LOCUS       NM_144717               1929 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens interleukin 20 receptor subunit beta (IL20RB), mRNA.
ACCESSION   NM_144717
VERSION     NM_144717.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Zhang,H., Liu,Y., Wang,B. and Wang,C.
  TITLE     Interleukin 20 receptor subunit beta (IL20RB) predicts poor
            prognosis and regulates immune cell infiltration in clear cell
            renal cell carcinoma
  JOURNAL   BMC Genom Data 23 (1), 58 (2022)
   PUBMED   35883015
  REMARK    GeneRIF: Interleukin 20 receptor subunit beta (IL20RB) predicts
            poor prognosis and regulates immune cell infiltration in clear cell
            renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   4  (bases 1 to 1929)
  AUTHORS   Keller,K.E., Yang,Y.F., Sun,Y.Y., Sykes,R., Gaudette,N.D.,
            Samples,J.R., Acott,T.S. and Wirtz,M.K.
  TITLE     Interleukin-20 receptor expression in the trabecular meshwork and
            its implication in glaucoma
  JOURNAL   J Ocul Pharmacol Ther 30 (2-3), 267-276 (2014)
   PUBMED   24455976
  REMARK    GeneRIF: Trabecular meshwork cells express IL-20 receptors;
            Mutation of the T104 residue in IL-20R2 leads to a reduction in
            STAT3 phosphorylation as well as decreased matrix metalloproteinase
            activity
REFERENCE   5  (bases 1 to 1929)
  AUTHORS   Okada,Y., Wu,D., Trynka,G., Raj,T., Terao,C., Ikari,K., Kochi,Y.,
            Ohmura,K., Suzuki,A., Yoshida,S., Graham,R.R., Manoharan,A.,
            Ortmann,W., Bhangale,T., Denny,J.C., Carroll,R.J., Eyler,A.E.,
            Greenberg,J.D., Kremer,J.M., Pappas,D.A., Jiang,L., Yin,J., Ye,L.,
            Su,D.F., Yang,J., Xie,G., Keystone,E., Westra,H.J., Esko,T.,
            Metspalu,A., Zhou,X., Gupta,N., Mirel,D., Stahl,E.A., Diogo,D.,
            Cui,J., Liao,K., Guo,M.H., Myouzen,K., Kawaguchi,T., Coenen,M.J.,
            van Riel,P.L., van de Laar,M.A., Guchelaar,H.J., Huizinga,T.W.,
            Dieude,P., Mariette,X., Bridges,S.L. Jr., Zhernakova,A., Toes,R.E.,
            Tak,P.P., Miceli-Richard,C., Bang,S.Y., Lee,H.S., Martin,J.,
            Gonzalez-Gay,M.A., Rodriguez-Rodriguez,L., Rantapaa-Dahlqvist,S.,
            Arlestig,L., Choi,H.K., Kamatani,Y., Galan,P., Lathrop,M., Eyre,S.,
            Bowes,J., Barton,A., de Vries,N., Moreland,L.W., Criswell,L.A.,
            Karlson,E.W., Taniguchi,A., Yamada,R., Kubo,M., Liu,J.S., Bae,S.C.,
            Worthington,J., Padyukov,L., Klareskog,L., Gregersen,P.K.,
            Raychaudhuri,S., Stranger,B.E., De Jager,P.L., Franke,L.,
            Visscher,P.M., Brown,M.A., Yamanaka,H., Mimori,T., Takahashi,A.,
            Xu,H., Behrens,T.W., Siminovitch,K.A., Momohara,S., Matsuda,F.,
            Yamamoto,K. and Plenge,R.M.
  CONSRTM   RACI consortium; GARNET consortium
  TITLE     Genetics of rheumatoid arthritis contributes to biology and drug
            discovery
  JOURNAL   Nature 506 (7488), 376-381 (2014)
   PUBMED   24390342
REFERENCE   6  (bases 1 to 1929)
  AUTHORS   Pletnev,S., Magracheva,E., Kozlov,S., Tobin,G., Kotenko,S.V.,
            Wlodawer,A. and Zdanov,A.
  TITLE     Characterization of the recombinant extracellular domains of human
            interleukin-20 receptors and their complexes with interleukin-19
            and interleukin-20
  JOURNAL   Biochemistry 42 (43), 12617-12624 (2003)
   PUBMED   14580208
  REMARK    GeneRIF: forms stable complex with interleukin-19 and
            interleukin-20 [IL-20R1][IL-20R2]
REFERENCE   7  (bases 1 to 1929)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1929)
  AUTHORS   Parrish-Novak,J., Xu,W., Brender,T., Yao,L., Jones,C., West,J.,
            Brandt,C., Jelinek,L., Madden,K., McKernan,P.A., Foster,D.C.,
            Jaspers,S. and Chandrasekher,Y.A.
  TITLE     Interleukins 19, 20, and 24 signal through two distinct receptor
            complexes. Differences in receptor-ligand interactions mediate
            unique biological functions
  JOURNAL   J Biol Chem 277 (49), 47517-47523 (2002)
   PUBMED   12351624
REFERENCE   9  (bases 1 to 1929)
  AUTHORS   Dumoutier,L., Leemans,C., Lejeune,D., Kotenko,S.V. and Renauld,J.C.
  TITLE     Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through
            IL-20 receptor complexes of two types
  JOURNAL   J Immunol 167 (7), 3545-3549 (2001)
   PUBMED   11564763
REFERENCE   10 (bases 1 to 1929)
  AUTHORS   Blumberg,H., Conklin,D., Xu,W.F., Grossmann,A., Brender,T.,
            Carollo,S., Eagan,M., Foster,D., Haldeman,B.A., Hammond,A.,
            Haugen,H., Jelinek,L., Kelly,J.D., Madden,K., Maurer,M.F.,
            Parrish-Novak,J., Prunkard,D., Sexson,S., Sprecher,C., Waggie,K.,
            West,J., Whitmore,T.E., Yao,L., Kuechle,M.K., Dale,B.A. and
            Chandrasekher,Y.A.
  TITLE     Interleukin 20: discovery, receptor identification, and role in
            epidermal function
  JOURNAL   Cell 104 (1), 9-19 (2001)
   PUBMED   11163236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358305.1 and BC063696.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144717.3.
            
            Summary: IL20RB and IL20RA (MIM 605620) form a heterodimeric
            receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al.,
            2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063696.1, AY358305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329582.9/ ENSP00000328133.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1922              AY358305.1         119-2040
            1923-1929           BC063696.1         1905-1911
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..1929
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /note="interleukin 20 receptor subunit beta"
                     /db_xref="GeneID:53833"
                     /db_xref="HGNC:HGNC:6004"
                     /db_xref="MIM:605621"
     exon            1..219
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1067
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /note="fibronectin type III domain containing 6;
                     interleukin-20 receptor II; IL-20 receptor subunit beta;
                     interleukin 20 receptor beta subunit"
                     /codon_start=1
                     /product="interleukin-20 receptor subunit beta precursor"
                     /protein_id="NP_653318.2"
                     /db_xref="CCDS:CCDS3093.1"
                     /db_xref="GeneID:53833"
                     /db_xref="HGNC:HGNC:6004"
                     /db_xref="MIM:605621"
                     /translation="MQTFTMVLEEIWTSLFMWFFYALIPCLLTDEVAILPAPQNLSVL
                     STNMKHLLMWSPVIAPGETVYYSVEYQGEYESLYTSHIWIPSSWCSLTEGPECDVTDD
                     ITATVPYNLRVRATLGSQTSAWSILKHPFNRNSTILTRPGMEITKDGFHLVIELEDLG
                     PQFEFLVAYWRREPGAEEHVKMVRSGGIPVHLETMEPGAAYCVKAQTFVKAIGRYSAF
                     SQTECVEVQGEAIPLVLALFAFVGFMLILVVVPLFVWKMGRLLQYSCCPVVVLPDTLK
                     ITNSPQKLISCRREEVDACATAVMSPEELLRAWIS"
     exon            220..346
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     exon            347..537
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     exon            538..662
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     exon            663..813
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     exon            814..956
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1929
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /note="hexamer: AATAAA"
     polyA_site      1929
                     /gene="IL20RB"
                     /gene_synonym="DIRS1; FNDC6; IL-20R-beta; IL-20R2;
                     IL-20RB"
                     /note="major polyA site"
ORIGIN      
        1 agaacaattc aggcttcgct gcgactcaga cctcagctcc aacatatgca ttctgaagaa
       61 agatggctga gatggacaga atgctttatt ttggaaagaa acaatgttct aggtcaaact
      121 gagtctacca aatgcagact ttcacaatgg ttctagaaga aatctggaca agtcttttca
      181 tgtggttttt ctacgcattg attccatgtt tgctcacaga tgaagtggcc attctgcctg
      241 cccctcagaa cctctctgta ctctcaacca acatgaagca tctcttgatg tggagcccag
      301 tgatcgcgcc tggagaaaca gtgtactatt ctgtcgaata ccagggggag tacgagagcc
      361 tgtacacgag ccacatctgg atccccagca gctggtgctc actcactgaa ggtcctgagt
      421 gtgatgtcac tgatgacatc acggccactg tgccatacaa ccttcgtgtc agggccacat
      481 tgggctcaca gacctcagcc tggagcatcc tgaagcatcc ctttaataga aactcaacca
      541 tccttacccg acctgggatg gagatcacca aagatggctt ccacctggtt attgagctgg
      601 aggacctggg gccccagttt gagttccttg tggcctactg gaggagggag cctggtgccg
      661 aggaacatgt caaaatggtg aggagtgggg gtattccagt gcacctagaa accatggagc
      721 caggggctgc atactgtgtg aaggcccaga cattcgtgaa ggccattggg aggtacagcg
      781 ccttcagcca gacagaatgt gtggaggtgc aaggagaggc cattcccctg gtactggccc
      841 tgtttgcctt tgttggcttc atgctgatcc ttgtggtcgt gccactgttc gtctggaaaa
      901 tgggccggct gctccagtac tcctgttgcc ccgtggtggt cctcccagac accttgaaaa
      961 taaccaattc accccagaag ttaatcagct gcagaaggga ggaggtggat gcctgtgcca
     1021 cggctgtgat gtctcctgag gaactcctca gggcctggat ctcataggtt tgcggaaggg
     1081 cccaggtgaa gccgagaacc tggtctgcat gacatggaaa ccatgagggg acaagttgtg
     1141 tttctgtttt ccgccacgga caagggatga gagaagtagg aagagcctgt tgtctacaag
     1201 tctagaagca accatcagag gcagggtggt ttgtctaaca gaacactgac tgaggcttag
     1261 gggatgtgac ctctagactg ggggctgcca cttgctggct gagcaaccct gggaaaagtg
     1321 acttcatccc ttcggtccta agttttctca tctgtaatgg gggaattacc tacacacctg
     1381 ctaaacacac acacacagag tctctctcta tatatacaca cgtacacata aatacaccca
     1441 gcacttgcaa ggctagaggg aaactggtga cactctacag tctgactgat tcagtgtttc
     1501 tggagagcag gacataaatg tatgatgaga atgatcaagg actctacaca ctgggtggct
     1561 tggagagccc actttcccag aataatcctt gagagaaaag gaatcatggg agcaatggtg
     1621 ttgagttcac ttcaagccca atgccggtgc agaggggaat ggcttagcga gctctacagt
     1681 aggtgacctg gaggaaggtc acagccacac tgaaaatggg atgtgcatga acacggagga
     1741 tccatgaact actgtaaagt gttgacagtg tgtgcacact gcagacagca ggtgaaatgt
     1801 atgtgtgcaa tgcgacgaga atgcagaagt cagtaacatg tgcatgtttg ttgtgctcct
     1861 tttttctgtt ggtaaagtac agaattcagc aaataaaaag ggccaccctg gccaaaagcg
     1921 gtctttaaa
//
