LOCUS       NM_000206               1480 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens interleukin 2 receptor subunit gamma (IL2RG), mRNA.
ACCESSION   NM_000206
VERSION     NM_000206.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Gharib,E., Rejali,L., Piroozkhah,M., Zonoobi,E., Nasrabadi,P.N.,
            Arabsorkhi,Z., Baghdar,K., Shams,E., Sadeghi,A., Kuppen,P.J.K.,
            Salehi,Z. and Nazemalhosseini-Mojarad,E.
  TITLE     IL-2RG as a possible immunotherapeutic target in CRC predicting
            poor prognosis and regulated by miR-7-5p and miR-26b-5p
  JOURNAL   J Transl Med 22 (1), 439 (2024)
   PUBMED   38720389
  REMARK    GeneRIF: IL-2RG as a possible immunotherapeutic target in CRC
            predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Liu,R., Zeng,L.W., Li,H.F., Shi,J.G., Zhong,B., Shu,H.B. and Li,S.
  TITLE     PD-1 signaling negatively regulates the common cytokine receptor
            gamma chain via MARCH5-mediated ubiquitination and degradation to
            suppress anti-tumor immunity
  JOURNAL   Cell Res 33 (12), 923-939 (2023)
   PUBMED   37932447
  REMARK    GeneRIF: PD-1 signaling negatively regulates the common cytokine
            receptor gamma chain via MARCH5-mediated ubiquitination and
            degradation to suppress anti-tumor immunity.
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Shim,J.A., Lee,S.M., Jeong,J.W., Kim,H., Son,W.J., Park,J.H.,
            Song,P., Im,S.H., Bae,S., Park,J.H., Jo,Y. and Hong,C.
  TITLE     NFAT1 and NFkappaB regulates expression of the common gamma-chain
            cytokine receptor in activated T cells
  JOURNAL   Cell Commun Signal 21 (1), 309 (2023)
   PUBMED   37904191
  REMARK    GeneRIF: NFAT1 and NFkappaB regulates expression of the common
            gamma-chain cytokine receptor in activated T cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Ohbo,K., Takasawa,N., Ishii,N., Tanaka,N., Nakamura,M. and
            Sugamura,K.
  TITLE     Functional analysis of the human interleukin 2 receptor gamma chain
            gene promoter
  JOURNAL   J Biol Chem 270 (13), 7479-7486 (1995)
   PUBMED   7706294
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Bamborough,P., Hedgecock,C.J. and Richards,W.G.
  TITLE     The interleukin-2 and interleukin-4 receptors studied by molecular
            modelling
  JOURNAL   Structure 2 (9), 839-851 (1994)
   PUBMED   7529123
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Puck,J.M., Deschenes,S.M., Porter,J.C., Dutra,A.S., Brown,C.J.,
            Willard,H.F. and Henthorn,P.S.
  TITLE     The interleukin-2 receptor gamma chain maps to Xq13.1 and is
            mutated in X-linked severe combined immunodeficiency, SCIDX1
  JOURNAL   Hum Mol Genet 2 (8), 1099-1104 (1993)
   PUBMED   8401490
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Noguchi,M., Adelstein,S., Cao,X. and Leonard,W.J.
  TITLE     Characterization of the human interleukin-2 receptor gamma chain
            gene
  JOURNAL   J Biol Chem 268 (18), 13601-13608 (1993)
   PUBMED   8514792
REFERENCE   8  (bases 1 to 1480)
  AUTHORS   Allenspach,E.J., Rawlings,D.J., Petrovic,A. and Chen,K.
  TITLE     X-Linked Severe Combined Immunodeficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301584
REFERENCE   9  (bases 1 to 1480)
  AUTHORS   Takeshita,T., Asao,H., Ohtani,K., Ishii,N., Kumaki,S., Tanaka,N.,
            Munakata,H., Nakamura,M. and Sugamura,K.
  TITLE     Cloning of the gamma chain of the human IL-2 receptor
  JOURNAL   Science 257 (5068), 379-382 (1992)
   PUBMED   1631559
REFERENCE   10 (bases 1 to 1480)
  AUTHORS   Burton,J., Goldman,C.K., Rao,P., Moos,M. and Waldmann,T.A.
  TITLE     Association of intercellular adhesion molecule 1 with the
            multichain high-affinity interleukin 2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7329-7333 (1990)
   PUBMED   1976256
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC345219.1 and BC014972.1.
            
            On Dec 4, 2019 this sequence version replaced NM_000206.2.
            
            Summary: The protein encoded by this gene is an important signaling
            component of many interleukin receptors, including those of
            interleukin -2, -4, -7 and -21, and is thus referred to as the
            common gamma chain. Mutations in this gene cause X-linked severe
            combined immunodeficiency (XSCID), as well as X-linked combined
            immunodeficiency (XCID), a less severe immunodeficiency disorder.
            [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014972.1, D11086.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374202.7/ ENSP00000363318.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DC345219.1         57-90
            35-1480             BC014972.1         1-1446
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1480
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /note="interleukin 2 receptor subunit gamma"
                     /db_xref="GeneID:3561"
                     /db_xref="HGNC:HGNC:6010"
                     /db_xref="MIM:308380"
     exon            1..153
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1148
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /note="common cytokine receptor gamma chain; cytokine
                     receptor common subunit gamma; CD132 antigen; gammaC;
                     IL-2R subunit gamma; IL-2 receptor subunit gamma;
                     nonfunctional common cytokine receptor gamma chain;
                     interleukin 2 receptor, gamma"
                     /codon_start=1
                     /product="cytokine receptor common subunit gamma
                     precursor"
                     /protein_id="NP_000197.1"
                     /db_xref="CCDS:CCDS14406.1"
                     /db_xref="GeneID:3561"
                     /db_xref="HGNC:HGNC:6010"
                     /db_xref="MIM:308380"
                     /translation="MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTT
                     MPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKC
                     SHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENL
                     TLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKR
                     YTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISL
                     LCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSE
                     IPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET"
     exon            154..307
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..492
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..632
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..795
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..892
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..962
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1480
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="IL2RG"
                     /gene_synonym="CD132; CIDX; IL-2RG; IMD4; P64; SCIDX;
                     SCIDX1"
                     /note="major polyA site"
ORIGIN      
        1 acagacagac tacacccagg gaatgaagag caagcgccat gttgaagcca tcattaccat
       61 tcacatccct cttattcctg cagctgcccc tgctgggagt ggggctgaac acgacaattc
      121 tgacgcccaa tgggaatgaa gacaccacag ctgatttctt cctgaccact atgcccactg
      181 actccctcag tgtttccact ctgcccctcc cagaggttca gtgttttgtg ttcaatgtcg
      241 agtacatgaa ttgcacttgg aacagcagct ctgagcccca gcctaccaac ctcactctgc
      301 attattggta caagaactcg gataatgata aagtccagaa gtgcagccac tatctattct
      361 ctgaagaaat cacttctggc tgtcagttgc aaaaaaagga gatccacctc taccaaacat
      421 ttgttgttca gctccaggac ccacgggaac ccaggagaca ggccacacag atgctaaaac
      481 tgcagaatct ggtgatcccc tgggctccag agaacctaac acttcacaaa ctgagtgaat
      541 cccagctaga actgaactgg aacaacagat tcttgaacca ctgtttggag cacttggtgc
      601 agtaccggac tgactgggac cacagctgga ctgaacaatc agtggattat agacataagt
      661 tctccttgcc tagtgtggat gggcagaaac gctacacgtt tcgtgttcgg agccgcttta
      721 acccactctg tggaagtgct cagcattgga gtgaatggag ccacccaatc cactggggga
      781 gcaatacttc aaaagagaat cctttcctgt ttgcattgga agccgtggtt atctctgttg
      841 gctccatggg attgattatc agccttctct gtgtgtattt ctggctggaa cggacgatgc
      901 cccgaattcc caccctgaag aacctagagg atcttgttac tgaataccac gggaactttt
      961 cggcctggag tggtgtgtct aagggactgg ctgagagtct gcagccagac tacagtgaac
     1021 gactctgcct cgtcagtgag attcccccaa aaggaggggc ccttggggag gggcctgggg
     1081 cctccccatg caaccagcat agcccctact gggccccccc atgttacacc ctaaagcctg
     1141 aaacctgaac cccaatcctc tgacagaaga accccagggt cctgtagccc taagtggtac
     1201 taactttcct tcattcaacc cacctgcgtc tcatactcac ctcaccccac tgtggctgat
     1261 ttggaatttt gtgcccccat gtaagcaccc cttcatttgg cattccccac ttgagaatta
     1321 cccttttgcc ccgaacatgt ttttcttctc cctcagtctg gcccttcctt ttcgcaggat
     1381 tcttcctccc tccctctttc cctcccttcc tctttccatc taccctccga ttgttcctga
     1441 accgatgaga aataaagttt ctgttgataa tcatcaaaaa
//
