LOCUS       NM_014432               3486 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens interleukin 20 receptor subunit alpha (IL20RA),
            transcript variant 1, mRNA.
ACCESSION   NM_014432
VERSION     NM_014432.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3486)
  AUTHORS   Lamichhane,S., Mo,J.S., Sharma,G., Choi,T.Y. and Chae,S.C.
  TITLE     MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in
            inflammatory colitis and colorectal cancer
  JOURNAL   Inflamm Res 70 (8), 903-914 (2021)
   PUBMED   34283251
  REMARK    GeneRIF: MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway
            in inflammatory colitis and colorectal cancer.
REFERENCE   2  (bases 1 to 3486)
  AUTHORS   Gao,W., Wen,H., Liang,L., Dong,X., Du,R., Zhou,W., Zhang,X.,
            Zhang,C., Xiang,R. and Li,N.
  TITLE     IL20RA signaling enhances stemness and promotes the formation of an
            immunosuppressive microenvironment in breast cancer
  JOURNAL   Theranostics 11 (6), 2564-2580 (2021)
   PUBMED   33456560
  REMARK    GeneRIF: IL20RA signaling enhances stemness and promotes the
            formation of an immunosuppressive microenvironment in breast
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3486)
  AUTHORS   Zahradnik,J., Kolarova,L., Peleg,Y., Kolenko,P., Svidenska,S.,
            Charnavets,T., Unger,T., Sussman,J.L. and Schneider,B.
  TITLE     Flexible regions govern promiscuous binding of IL-24 to receptors
            IL-20R1 and IL-22R1
  JOURNAL   FEBS J 286 (19), 3858-3873 (2019)
   PUBMED   31152679
  REMARK    GeneRIF: Multiple sequence alignment explains the stabilizing
            effect of the mutated residues in the IL-24 variants by their
            presence in the related and more stable cytokines IL-20 and IL-19
REFERENCE   4  (bases 1 to 3486)
  AUTHORS   Wu,J., Yang,S., Yu,D., Gao,W., Liu,X., Zhang,K., Fu,X., Bao,W.,
            Zhang,K., Yu,J., Sun,L. and Wang,S.
  TITLE     CRISPR/cas9 mediated knockout of an intergenic variant rs6927172
            identified IL-20RA as a new risk gene for multiple autoimmune
            diseases
  JOURNAL   Genes Immun 20 (2), 103-111 (2019)
   PUBMED   29483615
  REMARK    GeneRIF: IL-20RA gene as a risk factor for multiple autoimmune
            diseases.
REFERENCE   5  (bases 1 to 3486)
  AUTHORS   McGovern,A., Schoenfelder,S., Martin,P., Massey,J., Duffus,K.,
            Plant,D., Yarwood,A., Pratt,A.G., Anderson,A.E., Isaacs,J.D.,
            Diboll,J., Thalayasingam,N., Ospelt,C., Barton,A., Worthington,J.,
            Fraser,P., Eyre,S. and Orozco,G.
  TITLE     Capture Hi-C identifies a novel causal gene, IL20RA, in the
            pan-autoimmune genetic susceptibility region 6q23
  JOURNAL   Genome Biol 17 (1), 212 (2016)
   PUBMED   27799070
  REMARK    GeneRIF: the DNA fragment containing the associated SNPs interacts
            through chromatin looping not only with TNFAIP3, but also with
            IL20RA, located 680 kb upstream.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3486)
  AUTHORS   Pletnev,S., Magracheva,E., Kozlov,S., Tobin,G., Kotenko,S.V.,
            Wlodawer,A. and Zdanov,A.
  TITLE     Characterization of the recombinant extracellular domains of human
            interleukin-20 receptors and their complexes with interleukin-19
            and interleukin-20
  JOURNAL   Biochemistry 42 (43), 12617-12624 (2003)
   PUBMED   14580208
  REMARK    GeneRIF: forms stable complex with interleukin-19 and
            interleukin-20 [IL-20R1][IL-20R2]
REFERENCE   7  (bases 1 to 3486)
  AUTHORS   Parrish-Novak,J., Xu,W., Brender,T., Yao,L., Jones,C., West,J.,
            Brandt,C., Jelinek,L., Madden,K., McKernan,P.A., Foster,D.C.,
            Jaspers,S. and Chandrasekher,Y.A.
  TITLE     Interleukins 19, 20, and 24 signal through two distinct receptor
            complexes. Differences in receptor-ligand interactions mediate
            unique biological functions
  JOURNAL   J Biol Chem 277 (49), 47517-47523 (2002)
   PUBMED   12351624
REFERENCE   8  (bases 1 to 3486)
  AUTHORS   Wang,M., Tan,Z., Zhang,R., Kotenko,S.V. and Liang,P.
  TITLE     Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric
            receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2
  JOURNAL   J Biol Chem 277 (9), 7341-7347 (2002)
   PUBMED   11706020
REFERENCE   9  (bases 1 to 3486)
  AUTHORS   Dumoutier,L., Leemans,C., Lejeune,D., Kotenko,S.V. and Renauld,J.C.
  TITLE     Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through
            IL-20 receptor complexes of two types
  JOURNAL   J Immunol 167 (7), 3545-3549 (2001)
   PUBMED   11564763
REFERENCE   10 (bases 1 to 3486)
  AUTHORS   Blumberg,H., Conklin,D., Xu,W.F., Grossmann,A., Brender,T.,
            Carollo,S., Eagan,M., Foster,D., Haldeman,B.A., Hammond,A.,
            Haugen,H., Jelinek,L., Kelly,J.D., Madden,K., Maurer,M.F.,
            Parrish-Novak,J., Prunkard,D., Sexson,S., Sprecher,C., Waggie,K.,
            West,J., Whitmore,T.E., Yao,L., Kuechle,M.K., Dale,B.A. and
            Chandrasekher,Y.A.
  TITLE     Interleukin 20: discovery, receptor identification, and role in
            epidermal function
  JOURNAL   Cell 104 (1), 9-19 (2001)
   PUBMED   11163236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135902.16.
            
            On Nov 18, 2020 this sequence version replaced NM_014432.3.
            
            Summary: This gene encodes a member of the type II cytokine
            receptor family. The encoded protein is a subunit of the receptor
            for interleukin 20, a cytokine that may be involved in epidermal
            function. The interleukin 20 receptor is a heterodimeric complex
            consisting of the encoded protein and interleukin 20 receptor beta.
            This gene and interleukin 20 receptor beta are highly expressed in
            skin, and are upregulated in psoriasis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF184971.1, AK315293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316649.10/ ENSP00000314976.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AL135902.16        58379-58703         c
            326-461             AL135902.16        30706-30841         c
            462-640             AL135902.16        25012-25190         c
            641-816             AL135902.16        23055-23230         c
            817-961             AL135902.16        22337-22481         c
            962-1101            AL135902.16        18359-18498         c
            1102-3486           AL135902.16        13709-16093         c
FEATURES             Location/Qualifiers
     source          1..3486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..3486
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /note="interleukin 20 receptor subunit alpha"
                     /db_xref="GeneID:53832"
                     /db_xref="HGNC:HGNC:6003"
                     /db_xref="MIM:605620"
     exon            1..325
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1899
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-20 receptor I; class II cytokine
                     receptor ZCYTOR7; cytokine receptor family 2 member 8;
                     interleukin 20 receptor, alpha; interleukin 20 receptor
                     alpha subunit"
                     /codon_start=1
                     /product="interleukin-20 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_055247.4"
                     /db_xref="CCDS:CCDS5181.1"
                     /db_xref="GeneID:53832"
                     /db_xref="HGNC:HGNC:6003"
                     /db_xref="MIM:605620"
                     /translation="MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGGLPKPANIT
                     FLSINMKNVLQWTPPEGLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETS
                     DYEHQYYAKVKAIWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEK
                     WKRNPEDLPVSMQQIYSNLKYNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHV
                     ESFVPGPPRRAQPSEKQCARTLKDQSSEFKAKIIFWYVLPVSITVFLFSVMGYSIYRY
                     IHVGKEKHPANLILIYGNEFDKRFFVPAEKIVINFITLNISDDSKISHQDMSLLGKSS
                     DVSSLNDPQPSGNLRPPQEEEEVKHLGYASHLMEIFCDSEENTEGTSLTQQESLSRTI
                     PPDKTVIEYEYDVRTTDICAGPEEQELSLQEEVSTQGTLLESQAALAVLGPQTLQYSY
                     TPQLQDLDPLAQEHTDSEEGPEEEPSTTLVDWDPQTGRLCIPSLSSFDQDSEGCEPSE
                     GDGLGEEGLLSRLYEEPAPDRPPGENETYLMQFMEEWGLYVQMEN"
     exon            326..461
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     exon            462..640
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     exon            641..816
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     exon            817..961
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1101
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..3486
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /note="hexamer: AATAAA"
     polyA_site      2180
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /note="major polyA site"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
                     /note="hexamer: AATAAA"
     polyA_site      3486
                     /gene="IL20RA"
                     /gene_synonym="CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA"
ORIGIN      
        1 atccagctgg gtagccgggg gagcgcgcgt gggggctccg cgagtcgctc gcccttggtt
       61 tctggggaag cctgggggac gcggctgtgg cggaggcgcc ctgggactca ggtcgcctgg
      121 agcgtggcac gcagagcccc aggcgcggag ctgaggccgc gcggccgcgc ttggccccag
      181 cgggcgtggg actgagcagt ctgctgcccc ccgacatgtg acccagcccc gccgcccatg
      241 cgggctcccg gccgcccggc cctgcggccg ctgccgctgc cgccgctgct gctgttgctc
      301 ctggcggcgc cttggggacg ggcagttccc tgtgtctctg gtggtttgcc taaacctgca
      361 aacatcacct tcttatccat caacatgaag aatgtcctac aatggactcc accagagggt
      421 cttcaaggag ttaaagttac ttacactgtg cagtatttca tatatgggca aaagaaatgg
      481 ctgaataaat cagaatgcag aaatatcaat agaacctact gtgatctttc tgctgaaact
      541 tctgactacg aacaccagta ttatgccaaa gttaaggcca tttggggaac aaagtgttcc
      601 aaatgggctg aaagtggacg gttctatcct tttttagaaa cacaaattgg cccaccagag
      661 gtggcactga ctacagatga gaagtccatt tctgttgtcc tgacagctcc agagaagtgg
      721 aagagaaatc cagaagacct tcctgtttcc atgcaacaaa tatactccaa tctgaagtat
      781 aacgtgtctg tgttgaatac taaatcaaac agaacgtggt cccagtgtgt gaccaaccac
      841 acgctggtgc tcacctggct ggagccgaac actctttact gcgtacacgt ggagtccttc
      901 gtcccagggc cccctcgccg tgctcagcct tctgagaagc agtgtgccag gactttgaaa
      961 gatcaatcat cagagttcaa ggctaaaatc atcttctggt atgttttgcc cgtatctatt
     1021 accgtgtttc ttttttctgt gatgggctat tccatctacc gatatatcca cgttggcaaa
     1081 gagaaacacc cagcaaattt gattttgatt tatggaaatg aatttgacaa aagattcttt
     1141 gtgcctgctg aaaaaatcgt gattaacttt atcaccctca atatctcgga tgattctaaa
     1201 atttctcatc aggatatgag tttactggga aaaagcagtg atgtatccag ccttaatgat
     1261 cctcagccca gcgggaacct gaggccccct caggaggaag aggaggtgaa acatttaggg
     1321 tatgcttcgc atttgatgga aattttttgt gactctgaag aaaacacgga aggtacttct
     1381 ctcacccagc aagagtccct cagcagaaca atacccccgg ataaaacagt cattgaatat
     1441 gaatatgatg tcagaaccac tgacatttgt gcggggcctg aagagcagga gctcagtttg
     1501 caggaggagg tgtccacaca aggaacatta ttggagtcgc aggcagcgtt ggcagtcttg
     1561 ggcccgcaaa cgttacagta ctcatacacc cctcagctcc aagacttaga ccccctggcg
     1621 caggagcaca cagactcgga ggaggggccg gaggaagagc catcgacgac cctggtcgac
     1681 tgggatcccc aaactggcag gctgtgtatt ccttcgctgt ccagcttcga ccaggattca
     1741 gagggctgcg agccttctga gggggatggg ctcggagagg agggtcttct atctagactc
     1801 tatgaggagc cggctccaga caggccacca ggagaaaatg aaacctatct catgcaattc
     1861 atggaggaat gggggttata tgtgcagatg gaaaactgat gccaacactt ccttttgcct
     1921 tttgtttcct gtgcaaacaa gtgagtcacc cctttgatcc cagccataaa gtacctggga
     1981 tgaaagaagt tttttccagt ttgtcagtgt ctgtgagaat tacttatttc ttttctctat
     2041 tctcatagca cgtgtgtgat tggttcatgc atgtaggtct cttaacaatg atggtgggcc
     2101 tctggagtcc aggggctggc cggttgttct atgcagagaa agcagtcaat aaatgtttgc
     2161 cagactgggt gcagaattta ttcaggtggg tgtactctgg cctcttggtt cattattttc
     2221 aaacaagcac acttgtacaa ttattttctg ggtacttccc atatgcacat agcactgtaa
     2281 aaaatatttc ccaaagatca ctcattttat aaataccact ttttcagaat tgggtttatt
     2341 gcgagcagga ggagatactt aaaacatgca catataccag gttggtggta agttggtcgc
     2401 atgtgaaaac ctcaactatt taatcatcat gattcatatt ttgagtgaat acatcaggca
     2461 cagaccttca tgatatcaca cactcttggc tactttaaga ggccatcttt aatactttat
     2521 gagtagttct ggagtgtaaa cataaacgag tattcttttg tagtcagaaa agtgtcctct
     2581 caataattta gtaggggctt attgtctctc aaaactaacc taaaagaaaa tgacacattt
     2641 tataatagaa tattacattt atttctggaa gtgtgttttc aaaaagatat ttacatagtc
     2701 tgtaaactag aaagtgttag gtaaagctct aggttactgt gttactatta taatattaaa
     2761 cattcgaata ggcagtcgtt caaagactct ttggaatatc tatgaatgaa tatcctctat
     2821 tcttataata ttaaaaccca taagtaaata taggacatac aagagaaatg agttaaatga
     2881 ctatgtaagg gagagtttat taaaatttga tgaaatttac tgtaggaact aaactatgcc
     2941 ataaaacaat agctttctag ttcatttcca gtaactgttc ccatctcctt taccacttgt
     3001 taagaaaatt aaattcttca gtcacgctgc tttaaaatgg gacaaaatct attaagttga
     3061 accatatata attgtggata tttggctgtt tttaatctga caagcagtaa cttcatatgg
     3121 tttgccttaa tatatatttg ttttagtcat gaactcataa tccattgatg ctctttcatg
     3181 agaagagata tcacccatat ttccttattg atattattgg tacaggcaga caaccctggt
     3241 aggagagatg gattctgggg tcatgacctt tcgtgattat ccgcaaatgc aaacagtttc
     3301 agatctaatg gtttaattta gggagtaatt atattaatca gagtgttctg ttattctcaa
     3361 tctttataga aacgattctg ctggttttga agaacagatg tattacacta actgtaaaag
     3421 tagttcaaga gtgagaaaga ataaattgtt attaagagca aaagaaaaat aaagtgattg
     3481 atgata
//
