LOCUS       NM_000877               5183 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens interleukin 1 receptor type 1 (IL1R1), transcript
            variant 1, mRNA.
ACCESSION   NM_000877 XM_005263928
VERSION     NM_000877.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5183)
  AUTHORS   Goodman,E.J., Biltz,R.G., Packer,J.M., DiSabato,D.J., Swanson,S.P.,
            Oliver,B., Quan,N., Sheridan,J.F. and Godbout,J.P.
  TITLE     Enhanced fear memory after social defeat in mice is dependent on
            interleukin-1 receptor signaling in glutamatergic neurons
  JOURNAL   Mol Psychiatry 29 (8), 2321-2334 (2024)
   PUBMED   38459193
  REMARK    GeneRIF: Enhanced fear memory after social defeat in mice is
            dependent on interleukin-1 receptor signaling in glutamatergic
            neurons.
REFERENCE   2  (bases 1 to 5183)
  AUTHORS   Park,H.J., Shin,M.S., Shin,J.J., Kim,H., Kang,B., Par-Young,J.,
            Unlu,S., Afinogenova,Y., Catanzaro,J., Young,J., Kim,M., Lee,S.J.,
            Jeon,S., You,S., Racke,M.K., Bucala,R. and Kang,I.
  TITLE     IL-1 receptor 1 signaling shapes the development of viral
            antigen-specific CD4+ T cell responses following COVID-19 mRNA
            vaccination
  JOURNAL   EBioMedicine 103, 105114 (2024)
   PUBMED   38640835
  REMARK    GeneRIF: IL-1 receptor 1 signaling shapes the development of viral
            antigen-specific CD4[+] T cell responses following COVID-19 mRNA
            vaccination.
REFERENCE   3  (bases 1 to 5183)
  AUTHORS   Zhang,Y., Zhang,Z.T., Wan,S.Y., Yang,J., Wei,Y.J., Chen,H.J.,
            Zhou,W.Z., Song,Q.Y., Niu,S.X., Zheng,L. and Huang,K.
  TITLE     ANGPTL3 negatively regulates IL-1beta-induced NF-kappaB activation
            by inhibiting the IL1R1-associated signaling complex assembly
  JOURNAL   J Mol Cell Biol 15 (8) (2024)
   PUBMED   37634084
  REMARK    GeneRIF: ANGPTL3 negatively regulates IL-1beta-induced NF-kappaB
            activation by inhibiting the IL1R1-associated signaling complex
            assembly.
REFERENCE   4  (bases 1 to 5183)
  AUTHORS   Chen,Z., Giotti,B., Kaluzova,M., Vallcorba,M.P., Rawat,K.,
            Price,G., Herting,C.J., Pinero,G., Cristea,S., Ross,J.L.,
            Ackley,J., Maximov,V., Szulzewsky,F., Thomason,W.,
            Marquez-Ropero,M., Angione,A., Nichols,N., Tsankova,N.M.,
            Michor,F., Shayakhmetov,D.M., Gutmann,D.H., Tsankov,A.M. and
            Hambardzumyan,D.
  TITLE     A paracrine circuit of IL-1beta/IL-1R1 between myeloid and tumor
            cells drives genotype-dependent glioblastoma progression
  JOURNAL   J Clin Invest 133 (22), e163802 (2023)
   PUBMED   37733448
  REMARK    GeneRIF: A paracrine circuit of IL-1beta/IL-1R1 between myeloid and
            tumor cells drives genotype-dependent glioblastoma progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5183)
  AUTHORS   Budhiparama,N.C., Lumban-Gaol,I., Sudoyo,H., Magetsari,R. and
            Wibawa,T.
  TITLE     The role of genetic polymorphisms of interleukin-1 (IL-1R1 and
            IL-1RN) in primary knee osteoarthritis in Indonesia
  JOURNAL   Sci Rep 13 (1), 7967 (2023)
   PUBMED   37198429
  REMARK    GeneRIF: The role of genetic polymorphisms of interleukin-1 (IL-1R1
            and IL-1RN) in primary knee osteoarthritis in Indonesia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5183)
  AUTHORS   McMahan,C.J., Slack,J.L., Mosley,B., Cosman,D., Lupton,S.D.,
            Brunton,L.L., Grubin,C.E., Wignall,J.M., Jenkins,N.A., Brannan,C.I.
            et al.
  TITLE     A novel IL-1 receptor, cloned from B cells by mammalian expression,
            is expressed in many cell types
  JOURNAL   EMBO J 10 (10), 2821-2832 (1991)
   PUBMED   1833184
REFERENCE   7  (bases 1 to 5183)
  AUTHORS   Copeland,N.G., Silan,C.M., Kingsley,D.M., Jenkins,N.A.,
            Cannizzaro,L.A., Croce,C.M., Huebner,K. and Sims,J.E.
  TITLE     Chromosomal location of murine and human IL-1 receptor genes
  JOURNAL   Genomics 9 (1), 44-50 (1991)
   PUBMED   1672292
REFERENCE   8  (bases 1 to 5183)
  AUTHORS   Chua,A.O. and Gubler,U.
  TITLE     Sequence of the cDNA for the human fibroblast type interleukin-1
            receptor
  JOURNAL   Nucleic Acids Res 17 (23), 10114 (1989)
   PUBMED   2532321
REFERENCE   9  (bases 1 to 5183)
  AUTHORS   Sims,J.E., Acres,R.B., Grubin,C.E., McMahan,C.J., Wignall,J.M.,
            March,C.J. and Dower,S.K.
  TITLE     Cloning the interleukin 1 receptor from human T cells
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 8946-8950 (1989)
   PUBMED   2530587
REFERENCE   10 (bases 1 to 5183)
  AUTHORS   Uhl,J., Newton,R.C., Giri,J.G., Sandlin,G. and Horuk,R.
  TITLE     Identification of IL-1 receptors on human monocytes
  JOURNAL   J Immunol 142 (5), 1576-1581 (1989)
   PUBMED   2521881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007271.4, HY092388.1,
            M27492.1, BE144272.1, AL548240.3 and BQ021163.1.
            
            On Nov 24, 2018 this sequence version replaced NM_000877.3.
            
            Summary: This gene encodes a cytokine receptor that belongs to the
            interleukin-1 receptor family. The encoded protein is a receptor
            for interleukin-1 alpha, interleukin-1 beta, and interleukin-1
            receptor antagonist. It is an important mediator involved in many
            cytokine-induced immune and inflammatory responses. This gene is
            located in a cluster of related cytokine receptor genes on
            chromosome 2q12. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) is transcribed from a
            downstream promoter compared to variant 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16896.1, SRR5189667.133797.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410023.6/ ENSP00000386380.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC007271.4         95260-95437
            179-396             HY092388.1         150-367
            397-3396            M27492.1           121-3120
            3397-3929           BE144272.1         87-619
            3930-4697           AL548240.3         111-878
            4698-5183           BQ021163.1         18-503              c
FEATURES             Location/Qualifiers
     source          1..5183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2-q12.1"
     gene            1..5183
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /note="interleukin 1 receptor type 1"
                     /db_xref="GeneID:3554"
                     /db_xref="HGNC:HGNC:5993"
                     /db_xref="MIM:147810"
     exon            1..275
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            276..352
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            353..419
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2068
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /EC_number="3.2.2.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin 1 receptor alpha, type I;
                     interleukin-1 receptor alpha; interleukin-1 receptor type
                     I; CD121 antigen-like family member A"
                     /codon_start=1
                     /product="interleukin-1 receptor type 1 isoform 1
                     precursor"
                     /protein_id="NP_000868.1"
                     /db_xref="CCDS:CCDS2055.1"
                     /db_xref="GeneID:3554"
                     /db_xref="HGNC:HGNC:5993"
                     /db_xref="MIM:147810"
                     /translation="MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPC
                     PLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSS
                     YCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQW
                     YKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITL
                     EENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGE
                     DYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNF
                     QKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYP
                     KTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRL
                     IIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQ
                     KHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHV
                     PLG"
     exon            420..654
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            655..844
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1013
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1079
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1197
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1349
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1493
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1661
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..5183
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5156..5161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /note="hexamer: AATAAA"
     polyA_site      5183
                     /gene="IL1R1"
                     /gene_synonym="CD121A; CRMO3; D2S1473; IL-1R-alpha;
                     IL-1RT1; IL1R; IL1RA; P80"
                     /note="major polyA site"
ORIGIN      
        1 agttcccggc cgcgagggcg ggcgcagctt gtggccggcg gccggagccg actcggagcg
       61 cgcggcgccg gccgggagga gccggagagc ggccgggccg ggcggtgggg gcgccggcct
      121 gccccgcgcg ccccagggag cggcaggaat gtgacaatcg cgcgcccgcg caccgaagca
      181 ctcctcgctc ggctcctagg gctctcgccc ctctgagctg agccgggttc cgcccggggc
      241 tgggatccca tcaccctcca cggccgtccg tccaggtaga cgcaccctct gaagatggtg
      301 actccctcct gagaagctgg accccttggt aaaagacaag gccttctcca agaagaatat
      361 gaaagtgtta ctcagactta tttgtttcat agctctactg atttcttctc tggaggctga
      421 taaatgcaag gaacgtgaag aaaaaataat tttagtgtca tctgcaaatg aaattgatgt
      481 tcgtccctgt cctcttaacc caaatgaaca caaaggcact ataacttggt ataaagatga
      541 cagcaagaca cctgtatcta cagaacaagc ctccaggatt catcaacaca aagagaaact
      601 ttggtttgtt cctgctaagg tggaggattc aggacattac tattgcgtgg taagaaattc
      661 atcttactgc ctcagaatta aaataagtgc aaaatttgtg gagaatgagc ctaacttatg
      721 ttataatgca caagccatat ttaagcagaa actacccgtt gcaggagacg gaggacttgt
      781 gtgcccttat atggagtttt ttaaaaatga aaataatgag ttacctaaat tacagtggta
      841 taaggattgc aaacctctac ttcttgacaa tatacacttt agtggagtca aagataggct
      901 catcgtgatg aatgtggctg aaaagcatag agggaactat acttgtcatg catcctacac
      961 atacttgggc aagcaatatc ctattacccg ggtaatagaa tttattactc tagaggaaaa
     1021 caaacccaca aggcctgtga ttgtgagccc agctaatgag acaatggaag tagacttggg
     1081 atcccagata caattgatct gtaatgtcac cggccagttg agtgacattg cttactggaa
     1141 gtggaatggg tcagtaattg atgaagatga cccagtgcta ggggaagact attacagtgt
     1201 ggaaaatcct gcaaacaaaa gaaggagtac cctcatcaca gtgcttaata tatcggaaat
     1261 tgaaagtaga ttttataaac atccatttac ctgttttgcc aagaatacac atggtataga
     1321 tgcagcatat atccagttaa tatatccagt cactaatttc cagaagcaca tgattggtat
     1381 atgtgtcacg ttgacagtca taattgtgtg ttctgttttc atctataaaa tcttcaagat
     1441 tgacattgtg ctttggtaca gggattcctg ctatgatttt ctcccaataa aagcttcaga
     1501 tggaaagacc tatgacgcat atatactgta tccaaagact gttggggaag ggtctacctc
     1561 tgactgtgat atttttgtgt ttaaagtctt gcctgaggtc ttggaaaaac agtgtggata
     1621 taagctgttc atttatggaa gggatgacta cgttggggaa gacattgttg aggtcattaa
     1681 tgaaaacgta aagaaaagca gaagactgat tatcatttta gtcagagaaa catcaggctt
     1741 cagctggctg ggtggttcat ctgaagagca aatagccatg tataatgctc ttgttcagga
     1801 tggaattaaa gttgtcctgc ttgagctgga gaaaatccaa gactatgaga aaatgccaga
     1861 atcgattaaa ttcattaagc agaaacatgg ggctatccgc tggtcagggg actttacaca
     1921 gggaccacag tctgcaaaga caaggttctg gaagaatgtc aggtaccaca tgccagtcca
     1981 gcgacggtca ccttcatcta aacaccagtt actgtcacca gccactaagg agaaactgca
     2041 aagagaggct cacgtgcctc tcgggtagca tggagaagtt gccaagagtt ctttaggtgc
     2101 ctcctgtctt atggcgttgc aggccaggtt atgcctcatg ctgacttgca gagttcatgg
     2161 aatgtaacta tatcatcctt tatccctgag gtcacctgga atcagattat taagggaata
     2221 agccatgacg tcaatagcag cccagggcac ttcagagtag agggcttggg aagatctttt
     2281 aaaaaggcag taggcccggt gtggtggctc acgcctataa tcccagcact ttgggaggct
     2341 gaagtgggtg gatcaccaga ggtcaggagt tcgagaccag cccagccaac atggcaaaac
     2401 cccatctcta ctaaaaatac aaaaatgagc taggcatggt ggcacacgcc tgtaatccca
     2461 gctacacctg aggctgaggc aggagaattg cttgaaccgg ggagacggag gttgcagtga
     2521 gccgagtttg ggccactgca ctctagcctg gcaacagagc aagactccgt ctcaaaaaaa
     2581 gggcaataaa tgccctctct gaatgtttga actgccaaga aaaggcatgg agacagcgaa
     2641 ctagaagaaa gggcaagaag gaaatagcca ccgtctacag atggcttagt taagtcatcc
     2701 acagcccaag ggcggggcta tgccttgtct ggggaccctg tagagtcact gaccctggag
     2761 cggctctcct gagaggtgct gcaggcaaag tgagactgac acctcactga ggaagggaga
     2821 catattcttg gagaactttc catctgcttg tattttccat acacatcccc agccagaagt
     2881 tagtgtccga agaccgaatt ttattttaca gagcttgaaa actcacttca atgaacaaag
     2941 ggattctcca ggattccaaa gttttgaagt catcttagct ttccacagga gggagagaac
     3001 ttaaaaaagc aacagtagca gggaattgat ccacttctta atgctttcct ccctggcatg
     3061 accatcctgt cctttgttat tatcctgcat tttacgtctt tggaggaaca gctccctagt
     3121 ggcttcctcc gtctgcaatg tcccttgcac agcccacaca tgaaccatcc ttcccatgat
     3181 gccgctcttc tgtcatcccg ctcctgctga aacacctccc aggggctcca cctgttcagg
     3241 agctgaagcc catgctttcc caccagcatg tcactcccag accacctccc tgccctgtcc
     3301 tccagcttcc cctcgctgtc ctgctgtgtg aattcccagg ttggcctggt ggccatgtcg
     3361 cctgccccca gcactcctct gtctctgctc ttgcctgcac ccttcctcct cctttgccta
     3421 ggaggccttc tcgcattttc tctagctgat cagaatttta ccaaaattca gaacatcctc
     3481 caattccaca gtctctggga gactttccct aagaggcgac ttcctctcca gccttctctc
     3541 tctggtcagg cccactgcag agatggtggt gagcacatct gggaggctgg tctccctcca
     3601 gctggaattg ctgctctctg agggagaggc tgtggtggct gtctctgtcc ctcactgcct
     3661 tccaggagca atttgcacat gtaacataga tttatgtaat gctttatgtt taaaaacatt
     3721 ccccaattat cttatttaat ttttgcaatt attctaattt tatatataga gaaagtgacc
     3781 tattttttaa aaaaatcaca ctctaagttc tattgaacct aggacttgag cctccatttc
     3841 tggcttctag tctggtgttc tgagtacttg atttcaggtc aataacggtc ccccctcact
     3901 ccacactggc acgtttgtga gaagaaatga cattttgcta ggaagtgacc gagtctagga
     3961 atgcttttat tcaagacacc aaattccaaa cttctaaatg ttggaatttt caaaaattgt
     4021 gtttagattt tatgaaaaac tcttctactt tcatctattc tttccctaga ggcaaacatt
     4081 tcttaaaatg tttcattttc attaaaaatg aaagccaaat ttatatgcca ccgattgcag
     4141 gacacaagca cagttttaag agttgtatga acatggagag gacttttggt ttttatattt
     4201 ctcgtattta atatgggtga acaccaactt ttatttggaa taataatttt cctcctaaac
     4261 aaaaacacat tgagtttaag tctctgactc ttgcctttcc acctgctttc tcctgggccc
     4321 gctttgcctg cttgaaggaa cagtgctgtt ctggagctgc tgttccaaca gacagggcct
     4381 agctttcatt tgacacacag actacagcca gaagcccatg gagcagggat gtcacgtctt
     4441 gaaaagccta ttagatgttt tacaaattta attttgcaga ttattttagt ctgtcatcca
     4501 gaaaatgtgt cagcatgcat agtgctaaga aagcaagcca atttggaaac ttaggttagt
     4561 gacaaaattg gccagagagt gggggtgatg atgaccaaga attacaagta gaatggcagc
     4621 tggaatttaa ggagggacaa gaatcaatgg ataagcgtgg gtggaggaag atccaaacag
     4681 aaaagtgcaa agttattccc catcttccaa gggttgaatt ctggaggaag aagacacatt
     4741 cctagttccc cgtgaacttc ctttgactta ttgtccccac taaaacaaaa caaaaaactt
     4801 ttaatgcctt ccacattaat tagattttct tgcagttttt ttatggcatt tttttaaaga
     4861 tgccctaagt gttgaagaag agtttgcaaa tgcaacaaaa tatttaatta ccggttgtta
     4921 aaactggttt agcacaattt atattttccc tctcttgcct ttcttatttg caataaaagg
     4981 tattgagcca ttttttaaat gacatttttg ataaattatg tttgtactag ttgatgaagg
     5041 agtttttttt aacctgttta tataattttg cagcagaagc caaatttttt gtatattaaa
     5101 gcaccaaatt catgtacagc atgcatcacg gatcaataga ctgtacttat tttccaataa
     5161 aattttcaaa ctttgtactg tta
//
