LOCUS       NM_002182               4745 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens interleukin 1 receptor accessory protein (IL1RAP),
            transcript variant 1, mRNA.
ACCESSION   NM_002182
VERSION     NM_002182.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Mulholland,M., Depuydt,M.A.C., Jakobsson,G., Ljungcrantz,I.,
            Grentzmann,A., To,F., Bengtsson,E., Jaensson Gyllenback,E.,
            Gronberg,C., Rattik,S., Liberg,D., Schiopu,A., Bjorkbacka,H.,
            Kuiper,J., Bot,I., Slutter,B. and Engelbertsen,D.
  TITLE     Interleukin-1 receptor accessory protein blockade limits the
            development of atherosclerosis and reduces plaque inflammation
  JOURNAL   Cardiovasc Res 120 (6), 581-595 (2024)
   PUBMED   38563353
  REMARK    GeneRIF: Interleukin-1 receptor accessory protein blockade limits
            the development of atherosclerosis and reduces plaque inflammation.
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Zarezadeh Mehrabadi,A., Shahba,F., Khorramdelazad,H.,
            Aghamohammadi,N., Karimi,M., Bagherzadeh,K., Khoshmirsafa,M.,
            Massoumi,R. and Falak,R.
  TITLE     Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet
            candidate for immunotherapy of human malignancies
  JOURNAL   Crit Rev Oncol Hematol 193, 104200 (2024)
   PUBMED   37981104
  REMARK    GeneRIF: Interleukin-1 receptor accessory protein (IL-1RAP): A
            magic bullet candidate for immunotherapy of human malignancies.
            Review article
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Cao,K., Liu,Z., Liu,J., Hu,Q., Shan,W., Hu,B., Shi,H. and Zhang,B.
  TITLE     Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1
            receptor accessory protein in human liver cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (18), 16247-16260 (2023)
   PUBMED   37700160
  REMARK    GeneRIF: Constitutive photomorphogenic protein 1 ubiquitinates
            interleukin-1 receptor accessory protein in human liver cancer.
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Yu,F., Xing,J., Li,L. and Xiang,M.
  TITLE     CircCRIM1 mediates proliferation, migration, and invasion of
            trophoblast cell through regulating miR-942-5p/IL1RAP axis
  JOURNAL   Am J Reprod Immunol 90 (1), e13699 (2023)
   PUBMED   37382169
  REMARK    GeneRIF: CircCRIM1 mediates proliferation, migration, and invasion
            of trophoblast cell through regulating miR-942-5p/IL1RAP axis.
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Agerstam,H., Lilljebjorn,H., Rissler,M., Sanden,C. and Fioretos,T.
  TITLE     IL1RAP is expressed in several subtypes of pediatric acute
            lymphoblastic leukemia and can be used as a target to eliminate
            ETV6::RUNX1-positive leukemia cells in preclinical models
  JOURNAL   Haematologica 108 (2), 599-604 (2023)
   PUBMED   36226493
  REMARK    GeneRIF: IL1RAP is expressed in several subtypes of pediatric acute
            lymphoblastic leukemia and can be used as a target to eliminate
            ETV6::RUNX1-positive leukemia cells in preclinical models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Huang,J., Gao,X., Li,S. and Cao,Z.
  TITLE     Recruitment of IRAK to the interleukin 1 receptor complex requires
            interleukin 1 receptor accessory protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12829-12832 (1997)
   PUBMED   9371760
REFERENCE   7  (bases 1 to 4745)
  AUTHORS   Wesche,H., Korherr,C., Kracht,M., Falk,W., Resch,K. and Martin,M.U.
  TITLE     The interleukin-1 receptor accessory protein (IL-1RAcP) is
            essential for IL-1-induced activation of interleukin-1
            receptor-associated kinase (IRAK) and stress-activated protein
            kinases (SAP kinases)
  JOURNAL   J Biol Chem 272 (12), 7727-7731 (1997)
   PUBMED   9065432
REFERENCE   8  (bases 1 to 4745)
  AUTHORS   Cao,Z., Xiong,J., Takeuchi,M., Kurama,T. and Goeddel,D.V.
  TITLE     TRAF6 is a signal transducer for interleukin-1
  JOURNAL   Nature 383 (6599), 443-446 (1996)
   PUBMED   8837778
REFERENCE   9  (bases 1 to 4745)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
REFERENCE   10 (bases 1 to 4745)
  AUTHORS   Greenfeder,S.A., Nunes,P., Kwee,L., Labow,M., Chizzonite,R.A. and
            Ju,G.
  TITLE     Molecular cloning and characterization of a second subunit of the
            interleukin 1 receptor complex
  JOURNAL   J Biol Chem 270 (23), 13757-13765 (1995)
   PUBMED   7775431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA024801.1, AB006537.1,
            BM194193.1 and BM973472.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002182.3.
            
            Summary: This gene encodes a component of the interleukin 1
            receptor complex, which initiates signalling events that result in
            the activation of interleukin 1-responsive genes. Alternative
            splicing of this gene results in membrane-bound and soluble
            isoforms differing in their C-terminus. The ratio of soluble to
            membrane-bound forms increases during acute-phase induction or
            stress. [provided by RefSeq, Jul 2018].
            
            Transcript Variant: This variant (1) encodes the membrane-bound
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006537.1, SRR1660803.224601.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447382.6/ ENSP00000390541.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA024801.1         36-52
            18-2344             AB006537.1         1-2327
            2345-2364           BM194193.1         122-141
            2365-4743           AB006537.1         2346-4724
            4744-4745           BM973472.1         23-24               c
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..4745
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /note="interleukin 1 receptor accessory protein"
                     /db_xref="GeneID:3556"
                     /db_xref="HGNC:HGNC:5995"
                     /db_xref="MIM:602626"
     exon            1..135
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            136..222
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            223..287
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1936
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /EC_number="3.2.2.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-1 receptor accessory protein beta;
                     interleukin-1 receptor 3; IL-1 receptor accessory protein"
                     /codon_start=1
                     /product="interleukin-1 receptor accessory protein isoform
                     1 precursor"
                     /protein_id="NP_002173.1"
                     /db_xref="CCDS:CCDS3298.1"
                     /db_xref="GeneID:3556"
                     /db_xref="HGNC:HGNC:5995"
                     /db_xref="MIM:602626"
                     /translation="MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPAR
                     IKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFR
                     PTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITC
                     PNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPE
                     NGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDS
                     RNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHA
                     RSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAH
                     FGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIV
                     TDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE
                     TKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSS
                     LKNV"
     exon            288..573
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..760
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..926
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            927..998
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1125
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1274
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1424
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1568
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..4745
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4719..4724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /note="hexamer: AATAAA"
     polyA_site      4745
                     /gene="IL1RAP"
                     /gene_synonym="C3orf13; IL-1RAcP; IL1R3"
                     /note="major polyA site"
ORIGIN      
        1 ggctcactgg ggaagactgc cgggatccag gtctccgggg tccgctttgg ccagaggcgc
       61 ggaaggaagc agtgcccggc gacactgcac ccatcccggc tgcttttgct gcgccctctc
      121 agcttcccaa gaaaggcatc gtcatgtgat catcacctaa gaactagaac atcagcaggc
      181 cctagaagcc tcactcttgc ccctcccttt aatatctcaa aggatgacac ttctgtggtg
      241 tgtagtgagt ctctactttt atggaatcct gcaaagtgat gcctcagaac gctgcgatga
      301 ctggggacta gacaccatga ggcaaatcca agtgtttgaa gatgagccag ctcgcatcaa
      361 gtgcccactc tttgaacact tcttgaaatt caactacagc acagcccatt cagctggcct
      421 tactctgatc tggtattgga ctaggcagga ccgggacctt gaggagccaa ttaacttccg
      481 cctccccgag aaccgcatta gtaaggagaa agatgtgctg tggttccggc ccactctcct
      541 caatgacact ggcaactata cctgcatgtt aaggaacact acatattgca gcaaagttgc
      601 atttcccttg gaagttgttc aaaaagacag ctgtttcaat tcccccatga aactcccagt
      661 gcataaactg tatatagaat atggcattca gaggatcact tgtccaaatg tagatggata
      721 ttttccttcc agtgtcaaac cgactatcac ttggtatatg ggctgttata aaatacagaa
      781 ttttaataat gtaatacccg aaggtatgaa cttgagtttc ctcattgcct taatttcaaa
      841 taatggaaat tacacatgtg ttgttacata tccagaaaat ggacgtacgt ttcatctcac
      901 caggactctg actgtaaagg tagtaggctc tccaaaaaat gcagtgcccc ctgtgatcca
      961 ttcacctaat gatcatgtgg tctatgagaa agaaccagga gaggagctac tcattccctg
     1021 tacggtctat tttagttttc tgatggattc tcgcaatgag gtttggtgga ccattgatgg
     1081 aaaaaaacct gatgacatca ctattgatgt caccattaac gaaagtataa gtcatagtag
     1141 aacagaagat gaaacaagaa ctcagatttt gagcatcaag aaagttacct ctgaggatct
     1201 caagcgcagc tatgtctgtc atgctagaag tgccaaaggc gaagttgcca aagcagccaa
     1261 ggtgaagcag aaagtgccag ctccaagata cacagtggaa ctggcttgtg gttttggagc
     1321 cacagtcctg ctagtggtga ttctcattgt tgtttaccat gtttactggc tagagatggt
     1381 cctattttac cgggctcatt ttggaacaga tgaaaccatt ttagatggaa aagagtatga
     1441 tatttatgta tcctatgcaa ggaatgcgga agaagaagaa tttgtattac tgaccctccg
     1501 tggagttttg gagaatgaat ttggatacaa gctgtgcatc tttgaccgag acagtctgcc
     1561 tgggggaatt gtcacagatg agactttgag cttcattcag aaaagcagac gcctcctggt
     1621 tgttctaagc cccaactacg tgctccaggg aacccaagcc ctcctggagc tcaaggctgg
     1681 cctagaaaat atggcctctc ggggcaacat caacgtcatt ttagtacagt acaaagctgt
     1741 gaaggaaacg aaggtgaaag agctgaagag ggctaagacg gtgctcacgg tcattaaatg
     1801 gaaaggggaa aaatccaagt atccacaggg caggttctgg aagcagctgc aggtggccat
     1861 gccagtgaag aaaagtccca ggcggtctag cagtgatgag cagggcctct cgtattcatc
     1921 tttgaaaaat gtatgaaagg aataatgaaa agggtaaaaa gaacaagggg tgctccagga
     1981 agaaagagtc cccccagtct tcattcgcag tttatggttt cataggcaaa aataatggtc
     2041 taagcctccc aatagggata aatttagggt gactgtgtgg ctgactattc tgcttcctca
     2101 ggcaacacta aagtttagaa agatatcatc aacgttctgt caccagtctc tgatgccact
     2161 atgttctttg caggcaaaga cttgttcaat gcgaatttcc ccttctacat tgtctatccc
     2221 tgtttttata tgtctccatt ctttttaaaa tcttaacata tggagcagcc tttcctatga
     2281 atttaaatat gcctttaaaa taagtcactg ttgacagggt catgagtttc cgagtatagt
     2341 tttcttttta tcttattttt actcgtccgt tgaaaagata atcaaggcct acattttagc
     2401 tgaggataat gaactttttt cctcattcgg ctgtataata cataaccaca gcaagactga
     2461 catccactta ggatgataca aagcagtgta actgaaaatg tttcttttaa ttgatttaaa
     2521 ggacttgtct tctataccac ccttgtcctc atctcaggta atttatgaaa tctatgtaaa
     2581 cttgaaaaat atttcttaat ttttgttttt gctccagtca attcctgatt atccacaggt
     2641 caacccacat tttttcattc cttctcccta tctgcttata tcgcattgct catttagagt
     2701 ttgcaggagg ctccatacta ggttcagtct gaaagaaatc tcctaatggt gctatagaga
     2761 gggaggtaac agaaagactc ttttagggca tttttctgac tcatgaaaag agcacagaaa
     2821 aggatgtttg gcaatttgtc ttttaagtct taaccttgct aatgtgaata ctgggaaagt
     2881 gattttttct cactcgtttt tgttgctcca ttgtaaaggg cggaggtcag tcttagtggc
     2941 cttgagagtt gcttttggca ttaatattct aagagaatta actgtatttc ctgtcaccta
     3001 ttcactagtg caggaaatat acttgctcca aataagtcag tatgagaagt cactgtcaat
     3061 gaaagttgtt ttgtttgttt tcagtaatat tttgctgttt ttaagacttg gaaaactaag
     3121 tgcagagttt acagagtggt aaatatctat gttacatgta gattatacat atatatacac
     3181 acgtgtatat gagatatata tcttatatct ccacaaacac aaattatata tatacatatc
     3241 cacacacata cattacatat atctgtgtat ataaatccac atgcacatga aatatatata
     3301 tatatataat ttgtgtgtgt gtatgtgtat gtatatgact ttaaatagct atgggtacaa
     3361 tattaaaaac cactggaact cttgtccagt ttttaaatta tgtttttact ggaatgtttt
     3421 tgtgtcagtg ttttctgtac atattatttg ttaattcaca gctcacagag tgatagttgt
     3481 catagttctt gccttcccta agtttatata aataacttaa gtattgctac agtttatcta
     3541 ggttgcagtg gcatctgctg tgcacagagc ttccatggtc actgctaagc agtagccagc
     3601 catcgggcat taattgattt cctactatat tcccagcaga cacatttaga aactaagcta
     3661 tgttaacctc agtgctcaac tatttgaact gttgagtgat aaaggaaaca aatataactg
     3721 taaatgaatc ttggtatcct gtgaaacaga ataattcgta atttaagaaa gcccttatcc
     3781 cggtaacatg aatgttgatg aacaaatgta aaattatatc ctatatttaa gtacccataa
     3841 taaatcattt ccctctataa gtgttattga ttattttaaa ttgaaaaaag tttcacttgg
     3901 atgaaaaaag tagaaaagta ggtcattctt ggatctactt ttttttagcc ttattaatat
     3961 ttttccctat tagaaaccac aattactccc tctattaacc cttcacttac tagaccagaa
     4021 aagaacttat tccagataag ctttgaatat caattcttac ataaacttta ggcaaacagg
     4081 gaatagtcta gtcaccaaag gaccattctc ttgccaatgc tgcattcctt ttgcactttt
     4141 ggattccata tttatcccaa atgctgttgg gcacccctag aaataccttg atgttttttc
     4201 tatttatatg cctgcctttg gtacttaatt ttacaaatgc tgtaatataa agcatatcaa
     4261 gtttatgtga tacgtatcat tgcaagagaa tttgtttcaa gatttttttt taatgttcca
     4321 gaagatggcc aatagagaac attcaaggga aatggggaaa cataatttag agaacaagaa
     4381 caaaccatgt ctcaaatttt tttaaaaaaa attaatggtt ttaaatatat gctataggga
     4441 cgttccatgc ccaggttaac aaagaactgt gatatataga gtgtctaatt acaaaatcat
     4501 atacgattta tttaattctc ttctgtattg taacttagat gattcccaag gactctaata
     4561 aaaaatcact tcattgtatt tggaaacaaa aacatcattc attaattact tattttcttt
     4621 ccataggttt taatattttg agagtgtctt ttttatttca ttcatgaact tttgtatttt
     4681 tcatttttca tttgatttgt aaatttactt atgttaaaaa taaaccattt attttcagct
     4741 ttgaa
//
