LOCUS       NM_018402               1066 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens interleukin 26 (IL26), mRNA.
ACCESSION   NM_018402
VERSION     NM_018402.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Niu,Q., Wang,M. and Liu,X.S.
  TITLE     The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy
            especially in tuberculous pleurisy
  JOURNAL   Respir Res 25 (1), 275 (2024)
   PUBMED   39003443
  REMARK    GeneRIF: The evolving landscape of IL-10, IL-22 and IL-26 in
            pleurisy especially in tuberculous pleurisy.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Hammitzsch,A., Ossadnik,A., Bachmann,Q., Merwald-Fraenk,H.,
            Lorenz,G., Witt,M., Wiesent,F., Muhlhofer,H., Simone,D.,
            Bowness,P., Heemann,U., Arbogast,M., Moog,P. and Schmaderer,C.
  TITLE     Increased interleukin-26 in the peripheral joints of patients with
            axial spondyloarthritis and psoriatic arthritis, co-localizing with
            CD68-positive synoviocytes
  JOURNAL   Front Immunol 15, 1355824 (2024)
   PUBMED   38799447
  REMARK    GeneRIF: Increased interleukin-26 in the peripheral joints of
            patients with axial spondyloarthritis and psoriatic arthritis,
            co-localizing with CD68-positive synoviocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Kovach,M.A., Kack,U., Che,K.F., Brundin,B., Konradsen,J.R. and
            Linden,A.
  TITLE     Systemic IL-26 correlates with improved asthma control in children
            sensitized to dog allergen
  JOURNAL   Respir Res 25 (1), 163 (2024)
   PUBMED   38622712
  REMARK    GeneRIF: Systemic IL-26 correlates with improved asthma control in
            children sensitized to dog allergen.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   He,W., Qian,Q.W., Liu,Q.Y., Li,Y.K., Miao,Q., Wang,Q.X., Ma,X.,
            You,Z.R. and Tang,R.Q.
  TITLE     IL-26 modulates T cell function in autoimmune hepatitis
  JOURNAL   J Dig Dis 24 (3), 231-242 (2023)
   PUBMED   37155188
  REMARK    GeneRIF: IL-26 modulates T cell function in autoimmune hepatitis.
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Mizuno,Y., Shibata,S., Ito,Y., Taira,H., Sugimoto,E., Awaji,K. and
            Sato,S.
  TITLE     Interleukin-26-DNA complexes promote inflammation and
            dermal-epidermal separation in a modified human cryosection model
            of bullous pemphigoid
  JOURNAL   Front Immunol 13, 1013382 (2022)
   PUBMED   36311716
  REMARK    GeneRIF: Interleukin-26-DNA complexes promote inflammation and
            dermal-epidermal separation in a modified human cryosection model
            of bullous pemphigoid.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1066)
  AUTHORS   Hor,S., Pirzer,H., Dumoutier,L., Bauer,F., Wittmann,S., Sticht,H.,
            Renauld,J.C., de Waal Malefyt,R. and Fickenscher,H.
  TITLE     The T-cell lymphokine interleukin-26 targets epithelial cells
            through the interleukin-20 receptor 1 and interleukin-10 receptor 2
            chains
  JOURNAL   J Biol Chem 279 (32), 33343-33351 (2004)
   PUBMED   15178681
  REMARK    GeneRIF: sensitivity to recombinant interleukin-26(IL-26) of
            various cell lines strictly correlated with the expression of IL-20
            receptor 1 and blocking antibodies against either IL-10 receptor 2
            or IL-20 receptor 1 inhibited IL-26-dependent signal transduction
REFERENCE   7  (bases 1 to 1066)
  AUTHORS   Sheikh,F., Baurin,V.V., Lewis-Antes,A., Shah,N.K., Smirnov,S.V.,
            Anantha,S., Dickensheets,H., Dumoutier,L., Renauld,J.C., Zdanov,A.,
            Donnelly,R.P. and Kotenko,S.V.
  TITLE     Cutting edge: IL-26 signals through a novel receptor complex
            composed of IL-20 receptor 1 and IL-10 receptor 2
  JOURNAL   J Immunol 172 (4), 2006-2010 (2004)
   PUBMED   14764663
  REMARK    GeneRIF: The active receptor complex for IL-26 is a heterodimer
            composed of two receptor proteins: IL-20 receptor 1 and IL-10
            receptor 2. Signaling through the IL-26 receptor results in
            activation of STAT1 and STAT3.
REFERENCE   8  (bases 1 to 1066)
  AUTHORS   Vandenbroeck,K., Cunningham,S., Goris,A., Alloza,I., Heggarty,S.,
            Graham,C., Bell,A. and Rooney,M.
  TITLE     Polymorphisms in the interferon-gamma/interleukin-26 gene region
            contribute to sex bias in susceptibility to rheumatoid arthritis
  JOURNAL   Arthritis Rheum 48 (10), 2773-2778 (2003)
   PUBMED   14558082
  REMARK    GeneRIF: common polymorphisms in the IFNgamma/IL-26 gene region may
            contribute to sex bias in susceptibility to rheumatoid arthritis,
            by distorting the propensity of female carriers versus male
            carriers to contract this disease.
REFERENCE   9  (bases 1 to 1066)
  AUTHORS   Goris,A., Marrosu,M.G. and Vandenbroeck,K.
  TITLE     Novel polymorphisms in the IL-10 related AK155 gene (chromosome
            12q15)
  JOURNAL   Genes Immun 2 (5), 284-286 (2001)
   PUBMED   11528524
REFERENCE   10 (bases 1 to 1066)
  AUTHORS   Knappe,A., Hor,S., Wittmann,S. and Fickenscher,H.
  TITLE     Induction of a novel cellular homolog of interleukin-10, AK155, by
            transformation of T lymphocytes with herpesvirus saimiri
  JOURNAL   J Virol 74 (8), 3881-3887 (2000)
   PUBMED   10729163
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007458.14 and AJ251549.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018402.1.
            
            Summary: This gene was identified by its overexpression
            specifically in herpesvirus samimiri-transformed T cells. The
            encoded protein is a member of the IL10 family of cytokines. It is
            a secreted protein and may function as a homodimer. This protein is
            thought to contribute to the transformed phenotype of T cells after
            infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ251549.1, CF271979.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA2142586 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229134.5/ ENSP00000229134.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC007458.14        165008-165026       c
            20-1066             AJ251549.1         1-1047
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1066
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /note="interleukin 26"
                     /db_xref="GeneID:55801"
                     /db_xref="HGNC:HGNC:17119"
                     /db_xref="MIM:605679"
     exon            1..225
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..570
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /codon_start=1
                     /product="interleukin-26 precursor"
                     /protein_id="NP_060872.1"
                     /db_xref="CCDS:CCDS8981.1"
                     /db_xref="GeneID:55801"
                     /db_xref="HGNC:HGNC:17119"
                     /db_xref="MIM:605679"
                     /translation="MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDA
                     LYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGC
                     KKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILL
                     SWIKKLLESSQ"
     exon            226..282
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /inference="alignment:Splign:2.1.0"
     exon            283..417
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /inference="alignment:Splign:2.1.0"
     exon            418..483
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1066
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1046..1051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /note="hexamer: AATAAA"
     polyA_site      1066
                     /gene="IL26"
                     /gene_synonym="AK155; IL-26"
                     /note="major polyA site"
ORIGIN      
        1 attagtatct cttgggctgc tgtgagtgac acacgctgag tggggtgaag ggaaatgctg
       61 gtgaatttca ttttgaggtg tgggttgctg ttagtcactc tgtctcttgc cattgccaag
      121 cacaagcaat cttccttcac caaaagttgt tacccaaggg gaacattgtc ccaagctgtt
      181 gacgctctct atatcaaagc agcatggctc aaagcaacga ttccagaaga ccgcataaaa
      241 aatatacgat tattaaaaaa gaaaacaaaa aagcagttta tgaaaaactg tcaatttcaa
      301 gaacagcttc tgtccttctt catggaagac gtttttggtc aactgcaatt gcaaggctgc
      361 aagaaaatac gctttgtgga ggactttcat agccttaggc agaaattgag ccactgtatt
      421 tcctgtgctt catcagctag agagatgaaa tccattacca ggatgaaaag aatattttat
      481 aggattggaa acaaaggaat ctacaaagcc atcagtgaac tggatattct tctttcctgg
      541 attaaaaaat tattggaaag cagtcagtaa accaaagcca agtacattga ttttacagtt
      601 attttgaaat acaataagaa ctgctagaaa tatgtttata acagtctatt tcttttaaaa
      661 actttttaac ataatactga cggcatgtta ggtgattcag aatagacaag aaggatttag
      721 taaattaacg ttttggatat aagttgtcac taatttgcac attttctgtg ttttcaaata
      781 atgtttccat tctgaacatg ttttgtcatt cacaagtaca ttgtgtcaac ttaatttaaa
      841 gtatgtaacc tgaattaact cgtgtaatat ttgtgtgtgg agtgggatgt ggggggtgga
      901 gggggaatga cagatttctg gaatgcaatg taatgttact gagacttaaa tagatgttat
      961 gtatatgatt gtctgtttaa gtgtttgaaa attgttaatt atgcccagtg tgaacttagt
     1021 acttaacaca ttttgatttt aattaaataa attgggtttc cttctc
//
