LOCUS       NM_016232               1997 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens interleukin 1 receptor like 1 (IL1RL1), transcript
            variant 1, mRNA.
ACCESSION   NM_016232
VERSION     NM_016232.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Terasjarvi,J.T., Toivonen,L., Mertsola,J., Peltola,V. and He,Q.
  TITLE     ST2 and IL-33 polymorphisms and the development of childhood
            asthma: a prospective birth cohort study in Finnish children
  JOURNAL   APMIS 132 (7), 515-525 (2024)
   PUBMED   38566447
  REMARK    GeneRIF: ST2 and IL-33 polymorphisms and the development of
            childhood asthma: a prospective birth cohort study in Finnish
            children.
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Ruan,J., Tian,Q., Li,S., Zhou,X., Sun,Q., Wang,Y., Xiao,Y., Li,M.,
            Chang,K. and Yi,X.
  TITLE     The IL-33-ST2 axis plays a vital role in endometriosis via
            promoting epithelial-mesenchymal transition by phosphorylating
            beta-catenin
  JOURNAL   Cell Commun Signal 22 (1), 318 (2024)
   PUBMED   38858740
  REMARK    GeneRIF: The IL-33-ST2 axis plays a vital role in endometriosis via
            promoting epithelial-mesenchymal transition by phosphorylating
            beta-catenin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1997)
  AUTHORS   Brunner,T.M., Serve,S., Marx,A.F., Fadejeva,J., Saikali,P.,
            Dzamukova,M., Duran-Hernandez,N., Kommer,C., Heinrich,F., Durek,P.,
            Heinz,G.A., Hofer,T., Mashreghi,M.F., Kuhn,R., Pinschewer,D.D. and
            Lohning,M.
  TITLE     A type 1 immunity-restricted promoter of the IL-33 receptor gene
            directs antiviral T-cell responses
  JOURNAL   Nat Immunol 25 (2), 256-267 (2024)
   PUBMED   38172258
  REMARK    GeneRIF: A type 1 immunity-restricted promoter of the IL-33
            receptor gene directs antiviral T-cell responses.
REFERENCE   4  (bases 1 to 1997)
  AUTHORS   Strickson,S., Houslay,K.F., Negri,V.A., Ohne,Y., Ottosson,T.,
            Dodd,R.B., Huntington,C.C., Baker,T., Li,J., Stephenson,K.E.,
            O'Connor,A.J., Sagawe,J.S., Killick,H., Moore,T., Rees,D.G.,
            Koch,S., Sanden,C., Wang,Y., Gubbins,E., Ghaedi,M., Kolbeck,R.,
            Saumyaa,S., Erjefalt,J.S., Sims,G.P., Humbles,A.A., Scott,I.C.,
            Romero Ros,X. and Cohen,E.S.
  TITLE     Oxidised IL-33 drives COPD epithelial pathogenesis via
            ST2-independent RAGE/EGFR signalling complex
  JOURNAL   Eur Respir J 62 (3), 2202210 (2023)
   PUBMED   37442582
  REMARK    GeneRIF: Oxidised IL-33 drives COPD epithelial pathogenesis via
            ST2-independent RAGE/EGFR signalling complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1997)
  AUTHORS   Naef,P., Radpour,R., Jaeger-Ruckstuhl,C.A., Bodmer,N.,
            Baerlocher,G.M., Doehner,H., Doehner,K., Riether,C. and
            Ochsenbein,A.F.
  TITLE     IL-33-ST2 signaling promotes stemness in subtypes of myeloid
            leukemia cells through the Wnt and Notch pathways
  JOURNAL   Sci Signal 16 (800), eadd7705 (2023)
   PUBMED   37643244
  REMARK    GeneRIF: IL-33-ST2 signaling promotes stemness in subtypes of
            myeloid leukemia cells through the Wnt and Notch pathways.
REFERENCE   6  (bases 1 to 1997)
  AUTHORS   Lohning,M., Stroehmann,A., Coyle,A.J., Grogan,J.L., Lin,S.,
            Gutierrez-Ramos,J.C., Levinson,D., Radbruch,A. and Kamradt,T.
  TITLE     T1/ST2 is preferentially expressed on murine Th2 cells, independent
            of interleukin 4, interleukin 5, and interleukin 10, and important
            for Th2 effector function
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6930-6935 (1998)
   PUBMED   9618516
REFERENCE   7  (bases 1 to 1997)
  AUTHORS   Kumar,S., Tzimas,M.N., Griswold,D.E. and Young,P.R.
  TITLE     Expression of ST2, an interleukin-1 receptor homologue, is induced
            by proinflammatory stimuli
  JOURNAL   Biochem Biophys Res Commun 235 (3), 474-478 (1997)
   PUBMED   9207179
REFERENCE   8  (bases 1 to 1997)
  AUTHORS   Yanagisawa,K., Naito,Y., Kuroiwa,K., Arai,T., Furukawa,Y.,
            Tomizuka,H., Miura,Y., Kasahara,T., Tetsuka,T. and Tominaga,S.
  TITLE     The expression of ST2 gene in helper T cells and the binding of ST2
            protein to myeloma-derived RPMI8226 cells
  JOURNAL   J Biochem 121 (1), 95-103 (1997)
   PUBMED   9058198
REFERENCE   9  (bases 1 to 1997)
  AUTHORS   Gayle,M.A., Slack,J.L., Bonnert,T.P., Renshaw,B.R., Sonoda,G.,
            Taguchi,T., Testa,J.R., Dower,S.K. and Sims,J.E.
  TITLE     Cloning of a putative ligand for the T1/ST2 receptor
  JOURNAL   J Biol Chem 271 (10), 5784-5789 (1996)
   PUBMED   8621446
REFERENCE   10 (bases 1 to 1997)
  AUTHORS   Tominaga,S., Yokota,T., Yanagisawa,K., Tsukamoto,T., Takagi,T. and
            Tetsuka,T.
  TITLE     Nucleotide sequence of a complementary DNA for human ST2
  JOURNAL   Biochim Biophys Acta 1171 (2), 215-218 (1992)
   PUBMED   1482686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB012701.3, AK291578.1,
            DB063031.1 and AC007248.4.
            
            On May 17, 2019 this sequence version replaced NM_016232.4.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 receptor family. Studies of the similar gene in mouse
            suggested that this receptor can be induced by proinflammatory
            stimuli, and may be involved in the function of helper T cells.
            This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1
            receptor, type II (IL1R2) and interleukin 1 receptor-like 2
            (IL1RL2) form a cytokine receptor gene cluster in a region mapped
            to chromosome 2q12. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB012701.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233954.6/ ENSP00000233954.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               AB012701.3         62-503
            443-1180            AK291578.1         462-1199
            1181-1506           AB012701.3         1242-1567
            1507-1907           DB063031.1         136-536
            1908-1971           AB012701.3         1969-2032
            1972-1997           AC007248.4         124772-124797
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..1997
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="interleukin 1 receptor like 1"
                     /db_xref="GeneID:9173"
                     /db_xref="HGNC:HGNC:5998"
                     /db_xref="MIM:601203"
     exon            1..61
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..271
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1881
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /EC_number="3.2.2.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; homolog of mouse growth stimulation-expressed;
                     interleukin 1 receptor-related protein"
                     /codon_start=1
                     /product="interleukin-1 receptor-like 1 isoform 1
                     precursor"
                     /protein_id="NP_057316.3"
                     /db_xref="CCDS:CCDS2057.1"
                     /db_xref="GeneID:9173"
                     /db_xref="HGNC:HGNC:5998"
                     /db_xref="MIM:601203"
                     /translation="MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSY
                     TVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANV
                     TIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYR
                     AHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPA
                     QNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSF
                     SNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIA
                     VCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTD
                     GASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTP
                     QITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQG
                     TIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ"
     exon            272..482
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..657
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..820
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..892
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1034
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1180
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1327
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1495
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1997
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttgtgaa actgtgggca gaaagttgag gaagaaagaa ctcaagtaca acccaatgag
       61 gttgagatat aggctactct tcccaactca gtcttgaaga gtatcaccaa ctgcctcatg
      121 tgtggtgacc ttcactgtcg tatgccagtg actcatctgg agtaatctca acaacgagtt
      181 accaatactt gctcttgatt gataaacaga atggggtttt ggatcttagc aattctcaca
      241 attctcatgt attccacagc agcaaagttt agtaaacaat catggggcct ggaaaatgag
      301 gctttaattg taagatgtcc tagacaagga aaacctagtt acaccgtgga ttggtattac
      361 tcacaaacaa acaaaagtat tcccactcag gaaagaaatc gtgtgtttgc ctcaggccaa
      421 cttctgaagt ttctaccagc tgcagttgct gattctggta tttatacctg tattgtcaga
      481 agtcccacat tcaataggac tggatatgcg aatgtcacca tatataaaaa acaatcagat
      541 tgcaatgttc cagattattt gatgtattca acagtatctg gatcagaaaa aaattccaaa
      601 atttattgtc ctaccattga cctctacaac tggacagcac ctcttgagtg gtttaagaat
      661 tgtcaggctc ttcaaggatc aaggtacagg gcgcacaagt catttttggt cattgataat
      721 gtgatgactg aggacgcagg tgattacacc tgtaaattta tacacaatga aaatggagcc
      781 aattatagtg tgacggcgac caggtccttc acggtcaagg atgagcaagg cttttctctg
      841 tttccagtaa tcggagcccc tgcacaaaat gaaataaagg aagtggaaat tggaaaaaac
      901 gcaaacctaa cttgctctgc ttgttttgga aaaggcactc agttcttggc tgccgtcctg
      961 tggcagctta atggaacaaa aattacagac tttggtgaac caagaattca acaagaggaa
     1021 gggcaaaatc aaagtttcag caatgggctg gcttgtctag acatggtttt aagaatagct
     1081 gacgtgaagg aagaggattt attgctgcag tacgactgtc tggccctgaa tttgcatggc
     1141 ttgagaaggc acaccgtaag actaagtagg aaaaatccaa ttgatcatca tagcatctac
     1201 tgcataattg cagtatgtag tgtattttta atgctaatca atgtcctggt tatcatccta
     1261 aaaatgttct ggattgaggc cactctgctc tggagagaca tagctaaacc ttacaagact
     1321 aggaatgatg gaaagctcta tgatgcttat gttgtctacc cacggaacta caaatccagt
     1381 acagatgggg ccagtcgtgt agagcacttt gttcaccaga ttctgcctga tgttcttgaa
     1441 aataaatgtg gctatacctt atgcatttat gggagagata tgctacctgg agaagatgta
     1501 gtcactgcag tggaaaccaa catacgaaag agcaggcggc acattttcat cctgacccct
     1561 cagatcactc acaataagga gtttgcctac gagcaggagg ttgccctgca ctgtgccctc
     1621 atccagaacg acgccaaggt gatacttatt gagatggagg ctctgagcga gctggacatg
     1681 ctgcaggctg aggcgcttca ggactccctc cagcatctta tgaaagtaca ggggaccatc
     1741 aagtggaggg aggaccacat tgccaataaa aggtccctga attctaaatt ctggaagcac
     1801 gtgaggtacc aaatgcctgt gccaagcaaa attcccagaa aggcctctag tttgactccc
     1861 ttggctgccc agaagcaata gtgcctgctg tgatgtgcaa aggcatctga gtttgaagct
     1921 ttcctgactt ctcctagctg gcttatgccc ctgcactgaa gtgtgaggag caggaatatt
     1981 aaagggattc aggcctc
//
