LOCUS       NM_000417               3218 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens interleukin 2 receptor subunit alpha (IL2RA),
            transcript variant 1, mRNA.
ACCESSION   NM_000417
VERSION     NM_000417.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Andrabi,S.B.A., Kalim,U.U., Palani,S., Khan,M.M., Khan,M.H.,
            Fagersund,J., Orpana,J., Paulin,N., Batkulwar,K., Junttila,S.,
            Buchacher,T., Gronroos,T., Toikka,L., Ammunet,T., Sen,P.,
            Oresic,M., Kumpulainen,V., Tuomisto,J.E.E., Sinha,R., Marson,A.,
            Rasool,O., Elo,L.L. and Lahesmaa,R.
  TITLE     Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive
            function of human CD4+ regulatory T cells by regulating IL2RA
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2315363121 (2024)
   PUBMED   38805281
  REMARK    GeneRIF: Long noncoding RNA LIRIL2R modulates FOXP3 levels and
            suppressive function of human CD4[+] regulatory T cells by
            regulating IL2RA.
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Lokau,J., Petasch,L.M. and Garbers,C.
  TITLE     The soluble IL-2 receptor alpha/CD25 as a modulator of IL-2
            function
  JOURNAL   Immunology 171 (3), 377-387 (2024)
   PUBMED   38037265
  REMARK    GeneRIF: The soluble IL-2 receptor alpha/CD25 as a modulator of
            IL-2 function.
            Review article
REFERENCE   3  (bases 1 to 3218)
  AUTHORS   Tishe,Z.H., Shawkat,S., Popy,M.N., Ahmed,A., Mumu,S.B., Apu,M.N.H.
            and Mostaid,M.S.
  TITLE     Interleukin gene polymorphisms and alopecia areata: A systematic
            review and meta-analysis
  JOURNAL   Medicine (Baltimore) 103 (8), e37300 (2024)
   PUBMED   38394507
  REMARK    GeneRIF: Interleukin gene polymorphisms and alopecia areata: A
            systematic review and meta-analysis.
REFERENCE   4  (bases 1 to 3218)
  AUTHORS   Ozdilli,K., Mervan Aytac,H., Ceren Tuncel,F., Oyaci,Y., Pehlivan,M.
            and Pehlivan,S.
  TITLE     Evaluation of gene-gene interaction between the interleukin (IL)-2
            and IL-2RA gene polymorphisms in schizophrenia patients in the
            Turkish Population
  JOURNAL   Neurosciences (Riyadh) 29 (1), 51-56 (2024)
   PUBMED   38195135
  REMARK    GeneRIF: Evaluation of gene-gene interaction between the
            interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia
            patients in the Turkish Population.
REFERENCE   5  (bases 1 to 3218)
  AUTHORS   Pehlivan,S., Aytac,H.M., Nursal,A.F., Tuncel,F.C. and Pehlivan,M.
  TITLE     IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated
            with bipolar disorder and its clinical findings
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (5), 441-452 (2024)
   PUBMED   37843874
  REMARK    GeneRIF: IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be
            associated with bipolar disorder and its clinical findings.
REFERENCE   6  (bases 1 to 3218)
  AUTHORS   Wang,F., Hou,H., Wang,T., Luo,Y., Tang,G., Wu,S., Zhou,H. and
            Sun,Z.
  TITLE     Establishing a model for predicting the outcome of COVID-19 based
            on combination of laboratory tests
  JOURNAL   Travel Med Infect Dis 36, 101782 (2020)
   PUBMED   32526372
REFERENCE   7  (bases 1 to 3218)
  AUTHORS   Purvis,S.F., Georges,D.L., Williams,T.M. and Lederman,M.M.
  TITLE     Suppression of interleukin-2 and interleukin-2 receptor expression
            in Jurkat cells stably expressing the human immunodeficiency virus
            Tat protein
  JOURNAL   Cell Immunol 144 (1), 32-42 (1992)
   PUBMED   1394441
REFERENCE   8  (bases 1 to 3218)
  AUTHORS   Carter,C.R., Hancock,B.W. and Rees,R.C.
  TITLE     The augmentation of lymphokine-activated killer activity following
            pulsing of human peripheral blood mononuclear cells with
            recombinant human interleukin-2
  JOURNAL   Cancer Immunol Immunother 35 (4), 264-270 (1992)
   PUBMED   1511461
REFERENCE   9  (bases 1 to 3218)
  AUTHORS   Kanegane,H., Miyawaki,T., Kato,K., Yokoi,T., Uehara,T., Yachie,A.
            and Taniguchi,N.
  TITLE     A novel subpopulation of CD45RA+ CD4+ T cells expressing IL-2
            receptor alpha-chain (CD25) and having a functionally transitional
            nature into memory cells
  JOURNAL   Int Immunol 3 (12), 1349-1356 (1991)
   PUBMED   1685671
REFERENCE   10 (bases 1 to 3218)
  AUTHORS   Kuziel,W.A. and Greene,W.C.
  TITLE     Interleukin-2 and the IL-2 receptor: new insights into structure
            and function
  JOURNAL   J Invest Dermatol 94 (6 Suppl), 27S-32S (1990)
   PUBMED   1693645
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157395.17, X01057.1 and
            AL137186.18.
            
            On Aug 31, 2019 this sequence version replaced NM_000417.2.
            
            Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta
            (IL2RB) chains, together with the common gamma chain (IL2RG),
            constitute the high-affinity IL2 receptor. Homodimeric alpha chains
            (IL2RA) result in low-affinity receptor, while homodimeric beta
            (IL2RB) chains produce a medium-affinity receptor. Normally an
            integral-membrane protein, soluble IL2RA has been isolated and
            determined to result from extracellular proteolyisis.
            Alternately-spliced IL2RA mRNAs have been isolated, but the
            significance of each is presently unknown. Mutations in this gene
            are associated with interleukin 2 receptor alpha deficiency.
            Patients with severe Coronavirus Disease 2019 (COVID-19), the
            disease caused by the novel severe acute respiratory syndrome
            coronavirus 2 (SARS-CoV-2), have significantly elevated levels of
            IL2R in their plasma. Similarly, serum IL-2R levels are found to be
            elevated in patients with different types of carcinomas. Certain
            IL2RA and IL2RB gene polymorphisms have been associated with lung
            cancer risk. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1705556.1, X01057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 prognosis
            MANE Ensembl match     :: ENST00000379959.8/ ENSP00000369293.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AL157395.17        6404-6462           c
            60-2364             X01057.1           24-2328
            2365-3218           AL137186.18        144392-145245       c
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..3218
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /note="interleukin 2 receptor subunit alpha"
                     /db_xref="GeneID:3559"
                     /db_xref="HGNC:HGNC:6008"
                     /db_xref="MIM:147730"
     exon            1..280
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1035
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TAC antigen; IL-2R subunit alpha; IL-2 receptor
                     subunit alpha; interleukin 2 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-2 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_000408.1"
                     /db_xref="CCDS:CCDS7076.1"
                     /db_xref="GeneID:3559"
                     /db_xref="HGNC:HGNC:6008"
                     /db_xref="MIM:147730"
                     /translation="MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEG
                     TMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQK
                     ERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALH
                     RGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTT
                     DFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI"
     exon            281..472
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            473..583
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            584..799
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            800..871
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            872..943
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1010
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..3218
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3197..3202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /note="hexamer: AATAAA"
     polyA_site      3218
                     /gene="IL2RA"
                     /gene_synonym="CD25; IDDM10; IL2R; IMD41; p55; TCGFR"
                     /note="major polyA site"
ORIGIN      
        1 agtttcctgg ctgaacacgc cagcccaata cttaaagaga gcaactcctg actccgatag
       61 agactggatg gacccacaag ggtgacagcc caggcggacc gatcttccca tcccacatcc
      121 tccggcgcga tgccaaaaag aggctgacgg caactgggcc ttctgcagag aaagacctcc
      181 gcttcactgc cccggctggt cccaagggtc aggaagatgg attcatacct gctgatgtgg
      241 ggactgctca cgttcatcat ggtgcctggc tgccaggcag agctctgtga cgatgacccg
      301 ccagagatcc cacacgccac attcaaagcc atggcctaca aggaaggaac catgttgaac
      361 tgtgaatgca agagaggttt ccgcagaata aaaagcgggt cactctatat gctctgtaca
      421 ggaaactcta gccactcgtc ctgggacaac caatgtcaat gcacaagctc tgccactcgg
      481 aacacaacga aacaagtgac acctcaacct gaagaacaga aagaaaggaa aaccacagaa
      541 atgcaaagtc caatgcagcc agtggaccaa gcgagccttc caggtcactg cagggaacct
      601 ccaccatggg aaaatgaagc cacagagaga atttatcatt tcgtggtggg gcagatggtt
      661 tattatcagt gcgtccaggg atacagggct ctacacagag gtcctgctga gagcgtctgc
      721 aaaatgaccc acgggaagac aaggtggacc cagccccagc tcatatgcac aggtgaaatg
      781 gagaccagtc agtttccagg tgaagagaag cctcaggcaa gccccgaagg ccgtcctgag
      841 agtgagactt cctgcctcgt cacaacaaca gattttcaaa tacagacaga aatggctgca
      901 accatggaga cgtccatatt tacaacagag taccaggtag cagtggccgg ctgtgttttc
      961 ctgctgatca gcgtcctcct cctgagtggg ctcacctggc agcggagaca gaggaagagt
     1021 agaagaacaa tctagaaaac caaaagaaca agaatttctt ggtaagaagc cgggaacaga
     1081 caacagaagt catgaagccc aagtgaaatc aaaggtgcta aatggtcgcc caggagacat
     1141 ccgttgtgct tgcctgcgtt ttggaagctc tgaagtcaca tcacaggaca cggggcagtg
     1201 gcaaccttgt ctctatgcca gctcagtccc atcagagagc gagcgctacc cacttctaaa
     1261 tagcaatttc gccgttgaag aggaagggca aaaccactag aactctccat cttattttca
     1321 tgtatatgtg ttcattaaag catgaatggt atggaactct ctccacccta tatgtagtat
     1381 aaagaaaagt aggtttacat tcatctcatt ccaacttccc agttcaggag tcccaaggaa
     1441 agccccagca ctaacgtaaa tacacaacac acacactcta ccctatacaa ctggacattg
     1501 tctgcgtggt tcctttctca gccgcttctg actgctgatt ctcccgttca cgttgcctaa
     1561 taaacatcct tcaagaactc tgggctgcta cccagaaatc attttaccct tggctcaatc
     1621 ctctaagcta acccccttct actgagcctt cagtcttgaa tttctaaaaa acagaggcca
     1681 tggcagaata atctttgggt aacttcaaaa cggggcagcc aaacccatga ggcaatgtca
     1741 ggaacagaag gatgaatgag gtcccaggca gagaatcata cttagcaaag ttttacctgt
     1801 gcgttactaa ttggcctctt taagagttag tttctttggg attgctatga atgataccct
     1861 gaatttggcc tgcactaatt tgatgtttac aggtggacac acaaggtgca aatcaatgcg
     1921 tacgtttcct gagaagtgtc taaaaacacc aaaaagggat ccgtacattc aatgtttatg
     1981 caaggaagga aagaaagaag gaagtgaaga gggagaaggg atggaggtca cactggtaga
     2041 acgtaaccac ggaaaagagc gcatcaggcc tggcacggtg gctcaggcct ataaccccag
     2101 ctccctagga gaccaaggcg ggagcatctc ttgaggccag gagtttgaga ccagcctggg
     2161 cagcatagca agacacatcc ctacaaaaaa ttagaaattg gctggatgtg gtggcatacg
     2221 cctgtagtcc tagccactca ggaggctgag gcaggaggat tgcttgagcc caggagttcg
     2281 aggctgcagt cagtcatgat ggcaccactg cactccagcc tgggcaacag agcaagatcc
     2341 tgtctttaag gaaaaaaaga caagatgagc ataccagcag tccttgaaca ttatcaaaaa
     2401 gttcagcata ttagaatcac cgggaggcct tgttaaaaga gttcgctggg cccatcttca
     2461 gagtctctga gttgttggtc tggaatagag ccaaatgttt tgtgtgtcta acaattccca
     2521 ggtgctgttg ctgctgctac tattccagga acacactttg agaaccattg tgttattgct
     2581 ctgcacgccc acccactctc aactcccacg aaaaaaatca acttccagag ctaagatttc
     2641 ggtggaagtc ctggttccat atctggtgca agatctcccc tcacgaatca gttgagtcaa
     2701 cattctagct caacaacatc acacgattaa cattaacgaa aattattcat ttgggaaact
     2761 atcagccagt tttcacttct gaaggggcag gagagtgtta tgagaaatca cggcagtttt
     2821 cagcagggtc cagattcaga ttaaataact attttctgtc atttctgtga ccaaccacat
     2881 acaaacagac tcatctgtgc actctccccc tcccccttca ggtatatgtt ttctgagtaa
     2941 agttgaaaag aatctcagac cagaaaatat agatatatat ttaaatctta cttgagtaga
     3001 actgattacg acttttgggt gttgaggggt ctataagatc aaaacttttc catgataata
     3061 ctaagatgtt atcgaccatt tatctgtcct tctctcaaaa gtgtatggtg gaattttcca
     3121 gaagctatgt gatacgtgat gatgtcatca ctctgctgtt aacatataat aaatttattg
     3181 ctattgttta taaaagaata aatgatattt tttaaaaa
//
