LOCUS       NM_006850               1976 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens interleukin 24 (IL24), transcript variant 1, mRNA.
ACCESSION   NM_006850
VERSION     NM_006850.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Mahmood,A.S. and Al-Bassam,W.W.
  TITLE     Serum level of interleukin-24 and its polymorphism in eczematic
            Iraqi patients
  JOURNAL   Medicine (Baltimore) 103 (25), e38635 (2024)
   PUBMED   38905384
  REMARK    GeneRIF: Serum level of interleukin-24 and its polymorphism in
            eczematic Iraqi patients.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Shibata,N., Ohashi,Y., Tsukada,A., Iwase,D., Aikawa,J., Mukai,M.,
            Metoki,Y., Uekusa,Y., Sato,M., Inoue,G., Takaso,M. and Uchida,K.
  TITLE     IL24 Expression in Synovial Myofibroblasts: Implications for Female
            Osteoarthritis Pain through Propensity Score Matching Analysis
  JOURNAL   Medicina (Kaunas) 60 (5), 741 (2024)
   PUBMED   38792924
  REMARK    GeneRIF: IL24 Expression in Synovial Myofibroblasts: Implications
            for Female Osteoarthritis Pain through Propensity Score Matching
            Analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Bordon,Y.
  TITLE     Hypoxia and IL-24 drive a sterile wound healing pathway
  JOURNAL   Nat Rev Immunol 23 (6), 344 (2023)
   PUBMED   37165170
  REMARK    GeneRIF: Hypoxia and IL-24 drive a sterile wound healing pathway.
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Allen,M., Pratscher,B., Krepler,C., Frei,K., Schofer,C.,
            Pehamberger,H., Muller,M. and Lucas,T.
  TITLE     Alternative splicing of IL-24 in melanocytes by deletion of exons 3
            and 5
  JOURNAL   Int J Immunogenet 32 (6), 375-378 (2005)
   PUBMED   16313301
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Allen,M., Pratscher,B., Roka,F., Krepler,C., Wacheck,V.,
            Schofer,C., Pehamberger,H., Muller,M. and Lucas,T.
  TITLE     Loss of novel mda-7 splice variant (mda-7s) expression is
            associated with metastatic melanoma
  JOURNAL   J Invest Dermatol 123 (3), 583-588 (2004)
   PUBMED   15304100
  REMARK    GeneRIF: mda-7s expression is linked to a non-metastatic phenotype
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Huang,E.Y., Madireddi,M.T., Gopalkrishnan,R.V., Leszczyniecka,M.,
            Su,Z., Lebedeva,I.V., Kang,D., Jiang,H., Lin,J.J., Alexandre,D.,
            Chen,Y., Vozhilla,N., Mei,M.X., Christiansen,K.A., Sivo,F.,
            Goldstein,N.I., Mhashilkar,A.B., Chada,S., Huberman,E., Pestka,S.
            and Fisher,P.B.
  TITLE     Genomic structure, chromosomal localization and expression profile
            of a novel melanoma differentiation associated (mda-7) gene with
            cancer specific growth suppressing and apoptosis inducing
            properties
  JOURNAL   Oncogene 20 (48), 7051-7063 (2001)
   PUBMED   11704829
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Su,Z.Z., Madireddi,M.T., Lin,J.J., Young,C.S., Kitada,S.,
            Reed,J.C., Goldstein,N.I. and Fisher,P.B.
  TITLE     The cancer growth suppressor gene mda-7 selectively induces
            apoptosis in human breast cancer cells and inhibits tumor growth in
            nude mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14400-14405 (1998)
   PUBMED   9826712
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Jiang,H., Su,Z.Z., Lin,J.J., Goldstein,N.I., Young,C.S. and
            Fisher,P.B.
  TITLE     The melanoma differentiation associated gene mda-7 suppresses
            cancer cell growth
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9160-9165 (1996)
   PUBMED   8799171
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Jiang,H., Lin,J.J., Su,Z.Z., Goldstein,N.I. and Fisher,P.B.
  TITLE     Subtraction hybridization identifies a novel melanoma
            differentiation associated gene, mda-7, modulated during human
            melanoma differentiation, growth and progression
  JOURNAL   Oncogene 11 (12), 2477-2486 (1995)
   PUBMED   8545104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP222545.1, U16261.1 and
            AY641441.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 8, 2010 this sequence version replaced NM_006850.2.
            
            Summary: This gene encodes a member of the IL10 family of
            cytokines. It was identified as a gene induced during terminal
            differentiation in melanoma cells. The protein encoded by this gene
            can induce apoptosis selectively in various cancer cells.
            Overexpression of this gene leads to elevated expression of several
            GADD family genes, which correlates with the induction of
            apoptosis. The phosphorylation of mitogen-activated protein kinase
            14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are
            found to be induced by this gene in melanoma cells, but not in
            normal immortal melanocytes. Alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16261.1, SRR14038197.710778.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294984.7/ ENSP00000294984.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP222545.1         1-1
            2-1391              U16261.1           1-1390
            1392-1976           AY641441.1         1235-1819
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1976
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="interleukin 24"
                     /db_xref="GeneID:11009"
                     /db_xref="HGNC:HGNC:11346"
                     /db_xref="MIM:604136"
     exon            1..173
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     exon            174..319
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..896
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-4-induced secreted protein; suppression of
                     tumorigenicity 16 (melanoma differentiation);
                     melanocyte-associated Mda-7; melanoma
                     differentiation-associated gene 7 protein"
                     /codon_start=1
                     /product="interleukin-24 isoform 1 precursor"
                     /protein_id="NP_006841.1"
                     /db_xref="CCDS:CCDS1471.1"
                     /db_xref="GeneID:11009"
                     /db_xref="HGNC:HGNC:11346"
                     /db_xref="MIM:604136"
                     /translation="MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWS
                     QVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSD
                     AESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMF
                     SIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL"
     exon            320..515
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     exon            516..578
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     exon            579..737
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     exon            738..812
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1976
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="hexamer: AATAAA"
     polyA_site      1306
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="hexamer: AATAAA"
     polyA_site      1702
                     /gene="IL24"
                     /gene_synonym="C49A; FISP; IL10B; MDA7; MOB5; ST16"
                     /note="major polyA site"
ORIGIN      
        1 gcttgcctgc aaacctttac ttctgaaatg acttccacgg ctgggacggg aaccttccac
       61 ccacagctat gcctctgatt ggtgaatggt gaaggtgcct gtctaacttt tctgtaaaaa
      121 gaaccagctg cctccaggca gccagccctc aagcatcact tacaggacca gagggacaag
      181 acatgactgt gatgaggagc tgctttcgcc aatttaacac caagaagaat tgaggctgct
      241 tgggaggaag gccaggagga acacgagact gagagatgaa ttttcaacag aggctgcaaa
      301 gcctgtggac tttagccaga cccttctgcc ctcctttgct ggcgacagcc tctcaaatgc
      361 agatggttgt gctcccttgc ctgggtttta ccctgcttct ctggagccag gtatcagggg
      421 cccagggcca agaattccac tttgggccct gccaagtgaa gggggttgtt ccccagaaac
      481 tgtgggaagc cttctgggct gtgaaagaca ctatgcaagc tcaggataac atcacgagtg
      541 cccggctgct gcagcaggag gttctgcaga acgtctcgga tgctgagagc tgttaccttg
      601 tccacaccct gctggagttc tacttgaaaa ctgttttcaa aaactaccac aatagaacag
      661 ttgaagtcag gactctgaag tcattctcta ctctggccaa caactttgtt ctcatcgtgt
      721 cacaactgca acccagtcaa gaaaatgaga tgttttccat cagagacagt gcacacaggc
      781 ggtttctgct attccggaga gcattcaaac agttggacgt agaagcagct ctgaccaaag
      841 cccttgggga agtggacatt cttctgacct ggatgcagaa attctacaag ctctgaatgt
      901 ctagaccagg acctccctcc ccctggcact ggtttgttcc ctgtgtcatt tcaaacagtc
      961 tcccttccta tgctgttcac tggacacttc acgcccttgg ccatgggtcc cattcttggc
     1021 ccaggattat tgtcaaagaa gtcattcttt aagcagcgcc agtgacagtc agggaaggtg
     1081 cctctggatg ctgtgaagag tctacagaga agattcttgt atttattaca actctattta
     1141 attaatgtca gtatttcaac tgaagttcta tttatttgtg agactgtaag ttacatgaag
     1201 gcagcagaat attgtgcccc atgcttcttt acccctcaca atccttgcca cagtgtgggg
     1261 cagtggatgg gtgcttagta agtacttaat aaactgtggt gctttttttg gcctgtcttt
     1321 ggattgttaa aaaacagaga gggatgcttg gatgtaaaac tgaacttcag agcatgaaaa
     1381 tcacactgtc ttctgatatc tgcagggaca gagcattggg gtgggggtaa ggtgcatctg
     1441 tttgaaaagt aaacgataaa atgtggatta aagtgcccag cacaaagcag atcctcaata
     1501 aacatttcat ttcccaccca cactcgccag ctcaccccat catccctttc ccttggtgcc
     1561 ctcctttttt ttttatccta gtcattcttc cctaatcttc cacttgagtg tcaagctgac
     1621 cttgctgatg gtgacattgc acctggatgt actatccaat ctgtgatgac attccctgct
     1681 aataaaagac aacataactc aagtctggca gactttcttc tctatttctg gatgaatgcc
     1741 cagtgagact gtgttgtaca gctagaaaag gccttcttcc caatagcaag gctgtgcatc
     1801 tagcctcaag ctctggctga actttgtggt cgacatcaat ctaaagatac agtgtctgac
     1861 tataaccttg ttccaaaaac ctaggcaaag agtatatgta ggaggtggga tatcacttcc
     1921 atgacataag tgctattgca gagccgtggc cacccaggaa ctcctgactg ctttcc
//
