LOCUS       NM_004633               1462 bp    mRNA    linear   PRI 26-FEB-2024
DEFINITION  Homo sapiens interleukin 1 receptor type 2 (IL1R2), transcript
            variant 1, mRNA.
ACCESSION   NM_004633
VERSION     NM_004633.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Zhou,N., Liu,L. and Li,Q.
  TITLE     IL1R2 promotes retinal angiogenesis to participate in retinopathy
            of prematurity by activating the HIF1alpha/PFKFB3 pathway
  JOURNAL   Exp Eye Res 239, 109750 (2024)
   PUBMED   38097102
  REMARK    GeneRIF: IL1R2 promotes retinal angiogenesis to participate in
            retinopathy of prematurity by activating the HIF1alpha/PFKFB3
            pathway.
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Zhao,M., Liu,A., Wu,J., Mo,L., Lu,F. and Wan,G.
  TITLE     Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of
            ischemic stroke via bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 103 (4), e36109 (2024)
   PUBMED   38277520
  REMARK    GeneRIF: Il1r2 and Tnfrsf12a in transcranial magnetic stimulation
            effect of ischemic stroke via bioinformatics analysis.
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Fattahi,A., Zarezadeh,R., Rastgar Rezaei,Y., Mettler,L., Nouri,M.,
            Schmutzler,A.G. and Salmassi,A.
  TITLE     Expression of interleukin-1beta and its receptor in human granulosa
            cells and their association with steroidogenesis
  JOURNAL   Tissue Cell 85, 102230 (2023)
   PUBMED   37820554
  REMARK    GeneRIF: Expression of interleukin-1beta and its receptor in human
            granulosa cells and their association with steroidogenesis.
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Li,M., Song,J., Yin,P., Chen,H., Wang,Y., Xu,C., Jiang,F., Wang,H.,
            Han,B., Du,X., Wang,W., Li,G. and Zhong,D.
  TITLE     Single-cell analysis reveals novel clonally expanded monocytes
            associated with IL1beta-IL1R2 pair in acute inflammatory
            demyelinating polyneuropathy
  JOURNAL   Sci Rep 13 (1), 5862 (2023)
   PUBMED   37041166
  REMARK    GeneRIF: Single-cell analysis reveals novel clonally expanded
            monocytes associated with IL1beta-IL1R2 pair in acute inflammatory
            demyelinating polyneuropathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Lin,X., Tong,X., Zhang,Y., Gu,W., Huang,Q., Zhang,Y., Zhuo,F.,
            Zhao,F., Jin,X., Li,C., Huang,D., Zhang,S. and Dai,Y.
  TITLE     Decreased Expression of EZH2 in Granulosa Cells Contributes to
            Endometriosis-Associated Infertility by Targeting IL-1R2
  JOURNAL   Endocrinology 164 (2) (2022)
   PUBMED   36524678
  REMARK    GeneRIF: Decreased Expression of EZH2 in Granulosa Cells
            Contributes to Endometriosis-Associated Infertility by Targeting
            IL-1R2.
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Sadouk,M.B., Pelletier,J.P., Tardif,G., Kiansa,K., Cloutier,J.M.
            and Martel-Pelletier,J.
  TITLE     Human synovial fibroblasts coexpress IL-1 receptor type I and type
            II mRNA. The increased level of the IL-1 receptor in osteoarthritic
            cells is related to an increased level of the type I receptor
  JOURNAL   Lab Invest 73 (3), 347-355 (1995)
   PUBMED   7564267
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Fasano,M.B., Cousart,S., Neal,S. and McCall,C.E.
  TITLE     Increased expression of the interleukin 1 receptor on blood
            neutrophils of humans with the sepsis syndrome
  JOURNAL   J Clin Invest 88 (5), 1452-1459 (1991)
   PUBMED   1834697
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Dripps,D.J., Verderber,E., Ng,R.K., Thompson,R.C. and
            Eisenberg,S.P.
  TITLE     Interleukin-1 receptor antagonist binds to the type II
            interleukin-1 receptor on B cells and neutrophils
  JOURNAL   J Biol Chem 266 (30), 20311-20315 (1991)
   PUBMED   1834644
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   McMahan,C.J., Slack,J.L., Mosley,B., Cosman,D., Lupton,S.D.,
            Brunton,L.L., Grubin,C.E., Wignall,J.M., Jenkins,N.A., Brannan,C.I.
            et al.
  TITLE     A novel IL-1 receptor, cloned from B cells by mammalian expression,
            is expressed in many cell types
  JOURNAL   EMBO J 10 (10), 2821-2832 (1991)
   PUBMED   1833184
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Granowitz,E.V., Clark,B.D., Mancilla,J. and Dinarello,C.A.
  TITLE     Interleukin-1 receptor antagonist competitively inhibits the
            binding of interleukin-1 to the type II interleukin-1 receptor
  JOURNAL   J Biol Chem 266 (22), 14147-14150 (1991)
   PUBMED   1830582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC039031.1 and AC007165.4.
            
            On Nov 23, 2018 this sequence version replaced NM_004633.3.
            
            Summary: The protein encoded by this gene is a cytokine receptor
            that belongs to the interleukin 1 receptor family. This protein
            binds interleukin alpha (IL1A), interleukin beta (IL1B), and
            interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy
            receptor that inhibits the activity of its ligands. Interleukin 4
            (IL4) is reported to antagonize the activity of interleukin 1 by
            inducing the expression and release of this cytokine. This gene and
            three other genes form a cytokine receptor gene cluster on
            chromosome 2q12. Alternative splicing results in multiple
            transcript variants and protein isoforms. Alternative splicing
            produces both membrane-bound and soluble proteins. A soluble
            protein is also produced by proteolytic cleavage. [provided by
            RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130412.1, BC039031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332549.8/ ENSP00000330959.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1341              BC039031.1         117-1457
            1342-1462           AC007165.4         26553-26673
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1462
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="interleukin 1 receptor type 2"
                     /db_xref="GeneID:7850"
                     /db_xref="HGNC:HGNC:5994"
                     /db_xref="MIM:147811"
     exon            1..52
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            53..180
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1310
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; type II interleukin-1 receptor, beta; antigen
                     CDw121b; IL-1R-beta; interleukin-1 receptor beta;
                     interleukin-1 receptor type II; CD121 antigen-like family
                     member B; IL-1 type II receptor"
                     /codon_start=1
                     /product="interleukin-1 receptor type 2 isoform 1
                     precursor"
                     /protein_id="NP_004624.1"
                     /db_xref="CCDS:CCDS2054.1"
                     /db_xref="GeneID:7850"
                     /db_xref="HGNC:HGNC:5994"
                     /db_xref="MIM:147811"
                     /translation="MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGE
                     PVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQED
                     SGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR
                     DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQY
                     NITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTA
                     NDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSF
                     QTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQD
                     FQSYPK"
     exon            181..445
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            446..626
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            627..801
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            802..864
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1000
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1143
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1462
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="hexamer: AATAAA"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="hexamer: AATAAT"
     polyA_site      1335
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="major polyA site"
     polyA_site      1341
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="major polyA site"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
                     /note="hexamer: AGTAAA"
     polyA_site      1462
                     /gene="IL1R2"
                     /gene_synonym="CD121b; CDw121b; IL-1R-2; IL-1RT-2;
                     IL-1RT2; IL1R2c; IL1RB"
ORIGIN      
        1 gctggaggtg aaagtctggc ctggcagcct tccccaggtg agcagcaaca aggccacgtg
       61 ctgctgggtc tcagtcctcc acttcccgtg tcctctggaa gttgtcagga gcaatgttgc
      121 gcttgtacgt gttggtaatg ggagtttctg ccttcaccct tcagcctgcg gcacacacag
      181 gggctgccag aagctgccgg tttcgtggga ggcattacaa gcgggagttc aggctggaag
      241 gggagcctgt agccctgagg tgcccccagg tgccctactg gttgtgggcc tctgtcagcc
      301 cccgcatcaa cctgacatgg cataaaaatg actctgctag gacggtccca ggagaagaag
      361 agacacggat gtgggcccag gacggtgctc tgtggcttct gccagccttg caggaggact
      421 ctggcaccta cgtctgcact actagaaatg cttcttactg tgacaaaatg tccattgagc
      481 tcagagtttt tgagaataca gatgctttcc tgccgttcat ctcatacccg caaattttaa
      541 ccttgtcaac ctctggggta ttagtatgcc ctgacctgag tgaattcacc cgtgacaaaa
      601 ctgacgtgaa gattcaatgg tacaaggatt ctcttctttt ggataaagac aatgagaaat
      661 ttctaagtgt gagggggacc actcacttac tcgtacacga tgtggccctg gaagatgctg
      721 gctattaccg ctgtgtcctg acatttgccc atgaaggcca gcaatacaac atcactagga
      781 gtattgagct acgcatcaag aaaaaaaaag aagagaccat tcctgtgatc atttcccccc
      841 tcaagaccat atcagcttct ctggggtcaa gactgacaat cccgtgtaag gtgtttctgg
      901 gaaccggcac acccttaacc accatgctgt ggtggacggc caatgacacc cacatagaga
      961 gcgcctaccc gggaggccgc gtgaccgagg ggccacgcca ggaatattca gaaaataatg
     1021 agaactacat tgaagtgcca ttgatttttg atcctgtcac aagagaggat ttgcacatgg
     1081 attttaaatg tgttgtccat aataccctga gttttcagac actacgcacc acagtcaagg
     1141 aagcctcctc cacgttctcc tggggcattg tgctggcccc actttcactg gccttcttgg
     1201 ttttgggggg aatatggatg cacagacggt gcaaacacag aactggaaaa gcagatggtc
     1261 tgactgtgct atggcctcat catcaagact ttcaatccta tcccaagtga aataaatgga
     1321 atgaaataat tcaaacacaa actccgtacg tcttctctta tggaagtggc tgtgtctttt
     1381 tgagggactc tgttctttgc ctcagttgtc taccaaaggt gccacattta tagtggcttt
     1441 gtagtaaagg actaaagtct ta
//
