LOCUS       NM_000878               4034 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens interleukin 2 receptor subunit beta (IL2RB),
            transcript variant 1, mRNA.
ACCESSION   NM_000878
VERSION     NM_000878.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4034)
  AUTHORS   Zhou,J., Zhang,Y. and Zhuang,Q.
  TITLE     IL2RB affects Th1/Th2 and Th17 responses of peripheral blood
            mononuclear cells from septic patients
  JOURNAL   Allergol Immunopathol (Madr) 51 (3), 1-7 (2023)
   PUBMED   37169553
  REMARK    GeneRIF: IL2RB affects Th1/Th2 and Th17 responses of peripheral
            blood mononuclear cells from septic patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4034)
  AUTHORS   Liao,Y., Ke,B., Long,X., Xu,J. and Wu,Y.
  TITLE     Upregulated Expression of IL2RB Causes Disorder of Immune
            Microenvironment in Patients with Kawasaki Disease
  JOURNAL   Biomed Res Int 2022, 2114699 (2022)
   PUBMED   35924269
  REMARK    GeneRIF: Upregulated Expression of IL2RB Causes Disorder of Immune
            Microenvironment in Patients with Kawasaki Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4034)
  AUTHORS   Gao,H., Wang,L., Ren,J., Liu,Y., Liang,S., Zhang,B. and Sun,X.
  TITLE     Interleukin 2 receptor subunit beta as a novel hub gene plays a
            potential role in the immune microenvironment of abdominal aortic
            aneurysms
  JOURNAL   Gene 827, 146472 (2022)
   PUBMED   35381314
  REMARK    GeneRIF: Interleukin 2 receptor subunit beta as a novel hub gene
            plays a potential role in the immune microenvironment of abdominal
            aortic aneurysms.
REFERENCE   4  (bases 1 to 4034)
  AUTHORS   Gatselis,N.K., Lygoura,V., Lyberopoulou,A., Giannoulis,G.,
            Samakidou,A., Vaiou,A., Vatidis,G., Antoniou,K., Stefos,A.,
            Georgiadou,S., Sagris,D., Sveroni,D., Stergioula,D., Gabeta,S.,
            Ntaios,G. and Dalekos,G.N.
  TITLE     Soluble IL-2R Levels at Baseline Predict the Development of Severe
            Respiratory Failure and Mortality in COVID-19 Patients
  JOURNAL   Viruses 14 (4), 787 (2022)
   PUBMED   35458517
  REMARK    GeneRIF: Soluble IL-2R Levels at Baseline Predict the Development
            of Severe Respiratory Failure and Mortality in COVID-19 Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4034)
  AUTHORS   Luo,K., Chen,Y., Yang,J., Tao,Q. and Luo,M.
  TITLE     Liver Injury and Elevated Levels of Interleukins, Interleukin-2
            Receptor, and Interleukin-6 Predict the Severity in Patients With
            COVID-19
  JOURNAL   Front Public Health 9, 778340 (2021)
   PUBMED   34970527
  REMARK    GeneRIF: Liver Injury and Elevated Levels of Interleukins,
            Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in
            Patients With COVID-19.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4034)
  AUTHORS   Cohen,C.J., Rebollo,R., Babovic,S., Dai,E.L., Robinson,W.P. and
            Mager,D.L.
  TITLE     Placenta-specific expression of the interleukin-2 (IL-2) receptor
            beta subunit from an endogenous retroviral promoter
  JOURNAL   J Biol Chem 286 (41), 35543-35552 (2011)
   PUBMED   21865161
  REMARK    GeneRIF: LTR of the THE1D retroelement family has been domesticated
            as an alternative promoter of human IL2RB, the gene encoding the
            beta subunit of the IL-2 receptor.
REFERENCE   7  (bases 1 to 4034)
  AUTHORS   Purvis,S.F., Georges,D.L., Williams,T.M. and Lederman,M.M.
  TITLE     Suppression of interleukin-2 and interleukin-2 receptor expression
            in Jurkat cells stably expressing the human immunodeficiency virus
            Tat protein
  JOURNAL   Cell Immunol 144 (1), 32-42 (1992)
   PUBMED   1394441
REFERENCE   8  (bases 1 to 4034)
  AUTHORS   Maslinski,W., Remillard,B., Tsudo,M. and Strom,T.B.
  TITLE     Interleukin-2 (IL-2) induces tyrosine kinase-dependent
            translocation of active raf-1 from the IL-2 receptor into the
            cytosol
  JOURNAL   J Biol Chem 267 (22), 15281-15284 (1992)
   PUBMED   1639773
REFERENCE   9  (bases 1 to 4034)
  AUTHORS   Torigoe,T., Saragovi,H.U. and Reed,J.C.
  TITLE     Interleukin 2 regulates the activity of the lyn protein-tyrosine
            kinase in a B-cell line
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2674-2678 (1992)
   PUBMED   1557373
REFERENCE   10 (bases 1 to 4034)
  AUTHORS   Miyazaki,T., Maruyama,M., Yamada,G., Hatakeyama,M. and Taniguchi,T.
  TITLE     The integrity of the conserved 'WS motif' common to IL-2 and other
            cytokine receptors is essential for ligand binding and signal
            transduction
  JOURNAL   EMBO J 10 (11), 3191-3197 (1991)
   PUBMED   1915291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312860.1, AL022314.1 and
            AA834613.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000878.4.
            
            Summary: The interleukin 2 receptor, which is involved in T
            cell-mediated immune responses, is present in 3 forms with respect
            to ability to bind interleukin 2. The low affinity form is a
            monomer of the alpha subunit and is not involved in signal
            transduction. The intermediate affinity form consists of an
            alpha/beta subunit heterodimer, while the high affinity form
            consists of an alpha/beta/gamma subunit heterotrimer. Both the
            intermediate and high affinity forms of the receptor are involved
            in receptor-mediated endocytosis and transduction of mitogenic
            signals from interleukin 2. The protein encoded by this gene
            represents the beta subunit and is a type I membrane protein. The
            use of alternative promoters results in multiple transcript
            variants encoding the same protein. The protein is primarily
            expressed in the hematopoietic system. The use by some variants of
            an alternate promoter in an upstream long terminal repeat (LTR)
            results in placenta-specific expression. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312860.1, M26062.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216223.10/ ENSP00000216223.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1781              AK312860.1         1-1781
            1782-4030           AL022314.1         78527-80775         c
            4031-4034           AA834613.1         11-14               c
FEATURES             Location/Qualifiers
     source          1..4034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..4034
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /note="interleukin 2 receptor subunit beta"
                     /db_xref="GeneID:3560"
                     /db_xref="HGNC:HGNC:6009"
                     /db_xref="MIM:146710"
     exon            1..92
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            93..213
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1781
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /note="interleukin 15 receptor, beta; high affinity IL-2
                     receptor beta subunit; CD122 antigen; p75; IL-2RB; IL-2R
                     subunit beta; IL-2 receptor subunit beta; interleukin-15
                     receptor subunit beta; high affinity IL-2 receptor subunit
                     beta; interleukin 2 receptor, beta"
                     /codon_start=1
                     /product="interleukin-2 receptor subunit beta precursor"
                     /protein_id="NP_000869.1"
                     /db_xref="CCDS:CCDS13942.1"
                     /db_xref="GeneID:3560"
                     /db_xref="HGNC:HGNC:6009"
                     /db_xref="MIM:146710"
                     /translation="MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANI
                     SCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVD
                     IVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHY
                     FERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFT
                     TWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKK
                     VLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVT
                     QLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDP
                     DEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGA
                     GEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREG
                     VSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV"
     exon            214..328
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            329..407
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            408..513
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            514..662
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            663..828
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            829..943
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1028
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..4034
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3999..4004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /note="hexamer: AATAAA"
     polyA_site      4034
                     /gene="IL2RB"
                     /gene_synonym="CD122; IL15RB; IMD63; P70-75"
                     /note="major polyA site"
ORIGIN      
        1 agagctcagc agggccctgg agagatggcc acggtcccag caccggggag gactggagag
       61 cgcgcgctgc caccgcccca tgtctcagcc agggcttcct tcctcggctc caccctgtgg
      121 atgtaatggc ggcccctgct ctgtcctggc gtctgcccct cctcatcctc ctcctgcccc
      181 tggctacctc ttgggcatct gcagcggtga atggcacttc ccagttcaca tgcttctaca
      241 actcgagagc caacatctcc tgtgtctgga gccaagatgg ggctctgcag gacacttcct
      301 gccaagtcca tgcctggccg gacagacggc ggtggaacca aacctgtgag ctgctccccg
      361 tgagtcaagc atcctgggcc tgcaacctga tcctcggagc cccagattct cagaaactga
      421 ccacagttga catcgtcacc ctgagggtgc tgtgccgtga gggggtgcga tggagggtga
      481 tggccatcca ggacttcaag ccctttgaga accttcgcct gatggccccc atctccctcc
      541 aagttgtcca cgtggagacc cacagatgca acataagctg ggaaatctcc caagcctccc
      601 actactttga aagacacctg gagttcgagg cccggacgct gtccccaggc cacacctggg
      661 aggaggcccc cctgctgact ctcaagcaga agcaggaatg gatctgcctg gagacgctca
      721 ccccagacac ccagtatgag tttcaggtgc gggtcaagcc tctgcaaggc gagttcacga
      781 cctggagccc ctggagccag cccctggcct tcaggacaaa gcctgcagcc cttgggaagg
      841 acaccattcc gtggctcggc cacctcctcg tgggcctcag cggggctttt ggcttcatca
      901 tcttagtgta cttgctgatc aactgcagga acaccgggcc atggctgaag aaggtcctga
      961 agtgtaacac cccagacccc tcgaagttct tttcccagct gagctcagag catggaggag
     1021 acgtccagaa gtggctctct tcgcccttcc cctcatcgtc cttcagccct ggcggcctgg
     1081 cacctgagat ctcgccacta gaagtgctgg agagggacaa ggtgacgcag ctgctcctgc
     1141 agcaggacaa ggtgcctgag cccgcatcct taagcagcaa ccactcgctg accagctgct
     1201 tcaccaacca gggttacttc ttcttccacc tcccggatgc cttggagata gaggcctgcc
     1261 aggtgtactt tacttacgac ccctactcag aggaagaccc tgatgagggt gtggccgggg
     1321 cacccacagg gtcttccccc caacccctgc agcctctgtc aggggaggac gacgcctact
     1381 gcaccttccc ctccagggat gacctgctgc tcttctcccc cagtctcctc ggtggcccca
     1441 gccccccaag cactgcccct gggggcagtg gggccggtga agagaggatg cccccttctt
     1501 tgcaagaaag agtccccaga gactgggacc cccagcccct ggggcctccc accccaggag
     1561 tcccagacct ggtggatttt cagccacccc ctgagctggt gctgcgagag gctggggagg
     1621 aggtccctga cgctggcccc agggagggag tcagtttccc ctggtccagg cctcctgggc
     1681 agggggagtt cagggccctt aatgctcgcc tgcccctgaa cactgatgcc tacttgtccc
     1741 tccaagaact ccagggtcag gacccaactc acttggtgta gacagatggc cagggtggga
     1801 ggcaggcagc tgcctgctct gcgccgagcc tcagaaggac cctgttgagg gtcctcagtc
     1861 cactgctgag gacactcagt gtccagttgc agctggactt ctccacccgg atggccccca
     1921 cccagtcctg cacacttggt ccatccattt ccaaacctcc actgctgctc ccgggtcctg
     1981 ctgcccgagc caggaactgt gtgtgttgca ggggggcagt aactccccaa ctccctcgtt
     2041 aatcacagga tcccacgaat ttaggctcag aagcatcgct cctctccagc cctgcagcta
     2101 ttcaccaata tcagtcctcg cggctctcca gggctccctg ccctgacctc ttccctgggt
     2161 tttctgcccc agcctcctcc ttccctcccc tccccgtcca cagggcagcc tgagcgtgct
     2221 ttccaaaacc caaatatggc cacgctcccc ctcggttcaa aaccttgcac aggtcccact
     2281 gccctcagcc ccacttctca gcctggtact tgtacctccg gtgtcgtgtg gggacatccc
     2341 cttctgcaat cctccctacc gtcctcctga gccactcaga gctccctcac accccctctg
     2401 ttgcacatgc tattccctgg ggctgctgtg cgctccccct catctaggtg acaaacttcc
     2461 ctgactcttc aagtgccggt tttgcttctc ctggagggaa gcactgcctc ccttaatctg
     2521 ccagaaactt ctagcgtcag tgctggaggg agaagctgtc agggacccag ggcgcctgga
     2581 gaaagaggcc ctgttactat tcctttggga tctctgaggc ctcagagtgc ttggctgctg
     2641 tatctttaat gctggggccc aagtaagggc acagatcccc ccacaaagtg gatgcctgct
     2701 gcatcttccc acagtggctt cacagaccca caagagaagc tgatggggag taaaccctgg
     2761 agtccgaggc ccaggcagca gccccgccta gtggtgggcc ctgatgctgc caggcctggg
     2821 acctcccact gccccctcca ctggaggggt ctcctctgca gctcagggac tggcacactg
     2881 gcctccagaa gggcagctcc acagggcagg gcctcattat ttttcactgc cccagacaca
     2941 gtgcccaaca ccccgtcgta taccctggat gaacgaatta attacctggc accacctcgt
     3001 ctgggctccc tgcgcctgac attcacacag agaggcagag tcccgtgccc attaggtctg
     3061 gcatgccccc tcctgcaagg ggctcaaccc cctaccccga cccctccacg tatctttcct
     3121 aggcagatca cgttgcaatg gctcaaacaa cattccaccc cagcaggaca gtgaccccag
     3181 tcccagctaa ctctgacctg ggagccctca ggcacctgca cttacaggcc ttgctcacag
     3241 ctgattgggc acctgaccac acgcccccac aggctctgac cagcagccta tgagggggtt
     3301 tggcaccaag ctctgtccaa tcaggtaggc tgggcctgaa ctagccaatc agatcaactc
     3361 tgtcttgggc gtttgaactc agggagggag gcccttggga gcaggtgctt gtggacaagg
     3421 ctccacaagc gttgagcctt ggaaaggtag acaagcgttg agccactaag cagaggacct
     3481 tgggttccca atacaaaaat acctactgct gagagggctg ctgaccattt ggtcaggatt
     3541 cctgttgcct ttatatccaa aataaactcc cctttcttga ggttgtctga gtcttgggtc
     3601 tatgccttga aaaaagctga attattggac agtctcacct cctgccatag ggtcctgaat
     3661 gtttcagacc acaaggggct ccacaccttt gctgtgtgtt ctggggcaac ctactaatcc
     3721 tctctgcaag tcggtctcct tatcccccca aatggaaatt gtatttgcct tctccacttt
     3781 gggaggctcc cacttcttgg gagggttaca ttttttaagt cttaatcatt tgtgacatat
     3841 gtatctatac atccgtatct tttaatgatc cgtgtgtacc atctttgtga ttatttcctt
     3901 aatatttttt ctttaagtca gttcattttc gttgaaatac atttatttaa agaaaaatct
     3961 ttgttactct gtaaatgaaa aaacccattt tcgctataaa taaaaggtaa ctgtacaaaa
     4021 taagtacaat gcaa
//
