LOCUS       NM_004843               2950 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.
ACCESSION   NM_004843
VERSION     NM_004843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Martin,E., Winter,S., Garcin,C., Tanita,K., Hoshino,A., Lenoir,C.,
            Fournier,B., Migaud,M., Boutboul,D., Simonin,M., Fernandes,A.,
            Bastard,P., Le Voyer,T., Roupie,A.L., Ben Ahmed,Y.,
            Leruez-Ville,M., Burgard,M., Rao,G., Ma,C.S., Masson,C.,
            Soudais,C., Picard,C., Bustamante,J., Tangye,S.G., Cheikh,N.,
            Seppanen,M., Puel,A., Daly,M., Casanova,J.L., Neven,B., Fischer,A.
            and Latour,S.
  TITLE     Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA
            deficiency
  JOURNAL   Nature 628 (8008), 620-629 (2024)
   PUBMED   38509369
  REMARK    GeneRIF: Role of IL-27 in Epstein-Barr virus infection revealed by
            IL-27RA deficiency.
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Brownlie,R.J., Kennedy,R., Wilson,E.B., Milanovic,M., Taylor,C.F.,
            Wang,D., Davies,J.R., Owston,H., Adams,E.J., Stephenson,S.,
            Caeser,R., Gewurz,B.E., Giannoudis,P.V., Scuoppo,C., McGonagle,D.,
            Hodson,D.J., Tooze,R.M., Doody,G.M., Cook,G., Westhead,D.R. and
            Klein,U.
  TITLE     Cytokine receptor IL27RA is an NF-kappaB-responsive gene involved
            in CD38 upregulation in multiple myeloma
  JOURNAL   Blood Adv 7 (15), 3874-3890 (2023)
   PUBMED   36867577
  REMARK    GeneRIF: Cytokine receptor IL27RA is an NF-kappaB-responsive gene
            involved in CD38 upregulation in multiple myeloma.
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Jin,Y., Fyfe,P.K., Gardner,S., Wilmes,S., Bubeck,D. and Moraga,I.
  TITLE     Structural insights into the assembly and activation of the IL-27
            signaling complex
  JOURNAL   EMBO Rep 23 (10), e55450 (2022)
   PUBMED   35920255
  REMARK    GeneRIF: Structural insights into the assembly and activation of
            the IL-27 signaling complex.
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   Aghayev,T., Mazitova,A.M., Fang,J.R., Peshkova,I.O., Rausch,M.,
            Hung,M., White,K.F., Masia,R., Titerina,E.K., Fatkhullina,A.R.,
            Cousineau,I., Turcotte,S., Zhigarev,D., Marchenko,A.,
            Khoziainova,S., Makhov,P., Tan,Y.F., Kossenkov,A.V., Wiest,D.L.,
            Stagg,J., Wang,X.W., Campbell,K.S., Dzutsev,A.K., Trinchieri,G.,
            Hill,J.A., Grivennikov,S.I. and Koltsova,E.K.
  TITLE     IL27 Signaling Serves as an Immunologic Checkpoint for Innate
            Cytotoxic Cells to Promote Hepatocellular Carcinoma
  JOURNAL   Cancer Discov 12 (8), 1960-1983 (2022)
   PUBMED   35723626
  REMARK    GeneRIF: IL27 Signaling Serves as an Immunologic Checkpoint for
            Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma.
REFERENCE   5  (bases 1 to 2950)
  AUTHORS   Wu,M., Xia,X., Hu,J., Fowlkes,N.W. and Li,S.
  TITLE     WSX1 act as a tumor suppressor in hepatocellular carcinoma by
            downregulating neoplastic PD-L1 expression
  JOURNAL   Nat Commun 12 (1), 3500 (2021)
   PUBMED   34108491
  REMARK    GeneRIF: WSX1 act as a tumor suppressor in hepatocellular carcinoma
            by downregulating neoplastic PD-L1 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2950)
  AUTHORS   Pflanz,S., Hibbert,L., Mattson,J., Rosales,R., Vaisberg,E.,
            Bazan,J.F., Phillips,J.H., McClanahan,T.K., de Waal Malefyt,R. and
            Kastelein,R.A.
  TITLE     WSX-1 and glycoprotein 130 constitute a signal-transducing receptor
            for IL-27
  JOURNAL   J Immunol 172 (4), 2225-2231 (2004)
   PUBMED   14764690
  REMARK    GeneRIF: WSX-1 together with the cytokine receptor gp130
            constitutes a functional signal-transducing receptor for IL-27.
REFERENCE   7  (bases 1 to 2950)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2950)
  AUTHORS   Takeda,A., Hamano,S., Yamanaka,A., Hanada,T., Ishibashi,T.,
            Mak,T.W., Yoshimura,A. and Yoshida,H.
  TITLE     Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet
            through activation of STAT1 during initial Th1 commitment
  JOURNAL   J Immunol 170 (10), 4886-4890 (2003)
   PUBMED   12734330
  REMARK    GeneRIF: WSX-1 is essential for transcriptional activation of STAT1
            and for augmenting the induction of T-bet expression during
            initiation of Th1 cell differentiation.
REFERENCE   9  (bases 1 to 2950)
  AUTHORS   Pflanz,S., Timans,J.C., Cheung,J., Rosales,R., Kanzler,H.,
            Gilbert,J., Hibbert,L., Churakova,T., Travis,M., Vaisberg,E.,
            Blumenschein,W.M., Mattson,J.D., Wagner,J.L., To,W., Zurawski,S.,
            McClanahan,T.K., Gorman,D.M., Bazan,J.F., de Waal Malefyt,R.,
            Rennick,D. and Kastelein,R.A.
  TITLE     IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein,
            induces proliferation of naive CD4+ T cells
  JOURNAL   Immunity 16 (6), 779-790 (2002)
   PUBMED   12121660
REFERENCE   10 (bases 1 to 2950)
  AUTHORS   Sprecher,C.A., Grant,F.J., Baumgartner,J.W., Presnell,S.R.,
            Schrader,S.K., Yamagiwa,T., Whitmore,T.E., O'Hara,P.J. and
            Foster,D.F.
  TITLE     Cloning and characterization of a novel class I cytokine receptor
  JOURNAL   Biochem Biophys Res Commun 246 (1), 82-90 (1998)
   PUBMED   9600072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF053004.1, AF106912.1 and
            AC022098.9.
            
            On Nov 22, 2018 this sequence version replaced NM_004843.3.
            
            Summary: In mice, CD4+ helper T-cells differentiate into type 1
            (Th1) cells, which are critical for cell-mediated immunity,
            predominantly under the influence of IL12. Also, IL4 influences
            their differentiation into type 2 (Th2) cells, which are critical
            for most antibody responses. Mice deficient in these cytokines,
            their receptors, or associated transcription factors have impaired,
            but are not absent of, Th1 or Th2 immune responses. This gene
            encodes a protein which is similar to the mouse T-cell cytokine
            receptor Tccr at the amino acid level, and is predicted to be a
            glycosylated transmembrane protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106912.1, AY358876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263379.4/ ENSP00000263379.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1662              AF053004.1         28-1689
            1663-2651           AF106912.1         1677-2665
            2652-2950           AC022098.9         90297-90595
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2950
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /note="interleukin 27 receptor subunit alpha"
                     /db_xref="GeneID:9466"
                     /db_xref="HGNC:HGNC:17290"
                     /db_xref="MIM:605350"
     exon            1..211
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2022
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /note="T-cell cytokine receptor type 1; class I cytokine
                     receptor; interleukin 27 receptor, alpha; IL-27R-alpha;
                     IL-27R subunit alpha; cytokine receptor-like 1; IL-27
                     receptor subunit alpha; type I T-cell cytokine receptor;
                     cytokine receptor WSX-1"
                     /codon_start=1
                     /product="interleukin-27 receptor subunit alpha precursor"
                     /protein_id="NP_004834.1"
                     /db_xref="CCDS:CCDS12303.1"
                     /db_xref="GeneID:9466"
                     /db_xref="HGNC:HGNC:17290"
                     /db_xref="MIM:605350"
                     /translation="MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGV
                     GPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDK
                     LLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHK
                     VLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWG
                     EWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRE
                     LSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGS
                     TELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRIT
                     VTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLT
                     HYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHL
                     PDNTLRWKVLPGILFLWGLFLLGCGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSS
                     GQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEEL
                     GLLGPPRPQVLA"
     exon            212..329
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..487
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..645
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..805
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..879
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1063
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1252
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1354
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1513
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1639
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1733
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1827
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2950
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /note="hexamer: AATAAA"
     polyA_site      2950
                     /gene="IL27RA"
                     /gene_synonym="CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1"
                     /note="major polyA site"
ORIGIN      
        1 gttcggcttc ccgttgccgc ctcgggcgct gtacccagag ctcgaagagg agcagcgcgg
       61 ccgcgcggac ccggcaaggc tgggccggac tcggggctcc cgagggacgc catgcgggga
      121 ggcaggggcg cccctttctg gctgtggccg ctgcccaagc tggcgctgct gcctctgttg
      181 tgggtgcttt tccagcggac gcgtccccag ggcagcgccg ggccactgca gtgctacgga
      241 gttggaccct tgggcgactt gaactgctcg tgggagcctc ttggggacct gggagccccc
      301 tccgagttac acctccagag ccaaaagtac cgttccaaca aaacccagac tgtggcagtg
      361 gcagccggac ggagctgggt ggccattcct cgggaacagc tcaccatgtc tgacaaactc
      421 cttgtctggg gcactaaggc aggccagcct ctctggcccc ccgtcttcgt gaacctagaa
      481 acccaaatga agccaaacgc cccccggctg ggccctgacg tggacttttc cgaggatgac
      541 cccctggagg ccactgtcca ttgggcccca cctacatggc catctcataa agttctgatc
      601 tgccagttcc actaccgaag atgtcaggag gcggcctgga ccctgctgga accggagctg
      661 aagaccatac ccctgacccc tgttgagatc caagatttgg agctagccac tggctacaaa
      721 gtgtatggcc gctgccggat ggagaaagaa gaggatttgt ggggcgagtg gagccccatt
      781 ttgtccttcc agacaccgcc ttctgctcca aaagatgtgt gggtatcagg gaacctctgt
      841 gggacgcctg gaggagagga acctttgctt ctatggaagg ccccagggcc ctgtgtgcag
      901 gtgagctaca aagtctggtt ctgggttgga ggtcgtgagc tgagtccaga aggaattacc
      961 tgctgctgct ccctaattcc cagtggggcg gagtgggcca gggtgtccgc tgtcaacgcc
     1021 acaagctggg agcctctcac caacctctct ttggtctgct tggattcagc ctctgccccc
     1081 cgtagcgtgg cagtcagcag catcgctggg agcacggagc tactggtgac ctggcaaccg
     1141 gggcctgggg aaccactgga gcatgtagtg gactgggctc gagatgggga ccccctggag
     1201 aaactcaact gggtccggct tccccctggg aacctcagtg ctctgttacc agggaatttc
     1261 actgtcgggg tcccctatcg aatcactgtg accgcagtct ctgcttcagg cttggcctct
     1321 gcatcctccg tctgggggtt cagggaggaa ttagcacccc tagtggggcc aacgctttgg
     1381 cgactccaag atgcccctcc agggaccccc gccatagcgt ggggagaggt cccaaggcac
     1441 cagcttcgag gccacctcac ccactacacc ttgtgtgcac agagtggaac cagcccctcc
     1501 gtctgcatga atgtgagtgg caacacacag agtgtcaccc tgcctgacct tccttggggt
     1561 ccctgtgagc tgtgggtgac agcatctacc atcgctggac agggccctcc tggtcccatc
     1621 ctccggcttc atctaccaga taacaccctg aggtggaaag ttctgccggg catcctattc
     1681 ttgtggggct tgttcctgtt ggggtgtggc ctgagcctgg ccacctctgg aaggtgctac
     1741 cacctaaggc acaaagtgct gccccgctgg gtctgggaga aagttcctga tcctgccaac
     1801 agcagttcag gccagcccca catggagcaa gtacctgagg cccagcccct tggggacttg
     1861 cccatcctgg aagtggagga gatggagccc ccgccggtta tggagtcctc ccagcccgcc
     1921 caggccaccg ccccgcttga ctctgggtat gagaagcact tcctgcccac acctgaggag
     1981 ctgggccttc tggggccccc caggccacag gttctggcct gaaccacacg tctggctggg
     2041 ggctgccagc caggctagag ggatgctcat gcaggttgca ccccagtcct ggattagccc
     2101 tcttgatgga tgaagacact gaggactcag agaggctgag tcacttacct gaggacaccc
     2161 agccaggcag agctgggatt gaaggacccc tatagagaag ggcttggccc ccatggggaa
     2221 gacacggatg gaaggtggag caaaggaaaa tacatgaaat tgagagtggc agctgcctgc
     2281 caaaatctgt tccgctgtaa cagaactgaa tttggacccc agcacagtgg ctcacgcctg
     2341 taatcccagc actttggcag gccaaggtgg aaggatcact tagagctagg agtttgagac
     2401 cagcctgggc aatatagcaa gacccctcac tacaaaaata aaacatcaaa aacaaaaaca
     2461 attagctggg catgatggca cacacctgta gtccgagcca cttgggaggc tgaggtggga
     2521 ggatcggttg agcccaggag ttcgaagctg cagggacctc tgattgcacc actgcactcc
     2581 aggctgggta acagaatgag accttatctc aaaaataaac aaactaataa aaagcaaaaa
     2641 aaaaaaaaaa agaaaagaaa aaacactgca tttgggcacc atctcagctc ccttgcatcc
     2701 aggtgcagca tggactgagt tcttgacaac agaatgtggt cagaagtgac atatgccaac
     2761 acggggtctg ggtgggggct cccccacatc ctttccttgc ctatgagctg gaacataaca
     2821 catgcctatg atccagcttt ggtcataccc aaggggaagg tggagcaaga aatgaaaagg
     2881 aacctgaatc cctgaatgac tgcatggata gaaccactaa gaaaaataaa cttttatatt
     2941 tttatagcta
//
