LOCUS       NM_003854               2565 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens interleukin 1 receptor like 2 (IL1RL2), transcript
            variant 1, mRNA.
ACCESSION   NM_003854
VERSION     NM_003854.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Ahmad,F., Alam,M.A., Ansari,A.W., Jochebeth,A., Leo,R.,
            Al-Abdulla,M.N., Al-Khawaga,S., AlHammadi,A., Al-Malki,A., Al
            Naama,K., Ahmad,A., Buddenkotte,J. and Steinhoff,M.
  TITLE     Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory
            Skin Diseases
  JOURNAL   J Invest Dermatol 144 (2), 206-224 (2024)
   PUBMED   38189700
  REMARK    GeneRIF: Emerging Role of the IL-36/IL-36R Axis in Multiple
            Inflammatory Skin Diseases.
            Review article
REFERENCE   2  (bases 1 to 2565)
  AUTHORS   Hassi,N.K., Weston,T., Rinaldi,G., Ng,J.C., Smahi,A., Twelves,S.,
            Davan-Wetton,C., Fakhreddine,D., Fraternali,F. and Capon,F.
  TITLE     In Silico and In Vitro Analysis of IL36RN Alterations Reveals
            Critical Residues for the Function of the Interleukin-36 Receptor
            Complex
  JOURNAL   J Invest Dermatol 143 (12), 2468-2475 (2023)
   PUBMED   37414245
  REMARK    GeneRIF: In Silico and In Vitro Analysis of IL36RN Alterations
            Reveals Critical Residues for the Function of the Interleukin-36
            Receptor Complex.
REFERENCE   3  (bases 1 to 2565)
  AUTHORS   Baker,K.J., Brint,E. and Houston,A.
  TITLE     Transcriptomic and functional analyses reveal a tumour-promoting
            role for the IL-36 receptor in colon cancer and crosstalk between
            IL-36 signalling and the IL-17/ IL-23 axis
  JOURNAL   Br J Cancer 128 (5), 735-747 (2023)
   PUBMED   36482185
  REMARK    GeneRIF: Transcriptomic and functional analyses reveal a
            tumour-promoting role for the IL-36 receptor in colon cancer and
            crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.
REFERENCE   4  (bases 1 to 2565)
  AUTHORS   Sullivan,G.P., Davidovich,P., Munoz-Wolf,N., Ward,R.W., Hernandez
            Santana,Y.E., Clancy,D.M., Gorman,A., Najda,Z., Turk,B.,
            Walsh,P.T., Lavelle,E.C. and Martin,S.J.
  TITLE     Myeloid cell-derived proteases produce a proinflammatory form of
            IL-37 that signals via IL-36 receptor engagement
  JOURNAL   Sci Immunol 7 (78), eade5728 (2022)
   PUBMED   36525507
  REMARK    GeneRIF: Myeloid cell-derived proteases produce a proinflammatory
            form of IL-37 that signals via IL-36 receptor engagement.
REFERENCE   5  (bases 1 to 2565)
  AUTHORS   Manzanares-Meza,L.D., Valle-Rios,R. and Medina-Contreras,O.
  TITLE     Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and
            Many Implications
  JOURNAL   J Interferon Cytokine Res 42 (2), 49-61 (2022)
   PUBMED   35171706
  REMARK    GeneRIF: Interleukin-1 Receptor-Like 2: One Receptor, Three
            Agonists, and Many Implications.
            Review article
REFERENCE   6  (bases 1 to 2565)
  AUTHORS   Ozkara,C., Uzan,M., Tanriverdi,T., Baykara,O., Ekinci,B., Yeni,N.,
            Kafadar,A. and Buyru,N.
  TITLE     Lack of association between IL-1beta/alpha gene polymorphisms and
            temporal lobe epilepsy with hippocampal sclerosis
  JOURNAL   Seizure 15 (5), 288-291 (2006)
   PUBMED   16546408
  REMARK    GeneRIF: IL-1alpha and IL-1beta gene polymorphisms do not act as a
            strong susceptibility factor for MTLE-HS in individuals of Turkish
            ancestry
REFERENCE   7  (bases 1 to 2565)
  AUTHORS   Debets,R., Timans,J.C., Homey,B., Zurawski,S., Sana,T.R., Lo,S.,
            Wagner,J., Edwards,G., Clifford,T., Menon,S., Bazan,J.F. and
            Kastelein,R.A.
  TITLE     Two novel IL-1 family members, IL-1 delta and IL-1 epsilon,
            function as an antagonist and agonist of NF-kappa B activation
            through the orphan IL-1 receptor-related protein 2
  JOURNAL   J Immunol 167 (3), 1440-1446 (2001)
   PUBMED   11466363
REFERENCE   8  (bases 1 to 2565)
  AUTHORS   Dale,M. and Nicklin,M.J.
  TITLE     Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1,
            IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human
            chromosome 2q
  JOURNAL   Genomics 57 (1), 177-179 (1999)
   PUBMED   10191101
REFERENCE   9  (bases 1 to 2565)
  AUTHORS   Torigoe,K., Ushio,S., Okura,T., Kobayashi,S., Taniai,M.,
            Kunikata,T., Murakami,T., Sanou,O., Kojima,H., Fujii,M., Ohta,T.,
            Ikeda,M., Ikegami,H. and Kurimoto,M.
  TITLE     Purification and characterization of the human interleukin-18
            receptor
  JOURNAL   J Biol Chem 272 (41), 25737-25742 (1997)
   PUBMED   9325300
REFERENCE   10 (bases 1 to 2565)
  AUTHORS   Lovenberg,T.W., Crowe,P.D., Liu,C., Chalmers,D.T., Liu,X.J.,
            Liaw,C., Clevenger,W., Oltersdorf,T., De Souza,E.B. and Maki,R.A.
  TITLE     Cloning of a cDNA encoding a novel interleukin-1 receptor related
            protein (IL 1R-rp2)
  JOURNAL   J Neuroimmunol 70 (2), 113-122 (1996)
   PUBMED   8898719
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF284434.1, BC107064.2 and
            CA448166.1.
            
            On Nov 24, 2018 this sequence version replaced NM_003854.3.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 receptor family. An experiment with transient gene
            expression demonstrated that this receptor was incapable of binding
            to interleukin 1 alpha and interleukin 1 beta with high affinity.
            This gene and four other interleukin 1 receptor family genes,
            including interleukin 1 receptor, type I (IL1R1), interleukin 1
            receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1),
            and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor
            gene cluster in a region mapped to chromosome 2q12. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), as well as variant 2, encodes
            the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF284434.1, U49065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264257.7/ ENSP00000264257.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1531              AF284434.1         59-1589
            1532-1743           BC107064.2         1111-1322
            1744-1914           AF284434.1         1802-1972
            1915-2565           CA448166.1         14-664              c
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..2565
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /note="interleukin 1 receptor like 2"
                     /db_xref="GeneID:8808"
                     /db_xref="HGNC:HGNC:5999"
                     /db_xref="MIM:604512"
     exon            1..64
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            65..134
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1804
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /EC_number="3.2.2.6"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; interleukin-1 receptor-related protein 2; IL-1
                     receptor-related protein 2; IL-36 receptor"
                     /codon_start=1
                     /product="interleukin-1 receptor-like 2 isoform a
                     precursor"
                     /protein_id="NP_003845.2"
                     /db_xref="CCDS:CCDS2056.1"
                     /db_xref="GeneID:8808"
                     /db_xref="HGNC:HGNC:5999"
                     /db_xref="MIM:604512"
                     /translation="MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTF
                     PPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDS
                     CHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIK
                     WYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITE
                     RAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDE
                     SKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDF
                     RAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKP
                     HKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIV
                     IVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKH
                     GAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCYRTAGPELGSR
                     RKKCTLTTG"
     exon            135..369
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..565
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..725
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..800
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..930
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1067
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1211
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1373
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1754
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2565
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2519
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /note="major polyA site"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /note="hexamer: AATAAA"
     polyA_site      2565
                     /gene="IL1RL2"
                     /gene_synonym="IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2"
                     /note="major polyA site"
ORIGIN      
        1 gctcgtgtcc ctgtcatatt ttccactctc cacgaggtcc tgcgcgcttc aatcctgcag
       61 gcagcccggt ttggggatgt ggtccttgct gctctgcggg ttgtccatcg cccttccact
      121 gtctgtcaca gcagatggat gcaaggacat ttttatgaaa aatgagatac tttcagcaag
      181 ccagcctttt gcttttaatt gtacattccc tcccataaca tctggggaag tcagtgtaac
      241 atggtataaa aattctagca aaatcccagt gtccaaaatc atacagtcta gaattcacca
      301 ggacgagact tggattttgt ttctccccat ggaatggggg gactcaggag tctaccaatg
      361 tgttataaag ggtagagaca gctgtcatag aatacatgta aacctaactg tttttgaaaa
      421 acattggtgt gacacttcca taggtggttt accaaattta tcagatgagt acaagcaaat
      481 attacatctt ggaaaagatg atagtctcac atgtcatctg cacttcccga agagttgtgt
      541 tttgggtcca ataaagtggt ataaggactg taacgagatt aaaggggagc ggttcactgt
      601 tttggaaacc aggcttttgg tgagcaatgt ctcggcagag gacagaggga actacgcgtg
      661 tcaagccata ctgacacact cagggaagca gtacgaggtt ttaaatggca tcactgtgag
      721 cattacagaa agagctggat atggaggaag tgtccctaaa atcatttatc caaaaaatca
      781 ttcaattgaa gtacagcttg gtaccactct gattgtggac tgcaatgtaa cagacaccaa
      841 ggataataca aatctacgat gctggagagt caataacact ttggtggatg attactatga
      901 tgaatccaaa cgaatcagag aaggggtgga aacccatgtc tcttttcggg aacataattt
      961 gtacacagta aacatcacct tcttggaagt gaaaatggaa gattatggcc ttcctttcat
     1021 gtgccacgct ggagtgtcca cagcatacat tatattacag ctcccagctc cggattttcg
     1081 agcttacttg ataggagggc ttatcgcctt ggtggctgtg gctgtgtctg ttgtgtacat
     1141 atacaacatt tttaagatcg acattgttct ttggtatcga agtgccttcc attctacaga
     1201 gaccatagta gatgggaagc tgtatgacgc ctatgtctta taccccaagc cccacaagga
     1261 aagccagagg catgccgtgg atgccctggt gttgaatatc ctgcccgagg tgttggagag
     1321 acaatgtgga tataagttgt ttatattcgg cagagatgaa ttccctggac aagccgtggc
     1381 caatgtcatc gatgaaaacg ttaagctgtg caggaggctg attgtcattg tggtccccga
     1441 atcgctgggc tttggcctgt tgaagaacct gtcagaagaa caaatcgcgg tctacagtgc
     1501 cctgatccag gacgggatga aggttattct cattgagctg gagaaaatcg aggactacac
     1561 agtcatgcca gagtcaattc agtacatcaa acagaagcat ggtgccatcc ggtggcatgg
     1621 ggacttcacg gagcagtcac agtgtatgaa gaccaagttt tggaagacag tgagatacca
     1681 catgccgccc agaaggtgtc ggccgtttcc tccggtccag ctgctgcagc acacaccttg
     1741 ctaccgcacc gcaggcccag aactaggctc aagaagaaag aagtgtactc tcacgactgg
     1801 ctaagacttg ctggactgac acctatggct ggaagatgac ttgttttgct ccatgtctcc
     1861 tcattcctac acctattttc tgctgcagga tgaggctagg gttagcattc tagacaccca
     1921 gttgagctca ggcgtagaga agaggaggat gggataagaa ctggggccat ccccatgtca
     1981 tggtgggtga gagctggggc catccccgtg gtcatggagg gtgagagctg ggggttatcc
     2041 ccatggtcat ggagggtgag ggctggtcgg gggaggcatc cccaagtcat ggtgggtgag
     2101 agctcggagc atccccatgt catggtgggt gagatctggg ggtatccctg tgtcatggtg
     2161 ggtgagggcg ggtggtcatc cacatggtca tagtgggtga gagctggggg tatccctaca
     2221 tcatggtggg tgagagctgg gagcatcccc atgtcatggt gggcgagatc tggggggtat
     2281 ccccacgtca tggtggatga gagctggggg aatcaccatg tcatggtggg tgagatcttg
     2341 ggggatcacc tgtcatggtg ggtgagagct ggggggatca cctgtcatgg tgggtgagag
     2401 ttgggattca tccccatgtc atggtgggct gagcccacat ggaagcctgt gcttggacag
     2461 cgtatgccct tttctctgtt tttccacaat gaacaattaa actgtaaatg ttaaaaatat
     2521 cagtaatttg tgaaataaat tttattctca tttgagcaac ataaa
//
