LOCUS       NM_145659               1044 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 27 (IL27), mRNA.
ACCESSION   NM_145659
VERSION     NM_145659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1044)
  AUTHORS   Luo,Y.H., Zhang,Y.Y., Li,M.Q., Zhang,X.Y. and Zheng,Z.M.
  TITLE     Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy
            Complications
  JOURNAL   Am J Reprod Immunol 92 (4), e13942 (2024)
   PUBMED   39422056
  REMARK    GeneRIF: Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy
            Complications.
            Review article
REFERENCE   2  (bases 1 to 1044)
  AUTHORS   Korobova,Z.R., Arsentieva,N.A., Santoni,A. and Totolian,A.A.
  TITLE     Role of IL-27 in COVID-19: A Thin Line between Protection and
            Disease Promotion
  JOURNAL   Int J Mol Sci 25 (14), 7953 (2024)
   PUBMED   39063193
  REMARK    GeneRIF: Role of IL-27 in COVID-19: A Thin Line between Protection
            and Disease Promotion.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1044)
  AUTHORS   Hernandez-Sarmiento,L.J., Tamayo-Molina,Y.S., Valdes-Lopez,J.F. and
            Urcuqui-Inchima,S.
  TITLE     Interleukin 27, Similar to Interferons, Modulates Gene Expression
            of Tripartite Motif (TRIM) Family Members and Interferes with
            Mayaro Virus Replication in Human Macrophages
  JOURNAL   Viruses 16 (6), 996 (2024)
   PUBMED   38932287
  REMARK    GeneRIF: Interleukin 27, Similar to Interferons, Modulates Gene
            Expression of Tripartite Motif (TRIM) Family Members and Interferes
            with Mayaro Virus Replication in Human Macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1044)
  AUTHORS   Jing,Q., Liu,X., Lv,Z. and Xue,D.
  TITLE     IL27 and IL1RN are causally associated with acute pancreatitis: a
            Mendelian randomization study
  JOURNAL   Aging (Albany NY) 16 (10), 8572-8584 (2024)
   PUBMED   38742942
  REMARK    GeneRIF: IL27 and IL1RN are causally associated with acute
            pancreatitis: a Mendelian randomization study.
REFERENCE   5  (bases 1 to 1044)
  AUTHORS   Gao,L., Xiong,Y.J., Liang,Y.X., Huang,P.F., Liu,S., Xiao,Y.,
            Huang,Q., Wang,H. and Wu,H.M.
  TITLE     The effects of IL-27 and IL-35 gene variation and expression levels
            on the susceptibility and clinical manifestations of pulmonary
            tuberculosis
  JOURNAL   Front Immunol 15, 1267624 (2024)
   PUBMED   38690286
  REMARK    GeneRIF: The effects of IL-27 and IL-35 gene variation and
            expression levels on the susceptibility and clinical manifestations
            of pulmonary tuberculosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1044)
  AUTHORS   Larousserie,F., Bardel,E., Pflanz,S., Arnulf,B., Lome-Maldonado,C.,
            Hermine,O., Bregeaud,L., Perennec,M., Brousse,N., Kastelein,R. and
            Devergne,O.
  TITLE     Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr
            virus- and human T-cell leukemia virus type 1-associated lymphomas:
            heterogeneous expression of EBI3 subunit by tumoral cells
  JOURNAL   Am J Pathol 166 (4), 1217-1228 (2005)
   PUBMED   15793300
  REMARK    GeneRIF: EBI3 may play a role, independently from its association
            to p28, in regulating anti-viral or anti-tumoral immune responses
REFERENCE   7  (bases 1 to 1044)
  AUTHORS   Pflanz,S., Hibbert,L., Mattson,J., Rosales,R., Vaisberg,E.,
            Bazan,J.F., Phillips,J.H., McClanahan,T.K., de Waal Malefyt,R. and
            Kastelein,R.A.
  TITLE     WSX-1 and glycoprotein 130 constitute a signal-transducing receptor
            for IL-27
  JOURNAL   J Immunol 172 (4), 2225-2231 (2004)
   PUBMED   14764690
  REMARK    GeneRIF: IL-27 triggers STAT activation and gene transcription of a
            subset of inflammatory cytokines in primary human mast cells and in
            human monocytes.
REFERENCE   8  (bases 1 to 1044)
  AUTHORS   Lucas,S., Ghilardi,N., Li,J. and de Sauvage,F.J.
  TITLE     IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through
            Stat1-dependent and -independent mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15047-15052 (2003)
   PUBMED   14657353
  REMARK    GeneRIF: IL-27 regulates IL-12 responsiveness of naive CD4+ T cells
            through Stat1-dependent and -independent mechanisms
REFERENCE   9  (bases 1 to 1044)
  AUTHORS   Takeda,A., Hamano,S., Yamanaka,A., Hanada,T., Ishibashi,T.,
            Mak,T.W., Yoshimura,A. and Yoshida,H.
  TITLE     Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet
            through activation of STAT1 during initial Th1 commitment
  JOURNAL   J Immunol 170 (10), 4886-4890 (2003)
   PUBMED   12734330
REFERENCE   10 (bases 1 to 1044)
  AUTHORS   Pflanz,S., Timans,J.C., Cheung,J., Rosales,R., Kanzler,H.,
            Gilbert,J., Hibbert,L., Churakova,T., Travis,M., Vaisberg,E.,
            Blumenschein,W.M., Mattson,J.D., Wagner,J.L., To,W., Zurawski,S.,
            McClanahan,T.K., Gorman,D.M., Bazan,J.F., de Waal Malefyt,R.,
            Rennick,D. and Kastelein,R.A.
  TITLE     IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein,
            induces proliferation of naive CD4+ T cells
  JOURNAL   Immunity 16 (6), 779-790 (2002)
   PUBMED   12121660
  REMARK    GeneRIF: an early product of activated antigen-presenting cells;
            drives rapid clonal expansion of naive but not memory CD4(+) T
            cells
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC062422.1, AY099296.1 and
            AC138894.2.
            
            On Apr 8, 2005 this sequence version replaced NM_145659.2.
            
            Summary: The protein encoded by this gene is one of the subunits of
            a heterodimeric cytokine complex. This protein is related to
            interleukin 12A (IL12A). It interacts with Epstein-Barr virus
            induced gene 3 (EBI3), a protein similar to interleukin 12B
            (IL12B), and forms a complex that has been shown to drive rapid
            expansion of naive but not memory CD4(+) T cells. The complex is
            also found to synergize strongly with interleukin 12 to trigger
            interferon gamma (IFNG) production of naive CD4(+) T cells. The
            biological effects of this cytokine are mediated by the class I
            cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062422.1, SRR1163655.14857.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356897.1/ ENSP00000349365.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BC062422.1         4-200
            198-378             AY099296.1         175-355
            379-881             BC062422.1         382-884
            882-1044            AC138894.2         30460-30622
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1-p11.2"
     gene            1..1044
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /note="interleukin 27"
                     /db_xref="GeneID:246778"
                     /db_xref="HGNC:HGNC:19157"
                     /db_xref="MIM:608273"
     exon            1..54
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..755
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /note="IL-27 p28 subunit; interleukin-27 subunit alpha;
                     IL27-A; IL-27-A; IL-27 subunit alpha; interleukin-30"
                     /codon_start=1
                     /product="interleukin-27 subunit alpha precursor"
                     /protein_id="NP_663634.2"
                     /db_xref="CCDS:CCDS10633.1"
                     /db_xref="GeneID:246778"
                     /db_xref="HGNC:HGNC:19157"
                     /db_xref="MIM:608273"
                     /translation="MGQTAGDLGWRLSLLLLPLLLVQAGVWGFPRPPGRPQLSLQELR
                     REFTVSLHLARKLLSEVRGQAHRFAESHLPGVNLYLLPLGEQLPDVSLTFQAWRRLSD
                     PERLCFISTTLQPFHALLGGLGTQGRWTNMERMQLWAMRLDLRDLQRHLRFQVLAAGF
                     NLPEEEEEEEEEEEEERKGLLPGALGSALQGPAQVSWPQLLSTYRLLHSLELVLSRAV
                     RELLLLSKAGHSVWPLGFPTLSPQP"
     exon            55..227
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /inference="alignment:Splign:2.1.0"
     exon            228..326
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /inference="alignment:Splign:2.1.0"
     exon            327..485
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /inference="alignment:Splign:2.1.0"
     exon            486..1044
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /note="hexamer: AATAAA"
     polyA_site      1044
                     /gene="IL27"
                     /gene_synonym="IL-27; IL-27A; IL27A; IL27p28; IL30; p28"
                     /note="major polyA site"
ORIGIN      
        1 gaccaaagag gctgggcccc gccatgggcc agacggcagg cgaccttggc tggcggctca
       61 gcctgttgct gcttcccttg ctcctggttc aagctggtgt ctggggattc ccaaggcccc
      121 cagggaggcc ccagctgagc ctgcaggagc tgcggaggga gttcacagtc agcctgcatc
      181 tcgccaggaa gctgctctcc gaggttcggg gccaggccca ccgctttgcg gaatctcacc
      241 tgccaggagt gaacctgtac ctcctgcccc tgggagagca gctccctgat gtttccctga
      301 ccttccaggc ctggcgccgc ctctctgacc cggagcgtct ctgcttcatc tccaccacgc
      361 ttcagccctt ccatgccctg ctgggagggc tggggaccca gggccgctgg accaacatgg
      421 agaggatgca gctgtgggcc atgaggctgg acctccgcga tctgcagcgg cacctccgct
      481 tccaggtgct ggctgcagga ttcaacctcc cggaggagga ggaggaggaa gaggaggagg
      541 aggaggagga gaggaagggg ctgctcccag gggcactggg cagcgcctta cagggcccgg
      601 cccaggtgtc ctggccccag ctcctctcca cctaccgcct gctgcactcc ttggagctcg
      661 tcttatctcg ggccgtgcgg gagttgctgc tgctgtccaa ggctgggcac tcagtctggc
      721 ccttggggtt cccaacattg agcccccagc cctgatcggt ggcttcttag ccccctgccc
      781 cccacccttt agaactttag gactggagtc ttggcatcag ggcagccttc gcatcatcag
      841 ccttggacaa gggagggctc ttccagcccc ctgccccagg ctctacccag taactgaaag
      901 cccctctggt cctcgccagc tatttatttc ttggatattt atttattgtt tagggagatg
      961 atggtttatt tattgtcttg gggcccgatg gtcctcctcg ggccaagccc ccatgctggg
     1021 tgcccaataa agcactctca tcca
//
