LOCUS       NM_173842               1704 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens interleukin 1 receptor antagonist (IL1RN), transcript
            variant 1, mRNA.
ACCESSION   NM_173842
VERSION     NM_173842.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1704)
  AUTHORS   Wang,R., Zhu,Z., Peng,S., Xu,J., Chen,Y., Wei,S. and Liu,X.
  TITLE     Exosome microRNA-125a-5p derived from epithelium promotes M1
            macrophage polarization by targeting IL1RN in chronic obstructive
            pulmonary disease
  JOURNAL   Int Immunopharmacol 137, 112466 (2024)
   PUBMED   38875998
  REMARK    GeneRIF: Exosome microRNA-125a-5p derived from epithelium promotes
            M1 macrophage polarization by targeting IL1RN in chronic
            obstructive pulmonary disease.
REFERENCE   2  (bases 1 to 1704)
  AUTHORS   Jing,Q., Liu,X., Lv,Z. and Xue,D.
  TITLE     IL27 and IL1RN are causally associated with acute pancreatitis: a
            Mendelian randomization study
  JOURNAL   Aging (Albany NY) 16 (10), 8572-8584 (2024)
   PUBMED   38742942
  REMARK    GeneRIF: IL27 and IL1RN are causally associated with acute
            pancreatitis: a Mendelian randomization study.
REFERENCE   3  (bases 1 to 1704)
  AUTHORS   Cardoso,J.M., Ribeiro,A.C., Botelho,J., Proenca,L., Noronha,S. and
            Alves,R.C.
  TITLE     The Influence of Genetic Polymorphisms on the Expression of
            Interleukin-1beta, Prostaglandin E2 and Tumor Necrosis Factor Alpha
            in Peri-Implant Crevicular Fluid: A Cross-Sectional Study
  JOURNAL   Int J Mol Sci 25 (1), 651 (2024)
   PUBMED   38203822
  REMARK    GeneRIF: The Influence of Genetic Polymorphisms on the Expression
            of Interleukin-1beta, Prostaglandin E2 and Tumor Necrosis Factor
            Alpha in Peri-Implant Crevicular Fluid: A Cross-Sectional Study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1704)
  AUTHORS   Yigit,S., Nursal,A.F., Keskin,A., Kaya,S., Kuruca,N. and Sezer,O.
  TITLE     Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR variants with
            FMF-related amyloidosis in a Turkish cohort
  JOURNAL   J Investig Med 72 (1), 17-25 (2024)
   PUBMED   37803493
  REMARK    GeneRIF: Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR
            variants with FMF-related amyloidosis in a Turkish cohort.
REFERENCE   5  (bases 1 to 1704)
  AUTHORS   Mochizuki,T., Ushiki,T., Suzuki,K., Sato,M., Ishiguro,H.,
            Suwabe,T., Watanabe,S., Edama,M., Omori,G., Yamamoto,N. and
            Kawase,T.
  TITLE     Elevated IL-1beta and Comparable IL-1 Receptor Antagonist Levels
            Are Characteristic Features of L-PRP in Female College Athletes
            Compared to Male Professional Soccer Players
  JOURNAL   Int J Mol Sci 24 (24), 17487 (2023)
   PUBMED   38139317
  REMARK    GeneRIF: Elevated IL-1beta and Comparable IL-1 Receptor Antagonist
            Levels Are Characteristic Features of L-PRP in Female College
            Athletes Compared to Male Professional Soccer Players.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1704)
  AUTHORS   Tabibzadeh,S. and Sun,X.Z.
  TITLE     Cytokine expression in human endometrium throughout the menstrual
            cycle
  JOURNAL   Hum Reprod 7 (9), 1214-1221 (1992)
   PUBMED   1479000
REFERENCE   7  (bases 1 to 1704)
  AUTHORS   Steinkasserer,A., Spurr,N.K., Cox,S., Jeggo,P. and Sim,R.B.
  TITLE     The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome
            2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci
  JOURNAL   Genomics 13 (3), 654-657 (1992)
   PUBMED   1386337
REFERENCE   8  (bases 1 to 1704)
  AUTHORS   Stockman,B.J., Scahill,T.A., Roy,M., Ulrich,E.L.,
            Strakalaitis,N.A., Brunner,D.P., Yem,A.W. and Deibel,M.R. Jr.
  TITLE     Secondary structure and topology of interleukin-1 receptor
            antagonist protein determined by heteronuclear three-dimensional
            NMR spectroscopy
  JOURNAL   Biochemistry 31 (23), 5237-5245 (1992)
   PUBMED   1534997
REFERENCE   9  (bases 1 to 1704)
  AUTHORS   Lennard,A., Gorman,P., Carrier,M., Griffiths,S., Scotney,H.,
            Sheer,D. and Solari,R.
  TITLE     Cloning and chromosome mapping of the human interleukin-1 receptor
            antagonist gene
  JOURNAL   Cytokine 4 (2), 83-89 (1992)
   PUBMED   1385987
REFERENCE   10 (bases 1 to 1704)
  AUTHORS   Haskill,S., Martin,G., Van Le,L., Morris,J., Peace,A., Bigler,C.F.,
            Jaffe,G.J., Hammerberg,C., Sporn,S.A., Fong,S. et al.
  TITLE     cDNA cloning of an intracellular form of the human interleukin 1
            receptor antagonist associated with epithelium
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3681-3685 (1991)
   PUBMED   1827201
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI766516.1, BC009745.2 and
            AC024704.9.
            
            On Jun 2, 2019 this sequence version replaced NM_173842.2.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. This protein inhibits the activities
            of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and
            modulates a variety of interleukin 1 related immune and
            inflammatory responses, particularly in the acute phase of
            infection and inflammation. This gene and five other closely
            related cytokine genes form a gene cluster spanning approximately
            400 kb on chromosome 2. A polymorphism of this gene is reported to
            be associated with increased risk of osteoporotic fractures and
            gastric cancer. Several alternatively spliced transcript variants
            encoding distinct isoforms have been reported. [provided by RefSeq,
            Aug 2020].
            
            Transcript Variant: This variant (1) differs in the 5' end compared
            to variant 2, resulting in an isoform (1) that has a distinct and
            shorter N-terminus, as compared to the longest isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52015.1, DRR138517.1048542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000409930.4/ ENSP00000387173.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               BI766516.1         38-471
            435-1524            BC009745.2         385-1474
            1525-1525           AC024704.9         39961-39961
            1526-1704           BC009745.2         1476-1654
FEATURES             Location/Qualifiers
     source          1..1704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..1704
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /note="interleukin 1 receptor antagonist"
                     /db_xref="GeneID:3557"
                     /db_xref="HGNC:HGNC:6000"
                     /db_xref="MIM:147679"
     exon            1..143
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..561
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; intracellular IL-1 receptor antagonist type II;
                     interleukin-1 receptor antagonist protein; intracellular
                     interleukin-1 receptor antagonist (icIL-1ra); type II
                     interleukin-1 receptor antagonist; IL1 inhibitor"
                     /codon_start=1
                     /product="interleukin-1 receptor antagonist protein
                     isoform 1 precursor"
                     /protein_id="NP_776214.1"
                     /db_xref="CCDS:CCDS46396.1"
                     /db_xref="GeneID:3557"
                     /db_xref="HGNC:HGNC:6000"
                     /db_xref="MIM:147679"
                     /translation="MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVN
                     QKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETR
                     LQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTN
                     MPDEGVMVTKFYFQEDE"
     exon            144..232
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            233..345
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            346..1704
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /note="hexamer: AATAAA"
     polyA_site      1704
                     /gene="IL1RN"
                     /gene_synonym="CRMO2; DIRA; ICIL-1RA; IL-1ra; IL-1ra3;
                     IL-1RN; IL1F3; IL1RA; IRAP; MVCD4"
                     /note="major polyA site"
ORIGIN      
        1 agtccactgc cttgctgcag tcacagaatg gaaatctgca gaggcctccg cagtcaccta
       61 atcactctcc tcctcttcct gttccattca gagacgatct gccgaccctc tgggagaaaa
      121 tccagcaaga tgcaagcctt cagaatctgg gatgttaacc agaagacctt ctatctgagg
      181 aacaaccaac tagttgctgg atacttgcaa ggaccaaatg tcaatttaga agaaaagata
      241 gatgtggtac ccattgagcc tcatgctctg ttcttgggaa tccatggagg gaagatgtgc
      301 ctgtcctgtg tcaagtctgg tgatgagacc agactccagc tggaggcagt taacatcact
      361 gacctgagcg agaacagaaa gcaggacaag cgcttcgcct tcatccgctc agacagtggc
      421 cccaccacca gttttgagtc tgccgcctgc cccggttggt tcctctgcac agcgatggaa
      481 gctgaccagc ccgtcagcct caccaatatg cctgacgaag gcgtcatggt caccaaattc
      541 tacttccagg aggacgagta gtactgccca ggcctgcctg ttcccattct tgcatggcaa
      601 ggactgcagg gactgccagt ccccctgccc cagggctccc ggctatgggg gcactgagga
      661 ccagccattg aggggtggac cctcagaagg cgtcacaaca acctggtcac aggactctgc
      721 ctcctcttca actgaccagc ctccatgctg cctccagaat ggtctttcta atgtgtgaat
      781 cagagcacag cagcccctgc acaaagccct tccatgtcgc ctctgcattc aggatcaaac
      841 cccgaccacc tgcccaacct gctctcctct tgccactgcc tcttcctccc tcattccacc
      901 ttcccatgcc ctggatccat caggccactt gatgaccccc aaccaagtgg ctcccacacc
      961 ctgttttaca aaaaagaaaa gaccagtcca tgagggaggt ttttaagggt ttgtggaaaa
     1021 tgaaaattag gatttcatga tttttttttt tcagtccccg tgaaggagag cccttcattt
     1081 ggagattatg ttctttcggg gagaggctga ggacttaaaa tattcctgca tttgtgaaat
     1141 gatggtgaaa gtaagtggta gcttttccct tctttttctt ctttttttgt gatgtcccaa
     1201 cttgtaaaaa ttaaaagtta tggtactatg ttagccccat aatttttttt ttccttttaa
     1261 aacacttcca taatctggac tcctctgtcc aggcactgct gcccagcctc caagctccat
     1321 ctccactcca gattttttac agctgcctgc agtactttac ctcctatcag aagtttctca
     1381 gctcccaagg ctctgagcaa atgtggctcc tgggggttct ttcttcctct gctgaaggaa
     1441 taaattgctc cttgacattg tagagcttct ggcacttgga gacttgtatg aaagatggct
     1501 gtgcctctgc ctgtctcccc caccgggctg ggagctctgc agagcaggaa acatgactcg
     1561 tatatgtctc aggtccctgc agggccaagc acctagcctc gctcttggca ggtactcagc
     1621 gaatgaatgc tgtatatgtt gggtgcaaag ttccctactt cctgtgactt cagctctgtt
     1681 ttacaataaa atcttgaaaa tgcc
//
