LOCUS       NM_173161               1013 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens interleukin 1 family member 10 (IL1F10), transcript
            variant 2, mRNA.
ACCESSION   NM_173161
VERSION     NM_173161.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1013)
  AUTHORS   da Silva,P., Mora,J., You,X., Wiechmann,S., Putyrski,M.,
            Garcia-Pardo,J., Kannt,A., Ernst,A., Bruene,B. and Weigert,A.
  TITLE     Neutralizing IL-38 activates gammadelta T cell-dependent antitumor
            immunity and sensitizes for chemotherapy
  JOURNAL   J Immunother Cancer 12 (8), e008641 (2024)
   PUBMED   39209451
  REMARK    GeneRIF: Neutralizing IL-38 activates gammadelta T cell-dependent
            antitumor immunity and sensitizes for chemotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1013)
  AUTHORS   Wu,H., Yang,J., Yuan,L., Tan,Z., Zhang,X., Hambly,B.D., Bao,S. and
            Tao,K.
  TITLE     IL-38 promotes the development of prostate cancer
  JOURNAL   Front Immunol 15, 1384416 (2024)
   PUBMED   38779687
  REMARK    GeneRIF: IL-38 promotes the development of prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1013)
  AUTHORS   Bani-Wais,D.F.N. and Ad'hiah,A.H.
  TITLE     The 5' untranslated region variant rs3811050 C/T of the
            interleukin-38 encoding gene is associated with susceptibility to
            rheumatoid arthritis in Iraqi women
  JOURNAL   Mol Biol Rep 51 (1), 589 (2024)
   PUBMED   38683405
  REMARK    GeneRIF: The 5' untranslated region variant rs3811050 C/T of the
            interleukin-38 encoding gene is associated with susceptibility to
            rheumatoid arthritis in Iraqi women.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1013)
  AUTHORS   Haghshenas,M.R., Khademolhosseini,A., Dehghanian,A.R.,
            Ghanipour,F., Ghaderi,H., Khansalar,S. and Sotoodeh Jahromi,A.
  TITLE     Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary
            Brain Tumors
  JOURNAL   Iran J Immunol 21 (1), 65-73 (2024)
   PUBMED   38372219
  REMARK    GeneRIF: Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in
            Primary Brain Tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1013)
  AUTHORS   Gao,Y., Cai,L., Wu,Y., Jiang,M., Zhang,Y., Ren,W., Song,Y., Li,L.,
            Lei,Z., Wu,Y., Zhu,L., Li,J., Li,D., Li,G., Luo,C. and Tao,L.
  TITLE     Emerging functions and therapeutic targets of IL-38 in central
            nervous system diseases
  JOURNAL   CNS Neurosci Ther 30 (2), e14550 (2024)
   PUBMED   38334236
  REMARK    GeneRIF: Emerging functions and therapeutic targets of IL-38 in
            central nervous system diseases.
            Review article
REFERENCE   6  (bases 1 to 1013)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   7  (bases 1 to 1013)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   8  (bases 1 to 1013)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
REFERENCE   9  (bases 1 to 1013)
  AUTHORS   Nothwang,H.G., Strahm,B., Denich,D., Kubler,M., Schwabe,J.,
            Gingrich,J.C., Jauch,A., Cox,A., Nicklin,M.J., Kurnit,D.M. and
            Hildebrandt,F.
  TITLE     Molecular cloning of the interleukin-1 gene cluster: construction
            of an integrated YAC/PAC contig and a partial transcriptional map
            in the region of chromosome 2q13
  JOURNAL   Genomics 41 (3), 370-378 (1997)
   PUBMED   9169134
REFERENCE   10 (bases 1 to 1013)
  AUTHORS   Nicklin,M.J., Weith,A. and Duff,G.W.
  TITLE     A physical map of the region encompassing the human interleukin-1
            alpha, interleukin-1 beta, and interleukin-1 receptor antagonist
            genes
  JOURNAL   Genomics 19 (2), 382-384 (1994)
   PUBMED   8188271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY029413.1 and AY358846.1.
            
            On Jun 2, 2019 this sequence version replaced NM_173161.2.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. This gene and eight other
            interleukin 1 family genes form a cytokine gene cluster on
            chromosome 2. This cytokine is thought to participate in a network
            of interleukin 1 family members to regulate adapted and innate
            immune responses. Two alternatively spliced transcript variants
            encoding the same protein have been reported. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029413.1, AY358846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341010.6/ ENSP00000341794.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1008              AY029413.1         1-1008
            1009-1013           AY358846.1         997-1001
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..1013
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /note="interleukin 1 family member 10"
                     /db_xref="GeneID:84639"
                     /db_xref="HGNC:HGNC:15552"
                     /db_xref="MIM:615296"
     exon            1..47
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..107
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..534
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /note="interleukin-1 HY2; interleukin-1 receptor
                     antagonist FKSG75; interleukin-1 receptor antagonist-like
                     FIL1 theta; IL-1F10 (canonical form IL-1F10a); IL-1 theta;
                     interleukin-38; family of interleukin 1-theta; interleukin
                     1 family member 10 (theta)"
                     /codon_start=1
                     /product="interleukin-1 family member 10"
                     /protein_id="NP_775184.1"
                     /db_xref="CCDS:CCDS2112.1"
                     /db_xref="GeneID:84639"
                     /db_xref="HGNC:HGNC:15552"
                     /db_xref="MIM:615296"
                     /translation="MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICI
                     LPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFF
                     QSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW"
     exon            108..193
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /inference="alignment:Splign:2.1.0"
     exon            194..321
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..1013
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /note="hexamer: AATAAA"
     polyA_site      1013
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /note="major polyA site"
ORIGIN      
        1 agttggagtc tccagggatc agggttccag gaactcagga tctgcagtga ggaccagaca
       61 ccactgattg caggaatgtg ttccctcccc atggcaagat actacataat taaatatgca
      121 gaccagaagg ctctatacac aagagatggc cagctgctgg tgggagatcc tgttgcagac
      181 aactgctgtg cagagaagat ctgcatactt cctaacagag gcttggcccg caccaaggtc
      241 cccattttcc tggggatcca gggagggagc cgctgcctgg catgtgtgga gacagaagag
      301 gggccttccc tacagctgga ggatgtgaac attgaggaac tgtacaaagg tggtgaagag
      361 gccacacgct tcaccttctt ccagagcagc tcaggctccg ccttcaggct tgaggctgct
      421 gcctggcctg gctggttcct gtgtggcccg gcagagcccc agcagccagt acagctcacc
      481 aaggagagtg agccctcagc ccgtaccaag ttttactttg aacagagctg gtagggagac
      541 aggaaactgc gttttagcct tgtgccccca aaccaagctc atcctgctca gggtctatgg
      601 taggcagaat aatgtccccc gaaatatgtc cacatcctaa tcccaagatc tgtgcatatg
      661 ttaccataca tgtccaaaga ggttttgcaa atgtgattat gttaaggatc ttgaaatgag
      721 gagacaatcc tgggttatcc ttgtgggctc agtttaatca caagaaggag gcaggaaggg
      781 agagtcagag agagaatgga agataccatg cttctaattt tgaagatgga gtgaggggcc
      841 ttgagccaac aaatgcaggt gtttttagaa ggtggaaaag ccaagggaac ggattctcct
      901 ctagagtctc cggaaggaac acagctcttg acacatggat ttcagctcag tgacacccat
      961 ttcagacttc tgacctccac aactataaaa taataaactt gtgttattgt aaa
//
