LOCUS       NM_000586               1029 bp    mRNA    linear   PRI 08-NOV-2024
DEFINITION  Homo sapiens interleukin 2 (IL2), mRNA.
ACCESSION   NM_000586
VERSION     NM_000586.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Katsuyama,E., Humbel,M., Suarez-Fueyo,A., Satyam,A., Yoshida,N.,
            Kyttaris,V.C., Tsokos,M.G. and Tsokos,G.C.
  TITLE     CD38 in SLE CD4 T cells promotes Ca2+ flux and suppresses
            interleukin-2 production by enhancing the expression of GM2 on the
            surface membrane
  JOURNAL   Nat Commun 15 (1), 8304 (2024)
   PUBMED   39333474
  REMARK    GeneRIF: CD38 in SLE CD4 T cells promotes Ca[2+] flux and
            suppresses interleukin-2 production by enhancing the expression of
            GM2 on the surface membrane.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Cordeiro,F.P., Marchiori,L.L.M., Teixeira,D.C., Andraus,R.A.C. and
            Poli-Frederico,R.C.
  TITLE     Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss
            Evaluation in the Elderly
  JOURNAL   Noise Health 26 (121), 165-173 (2024)
   PUBMED   38904818
  REMARK    GeneRIF: Plasma Levels of Interleukin 2 (IL-2) Associated with
            Hearing Loss Evaluation in the Elderly.
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Spolski,R., Li,P. and Leonard,W.J.
  TITLE     Biology and regulation of IL-2: from molecular mechanisms to human
            therapy
  JOURNAL   Nat Rev Immunol 18 (10), 648-659 (2018)
   PUBMED   30089912
  REMARK    GeneRIF: IL-2 regulates CD4(+) T cell differentiation and function,
            the effector and memory responses of CD8(+) T cells, and the loss
            of IL-2 or responsiveness to IL-2 at least in part explains the
            exhausted phenotype that occurs during chronic viral infections and
            in tumour responses.
            Review article
REFERENCE   4  (bases 1 to 1029)
  AUTHORS   Abbas,A.K., Trotta,E., R Simeonov,D., Marson,A. and Bluestone,J.A.
  TITLE     Revisiting IL-2: Biology and therapeutic prospects
  JOURNAL   Sci Immunol 3 (25) (2018)
   PUBMED   29980618
  REMARK    Review article
REFERENCE   5  (bases 1 to 1029)
  AUTHORS   Ross,S.H. and Cantrell,D.A.
  TITLE     Signaling and Function of Interleukin-2 in T Lymphocytes
  JOURNAL   Annu Rev Immunol 36, 411-433 (2018)
   PUBMED   29677473
  REMARK    Review article
REFERENCE   6  (bases 1 to 1029)
  AUTHORS   Wrangle,J.M., Patterson,A., Johnson,C.B., Neitzke,D.J.,
            Mehrotra,S., Denlinger,C.E., Paulos,C.M., Li,Z., Cole,D.J. and
            Rubinstein,M.P.
  TITLE     IL-2 and Beyond in Cancer Immunotherapy
  JOURNAL   J Interferon Cytokine Res 38 (2), 45-68 (2018)
   PUBMED   29443657
  REMARK    Review article
REFERENCE   7  (bases 1 to 1029)
  AUTHORS   Arenas-Ramirez,N., Woytschak,J. and Boyman,O.
  TITLE     Interleukin-2: Biology, Design and Application
  JOURNAL   Trends Immunol 36 (12), 763-777 (2015)
   PUBMED   26572555
  REMARK    Review article
REFERENCE   8  (bases 1 to 1029)
  AUTHORS   Boyman,O., Kolios,A.G. and Raeber,M.E.
  TITLE     Modulation of T cell responses by IL-2 and IL-2 complexes
  JOURNAL   Clin Exp Rheumatol 33 (4 Suppl 92), S54-S57 (2015)
   PUBMED   26457438
  REMARK    Review article
REFERENCE   9  (bases 1 to 1029)
  AUTHORS   Purvis,S.F., Georges,D.L., Williams,T.M. and Lederman,M.M.
  TITLE     Suppression of interleukin-2 and interleukin-2 receptor expression
            in Jurkat cells stably expressing the human immunodeficiency virus
            Tat protein
  JOURNAL   Cell Immunol 144 (1), 32-42 (1992)
   PUBMED   1394441
REFERENCE   10 (bases 1 to 1029)
  AUTHORS   Brodie,C. and Gelfand,E.W.
  TITLE     Functional nerve growth factor receptors on human B lymphocytes.
            Interaction with IL-2
  JOURNAL   J Immunol 148 (11), 3492-3497 (1992)
   PUBMED   1316918
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022489.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 21, 2019 this sequence version replaced NM_000586.3.
            
            Summary: This gene is a member of the interleukin 2 (IL2) cytokine
            subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin,
            and thrombopoietin. The protein encoded by this gene is a secreted
            cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is
            important for the proliferation of T and B lymphocytes. The
            receptor of this cytokine (IL2R) is a heterotrimeric protein
            complex whose gamma chain is also shared by IL4 and IL7. The
            expression of this gene in mature thymocytes is monoallelic, which
            represents an unusual regulatory mode for controlling the precise
            expression of a single gene. The targeted disruption of a similar
            gene in mice leads to ulcerative colitis-like disease, which
            suggests an essential role of this gene in the immune response to
            antigenic stimuli. [provided by RefSeq, Sep 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S82692.1, BC070338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000226730.5/ ENSP00000226730.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               AC022489.7         32497-32928
            433-492             AC022489.7         33019-33078
            493-636             AC022489.7         35369-35512
            637-1029            AC022489.7         37360-37752
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..1029
                     /gene="IL2"
                     /gene_synonym="IL-2; lymphokine; TCGF"
                     /note="interleukin 2"
                     /db_xref="GeneID:3558"
                     /db_xref="HGNC:HGNC:6001"
                     /db_xref="MIM:147680"
     exon            1..432
                     /gene="IL2"
                     /gene_synonym="IL-2; lymphokine; TCGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..747
                     /gene="IL2"
                     /gene_synonym="IL-2; lymphokine; TCGF"
                     /note="T cell growth factor; aldesleukin; involved in
                     regulation of T-cell clonal expansion"
                     /codon_start=1
                     /product="interleukin-2 precursor"
                     /protein_id="NP_000577.2"
                     /db_xref="CCDS:CCDS3726.1"
                     /db_xref="GeneID:3558"
                     /db_xref="HGNC:HGNC:6001"
                     /db_xref="MIM:147680"
                     /translation="MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMI
                     LNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRP
                     RDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT"
     exon            433..492
                     /gene="IL2"
                     /gene_synonym="IL-2; lymphokine; TCGF"
                     /inference="alignment:Splign:2.1.0"
     exon            493..636
                     /gene="IL2"
                     /gene_synonym="IL-2; lymphokine; TCGF"
                     /inference="alignment:Splign:2.1.0"
     exon            637..1029
                     /gene="IL2"
                     /gene_synonym="IL-2; lymphokine; TCGF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcaccta agtgtgggct aatgtaacaa agagggattt cacctacatc cattcagtca
       61 gtctttgggg gtttaaagaa attccaaaga gtcatcagaa gaggaaaaat gaaggtaatg
      121 ttttttcaga caggtaaagt ctttgaaaat atgtgtaata tgtaaaacat tttgacaccc
      181 ccataatatt tttccagaat taacagtata aattgcatct cttgttcaag agttccctat
      241 cactctcttt aatcactact cacagtaacc tcaactcctg ccacaatgta caggatgcaa
      301 ctcctgtctt gcattgcact aagtcttgca cttgtcacaa acagtgcacc tacttcaagt
      361 tctacaaaga aaacacagct acaactggag catttactgc tggatttaca gatgattttg
      421 aatggaatta ataattacaa gaatcccaaa ctcaccagga tgctcacatt taagttttac
      481 atgcccaaga aggccacaga actgaaacat cttcagtgtc tagaagaaga actcaaacct
      541 ctggaggaag tgctaaattt agctcaaagc aaaaactttc acttaagacc cagggactta
      601 atcagcaata tcaacgtaat agttctggaa ctaaagggat ctgaaacaac attcatgtgt
      661 gaatatgctg atgagacagc aaccattgta gaatttctga acagatggat taccttttgt
      721 caaagcatca tctcaacact gacttgataa ttaagtgctt cccacttaaa acatatcagg
      781 ccttctattt atttaaatat ttaaatttta tatttattgt tgaatgtatg gtttgctacc
      841 tattgtaact attattctta atcttaaaac tataaatatg gatcttttat gattcttttt
      901 gtaagcccta ggggctctaa aatggtttca cttatttatc ccaaaatatt tattattatg
      961 ttgaatgtta aatatagtat ctatgtagat tggttagtaa aactatttaa taaatttgat
     1021 aaatataaa
//
