LOCUS       NM_172314               1167 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens interleukin 25 (IL25), transcript variant 2, mRNA.
ACCESSION   NM_172314
VERSION     NM_172314.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1167)
  AUTHORS   Liao,Y., Xu,Y., Mo,Z., Zhu,T., Dong,H., Zhou,W. and Xia,Q.
  TITLE     Interleukin-25 as a Potential Biomarker in Lung Metastasis of
            Hepatocellular Carcinoma with HBV History in Chinese Patients: A
            Single Center, Case-control Study
  JOURNAL   Int J Med Sci 21 (7), 1337-1343 (2024)
   PUBMED   38818476
  REMARK    GeneRIF: Interleukin-25 as a Potential Biomarker in Lung Metastasis
            of Hepatocellular Carcinoma with HBV History in Chinese Patients: A
            Single Center, Case-control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1167)
  AUTHORS   Dobrican-Baruta,C.T., Deleanu,D.M., Muntean,I.A., Nedelea,I.,
            Balan,R.G., Filip,G.A. and Procopciuc,L.M.
  TITLE     The Alarmin Triad-IL-25, IL-33, and TSLP-Serum Levels and Their
            Clinical Implications in Chronic Spontaneous Urticaria
  JOURNAL   Int J Mol Sci 25 (4), 2026 (2024)
   PUBMED   38396704
  REMARK    GeneRIF: The Alarmin Triad-IL-25, IL-33, and TSLP-Serum Levels and
            Their Clinical Implications in Chronic Spontaneous Urticaria.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1167)
  AUTHORS   Bahhar,I., Es,Z., Kose,O., Turna,A., Gunluoglu,M.Z., Cakir,A.,
            Durali,D. and Magnusson,F.C.
  TITLE     The IL-25/ILC2 axis promotes lung cancer with a concomitant
            accumulation of immune-suppressive cells in tumors in humans and
            mice
  JOURNAL   Front Immunol 14, 1244437 (2023)
   PUBMED   37781372
  REMARK    GeneRIF: The IL-25/ILC2 axis promotes lung cancer with a
            concomitant accumulation of immune-suppressive cells in tumors in
            humans and mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1167)
  AUTHORS   Mohammed H Al-Mquter,L.F. and Abdul Azeez Atiayh,S.
  TITLE     Evaluation of IL-6, IL-25 & IL-35 in the COVID 19 Patients and
            their Correlation to Demography Data in the Symptomatic Patients
  JOURNAL   Arch Razi Inst 78 (3), 1049-1056 (2023)
   PUBMED   38028847
  REMARK    GeneRIF: Evaluation of IL-6, IL-25 & IL-35 in the COVID 19 Patients
            and their Correlation to Demography Data in the Symptomatic
            Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1167)
  AUTHORS   Feng,J., Huang,L., Yang,S., Pan,J., Zhu,X. and Tang,D.
  TITLE     Proteomic Analysis by 4D Label-free MS-PRM Provides Insight into
            the Role and Regulatory Mechanisms of IL-25 in NK Cells
  JOURNAL   Protein Pept Lett 30 (10), 841-853 (2023)
   PUBMED   37702163
  REMARK    GeneRIF: Proteomic Analysis by 4D Label-free MS-PRM Provides
            Insight into the Role and Regulatory Mechanisms of IL-25 in NK
            Cells.
REFERENCE   6  (bases 1 to 1167)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 1167)
  AUTHORS   Kim,M.R., Manoukian,R., Yeh,R., Silbiger,S.M., Danilenko,D.M.,
            Scully,S., Sun,J., DeRose,M.L., Stolina,M., Chang,D., Van,G.Y.,
            Clarkin,K., Nguyen,H.Q., Yu,Y.B., Jing,S., Senaldi,G., Elliott,G.
            and Medlock,E.S.
  TITLE     Transgenic overexpression of human IL-17E results in eosinophilia,
            B-lymphocyte hyperplasia, and altered antibody production
  JOURNAL   Blood 100 (7), 2330-2340 (2002)
   PUBMED   12239140
  REMARK    GeneRIF: Transgenic overexpression from humans into mice results in
            eosinophilia, B-lymphocyte hyperplasia, and altered antibody
            production.
REFERENCE   8  (bases 1 to 1167)
  AUTHORS   Pan,G., French,D., Mao,W., Maruoka,M., Risser,P., Lee,J.,
            Foster,J., Aggarwal,S., Nicholes,K., Guillet,S., Schow,P. and
            Gurney,A.L.
  TITLE     Forced expression of murine IL-17E induces growth retardation,
            jaundice, a Th2-biased response, and multiorgan inflammation in
            mice
  JOURNAL   J Immunol 167 (11), 6559-6567 (2001)
   PUBMED   11714825
  REMARK    GeneRIF: Overexpression of IL-17E up-regulates gene expression of
            Th2 cytokines and induces growth retardation, jaundice, and
            multiorgan inflammation in a transgenic mouse model.
REFERENCE   9  (bases 1 to 1167)
  AUTHORS   Fort,M.M., Cheung,J., Yen,D., Li,J., Zurawski,S.M., Lo,S.,
            Menon,S., Clifford,T., Hunte,B., Lesley,R., Muchamuel,T.,
            Hurst,S.D., Zurawski,G., Leach,M.W., Gorman,D.M. and Rennick,D.M.
  TITLE     IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies
            in vivo
  JOURNAL   Immunity 15 (6), 985-995 (2001)
   PUBMED   11754819
REFERENCE   10 (bases 1 to 1167)
  AUTHORS   Lee,J., Ho,W.H., Maruoka,M., Corpuz,R.T., Baldwin,D.T.,
            Foster,J.S., Goddard,A.D., Yansura,D.G., Vandlen,R.L., Wood,W.I.
            and Gurney,A.L.
  TITLE     IL-17E, a novel proinflammatory ligand for the IL-17 receptor
            homolog IL-17Rh1
  JOURNAL   J Biol Chem 276 (2), 1660-1664 (2001)
   PUBMED   11058597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049829.4.
            
            On Apr 26, 2022 this sequence version replaced NM_172314.1.
            
            Summary: The protein encoded by this gene is a cytokine that shares
            sequence similarity with interleukin 17. This cytokine can induce
            NF-kappaB activation, and stimulate the production of interleukin
            8. Both this cytokine and interleukin 17B are ligands for the
            cytokine receptor IL17BR. Studies of a similar gene in mice suggest
            that this cytokine may be a pro-inflammatory cytokine favoring the
            Th2-type immune response. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses an alternate start codon,
            compared to variant 1. The resulting isoform (2) has a distinct
            N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461739.1, BC104931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155628, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397242.3/ ENSP00000380417.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AL049829.4         154867-155033
            168-388             AL049829.4         155234-155454
            389-1167            AL049829.4         157683-158461
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1167
                     /gene="IL25"
                     /gene_synonym="IL17E"
                     /note="interleukin 25"
                     /db_xref="GeneID:64806"
                     /db_xref="HGNC:HGNC:13765"
                     /db_xref="MIM:605658"
     exon            1..167
                     /gene="IL25"
                     /gene_synonym="IL17E"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..644
                     /gene="IL25"
                     /gene_synonym="IL17E"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; interleukin-17E"
                     /codon_start=1
                     /product="interleukin-25 isoform 2 precursor"
                     /protein_id="NP_758525.1"
                     /db_xref="CCDS:CCDS45086.1"
                     /db_xref="GeneID:64806"
                     /db_xref="HGNC:HGNC:13765"
                     /db_xref="MIM:605658"
                     /translation="MYQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVP
                     PLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSL
                     QTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVM
                     G"
     exon            168..388
                     /gene="IL25"
                     /gene_synonym="IL17E"
                     /inference="alignment:Splign:2.1.0"
     exon            389..1167
                     /gene="IL25"
                     /gene_synonym="IL17E"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaagtcac tccctaaaaa gacagtggaa ataaatttga ataaacaaaa caggcttgct
       61 gaaaataaaa tcaggactcc taacctgctc cagtcagcct gcttccacga ggcctgtcag
      121 tcagtgcccc acttgtgact gagtgtgcag tgcccagcat gtaccaggtg gttgcattct
      181 tggcaatggt catgggaacc cacacctaca gccactggcc cagctgctgc cccagcaaag
      241 ggcaggacac ctctgaggag ctgctgaggt ggagcactgt gcctgtgcct cccctagagc
      301 ctgctaggcc caaccgccac ccagagtcct gtagggccag tgaagatgga cccctcaaca
      361 gcagggccat ctccccctgg agatatgagt tggacagaga cttgaaccgg ctcccccagg
      421 acctgtacca cgcccgttgc ctgtgcccgc actgcgtcag cctacagaca ggctcccaca
      481 tggacccccg gggcaactcg gagctgctct accacaacca gactgtcttc taccggcggc
      541 catgccatgg cgagaagggc acccacaagg gctactgcct ggagcgcagg ctgtaccgtg
      601 tttccttagc ttgtgtgtgt gtgcggcccc gtgtgatggg ctagccggac ctgctggagg
      661 ctggtccctt tttgggaaac ctggagccag gtgtacaacc acttgccatg aagggccagg
      721 atgcccagat gcttggcccc tgtgaagtgc tgtctggagc agcaggatcc cgggacagga
      781 tggggggctt tggggaaagc ctgcacttct gcacattttg aaaagagcag ctgctgctta
      841 gggccgccgg aagctggtgt cctgtcattt tctctcagga aaggttttca aagttctgcc
      901 catttctgga ggccaccact cctgtctctt cctcttttcc catcccctgc taccctggcc
      961 cagcacaggc actttctaga tatttccccc ttgctggaga agaaagagcc cctggtttta
     1021 tttgtttgtt tactcatcac tcagtgagca tctactttgg gtgcattcta gtgtagttac
     1081 tagtcttttg acatggatga ttctgaggag gaagctgtta ttgaatgtat agagatttat
     1141 ccaaataaat atctttattt aaaaatg
//
