LOCUS       NM_181078               4837 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens interleukin 21 receptor (IL21R), transcript variant 2,
            mRNA.
ACCESSION   NM_181078
VERSION     NM_181078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4837)
  AUTHORS   Zang,Z., Yin,Y., Liu,C., Zhu,Q., Huang,X., Li,H. and Yang,R.
  TITLE     IL21R hypomethylation as a biomarker for distinguishing benign and
            malignant breast tumours
  JOURNAL   Epigenetics 19 (1), 2352683 (2024)
   PUBMED   38723244
  REMARK    GeneRIF: IL21R hypomethylation as a biomarker for distinguishing
            benign and malignant breast tumours.
REFERENCE   2  (bases 1 to 4837)
  AUTHORS   Xie,Y., Huang,Y., Li,Z.Y., Jiang,W., Shi,N.X., Lu,Y., Cao,G.,
            Yin,Z. and Lin,X.J.
  TITLE     Interleukin-21 receptor signaling promotes metabolic
            dysfunction-associated steatohepatitis-driven hepatocellular
            carcinoma by inducing immunosuppressive IgA+ B cells
  JOURNAL   Mol Cancer 23 (1), 95 (2024)
   PUBMED   38720319
  REMARK    GeneRIF: Interleukin-21 receptor signaling promotes metabolic
            dysfunction-associated steatohepatitis-driven hepatocellular
            carcinoma by inducing immunosuppressive IgA[+] B cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4837)
  AUTHORS   Wu,Z., Li,H., Xu,H., Feng,F., Zhang,F., Zhang,S., Wang,L. and Li,Y.
  TITLE     ChIP-seq analysis found IL21R, a target gene of GTF2I-the
            susceptibility gene for primary biliary cholangitis in Chinese Han
  JOURNAL   Hepatol Int 18 (2), 509-516 (2024)
   PUBMED   37713154
  REMARK    GeneRIF: ChIP-seq analysis found IL21R, a target gene of GTF2I-the
            susceptibility gene for primary biliary cholangitis in Chinese Han.
REFERENCE   4  (bases 1 to 4837)
  AUTHORS   Lahmar,R., Chabchoub,E., Zemni,R., Anis,M., Ghannouchi,N. and
            Slama,F.B.H.
  TITLE     Interleukin-21 receptor gene polymorphism (rs2285452 A/G) is
            associated with susceptibility to Behcet's disease
  JOURNAL   Int J Immunogenet 50 (4), 185-193 (2023)
   PUBMED   37243939
  REMARK    GeneRIF: Interleukin-21 receptor gene polymorphism (rs2285452 A/G)
            is associated with susceptibility to Behcet's disease.
REFERENCE   5  (bases 1 to 4837)
  AUTHORS   Carreno-Saavedra,N.M., Reyes-Perez,I.V., Machado-Sulbaran,A.C.,
            Martinez-Bonilla,G.E., Ramirez-Duenas,M.G., Munoz-Valle,J.F.,
            Olaya-Valdiviezo,V., Garcia-Iglesias,T., Martinez-Garcia,E.A. and
            Sanchez-Hernandez,P.E.
  TITLE     IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and
            High Levels of IL-21 Are Associated with Rheumatoid Arthritis in
            Mexican Patients
  JOURNAL   Genes (Basel) 14 (4), 878 (2023)
   PUBMED   37107636
  REMARK    GeneRIF: IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301)
            Polymorphism and High Levels of IL-21 Are Associated with
            Rheumatoid Arthritis in Mexican Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4837)
  AUTHORS   Hecker,M., Bohnert,A., Konig,I.R., Bein,G. and Hackstein,H.
  TITLE     Novel genetic variation of human interleukin-21 receptor is
            associated with elevated IgE levels in females
  JOURNAL   Genes Immun 4 (3), 228-233 (2003)
   PUBMED   12700598
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4837)
  AUTHORS   Asao,H., Okuyama,C., Kumaki,S., Ishii,N., Tsuchiya,S., Foster,D.
            and Sugamura,K.
  TITLE     Cutting edge: the common gamma-chain is an indispensable subunit of
            the IL-21 receptor complex
  JOURNAL   J Immunol 167 (1), 1-5 (2001)
   PUBMED   11418623
REFERENCE   8  (bases 1 to 4837)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
REFERENCE   9  (bases 1 to 4837)
  AUTHORS   Ozaki,K., Kikly,K., Michalovich,D., Young,P.R. and Leonard,W.J.
  TITLE     Cloning of a type I cytokine receptor most related to the IL-2
            receptor beta chain
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11439-11444 (2000)
   PUBMED   11016959
REFERENCE   10 (bases 1 to 4837)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292663.1, BC004348.1,
            AC002303.1 and AW576566.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_181078.2.
            
            Summary: The protein encoded by this gene is a cytokine receptor
            for interleukin 21 (IL21). It belongs to the type I cytokine
            receptors, and has been shown to form a heterodimeric receptor
            complex with the common gamma-chain, a receptor subunit also shared
            by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor
            transduces the growth promoting signal of IL21, and is important
            for the proliferation and differentiation of T cells, B cells, and
            natural killer (NK) cells. The ligand binding of this receptor
            leads to the activation of multiple downstream signaling molecules,
            including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a
            similar gene in mouse suggest a role for this gene in regulating
            immunoglobulin production. Three alternatively spliced transcript
            variants have been described. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (2) encodes the dominant isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004348.1, AK292663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337929.8/ ENSP00000338010.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2434              AK292663.1         13-2446
            2435-3353           BC004348.1         2059-2977
            3354-4403           AC002303.1         46837-47886
            4404-4837           AW576566.1         17-450              c
FEATURES             Location/Qualifiers
     source          1..4837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..4837
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /note="interleukin 21 receptor"
                     /db_xref="GeneID:50615"
                     /db_xref="HGNC:HGNC:6006"
                     /db_xref="MIM:605383"
     exon            1..445
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            446..510
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..2078
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; IL-21 receptor; novel interleukin receptor"
                     /codon_start=1
                     /product="interleukin-21 receptor isoform 1 precursor"
                     /protein_id="NP_851564.1"
                     /db_xref="CCDS:CCDS10630.1"
                     /db_xref="GeneID:50615"
                     /db_xref="HGNC:HGNC:6006"
                     /db_xref="MIM:605383"
                     /translation="MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHP
                     STLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQS
                     GNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQY
                     RNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWS
                     DPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERF
                     FMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTEL
                     QEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPC
                     SCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLK
                     PPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFT
                     SPGDEGPPRSYLRQWVVIPPPLSSPGPQAS"
     exon            511..613
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            614..813
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            814..968
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1146
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1246
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1328
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..4837
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3243..3248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /note="hexamer: AATAAA"
     polyA_site      3273
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /note="major polyA site"
     regulatory      4817..4822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /note="hexamer: AATAAA"
     polyA_site      4837
                     /gene="IL21R"
                     /gene_synonym="CD360; IMD56; NILR"
                     /note="major polyA site"
ORIGIN      
        1 actctgcaca tgcggctggg tggcagccag cggcctcaga cagacccact ggcgtctctc
       61 tgctgagtga ccgtaagctc ggcgtctggc cctctgcctg cctctccctg agtgtggctg
      121 acagccacgc agctgtgtct gtctgtctgc ggcccgtgca tccctgctgc ggccgcctgg
      181 taccttcctt gccgtctctt tcctctgtct gctgctctgt gggacacctg cctggaggcc
      241 cagctgcccg tcatcagagt gacaggtctt atgacagcct gattggtgac tcgggctggg
      301 tgtggattct caccccaggc ctctgcctgc tttctcagac cctcatctgt cacccccacg
      361 ctgaacccag ctgccacccc cagaagccca tcagactgcc cccagcacac ggaatggatt
      421 tctgagaaag aagccgaaac agaaggcccg tgggagtcag catgccgcgt ggctgggccg
      481 cccccttgct cctgctgctg ctccagggag gctggggctg ccccgacctc gtctgctaca
      541 ccgattacct ccagacggtc atctgcatcc tggaaatgtg gaacctccac cccagcacgc
      601 tcacccttac ctggcaagac cagtatgaag agctgaagga cgaggccacc tcctgcagcc
      661 tccacaggtc ggcccacaat gccacgcatg ccacctacac ctgccacatg gatgtattcc
      721 acttcatggc cgacgacatt ttcagtgtca acatcacaga ccagtctggc aactactccc
      781 aggagtgtgg cagctttctc ctggctgaga gcatcaagcc ggctccccct ttcaacgtga
      841 ctgtgacctt ctcaggacag tataatatct cctggcgctc agattacgaa gaccctgcct
      901 tctacatgct gaagggcaag cttcagtatg agctgcagta caggaaccgg ggagacccct
      961 gggctgtgag tccgaggaga aagctgatct cagtggactc aagaagtgtc tccctcctcc
     1021 ccctggagtt ccgcaaagac tcgagctatg agctgcaggt gcgggcaggg cccatgcctg
     1081 gctcctccta ccaggggacc tggagtgaat ggagtgaccc ggtcatcttt cagacccagt
     1141 cagaggagtt aaaggaaggc tggaaccctc acctgctgct tctcctcctg cttgtcatag
     1201 tcttcattcc tgccttctgg agcctgaaga cccatccatt gtggaggcta tggaagaaga
     1261 tatgggccgt ccccagccct gagcggttct tcatgcccct gtacaagggc tgcagcggag
     1321 acttcaagaa atgggtgggt gcacccttca ctggctccag cctggagctg ggaccctgga
     1381 gcccagaggt gccctccacc ctggaggtgt acagctgcca cccaccacgg agcccggcca
     1441 agaggctgca gctcacggag ctacaagaac cagcagagct ggtggagtct gacggtgtgc
     1501 ccaagcccag cttctggccg acagcccaga actcgggggg ctcagcttac agtgaggaga
     1561 gggatcggcc atacggcctg gtgtccattg acacagtgac tgtgctagat gcagaggggc
     1621 catgcacctg gccctgcagc tgtgaggatg acggctaccc agccctggac ctggatgctg
     1681 gcctggagcc cagcccaggc ctagaggacc cactcttgga tgcagggacc acagtcctgt
     1741 cctgtggctg tgtctcagct ggcagccctg ggctaggagg gcccctggga agcctcctgg
     1801 acagactaaa gccacccctt gcagatgggg aggactgggc tgggggactg ccctggggtg
     1861 gccggtcacc tggaggggtc tcagagagtg aggcgggctc acccctggcc ggcctggata
     1921 tggacacgtt tgacagtggc tttgtgggct ctgactgcag cagccctgtg gagtgtgact
     1981 tcaccagccc cggggacgaa ggaccccccc ggagctacct ccgccagtgg gtggtcattc
     2041 ctccgccact ttcgagccct ggaccccagg ccagctaatg aggctgactg gatgtccaga
     2101 gctggccagg ccactgggcc ctgagccaga gacaaggtca cctgggctgt gatgtgaaga
     2161 cacctgcagc ctttggtctc ctggatgggc ctttgagcct gatgtttaca gtgtctgtgt
     2221 gtgtgtgtgc atatgtgtgt gtgtgcatat gcatgtgtgt gtgtgtgtgt gtcttaggtg
     2281 cgcagtggca tgtccacgtg tgtgtgtgat tgcacgtgcc tgtgggcctg ggataatgcc
     2341 catggtactc catgcattca cctgccctgt gcatgtctgg actcacggag ctcacccatg
     2401 tgcacaagtg tgcacagtaa acgtgtttgt ggtcaacaga tgacaacagc cgtcctccct
     2461 cctagggtct tgtgttgcaa gttggtccac agcatctccg gggctttgtg ggatcagggc
     2521 attgcctgtg actgaggcgg agcccagccc tccagcgtct gcctccagga gctgcaagaa
     2581 gtccatattg ttccttatca cctgccaaca ggaagcgaaa ggggatggag tgagcccatg
     2641 gtgacctcgg gaatggcaat tttttgggcg gcccctggac gaaggtctga atcccgactc
     2701 tgataccttc tggctgtgct acctgagcca agtcgcctcc cctctctggg ctagagtttc
     2761 cttatccaga cagtggggaa ggcatgacac acctggggga aattggcgat gtcacccgtg
     2821 tacggtacgc agcccagagc agaccctcaa taaacgtcag cttccttcct tctgcggcca
     2881 gagccgaggc gggcgggggt gagaacatca atcgtcagcg acagcctggg cacccgcggg
     2941 gccgtcccgc ctgcagaggg ccactcgggg gggtttccag gcttaaaatc agtccgtttc
     3001 gtctcttgga aacagctccc caccaaccaa gatttctttt tctaacttct gctactaagt
     3061 ttttaaaaat tccctttatg cacccaagag atatttatta aacaccaatt acgtagcagg
     3121 ccatggctca tgggacccac cccccgtggc actcatggag ggggctgcag gttggaacta
     3181 tgcagtgtgc tccggccaca catcctgctg ggccccctac cctgccccaa ttcaatcctg
     3241 ccaataaatc ctgtcttatt tgttcatcct ggagaattga agggaggtca agttgtttgt
     3301 caatgatttg tcagagaacc tgttgaaatg tgaattaaga agctaagaaa atatttctta
     3361 gcaacatttt ctttttcttt tttttttttt tcttttgaga cagagtctca ctctcgtcgc
     3421 ccaggctgga atgcagtggt gcgatctcgg ctctctgcaa cctctgtctc ccgggttcaa
     3481 gcgatttcct gcgtcagccc cagagtagct ggaattacag gcacacacca ccacgcctgg
     3541 ctaatttttg tatttttagt agagctgggg ccaccctggc ccggccccgt cttcctcccc
     3601 aaaggtcaga ctgcaggctg cagggctgtg ctggaggagc cagctctagc tcacccatgc
     3661 ttttgcaaca gggtcgggtt ggaagtcagc acaggtcagt cctgcggaag gttccttcgt
     3721 gactcatctg tgaagtgggg tggttgggag aggtagctga gagaatgcat gagagtcctc
     3781 ggtgcctggc aggaggctgg aaggttctag aacactgatg gttataagag tgggactgtg
     3841 agcctgggat cggggggtgt gagacttgga tgggagcaca agagtggaaa cacagcttct
     3901 gcacggagca ggcgcagccc tcaacacccc gtgcacctgc accctaggga ctcttgggtc
     3961 cagatgtgct gtggttttca caccttcttg ggggcaacag gttccaggag ccacctgtgg
     4021 gtgccacctg agccacaggc tcccaggaaa gcagcacagc tctcctgcac ccagagcttg
     4081 ctgggtggcg gaggggaaca cagatggttg gggaaggcct gaggccagat tgggggactc
     4141 tggactgggg cagatgaggc tcctcagaat cccacctttg aagggaactc agcttataaa
     4201 cacagaggag caaagttgga gggccgggcg tagtggctca cacctgtgat ctcagcactt
     4261 tgggaggcca aggaaggtgg atcacttgag gccaggagtt cgagaccagc ctgggcaaca
     4321 tagcaaggcc ccatctctac aaaaattatt attttttaaa aaaattagcc aggtgtggtg
     4381 gtgcttgcct atagtcccag ctactcggga ggctaaggtg ggaggatcgc tggagcccag
     4441 gaatttgagg ctgcagtgag ctgtgattac accgttgcac tccagcctgg gtcacagatc
     4501 aagaccctgt ctcttaaaaa taaaagttgg agacaagagc tggctcacct gaaaggaggg
     4561 attagtaggt aggagggtgg atggaggatg gatggatgtg tgggtggata ggaagatggt
     4621 attaagttgg tgcaaaagtc tttgatatta ctcttaatgg ctttaataaa aagcttgaag
     4681 gaagaatgat tggttggata gacagagata aatgcatact ggaaacaaag ataaagataa
     4741 aacacaagtt ataccaggcc agcaactcta ttttgttcac tgcctttagt cccagcctgg
     4801 cacatagtag gcactcaata aagcctgatt tgtagca
//
