LOCUS       NM_021258               2817 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens interleukin 22 receptor subunit alpha 1 (IL22RA1),
            mRNA.
ACCESSION   NM_021258
VERSION     NM_021258.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Sajiir,H., Wong,K.Y., Muller,A., Keshvari,S., Burr,L., Aiello,E.,
            Mezza,T., Giaccari,A., Sebastiani,G., Dotta,F., Ramm,G.A.,
            Macdonald,G.A., McGuckin,M.A., Prins,J.B. and Hasnain,S.Z.
  TITLE     Pancreatic beta-cell IL-22 receptor deficiency induces
            age-dependent dysregulation of insulin biosynthesis and systemic
            glucose homeostasis
  JOURNAL   Nat Commun 15 (1), 4527 (2024)
   PUBMED   38811550
  REMARK    GeneRIF: Pancreatic beta-cell IL-22 receptor deficiency induces
            age-dependent dysregulation of insulin biosynthesis and systemic
            glucose homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Grk,M., Miskovic,R., Jeremic,I., Basaric,M., Dusanovic Pjevic,M.,
            Jekic,B., Miljanovic,D., Lazarevic,I., Despotovic,A., Cirkovic,A.
            and Banko,A.
  TITLE     Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes
            with Susceptibility to and Clinical Manifestations of SLE
  JOURNAL   Int J Mol Sci 24 (14), 11292 (2023)
   PUBMED   37511050
  REMARK    GeneRIF: Association of IL10RA, IL10RB, and IL22RA
            Polymorphisms/Haplotypes with Susceptibility to and Clinical
            Manifestations of SLE.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   de Brito,R.J.V.C., do Carmo,R.F., Silva,B.M.S., Barbosa
            Junior,W.L., Vasconcelos,L.R.S., Pereira,L.M.M.B. and Moura,P.
  TITLE     Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with
            Fibrosis Severity in Patients with Chronic Hepatitis C
  JOURNAL   Viral Immunol 35 (7), 509-513 (2022)
   PUBMED   35838587
  REMARK    GeneRIF: Lack of Association of Polymorphisms in IL22 and IL22RA1
            Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Albayrak,N., Orte Cano,C., Karimi,S., Dogahe,D., Van Praet,A.,
            Godefroid,A., Del Marmol,V., Grimaldi,D., Bondue,B., Van
            Vooren,J.P., Mascart,F. and Corbiere,V.
  TITLE     Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood
            Hematopoietic Cells in SARS-CoV-2 Infection
  JOURNAL   Front Immunol 13, 769839 (2022)
   PUBMED   35422799
  REMARK    GeneRIF: Distinct Expression Patterns of Interleukin-22 Receptor 1
            on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Abdelnabi,M.N., Flores Molina,M., Soucy,G., Quoc-Huy Trinh,V.,
            Bedard,N., Mazouz,S., Jouvet,N., Dion,J., Tran,S., Bilodeau,M.,
            Estall,J.L. and Shoukry,N.H.
  TITLE     Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in
            Non-Alcoholic Fatty Liver Disease-Related Fibrosis
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (6), 1269-1294 (2022)
   PUBMED   35970323
  REMARK    GeneRIF: Sex-Dependent Hepatoprotective Role of IL-22 Receptor
            Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Ramanathan,M. Jr., Spannhake,E.W. and Lane,A.P.
  TITLE     Chronic rhinosinusitis with nasal polyps is associated with
            decreased expression of mucosal interleukin 22 receptor
  JOURNAL   Laryngoscope 117 (10), 1839-1843 (2007)
   PUBMED   17906500
  REMARK    GeneRIF: study demonstrated IL-22R1 mRNA and protein expression on
            nasal epithelial cells; failure of medical and surgical therapy in
            chronic rhinosinusitis with nasal polyps is associated with
            significantly decreased expression of IL-22R1
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   Li,J., Tomkinson,K.N., Tan,X.Y., Wu,P., Yan,G., Spaulding,V.,
            Deng,B., Annis-Freeman,B., Heveron,K., Zollner,R., De Zutter,G.,
            Wright,J.F., Crawford,T.K., Liu,W., Jacobs,K.A., Wolfman,N.M.,
            Ling,V., Pittman,D.D., Veldman,G.M. and Fouser,L.A.
  TITLE     Temporal associations between interleukin 22 and the extracellular
            domains of IL-22R and IL-10R2
  JOURNAL   Int Immunopharmacol 4 (5), 693-708 (2004)
   PUBMED   15120653
  REMARK    Review article
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Logsdon,N.J., Jones,B.C., Josephson,K., Cook,J. and Walter,M.R.
  TITLE     Comparison of interleukin-22 and interleukin-10 soluble receptor
            complexes
  JOURNAL   J Interferon Cytokine Res 22 (11), 1099-1112 (2002)
   PUBMED   12513909
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Kotenko,S.V., Izotova,L.S., Mirochnitchenko,O.V., Esterova,E.,
            Dickensheets,H., Donnelly,R.P. and Pestka,S.
  TITLE     Identification of the functional interleukin-22 (IL-22) receptor
            complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both
            the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor,
            IL-TIF) receptor complexes
  JOURNAL   J Biol Chem 276 (4), 2725-2732 (2001)
   PUBMED   11035029
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Xie,M.H., Aggarwal,S., Ho,W.H., Foster,J., Zhang,Z., Stinson,J.,
            Wood,W.I., Goddard,A.D. and Gurney,A.L.
  TITLE     Interleukin (IL)-22, a novel human cytokine that signals through
            the interferon receptor-related proteins CRF2-4 and IL-22R
  JOURNAL   J Biol Chem 275 (40), 31335-31339 (2000)
   PUBMED   10875937
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313971.1 and BC029273.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021258.3.
            
            Summary: The protein encoded by this gene belongs to the class II
            cytokine receptor family, and has been shown to be a receptor for
            interleukin 22 (IL22). IL22 receptor is a protein complex that
            consists of this protein and interleukin 10 receptor, beta
            (IL10BR/CRFB4), a subunit also shared by the receptor complex for
            interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha
            (IL28RA) form a cytokine receptor gene cluster in the chromosomal
            region 1p36. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029273.1, AK292204.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270800.2/ ENSP00000270800.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AK313971.1         146-337
            193-492             BC029273.1         174-473
            493-1609            AK313971.1         638-1754
            1610-2817           BC029273.1         1591-2798
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2817
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /note="interleukin 22 receptor subunit alpha 1"
                     /db_xref="GeneID:58985"
                     /db_xref="HGNC:HGNC:13700"
                     /db_xref="MIM:605457"
     exon            1..101
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1783
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /note="IL-22RA1; zcytoR11; IL-22R-alpha-1; IL-22 receptor
                     subunit alpha-1; cytokine receptor class-II member 9;
                     cytokine receptor family 2 member 9; interleukin 22
                     receptor, alpha 1"
                     /codon_start=1
                     /product="interleukin-22 receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_067081.2"
                     /db_xref="CCDS:CCDS247.1"
                     /db_xref="GeneID:58985"
                     /db_xref="HGNC:HGNC:13700"
                     /db_xref="MIM:605457"
                     /translation="MRTLLTILTVGSLAAHAPEDPSDLLQHVKFQSSNFENILTWDSG
                     PEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSCNLTVETGNLTELYYARVTAVSAG
                     GRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIF
                     HDLFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCR
                     VKTLPDRTWTYSFSGAFLFSMGFLVAVLCYLSYRYVTKPPAPPNSLNVQRVLTFQPLR
                     FIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISI
                     LQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYAP
                     QATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQKEPPAGSCMLGGLSLQEV
                     TSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHP
                     MSLPLQPPSRPCSPSDQGPSPWGLLESLVCPKDEAKSPAPETSDLEQPTELDSLFRGL
                     ALTVQWES"
     exon            102..234
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..413
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..589
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..728
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..850
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..2817
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /note="hexamer: AATAAA"
     polyA_site      2817
                     /gene="IL22RA1"
                     /gene_synonym="CRF2-9; IL22R; IL22R1"
                     /note="major polyA site"
ORIGIN      
        1 agccctctct ctgtgcacgg cagagtagag gccaagggag ggctctgtgc cagccccgat
       61 gaggacgctg ctgaccatct tgactgtggg atccctggct gctcacgccc ctgaggaccc
      121 ctcggatctg ctccagcacg tgaaattcca gtccagcaac tttgaaaaca tcctgacgtg
      181 ggacagcggg ccggagggca ccccagacac ggtctacagc atcgagtata agacgtacgg
      241 agagagggac tgggtggcaa agaagggctg tcagcggatc acccggaagt cctgcaacct
      301 gacggtggag acgggcaacc tcacggagct ctactatgcc agggtcaccg ctgtcagtgc
      361 gggaggccgg tcagccacca agatgactga caggttcagc tctctgcagc acactaccct
      421 caagccacct gatgtgacct gtatctccaa agtgagatcg attcagatga ttgttcatcc
      481 tacccccacg ccaatccgtg caggcgatgg ccaccggcta accctggaag acatcttcca
      541 tgacctgttc taccacttag agctccaggt caaccgcacc taccaaatgc accttggagg
      601 gaagcagaga gaatatgagt tcttcggcct gacccctgac acagagttcc ttggcaccat
      661 catgatttgc gttcccacct gggccaagga gagtgccccc tacatgtgcc gagtgaagac
      721 actgccagac cggacatgga cctactcctt ctccggagcc ttcctgttct ccatgggctt
      781 cctcgtcgca gtactctgct acctgagcta cagatatgtc accaagccgc ctgcacctcc
      841 caactccctg aacgtccagc gagtcctgac tttccagccg ctgcgcttca tccaggagca
      901 cgtcctgatc cctgtctttg acctcagcgg ccccagcagt ctggcccagc ctgtccagta
      961 ctcccagatc agggtgtctg gacccaggga gcccgcagga gctccacagc ggcatagcct
     1021 gtccgagatc acctacttag ggcagccaga catctccatc ctccagccct ccaacgtgcc
     1081 acctccccag atcctctccc cactgtccta tgccccaaac gctgcccctg aggtcgggcc
     1141 cccatcctat gcacctcagg tgacccccga agctcaattc ccattctacg ccccacaggc
     1201 catctctaag gtccagcctt cctcctatgc ccctcaagcc actccggaca gctggcctcc
     1261 ctcctatggg gtatgcatgg aaggttctgg caaagactcc cccactggga cactttctag
     1321 tcctaaacac cttaggccta aaggtcagct tcagaaagag ccaccagctg gaagctgcat
     1381 gttaggtggc ctttctctgc aggaggtgac ctccttggct atggaggaat cccaagaagc
     1441 aaaatcattg caccagcccc tggggatttg cacagacaga acatctgacc caaatgtgct
     1501 acacagtggg gaggaaggga caccacagta cctaaagggc cagctccccc tcctctcctc
     1561 agtccagatc gagggccacc ccatgtccct ccctttgcaa cctccttccc gtccatgttc
     1621 cccctcggac caaggtccaa gtccctgggg cctgctggag tcccttgtgt gtcccaagga
     1681 tgaagccaag agcccagccc ctgagacctc agacctggag cagcccacag aactggattc
     1741 tcttttcaga ggcctggccc tgactgtgca gtgggagtcc tgaggggaat gggaaaggct
     1801 tggtgcttcc tccctgtccc tacccagtgt cacatccttg gctgtcaatc ccatgcctgc
     1861 ccacgccaca cactctgcga tctggcctca gacgggtgcc cttgagagaa gcagagggag
     1921 tggcatgcag ggcccctgcc atgggtgcgc tcctcaccgg agcaaagcag catgataagg
     1981 actgcagcgg gggagctctg gggagcagct tgtgtagaca agcgcgtgct cgctgagccc
     2041 tgcaaggcag aaatgacagt gcaaggagga aatgcaggga aactcccgag gtccagagcc
     2101 ccacctccta acaccatgga ttcaaagtgc tcagggaatt tgcctctcct tgccccattc
     2161 ctggccagtt tcacaatcta gctcgacaga gcatgaggcc cctgcctctt ctgtcattgt
     2221 tcaaaggtgg gaagagagcc tggaaaagaa ccaggcctgg aaaagaacca gaaggaggct
     2281 gggcagaacc agaacaacct gcacttctgc caaggccagg gccagcagga cggcaggact
     2341 ctagggaggg gtgtggcctg cagctcattc ccagccaggg caactgcctg acgttgcacg
     2401 atttcagctt cattcctctg atagaacaaa gcgaaatgca ggtccaccag ggagggagac
     2461 acacaagcct tttctgcagg caggagtttc agaccctatc ctgagaatgg ggtttgaaag
     2521 gaaggtgagg gctgtggccc ctggacgggt acaataacac actgtactga tgtcacaact
     2581 ttgcaagctc tgccttgggt tcagcccatc tgggctcaaa ttccagcctc accactcaca
     2641 agctgtgtga cttcaaacaa atgaaatcag tgcccagaac ctcggtttcc tcatctgtaa
     2701 tgtggggatc ataacaccta cctcatggag ttgtggtgaa gatgaaatga agtcatgtct
     2761 ttaaagtgct taatagtgcc tggtacatgg gcagtgccca ataaacggta gctattt
//
