LOCUS       NM_052962               2893 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens interleukin 22 receptor subunit alpha 2 (IL22RA2),
            transcript variant 1, mRNA.
ACCESSION   NM_052962
VERSION     NM_052962.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2893)
  AUTHORS   Csosza,G., Szucs,G., Rozgonyi,Z., Csoma,B., Losonczy,G., Muller,V.,
            Karlocai,K. and Lazar,Z.
  TITLE     Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary
            hypertension
  JOURNAL   Physiol Int 110 (4), 356-370 (2023)
   PUBMED   37975916
  REMARK    GeneRIF: Circulating apelin, IL22RA2 and VEGF in pre-capillary
            pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2893)
  AUTHORS   Gu,J., Zhou,P., Liu,Y., Xu,Q., Chen,X., Chen,M., Lu,C., Qu,C.,
            Tong,Y., Yu,Q., Lu,X., Yu,C. and Liu,Z.
  TITLE     Down-regulating Interleukin-22/Interleukin-22 binding protein axis
            promotes inflammation and aggravates diet-induced metabolic
            disorders
  JOURNAL   Mol Cell Endocrinol 557, 111776 (2022)
   PUBMED   36108991
  REMARK    GeneRIF: Down-regulating Interleukin-22/Interleukin-22 binding
            protein axis promotes inflammation and aggravates diet-induced
            metabolic disorders.
REFERENCE   3  (bases 1 to 2893)
  AUTHORS   Fantou,A., Lagrue,E., Laurent,T., Delbos,L., Blandin,S., Jarry,A.,
            Beriou,G., Braudeau,C., Salabert,N., Marin,E., Moreau,A.,
            Podevin,J., Bourreille,A., Josien,R. and Martin,J.C.
  TITLE     IL-22BP production is heterogeneously distributed in Crohn's
            disease
  JOURNAL   Front Immunol 13, 1034570 (2022)
   PUBMED   36311796
  REMARK    GeneRIF: IL-22BP production is heterogeneously distributed in
            Crohn's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2893)
  AUTHORS   de Brito,R.J.V.C., do Carmo,R.F., Silva,B.M.S., Costa,A.C.S.,
            Rocha,S.W.S., Vasconcelos,L.R.S., Pereira,L.M.M.B. and de
            Moura,P.M.M.F.
  TITLE     Liver expression of IL-22, IL-22R1 and IL-22BP in patients with
            chronic hepatitis C with different fibrosis stages
  JOURNAL   Cytokine 150, 155784 (2022)
   PUBMED   34920229
  REMARK    GeneRIF: Liver expression of IL-22, IL-22R1 and IL-22BP in patients
            with chronic hepatitis C with different fibrosis stages.
REFERENCE   5  (bases 1 to 2893)
  AUTHORS   Lucke,J., Sabihi,M., Zhang,T., Bauditz,L.F., Shiri,A.M.,
            Giannou,A.D. and Huber,S.
  TITLE     The good and the bad about separation anxiety: roles of IL-22 and
            IL-22BP in liver pathologies
  JOURNAL   Semin Immunopathol 43 (4), 591-607 (2021)
   PUBMED   33851257
  REMARK    GeneRIF: The good and the bad about separation anxiety: roles of
            IL-22 and IL-22BP in liver pathologies.
            Review article
REFERENCE   6  (bases 1 to 2893)
  AUTHORS   Wei,C.C., Ho,T.W., Liang,W.G., Chen,G.Y. and Chang,M.S.
  TITLE     Cloning and characterization of mouse IL-22 binding protein
  JOURNAL   Genes Immun 4 (3), 204-211 (2003)
   PUBMED   12700595
REFERENCE   7  (bases 1 to 2893)
  AUTHORS   Gruenberg,B.H., Schoenemeyer,A., Weiss,B., Toschi,L., Kunz,S.,
            Wolk,K., Asadullah,K. and Sabat,R.
  TITLE     A novel, soluble homologue of the human IL-10 receptor with
            preferential expression in placenta
  JOURNAL   Genes Immun 2 (6), 329-334 (2001)
   PUBMED   11607789
REFERENCE   8  (bases 1 to 2893)
  AUTHORS   Xu,W., Presnell,S.R., Parrish-Novak,J., Kindsvogel,W., Jaspers,S.,
            Chen,Z., Dillon,S.R., Gao,Z., Gilbert,T., Madden,K.,
            Schlutsmeyer,S., Yao,L., Whitmore,T.E., Chandrasekher,Y.,
            Grant,F.J., Maurer,M., Jelinek,L., Storey,H., Brender,T.,
            Hammond,A., Topouzis,S., Clegg,C.H. and Foster,D.C.
  TITLE     A soluble class II cytokine receptor, IL-22RA2, is a naturally
            occurring IL-22 antagonist
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9511-9516 (2001)
   PUBMED   11481447
REFERENCE   9  (bases 1 to 2893)
  AUTHORS   Kotenko,S.V., Izotova,L.S., Mirochnitchenko,O.V., Esterova,E.,
            Dickensheets,H., Donnelly,R.P. and Pestka,S.
  TITLE     Identification, cloning, and characterization of a novel soluble
            receptor that binds IL-22 and neutralizes its activity
  JOURNAL   J Immunol 166 (12), 7096-7103 (2001)
   PUBMED   11390454
REFERENCE   10 (bases 1 to 2893)
  AUTHORS   Dumoutier,L., Lejeune,D., Colau,D. and Renauld,J.C.
  TITLE     Cloning and characterization of IL-22 binding protein, a natural
            antagonist of IL-10-related T cell-derived inducible factor/IL-22
  JOURNAL   J Immunol 166 (12), 7090-7095 (2001)
   PUBMED   11390453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ313162.1, AY040566.1 and
            AI824338.1.
            
            On May 17, 2019 this sequence version replaced NM_052962.2.
            
            Summary: This gene encodes a member of the class II cytokine
            receptor family. The encoded soluble protein specifically binds to
            and inhibits interleukin 22 activity by blocking the interaction of
            interleukin 22 with its cell surface receptor. The encoded protein
            may be important in the regulation of inflammatory response, and
            has been implicated in the regulation of tumorigenesis in the
            colon. Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY040567.1, AY358737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568, SAMN03465410
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296980.7/ ENSP00000296980.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1235              AJ313162.1         7-1241
            1236-2882           AY040566.1         1117-2763
            2883-2893           AI824338.1         14-24               c
FEATURES             Location/Qualifiers
     source          1..2893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..2893
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /note="interleukin 22 receptor subunit alpha 2"
                     /db_xref="GeneID:116379"
                     /db_xref="HGNC:HGNC:14901"
                     /db_xref="MIM:606648"
     exon            1..232
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     exon            233..358
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1089
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin 22-binding protein; cytokine
                     receptor class-II member 10; cytokine receptor family type
                     2, soluble 1; interleukin 22 receptor, alpha 2"
                     /codon_start=1
                     /product="interleukin-22 receptor subunit alpha-2 isoform
                     1 precursor"
                     /protein_id="NP_443194.1"
                     /db_xref="CCDS:CCDS5182.1"
                     /db_xref="GeneID:116379"
                     /db_xref="HGNC:HGNC:14901"
                     /db_xref="MIM:606648"
                     /translation="MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNI
                     LQWQPGRALTGNSSVYFVQYKIMFSCSMKSSHQKPSGCWQHISCNFPGCRTLAKYGQR
                     QWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKI
                     DPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKV
                     YEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP"
     exon            359..494
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     exon            495..590
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     exon            591..769
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     exon            770..939
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     exon            940..2893
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1735..1740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /note="hexamer: ATTAAA"
     polyA_site      1758
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /note="major polyA site"
     regulatory      2872..2877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /note="hexamer: AATAAA"
     polyA_site      2893
                     /gene="IL22RA2"
                     /gene_synonym="CRF2-10; CRF2-S1; CRF2X; IL-22BP;
                     IL-22R-alpha-2; IL-22RA2; ZCYTOR16"
                     /note="major polyA site"
ORIGIN      
        1 ctttaccact actcgctata gagccctggt caagttctct ccacctctct atctatgtct
       61 cagtttcttc atctgtaaca tcaaatgaat aataatacca atctcctaga cttcataaga
      121 ggattaacaa agacaaaata tgggaaaaac ataacatggc gtcccataat tattagatct
      181 tattattgac actaaaatgg cattaaaatt accaaaagga agacagcatc tgtttcctct
      241 ttggtcctga gctggttaaa aggaacactg gttgcctgaa cagtcacact tgcaaccatg
      301 atgcctaaac attgctttct aggcttcctc atcagtttct tccttactgg tgtagcagga
      361 actcagtcaa cgcatgagtc tctgaagcct cagagggtac aatttcagtc ccgaaatttt
      421 cacaacattt tgcaatggca gcctgggagg gcacttactg gcaacagcag tgtctatttt
      481 gtgcagtaca aaatcatgtt ctcatgcagc atgaaaagct ctcaccagaa gccaagtgga
      541 tgctggcagc acatttcttg taacttccca ggctgcagaa cattggctaa atatggacag
      601 agacaatgga aaaataaaga agactgttgg ggtactcaag aactctcttg tgaccttacc
      661 agtgaaacct cagacataca ggaaccttat tacgggaggg tgagggcggc ctcggctggg
      721 agctactcag aatggagcat gacgccgcgg ttcactccct ggtgggaaac aaaaatagat
      781 cctccagtca tgaatataac ccaagtcaat ggctctttgt tggtaattct ccatgctcca
      841 aatttaccat atagatacca aaaggaaaaa aatgtatcta tagaagatta ctatgaacta
      901 ctataccgag tttttataat taacaattca ctagaaaagg agcaaaaggt ttatgaaggg
      961 gctcacagag cggttgaaat tgaagctcta acaccacact ccagctactg tgtagtggct
     1021 gaaatatatc agcccatgtt agacagaaga agtcagagaa gtgaagagag atgtgtggaa
     1081 attccatgac ttgtggaatt tggcattcag caatgtggaa attctaaagc tccctgagaa
     1141 caggatgact cgtgtttgaa ggatcttatt taaaattgtt tttgtatttt cttaaagcaa
     1201 tattcactgt tacaccttgg ggacttcttt gtttatccat tcttttatcc tttatatttc
     1261 atttgtaaac tatatttgaa cgacattccc cccgaaaaat tgaaatgtaa agatgaggca
     1321 gagaataaag tgttctatga aattcagaac tttatttctg aatgtaacat ccctaataac
     1381 aaccttcatt cttctaatac agcaaaataa aaatttaaca accaaggaat agtatttaag
     1441 aaaatgttga aataattttt ttaaaatagc attacagact gaggcggtcc tgaagcaatg
     1501 gtttttcact ctcttattga gccaattaaa ttgacattgc tttgacaatt taaaacttct
     1561 ataaaggtga atatttttca tacatttcta ttttatatga atatactttt tatatattta
     1621 ttattattaa atatttctac ttaatgaatc aaaattttgt tttaaagtct actttatgta
     1681 aataagaaca ggttttgggg aaaaaaatct tatgatttct ggattgatat ctgaattaaa
     1741 actatcaaca acaaggaagt ctgctctgta caattgtccc tcatttaaaa gatatattaa
     1801 gcttttcttt tctgtttgtt tttgttttgt ttagttttta atcctgtctt agaagaactt
     1861 atctttattc tcaaaattaa atgtaatttt tttagtgaca aagaagaaag gaaacctcat
     1921 tactcaatcc ttctggccaa gagtgtcttg cttgtggcgc cttcctcatc tctatatagg
     1981 aggatcccat gaatgatggt ttattgggaa ctgctggggt cgaccccata cagagaactc
     2041 agcttgaagc tggaagcaca cagtgggtag caggagaagg accggtgttg gtaggtgcct
     2101 acagagacta tagagctaga caaagccctc caaactggcc cctcctgctc actgcctctc
     2161 ctgagtagaa atctggtgac ctaaggctca gtgtggtcaa cagaaagctg ccttcttcac
     2221 ttgaggctaa gtcttcatat atgtttaagg ttgtctttct agtgaggaga tacatatcag
     2281 agaacatttg tacaattccc catgaaaatt gctccaaagt tgataacaat atagtcggtg
     2341 cttctagtta tatgcaagta ctcagtgata aatggattaa aaaatattca gaaatgtatt
     2401 ggggggtgga ggagaataag aggcagagca agagctagag aattggtttc cttgcttccc
     2461 tgtatgctca gaaaacattg atttgagcat agacgcagag actgaaaaaa aaatttactt
     2521 tgatctctgt ttttgaattc ttattattta tattttgctt actacctttt ttgccttttg
     2581 tccttttgtg gagagggcga tgaattaaga gtagtggggt gggtggcgag taagtaaaat
     2641 ttcaaatagc attttagtga atgcaattca gtagtcctga agcctgactt aataaaacaa
     2701 aattcattta tggttgtttc atgaaagtta ttagatagga tcaagttttg tttgtatatt
     2761 gtttgccttg ctctgttttt gcttttgtgc ttaggcaagt gcaaaatact ctatggaaat
     2821 cataattgtc atcttcttca tggtgttagg gatatattgt cacatgattt caataaatcc
     2881 tttttttgct tta
//
