LOCUS       NM_144701               2858 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens interleukin 23 receptor (IL23R), mRNA.
ACCESSION   NM_144701
VERSION     NM_144701.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Miyake,Y., Tanaka,K., Nagata,C., Furukawa,S., Andoh,A.,
            Yokoyama,T., Yoshimura,N., Mori,K., Ninomiya,T., Yamamoto,Y.,
            Takeshita,E., Ikeda,Y., Saito,M., Ohashi,K., Imaeda,H.,
            Kakimoto,K., Higuchi,K., Nunoi,H., Mizukami,Y., Suzuki,S.,
            Hiraoka,S., Okada,H., Kawasaki,K., Higashiyama,M., Hokari,R.,
            Miura,H., Miyake,T., Kumagi,T., Kato,H., Hato,N., Sayama,K. and
            Hiasa,Y.
  CONSRTM   Japan Ulcerative Colitis Study Group
  TITLE     Case-control study of IL23R rs76418789 polymorphism, smoking, and
            ulcerative colitis in Japan
  JOURNAL   Cytokine 183, 156743 (2024)
   PUBMED   39213891
  REMARK    GeneRIF: Case-control study of IL23R rs76418789 polymorphism,
            smoking, and ulcerative colitis in Japan.
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Rane,S.S., Shellard,E., Adamson,A., Eyre,S. and Warren,R.B.
  TITLE     IL23R mutations associated with decreased risk of psoriasis lead to
            the differential expression of genes implicated in the disease
  JOURNAL   Exp Dermatol 33 (9), e15180 (2024)
   PUBMED   39306854
  REMARK    GeneRIF: IL23R mutations associated with decreased risk of
            psoriasis lead to the differential expression of genes implicated
            in the disease.
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Ren,R., Tan,H., Wang,X., Wang,L. and Yang,B.
  TITLE     Gene polymorphisms of an interleukin-23 receptor associated with
            susceptibility to rheumatoid arthritis in the Western Chinese Han
            population
  JOURNAL   Int J Immunogenet 51 (2), 72-80 (2024)
   PUBMED   38196067
  REMARK    GeneRIF: Gene polymorphisms of an interleukin-23 receptor
            associated with susceptibility to rheumatoid arthritis in the
            Western Chinese Han population.
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Tishe,Z.H., Shawkat,S., Popy,M.N., Ahmed,A., Mumu,S.B., Apu,M.N.H.
            and Mostaid,M.S.
  TITLE     Interleukin gene polymorphisms and alopecia areata: A systematic
            review and meta-analysis
  JOURNAL   Medicine (Baltimore) 103 (8), e37300 (2024)
   PUBMED   38394507
  REMARK    GeneRIF: Interleukin gene polymorphisms and alopecia areata: A
            systematic review and meta-analysis.
REFERENCE   5  (bases 1 to 2858)
  AUTHORS   Yu,R.Y. and Gallagher,G.
  TITLE     A naturally occurring, soluble antagonist of human IL-23 inhibits
            the development and in vitro function of human Th17 cells
  JOURNAL   J Immunol 185 (12), 7302-7308 (2010)
   PUBMED   21076058
  REMARK    GeneRIF: A splice variant lacking exon 9 (Delta-9) encodes a
            soluble extracellular domain of IL23R. This binds the p19 component
            of IL23 and inhibits STAT3 activation in human CD4+ T-cells. Acting
            as an IL23 antagonist, it inhibits the secretion of IL17.
REFERENCE   6  (bases 1 to 2858)
  AUTHORS   Kan,S.H., Mancini,G. and Gallagher,G.
  TITLE     Identification and characterization of multiple splice forms of the
            human interleukin-23 receptor alpha chain in mitogen-activated
            leukocytes
  JOURNAL   Genes Immun 9 (7), 631-639 (2008)
   PUBMED   18754016
  REMARK    GeneRIF: Twenty-four splice forms of IL23R were observed including
            several that may encode proteins. Two encode the entire (Delta-9)
            or the majority of (Delta-8,9) the extracellular ligand-binding
            domain and may be soluble receptors.
REFERENCE   7  (bases 1 to 2858)
  AUTHORS   Mancini,G., Kan,S.H. and Gallagher,G.
  TITLE     A novel insertion variant of the human IL-23 receptor-alpha chain
            transcript
  JOURNAL   Genes Immun 9 (6), 566-569 (2008)
   PUBMED   18615094
  REMARK    GeneRIF: This report describes an insertion in the IL-23 receptor
            and due to consequent early termination within the intracellular
            region, causing a possible non-responsive receptor isoform.
            GeneRIF: An intronic insertion was discovered between exons 9 and
            10 of IL23R and termed exon 9a. This insertion has homology to the
            L1 retrotransposon protein and causes early translation
            termination.
REFERENCE   8  (bases 1 to 2858)
  AUTHORS   Parham,C., Chirica,M., Timans,J., Vaisberg,E., Travis,M.,
            Cheung,J., Pflanz,S., Zhang,R., Singh,K.P., Vega,F., To,W.,
            Wagner,J., O'Farrell,A.M., McClanahan,T., Zurawski,S., Hannum,C.,
            Gorman,D., Rennick,D.M., Kastelein,R.A., de Waal Malefyt,R. and
            Moore,K.W.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   9  (bases 1 to 2858)
  AUTHORS   Veal,C.D., Clough,R.L., Barber,R.C., Mason,S., Tillman,D.,
            Ferry,B., Jones,A.B., Ameen,M., Balendran,N., Powis,S.H.,
            Burden,A.D., Barker,J.N. and Trembath,R.C.
  TITLE     Identification of a novel psoriasis susceptibility locus at 1p and
            evidence of epistasis between PSORS1 and candidate loci
  JOURNAL   J Med Genet 38 (1), 7-13 (2001)
   PUBMED   11134234
REFERENCE   10 (bases 1 to 2858)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109843.25 and AL389925.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_144701.2.
            
            Summary: The protein encoded by this gene is a subunit of the
            receptor for IL23A/IL23. This protein pairs with the receptor
            molecule IL12RB1/IL12Rbeta1, and both are required for IL23A
            signaling. This protein associates constitutively with Janus kinase
            2 (JAK2), and also binds to transcription activator STAT3 in a
            ligand-dependent manner. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461422.1, SRR18074968.3514842.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347310.10/ ENSP00000321345.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AL109843.25        34077-34164
            89-187              AL109843.25        35715-35813
            188-484             AL109843.25        36965-37261
            485-608             AL109843.25        50459-50582
            609-769             AL109843.25        68360-68520
            770-915             AL109843.25        74533-74678
            916-1072            AL109843.25        87197-87353
            1073-1162           AL109843.25        104336-104425
            1163-1265           AL109843.25        107802-107904
            1266-1356           AL389925.10        8847-8937
            1357-2858           AL389925.10        11488-12989
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..2858
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /note="interleukin 23 receptor"
                     /db_xref="GeneID:149233"
                     /db_xref="HGNC:HGNC:19100"
                     /db_xref="MIM:607562"
     exon            1..88
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            89..187
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2007
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /note="IL-23R; IL-23 receptor"
                     /codon_start=1
                     /product="interleukin-23 receptor precursor"
                     /protein_id="NP_653302.2"
                     /db_xref="CCDS:CCDS637.1"
                     /db_xref="GeneID:149233"
                     /db_xref="HGNC:HGNC:19100"
                     /db_xref="MIM:607562"
                     /translation="MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKM
                     GMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCT
                     AECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVV
                     HVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIV
                     IPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTY
                     VQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNS
                     GLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLI
                     PKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDY
                     KKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLT
                     LKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNS
                     VEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRI
                     SLLEK"
     exon            188..484
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            485..608
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            609..769
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            770..915
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1072
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1162
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1265
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1356
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..2858
                     /gene="IL23R"
                     /gene_synonym="PSORS7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagtgag gaaagaagac atgacacagc caacaagggt ggcagcctgg ctctgaagtg
       61 gaattatgtg cttcaaacag gttgaaagag ggaaacagtc ttttcctgct tccagacatg
      121 aatcaggtca ctattcaatg ggatgcagta atagcccttt acatactctt cagctggtgt
      181 catggaggaa ttacaaatat aaactgctct ggccacatct gggtagaacc agccacaatt
      241 tttaagatgg gtatgaatat ctctatatat tgccaagcag caattaagaa ctgccaacca
      301 aggaaacttc atttttataa aaatggcatc aaagaaagat ttcaaatcac aaggattaat
      361 aaaacaacag ctcggctttg gtataaaaac tttctggaac cacatgcttc tatgtactgc
      421 actgctgaat gtcccaaaca ttttcaagag acactgatat gtggaaaaga catttcttct
      481 ggatatccgc cagatattcc tgatgaagta acctgtgtca tttatgaata ttcaggcaac
      541 atgacttgca cctggaatgc tgggaagctc acctacatag acacaaaata cgtggtacat
      601 gtgaagagtt tagagacaga agaagagcaa cagtatctca cctcaagcta tattaacatc
      661 tccactgatt cattacaagg tggcaagaag tacttggttt gggtccaagc agcaaacgca
      721 ctaggcatgg aagagtcaaa acaactgcaa attcacctgg atgatatagt gataccttct
      781 gcagccgtca tttccagggc tgagactata aatgctacag tgcccaagac cataatttat
      841 tgggatagtc aaacaacaat tgaaaaggtt tcctgtgaaa tgagatacaa ggctacaaca
      901 aaccaaactt ggaatgttaa agaatttgac accaatttta catatgtgca acagtcagaa
      961 ttctacttgg agccaaacat taagtacgta tttcaagtga gatgtcaaga aacaggcaaa
     1021 aggtactggc agccttggag ttcactgttt tttcataaaa cacctgaaac agttccccag
     1081 gtcacatcaa aagcattcca acatgacaca tggaattctg ggctaacagt tgcttccatc
     1141 tctacagggc accttacttc tgacaacaga ggagacattg gacttttatt gggaatgatc
     1201 gtctttgctg ttatgttgtc aattctttct ttgattggga tatttaacag atcattccga
     1261 actgggatta aaagaaggat cttattgtta ataccaaagt ggctttatga agatattcct
     1321 aatatgaaaa acagcaatgt tgtgaaaatg ctacaggaaa atagtgaact tatgaataat
     1381 aattccagtg agcaggtcct atatgttgat cccatgatta cagagataaa agaaatcttc
     1441 atcccagaac acaagcctac agactacaag aaggagaata caggacccct ggagacaaga
     1501 gactacccgc aaaactcgct attcgacaat actacagttg tatatattcc tgatctcaac
     1561 actggatata aaccccaaat ttcaaatttt ctgcctgagg gaagccatct cagcaataat
     1621 aatgaaatta cttccttaac acttaaacca ccagttgatt ccttagactc aggaaataat
     1681 cccaggttac aaaagcatcc taattttgct ttttctgttt caagtgtgaa ttcactaagc
     1741 aacacaatat ttcttggaga attaagcctc atattaaatc aaggagaatg cagttctcct
     1801 gacatacaaa actcagtaga ggaggaaacc accatgcttt tggaaaatga ttcacccagt
     1861 gaaactattc cagaacagac cctgcttcct gatgaatttg tctcctgttt ggggatcgtg
     1921 aatgaggagt tgccatctat taatacttat tttccacaaa atattttgga aagccacttc
     1981 aataggattt cactcttgga aaagtagagc tgtgtggtca aaatcaatat gagaaagctg
     2041 ccttgcaatc tgaacttggg ttttccctgc aatagaaatt gaattctgcc tctttttgaa
     2101 aaaaatgtat tcacatacaa atcttcacat ggacacatgt tttcatttcc cttggataaa
     2161 tacctaggta ggggattgct gggccatatg ataagcatat gtttcagttc taccaatctt
     2221 gtttccagag tagtgacatt tctgtgctcc taccatcacc atgtaagaat tcccgggagc
     2281 tccatgcctt tttaatttta gccattcttc tgcctcattt cttaaaatta gagaattaag
     2341 gtcccgaagg tggaacatgc ttcatggtca cacatacagg cacaaaaaca gcattatgtg
     2401 gacgcctcat gtatttttta tagagtcaac tatttcctct ttattttccc tcattgaaag
     2461 atgcaaaaca gctctctatt gtgtacagaa agggtaaata atgcaaaata cctggtagta
     2521 aaataaatgc tgaaaatttt cctttaaaat agaatcatta ggccaggcgt ggtggctcat
     2581 gcttgtaatc ccagcacttt ggtaggctga ggtaggtgga tcacctgagg tcaggagttc
     2641 gagtccagcc tggccaatat gctgaaaccc tgtctctact aaaattacaa aaattagccg
     2701 gccatggtgg caggtgcttg taatcccagc tacttgggag gctgaggcag gagaatcact
     2761 tgaaccagga aggcagaggt tgcactgagc tgagattgtg ccactgcact ccagcctggg
     2821 caacaagagc aaaactctgt ctggaaaaaa aaaaaaaa
//
