LOCUS       NM_020525               1165 bp    mRNA    linear   PRI 03-FEB-2025
DEFINITION  Homo sapiens interleukin 22 (IL22), mRNA.
ACCESSION   NM_020525
VERSION     NM_020525.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1165)
  AUTHORS   Liao,B., Chen,W., Qi,X., Yun,C. and Pang,Y.
  TITLE     Interleukin-22 improves ovulation in polycystic ovary syndrome via
            STAT3 signaling
  JOURNAL   Mol Hum Reprod 30 (10) (2024)
   PUBMED   39423135
  REMARK    GeneRIF: Interleukin-22 improves ovulation in polycystic ovary
            syndrome via STAT3 signaling.
REFERENCE   2  (bases 1 to 1165)
  AUTHORS   Hunzeker,Z.E., Zhao,L., Kim,A.M., Parker,J.M., Zhu,Z., Xiao,H.,
            Bai,Q., Wakefield,M.R. and Fang,Y.
  TITLE     The role of IL-22 in cancer
  JOURNAL   Med Oncol 41 (10), 240 (2024)
   PUBMED   39231878
  REMARK    GeneRIF: The role of IL-22 in cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1165)
  AUTHORS   Niu,Q., Wang,M. and Liu,X.S.
  TITLE     The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy
            especially in tuberculous pleurisy
  JOURNAL   Respir Res 25 (1), 275 (2024)
   PUBMED   39003443
  REMARK    GeneRIF: The evolving landscape of IL-10, IL-22 and IL-26 in
            pleurisy especially in tuberculous pleurisy.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1165)
  AUTHORS   Fang,Q., Xie,J., Zong,J., Zhou,Y., Zhou,Q., Yin,S., Cao,L., Yin,H.
            and Zhou,D.
  TITLE     Expression and diagnostic value of interleukin-22 in rheumatoid
            arthritis-associated interstitial lung disease
  JOURNAL   Int Immunopharmacol 134, 112173 (2024)
   PUBMED   38728884
  REMARK    GeneRIF: Expression and diagnostic value of interleukin-22 in
            rheumatoid arthritis-associated interstitial lung disease.
REFERENCE   5  (bases 1 to 1165)
  AUTHORS   Singh,A., Beaupre,M., Villegas-Novoa,C., Shiomitsu,K.,
            Gaudino,S.J., Tawch,S., Damle,R., Kempen,C., Choudhury,B.,
            McAleer,J.P., Sheridan,B.S., Denoya,P., Blumberg,R.S., Hearing,P.,
            Allbritton,N.L. and Kumar,P.
  TITLE     IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated
            amelioration of intestinal inflammation
  JOURNAL   Cell Rep 43 (5), 114206 (2024)
   PUBMED   38733584
  REMARK    GeneRIF: IL-22 promotes mucin-type O-glycosylation and MATH1[+]
            cell-mediated amelioration of intestinal inflammation.
            Erratum:[Cell Rep. 2024 Aug 27;43(8):114643. doi:
            10.1016/j.celrep.2024.114643.. PMID: 39097926]
REFERENCE   6  (bases 1 to 1165)
  AUTHORS   Kotenko,S.V., Izotova,L.S., Mirochnitchenko,O.V., Esterova,E.,
            Dickensheets,H., Donnelly,R.P. and Pestka,S.
  TITLE     Identification of the functional interleukin-22 (IL-22) receptor
            complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both
            the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor,
            IL-TIF) receptor complexes
  JOURNAL   J Biol Chem 276 (4), 2725-2732 (2001)
   PUBMED   11035029
REFERENCE   7  (bases 1 to 1165)
  AUTHORS   Dumoutier,L., Van Roost,E., Ameye,G., Michaux,L. and Renauld,J.C.
  TITLE     IL-TIF/IL-22: genomic organization and mapping of the human and
            mouse genes
  JOURNAL   Genes Immun 1 (8), 488-494 (2000)
   PUBMED   11197690
REFERENCE   8  (bases 1 to 1165)
  AUTHORS   Xie,M.H., Aggarwal,S., Ho,W.H., Foster,J., Zhang,Z., Stinson,J.,
            Wood,W.I., Goddard,A.D. and Gurney,A.L.
  TITLE     Interleukin (IL)-22, a novel human cytokine that signals through
            the interferon receptor-related proteins CRF2-4 and IL-22R
  JOURNAL   J Biol Chem 275 (40), 31335-31339 (2000)
   PUBMED   10875937
REFERENCE   9  (bases 1 to 1165)
  AUTHORS   Dumoutier,L., Van Roost,E., Colau,D. and Renauld,J.C.
  TITLE     Human interleukin-10-related T cell-derived inducible factor:
            molecular cloning and functional characterization as an
            hepatocyte-stimulating factor
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10144-10149 (2000)
   PUBMED   10954742
REFERENCE   10 (bases 1 to 1165)
  AUTHORS   Dumoutier,L., Louahed,J. and Renauld,J.C.
  TITLE     Cloning and characterization of IL-10-related T cell-derived
            inducible factor (IL-TIF), a novel cytokine structurally related to
            IL-10 and inducible by IL-9
  JOURNAL   J Immunol 164 (4), 1814-1819 (2000)
   PUBMED   10657629
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070261.1 and CD638517.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 11, 2018 this sequence version replaced NM_020525.4.
            
            Summary: This gene is a member of the IL10 family of cytokines that
            mediate cellular inflammatory responses. The encoded protein
            functions in antimicrobial defense at mucosal surfaces and in
            tissue repair. This protein also has pro-inflammatory properties
            and plays a role in in the pathogenesis of several intestinal
            diseases. The encoded protein is a crucial cytokine that regulates
            host immunity in infectious diseases, including COVID-19 (disease
            caused by SARS-CoV-2). [provided by RefSeq, Dec 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070261.1, CD639311.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000538666.6/ ENSP00000442424.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1162              BC070261.1         1-1162
            1163-1165           CD638517.1         557-559
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1165
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /note="interleukin 22"
                     /db_xref="GeneID:50616"
                     /db_xref="HGNC:HGNC:14900"
                     /db_xref="MIM:605330"
     exon            1..22
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /inference="alignment:Splign:2.1.0"
     exon            23..254
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..608
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /note="IL-10-related T-cell-derived inducible factor;
                     cytokine Zcyto18"
                     /codon_start=1
                     /product="interleukin-22 precursor"
                     /protein_id="NP_065386.1"
                     /db_xref="CCDS:CCDS8982.1"
                     /db_xref="GeneID:50616"
                     /db_xref="HGNC:HGNC:14900"
                     /db_xref="MIM:605330"
                     /translation="MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDK
                     SNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEE
                     VLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGE
                     IKAIGELDLLFMSLRNACI"
     exon            255..320
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /inference="alignment:Splign:2.1.0"
     exon            321..464
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /inference="alignment:Splign:2.1.0"
     exon            465..530
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1165
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="IL22"
                     /gene_synonym="IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa;
                     TIFIL-23; zcyto18"
                     /note="major polyA site"
ORIGIN      
        1 acaagcagaa tcttcagaac aggttctcct tccccagtca ccagttgctc gagttagaat
       61 tgtctgcaat ggccgccctg cagaaatctg tgagctcttt ccttatgggg accctggcca
      121 ccagctgcct ccttctcttg gccctcttgg tacagggagg agcagctgcg cccatcagct
      181 cccactgcag gcttgacaag tccaacttcc agcagcccta tatcaccaac cgcaccttca
      241 tgctggctaa ggaggctagc ttggctgata acaacacaga cgttcgtctc attggggaga
      301 aactgttcca cggagtcagt atgagtgagc gctgctatct gatgaagcag gtgctgaact
      361 tcacccttga agaagtgctg ttccctcaat ctgataggtt ccagccttat atgcaggagg
      421 tggtgccctt cctggccagg ctcagcaaca ggctaagcac atgtcatatt gaaggtgatg
      481 acctgcatat ccagaggaat gtgcaaaagc tgaaggacac agtgaaaaag cttggagaga
      541 gtggagagat caaagcaatt ggagaactgg atttgctgtt tatgtctctg agaaatgcct
      601 gcatttgacc agagcaaagc tgaaaaatga ataactaacc ccctttccct gctagaaata
      661 acaattagat gccccaaagc gatttttttt aaccaaaagg aagatgggaa gccaaactcc
      721 atcatgatgg gtggattcca aatgaacccc tgcgttagtt acaaaggaaa ccaatgccac
      781 ttttgtttat aagaccagaa ggtagacttt ctaagcatag atatttattg ataacatttc
      841 attgtaactg gtgttctata cacagaaaac aatttatttt ttaaataatt gtctttttcc
      901 ataaaaaaga ttactttcca ttcctttagg ggaaaaaacc cctaaatagc ttcatgtttc
      961 cataatcagt actttatatt tataaatgta tttattatta ttataagact gcattttatt
     1021 tatatcattt tattaatatg gatttattta tagaaacatc attcgatatt gctacttgag
     1081 tgtaaggcta atattgatat ttatgacaat aattatagag ctataacatg tttatttgac
     1141 ctcaataaac acttggatat cctaa
//
