning of the human IL-3 receptor cDNA reveals a shared
            beta subunit for the human IL-3 and GM-CSF receptors
  JOURNAL   Cell 66 (6), 1165-1174 (1991)
   PUBMED   1833064
REFERENCE   7  (bases 1 to 924)
  AUTHORS   Wagemaker,G., Burger,H., van Gils,F.C., van Leen,R.W. and
            Wielenga,J.J.
  TITLE     Interleukin-3
  JOURNAL   Biotherapy 2 (4), 337-345 (1990)
   PUBMED   2268499
  REMARK    Review article
REFERENCE   8  (bases 1 to 924)
  AUTHORS   Urdal,D.L., Price,V., Sassenfeld,H.M., Cosman,D., Gillis,S. and
            Park,L.S.
  TITLE     Molecular characterization of colony-stimulating factors and their
            receptors: human interleukin-3
  JOURNAL   Ann N Y Acad Sci 554, 167-176 (1989)
   PUBMED   2544122
REFERENCE   9  (bases 1 to 924)
  AUTHORS   Otsuka,T., Miyajima,A., Brown,N., Otsu,K., Abrams,J., Saeland,S.,
            Caux,C., de Waal Malefijt,R., de Vries,J., Meyerson,P. et al.
  TITLE     Isolation and characterization of an expressible cDNA encoding
            human IL-3. Induction of IL-3 mRNA in human T cell clones
  JOURNAL   J Immunol 140 (7), 2288-2295 (1988)
   PUBMED   3127463
REFERENCE   10 (bases 1 to 924)
  AUTHORS   Yang,Y.C., Ciarletta,A.B., Temple,P.A., Chung,M.P., Kovacic,S.,
            Witek-Giannotti,J.S., Leary,A.C., Kriz,R., Donahue,R.E., Wong,G.G.
            et al.
  TITLE     Human IL-3 (multi-CSF): identification by expression cloning of a
            novel hematopoietic growth factor related to murine IL-3
  JOURNAL   Cell 47 (1), 3-10 (1986)
   PUBMED   3489530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034228.6.
            
            On May 17, 2019 this sequence version replaced NM_000588.3.
            
            Summary: The protein encoded by this gene is a potent growth
            promoting cytokine. This cytokine is capable of supporting the
            proliferation of a broad range of hematopoietic cell types. It is
            involved in a variety of cell activities such as cell growth,
            differentiation and apoptosis. This cytokine has been shown to also
            possess neurotrophic activity, and it may be associated with
            neurologic disorders. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17115.1, M20137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296870.3/ ENSP00000296870.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC034228.6         17767-17980         c
            215-256             AC034228.6         17627-17668         c
            257-346             AC034228.6         16234-16323         c
            347-388             AC034228.6         16068-16109         c
            389-924             AC034228.6         15431-15966         c
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..924
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /note="interleukin 3"
                     /db_xref="GeneID:3562"
                     /db_xref="HGNC:HGNC:6011"
                     /db_xref="MIM:147740"
     exon            1..214
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..511
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /note="hematopoietic growth factor; P-cell stimulating
                     factor; mast-cell growth factor;
                     multilineage-colony-stimulating factor; multipotential
                     colony-stimulating factor; colony-stimulating factor,
                     multiple"
                     /codon_start=1
                     /product="interleukin-3 precursor"
                     /protein_id="NP_000579.2"
                     /db_xref="CCDS:CCDS4149.1"
                     /db_xref="GeneID:3562"
                     /db_xref="HGNC:HGNC:6011"
                     /db_xref="MIM:147740"
                     /translation="MSRLPVLLLLQLLVRPGLQAPMTQTTPLKTSWVNCSNMIDEIIT
                     HLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLP
                     CLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF"
     exon            215..256
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            257..346
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            347..388
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            389..924
                     /gene="IL3"
                     /gene_synonym="IL-3; MCGF; MULTI-CSF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccccac gaaggaccag aacaagacag agtgcctcct gccgatccaa acatgagccg
       61 cctgcccgtc ctgctcctgc tccaactcct ggtccgcccc ggactccaag ctcccatgac
      121 ccagacaacg cccttgaaga caagctgggt taactgctct aacatgatcg atgaaattat
      181 aacacactta aagcagccac ctttgccttt gctggacttc aacaacctca atggggaaga
      241 ccaagacatt ctgatggaaa ataaccttcg aaggccaaac ctggaggcat tcaacagggc
      301 tgtcaagagt ttacagaacg catcagcaat tgagagcatt cttaaaaatc tcctgccatg
      361 tctgcccctg gccacggccg cacccacgcg acatccaatc catatcaagg acggtgactg
      421 gaatgaattc cggaggaaac tgacgttcta tctgaaaacc cttgagaatg cgcaggctca
      481 acagacgact ttgagcctcg cgatcttttg agtccaacgt ccagctcgtt ctctgggcct
      541 tctcaccaca gagcctcggg acatcaaaaa cagcagaact tctgaaacct ctgggtcatc
      601 tctcacacat tccaggacca gaagcatttc accttttcct gcggcatcag atgaattgtt
      661 aattatctaa tttctgaaat gtgcagctcc catttggcct tgtgcggttg tgttctcatt
      721 tttatcccat tgagactatt tatttatgta tgtatgtatt tatttattta ttgcctggag
      781 tgtgaactgt atttatttta gcagaggagc catgtcctgc tgcttctgca aaaaactcag
      841 agtggggtgg ggagcatgtt catttgtacc tcgagtttta aactggttcc tagggatgtg
      901 tgagaataaa ctagactctg aaca
//
