LOCUS       NM_016584               1037 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens interleukin 23 subunit alpha (IL23A), mRNA.
ACCESSION   NM_016584
VERSION     NM_016584.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1037)
  AUTHORS   Ahmed,A., Joseph,A.M., Zhou,J., Horn,V., Uddin,J., Lyu,M., Goc,J.,
            Sockolow,R.E., Wing,J.B., Vivier,E., Sakaguchi,S. and
            Sonnenberg,G.F.
  CONSRTM   JRI Live Cell Bank
  TITLE     CTLA-4-expressing ILC3s restrain interleukin-23-mediated
            inflammation
  JOURNAL   Nature 630 (8018), 976-983 (2024)
   PUBMED   38867048
  REMARK    GeneRIF: CTLA-4-expressing ILC3s restrain interleukin-23-mediated
            inflammation.
REFERENCE   2  (bases 1 to 1037)
  AUTHORS   Chen,L., Huang,D., Huang,Z., Liu,X., He,M., Luo,M., Tang,Z.,
            Tan,G., Guo,Q. and Xiong,H.
  TITLE     Decreased HMGCS1 inhibits proliferation and inflammatory response
            of keratinocytes and ameliorates imiquimod-induced psoriasis via
            the STAT3/IL-23 axis
  JOURNAL   Int Immunopharmacol 133, 112033 (2024)
   PUBMED   38608446
  REMARK    GeneRIF: Decreased HMGCS1 inhibits proliferation and inflammatory
            response of keratinocytes and ameliorates imiquimod-induced
            psoriasis via the STAT3/IL-23 axis.
REFERENCE   3  (bases 1 to 1037)
  AUTHORS   Sisnett,D.J., Zutautas,K.B., Miller,J.E., Lingegowda,H., Ahn,S.H.,
            McCallion,A., Bougie,O., Lessey,B.A. and Tayade,C.
  TITLE     The Dysregulated IL-23/TH17 Axis in Endometriosis Pathophysiology
  JOURNAL   J Immunol 212 (9), 1428-1441 (2024)
   PUBMED   38466035
  REMARK    GeneRIF: The Dysregulated IL-23/TH17 Axis in Endometriosis
            Pathophysiology.
REFERENCE   4  (bases 1 to 1037)
  AUTHORS   Bao,S., Zheng,W., Yan,R. and Xu,J.
  TITLE     miRNA-21 promotes the progression of acute liver failure via the
            KLF6/autophagy/IL-23 signaling pathway
  JOURNAL   Mol Med Rep 29 (5) (2024)
   PUBMED   38516774
  REMARK    GeneRIF: miRNA-21 promotes the progression of acute liver failure
            via the KLF6/autophagy/IL-23 signaling pathway.
REFERENCE   5  (bases 1 to 1037)
  AUTHORS   Krueger,J.G., Eyerich,K., Kuchroo,V.K., Ritchlin,C.T., Abreu,M.T.,
            Elloso,M.M., Fourie,A., Fakharzadeh,S., Sherlock,J.P., Yang,Y.W.,
            Cua,D.J. and McInnes,I.B.
  TITLE     IL-23 past, present, and future: a roadmap to advancing IL-23
            science and therapy
  JOURNAL   Front Immunol 15, 1331217 (2024)
   PUBMED   38686385
  REMARK    GeneRIF: IL-23 past, present, and future: a roadmap to advancing
            IL-23 science and therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1037)
  AUTHORS   Pirhonen,J., Matikainen,S. and Julkunen,I.
  TITLE     Regulation of virus-induced IL-12 and IL-23 expression in human
            macrophages
  JOURNAL   J Immunol 169 (10), 5673-5678 (2002)
   PUBMED   12421946
REFERENCE   7  (bases 1 to 1037)
  AUTHORS   Parham,C., Chirica,M., Timans,J., Vaisberg,E., Travis,M.,
            Cheung,J., Pflanz,S., Zhang,R., Singh,K.P., Vega,F., To,W.,
            Wagner,J., O'Farrell,A.M., McClanahan,T., Zurawski,S., Hannum,C.,
            Gorman,D., Rennick,D.M., Kastelein,R.A., de Waal Malefyt,R. and
            Moore,K.W.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   8  (bases 1 to 1037)
  AUTHORS   Broberg,E.K., Setala,N., Eralinna,J.P., Salmi,A.A., Roytta,M. and
            Hukkanen,V.
  TITLE     Herpes simplex virus type 1 infection induces upregulation of
            interleukin-23 (p19) mRNA expression in trigeminal ganglia of
            BALB/c mice
  JOURNAL   J Interferon Cytokine Res 22 (6), 641-651 (2002)
   PUBMED   12162874
  REMARK    GeneRIF: Elevated expression of mRNA for IL-23(p19)was found in
            trigeminal ganglia of BALB/C mice infected with HSV-1 from early
            acute infection to the beginning of the latent phase.
REFERENCE   9  (bases 1 to 1037)
  AUTHORS   Wiekowski,M.T., Leach,M.W., Evans,E.W., Sullivan,L., Chen,S.C.,
            Vassileva,G., Bazan,J.F., Gorman,D.M., Kastelein,R.A., Narula,S.
            and Lira,S.A.
  TITLE     Ubiquitous transgenic expression of the IL-23 subunit p19 induces
            multiorgan inflammation, runting, infertility, and premature death
  JOURNAL   J Immunol 166 (12), 7563-7570 (2001)
   PUBMED   11390512
REFERENCE   10 (bases 1 to 1037)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM842783.1 and AB030000.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016584.2.
            
            Summary: This gene encodes a subunit of the heterodimeric cytokine
            interleukin 23 (IL23). IL23 is composed of this protein and the p40
            subunit of interleukin 12 (IL12B). The receptor of IL23 is formed
            by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific
            subunit, IL23R. Both IL23 and IL12 can activate the transcription
            activator STAT4, and stimulate the production of interferon-gamma
            (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T
            cells, IL23 preferentially acts on memory CD4(+) T cells. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359083.1, SRR1163658.347730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228534.6/ ENSP00000228534.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BM842783.1         6-23
            19-1037             AB030000.1         1-1019
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1037
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /note="interleukin 23 subunit alpha"
                     /db_xref="GeneID:51561"
                     /db_xref="HGNC:HGNC:15488"
                     /db_xref="MIM:605580"
     exon            1..323
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..731
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /note="interleukin-six, G-CSF related factor; interleukin
                     23 p19 subunit; JKA3 induced upon T-cell activation;
                     IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin-23
                     subunit p19; interleukin 23, alpha subunit p19"
                     /codon_start=1
                     /product="interleukin-23 subunit alpha precursor"
                     /protein_id="NP_057668.1"
                     /db_xref="CCDS:CCDS8916.1"
                     /db_xref="GeneID:51561"
                     /db_xref="HGNC:HGNC:15488"
                     /db_xref="MIM:605580"
                     /translation="MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLA
                     WSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEK
                     LLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLL
                     LRFKILRSLQAFVAVAARVFAHGAATLSP"
     exon            324..422
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /inference="alignment:Splign:2.1.0"
     exon            423..569
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /inference="alignment:Splign:2.1.0"
     exon            570..1037
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /note="hexamer: AATAAA"
     polyA_site      1037
                     /gene="IL23A"
                     /gene_synonym="IL-23; IL-23A; IL23P19; P19; SGRF"
                     /note="major polyA site"
ORIGIN      
        1 aacaggaagc agcttacaaa ctcggtgaac aactgaggga accaaaccag agacgcgctg
       61 aacagagaga atcaggctca aagcaagtgg aagtgggcag agattccacc aggactggtg
      121 caaggcgcag agccagccag atttgagaag aaggcaaaaa gatgctgggg agcagagctg
      181 taatgctgct gttgctgctg ccctggacag ctcagggcag agctgtgcct gggggcagca
      241 gccctgcctg gactcagtgc cagcagcttt cacagaagct ctgcacactg gcctggagtg
      301 cacatccact agtgggacac atggatctaa gagaagaggg agatgaagag actacaaatg
      361 atgttcccca tatccagtgt ggagatggct gtgaccccca aggactcagg gacaacagtc
      421 agttctgctt gcaaaggatc caccagggtc tgatttttta tgagaagctg ctaggatcgg
      481 atattttcac aggggagcct tctctgctcc ctgatagccc tgtgggccag cttcatgcct
      541 ccctactggg cctcagccaa ctcctgcagc ctgagggtca ccactgggag actcagcaga
      601 ttccaagcct cagtcccagc cagccatggc agcgtctcct tctccgcttc aaaatccttc
      661 gcagcctcca ggcctttgtg gctgtagccg cccgggtctt tgcccatgga gcagcaaccc
      721 tgagtcccta aaggcagcag ctcaaggatg gcactcagat ctccatggcc cagcaaggcc
      781 aagataaatc taccacccca ggcacctgtg agccaacagg ttaattagtc cattaatttt
      841 agtgggacct gcatatgttg aaaattacca atactgactg acatgtgatg ctgacctatg
      901 ataaggttga gtatttatta gatgggaagg gaaatttggg gattatttat cctcctgggg
      961 acagtttggg gaggattatt tattgtattt atattgaatt atgtactttt ttcaataaag
     1021 tcttattttt gtggcta
//
