LOCUS       NM_018724               1284 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens interleukin 20 (IL20), transcript variant 1, mRNA.
ACCESSION   NM_018724
VERSION     NM_018724.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Yemenoglu,H., Senkal,R., Kose,O., Yilmaz,A., Mataraci Karakas,S.
            and Akyildiz,K.
  TITLE     The effect of interleukin-20 on periodontal tissue destruction in
            individuals with periodontitis
  JOURNAL   J Periodontal Res 59 (3), 480-490 (2024)
   PUBMED   38356138
  REMARK    GeneRIF: The effect of interleukin-20 on periodontal tissue
            destruction in individuals with periodontitis.
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Chiriac,M.T., Hracsko,Z., Gunther,C., Gonzalez-Acera,M., Atreya,R.,
            Stolzer,I., Wittner,L., Dressel,A., Schickedanz,L.,
            Gamez-Belmonte,R., Erkert,L., Hundorfean,G., Zundler,S., Rath,T.,
            Vetrano,S., Danese,S., Sturm,G., Trajanoski,Z., Kuhl,A.A.,
            Siegmund,B., Hartmann,A., Wirtz,S., Siebler,J., Finotto,S.,
            Becker,C. and Neurath,M.F.
  TITLE     IL-20 controls resolution of experimental colitis by regulating
            epithelial IFN/STAT2 signalling
  JOURNAL   Gut 73 (2), 282-297 (2024)
   PUBMED   37884352
  REMARK    GeneRIF: IL-20 controls resolution of experimental colitis by
            regulating epithelial IFN/STAT2 signalling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Kaymak,T., Kaya,B., Wuggenig,P., Nuciforo,S., Goldi,A., Oswald,F.,
            Roux,J., Noti,M., Melhem,H., Hruz,P. and Niess,J.H.
  CONSRTM   Swiss EoE Cohort Study Group (SEECS)
  TITLE     IL-20 subfamily cytokines impair the oesophageal epithelial barrier
            by diminishing filaggrin in eosinophilic oesophagitis
  JOURNAL   Gut 72 (5), 821-833 (2023)
   PUBMED   35613844
  REMARK    GeneRIF: IL-20 subfamily cytokines impair the oesophageal
            epithelial barrier by diminishing filaggrin in eosinophilic
            oesophagitis.
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Lu,Y.S., Chiang,P.M., Huang,Y.C., Yang,S.J., Hung,L.Y.,
            Medeiros,L.J., Chen,Y.P., Chen,T.Y., Chang,M.S. and Chang,K.C.
  TITLE     Overexpression of interleukin-20 correlates with favourable
            prognosis in diffuse large B-cell lymphoma
  JOURNAL   Pathology 55 (1), 94-103 (2023)
   PUBMED   36175183
  REMARK    GeneRIF: Overexpression of interleukin-20 correlates with
            favourable prognosis in diffuse large B-cell lymphoma.
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Wang,H.H., Chen,W.Y., Huang,Y.H., Hsu,S.M., Tsao,Y.P., Hsu,Y.H. and
            Chang,M.S.
  TITLE     Interleukin-20 is involved in dry eye disease and is a potential
            therapeutic target
  JOURNAL   J Biomed Sci 29 (1), 36 (2022)
   PUBMED   35681232
  REMARK    GeneRIF: Interleukin-20 is involved in dry eye disease and is a
            potential therapeutic target.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Rich,B.E.
  TITLE     IL-20: a new target for the treatment of inflammatory skin disease
  JOURNAL   Expert Opin Ther Targets 7 (2), 165-174 (2003)
   PUBMED   12667095
  REMARK    Review article
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Parrish-Novak,J., Xu,W., Brender,T., Yao,L., Jones,C., West,J.,
            Brandt,C., Jelinek,L., Madden,K., McKernan,P.A., Foster,D.C.,
            Jaspers,S. and Chandrasekher,Y.A.
  TITLE     Interleukins 19, 20, and 24 signal through two distinct receptor
            complexes. Differences in receptor-ligand interactions mediate
            unique biological functions
  JOURNAL   J Biol Chem 277 (49), 47517-47523 (2002)
   PUBMED   12351624
  REMARK    GeneRIF: examination of ligand/receptor interactions and in signal
            transduction that may lead to specificity and distinct biology
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Wolk,K., Kunz,S., Asadullah,K. and Sabat,R.
  TITLE     Cutting edge: immune cells as sources and targets of the IL-10
            family members?
  JOURNAL   J Immunol 168 (11), 5397-5402 (2002)
   PUBMED   12023331
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Rich,B.E. and Kupper,T.S.
  TITLE     Cytokines: IL-20 - a new effector in skin inflammation
  JOURNAL   Curr Biol 11 (13), R531-R534 (2001)
   PUBMED   11470428
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Blumberg,H., Conklin,D., Xu,W.F., Grossmann,A., Brender,T.,
            Carollo,S., Eagan,M., Foster,D., Haldeman,B.A., Hammond,A.,
            Haugen,H., Jelinek,L., Kelly,J.D., Madden,K., Maurer,M.F.,
            Parrish-Novak,J., Prunkard,D., Sexson,S., Sprecher,C., Waggie,K.,
            West,J., Whitmore,T.E., Yao,L., Kuechle,M.K., Dale,B.A. and
            Chandrasekher,Y.A.
  TITLE     Interleukin 20: discovery, receptor identification, and role in
            epidermal function
  JOURNAL   Cell 104 (1), 9-19 (2001)
   PUBMED   11163236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098935.2.
            
            On Jul 8, 2020 this sequence version replaced NM_018724.3.
            
            Summary: The protein encoded by this gene is a cytokine
            structurally related to interleukin 10 (IL10). This cytokine has
            been shown to transduce its signal through signal transducer and
            activator of transcription 3 (STAT3) in keratinocytes. A specific
            receptor for this cytokine is found to be expressed in skin and
            upregulated dramatically in psoriatic skin, suggesting a role for
            this protein in epidermal function and psoriasis. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358320.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367098.6/ ENSP00000356065.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC098935.2         17652-17715
            65-253              AC098935.2         17852-18040
            254-319             AC098935.2         18328-18393
            320-472             AC098935.2         18513-18665
            473-547             AC098935.2         19413-19487
            548-1284            AC098935.2         20516-21252
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1284
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /note="interleukin 20"
                     /db_xref="GeneID:50604"
                     /db_xref="HGNC:HGNC:6002"
                     /db_xref="MIM:605619"
     exon            1..64
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /inference="alignment:Splign:2.1.0"
     exon            65..253
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..625
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; four alpha helix cytokine; cytokine Zcyto10"
                     /codon_start=1
                     /product="interleukin-20 isoform 1 precursor"
                     /protein_id="NP_061194.2"
                     /db_xref="CCDS:CCDS1470.1"
                     /db_xref="GeneID:50604"
                     /db_xref="HGNC:HGNC:6002"
                     /db_xref="MIM:605619"
                     /translation="MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRN
                     GFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPD
                     HYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVK
                     ALGELDILLQWMEETE"
     exon            254..319
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /inference="alignment:Splign:2.1.0"
     exon            320..472
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /inference="alignment:Splign:2.1.0"
     exon            473..547
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /inference="alignment:Splign:2.1.0"
     exon            548..1284
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1262..1267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /note="hexamer: AATAAA"
     polyA_site      1284
                     /gene="IL20"
                     /gene_synonym="IL-20; IL10D; ZCYTO10"
                     /note="major polyA site"
ORIGIN      
        1 gcactcagac tctgaactca gacctgaaat cttctcttca cgggaggctt ggcagttttt
       61 cttactcctg tggtctccag atttcaggcc taagatgaaa gcctctagtc ttgccttcag
      121 ccttctctct gctgcgtttt atctcctatg gactccttcc actggactga agacactcaa
      181 tttgggaagc tgtgtgatcg ccacaaacct tcaggaaata cgaaatggat tttctgagat
      241 acggggcagt gtgcaagcca aagatggaaa cattgacatc agaatcttaa ggaggactga
      301 gtctttgcaa gacacaaagc ctgcgaatcg atgctgcctc ctgcgccatt tgctaagact
      361 ctatctggac agggtattta aaaactacca gacccctgac cattatactc tccggaagat
      421 cagcagcctc gccaattcct ttcttaccat caagaaggac ctccggctct gtcatgccca
      481 catgacatgc cattgtgggg aggaagcaat gaagaaatac agccagattc tgagtcactt
      541 tgaaaagctg gaacctcagg cagcagttgt gaaggctttg ggggaactag acattcttct
      601 gcaatggatg gaggagacag aataggagga aagtgatgct gctgctaaga atattcgagg
      661 tcaagagctc cagtcttcaa tacctgcaga ggaggcatga ccccaaacca ccatctcttt
      721 actgtactag tcttgtgctg gtcacagtgt atcttattta tgcattactt gcttccttgc
      781 atgattgtct ttatgcatcc ccaatcttaa ttgagaccat acttgtataa gatttttgta
      841 atatctttct gctattggat atatttatta gttaatatat ttatttattt tttgctattt
      901 aatgtattta tttttttact tggacatgaa actttaaaaa aattcacaga ttatatttat
      961 aacctgacta gagcaggtga tgtattttta tacagtaaaa aaaaaaaacc ttgtaaattc
     1021 tagaagagtg gctagggggg ttattcattt gtattcaact aaggacatat ttactcatgc
     1081 tgatgctctg tgagatattt gaaattgaac caatgactac ttaggatggg ttgtggaata
     1141 agttttgatg tggaattgca catctacctt acaattactg accatcccca gtagactccc
     1201 cagtcccata attgtgtatc ttccagccag gaatcctaca cggccagcat gtatttctac
     1261 aaataaagtt ttctttgcat aaca
//
