LOCUS       NP_775184                152 aa            linear   PRI 17-SEP-2024
DEFINITION  interleukin-1 family member 10 [Homo sapiens].
ACCESSION   NP_775184
VERSION     NP_775184.1
DBSOURCE    REFSEQ: accession NM_173161.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 152)
  AUTHORS   da Silva,P., Mora,J., You,X., Wiechmann,S., Putyrski,M.,
            Garcia-Pardo,J., Kannt,A., Ernst,A., Bruene,B. and Weigert,A.
  TITLE     Neutralizing IL-38 activates gammadelta T cell-dependent antitumor
            immunity and sensitizes for chemotherapy
  JOURNAL   J Immunother Cancer 12 (8), e008641 (2024)
   PUBMED   39209451
  REMARK    GeneRIF: Neutralizing IL-38 activates gammadelta T cell-dependent
            antitumor immunity and sensitizes for chemotherapy.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 152)
  AUTHORS   Wu,H., Yang,J., Yuan,L., Tan,Z., Zhang,X., Hambly,B.D., Bao,S. and
            Tao,K.
  TITLE     IL-38 promotes the development of prostate cancer
  JOURNAL   Front Immunol 15, 1384416 (2024)
   PUBMED   38779687
  REMARK    GeneRIF: IL-38 promotes the development of prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 152)
  AUTHORS   Bani-Wais,D.F.N. and Ad'hiah,A.H.
  TITLE     The 5' untranslated region variant rs3811050 C/T of the
            interleukin-38 encoding gene is associated with susceptibility to
            rheumatoid arthritis in Iraqi women
  JOURNAL   Mol Biol Rep 51 (1), 589 (2024)
   PUBMED   38683405
  REMARK    GeneRIF: The 5' untranslated region variant rs3811050 C/T of the
            interleukin-38 encoding gene is associated with susceptibility to
            rheumatoid arthritis in Iraqi women.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 152)
  AUTHORS   Haghshenas,M.R., Khademolhosseini,A., Dehghanian,A.R.,
            Ghanipour,F., Ghaderi,H., Khansalar,S. and Sotoodeh Jahromi,A.
  TITLE     Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary
            Brain Tumors
  JOURNAL   Iran J Immunol 21 (1), 65-73 (2024)
   PUBMED   38372219
  REMARK    GeneRIF: Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in
            Primary Brain Tumors.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 152)
  AUTHORS   Gao,Y., Cai,L., Wu,Y., Jiang,M., Zhang,Y., Ren,W., Song,Y., Li,L.,
            Lei,Z., Wu,Y., Zhu,L., Li,J., Li,D., Li,G., Luo,C. and Tao,L.
  TITLE     Emerging functions and therapeutic targets of IL-38 in central
            nervous system diseases
  JOURNAL   CNS Neurosci Ther 30 (2), e14550 (2024)
   PUBMED   38334236
  REMARK    GeneRIF: Emerging functions and therapeutic targets of IL-38 in
            central nervous system diseases.
            Review article
REFERENCE   6  (residues 1 to 152)
  AUTHORS   Kumar,S., McDonnell,P.C., Lehr,R., Tierney,L., Tzimas,M.N.,
            Griswold,D.E., Capper,E.A., Tal-Singer,R., Wells,G.I., Doyle,M.L.
            and Young,P.R.
  TITLE     Identification and initial characterization of four novel members
            of the interleukin-1 family
  JOURNAL   J Biol Chem 275 (14), 10308-10314 (2000)
   PUBMED   10744718
REFERENCE   7  (residues 1 to 152)
  AUTHORS   Smith,D.E., Renshaw,B.R., Ketchem,R.R., Kubin,M., Garka,K.E. and
            Sims,J.E.
  TITLE     Four new members expand the interleukin-1 superfamily
  JOURNAL   J Biol Chem 275 (2), 1169-1175 (2000)
   PUBMED   10625660
REFERENCE   8  (residues 1 to 152)
  AUTHORS   Mulero,J.J., Pace,A.M., Nelken,S.T., Loeb,D.B., Correa,T.R.,
            Drmanac,R. and Ford,J.E.
  TITLE     IL1HY1: A novel interleukin-1 receptor antagonist gene
  JOURNAL   Biochem Biophys Res Commun 263 (3), 702-706 (1999)
   PUBMED   10512743
REFERENCE   9  (residues 1 to 152)
  AUTHORS   Nothwang,H.G., Strahm,B., Denich,D., Kubler,M., Schwabe,J.,
            Gingrich,J.C., Jauch,A., Cox,A., Nicklin,M.J., Kurnit,D.M. and
            Hildebrandt,F.
  TITLE     Molecular cloning of the interleukin-1 gene cluster: construction
            of an integrated YAC/PAC contig and a partial transcriptional map
            in the region of chromosome 2q13
  JOURNAL   Genomics 41 (3), 370-378 (1997)
   PUBMED   9169134
REFERENCE   10 (residues 1 to 152)
  AUTHORS   Nicklin,M.J., Weith,A. and Duff,G.W.
  TITLE     A physical map of the region encompassing the human interleukin-1
            alpha, interleukin-1 beta, and interleukin-1 receptor antagonist
            genes
  JOURNAL   Genomics 19 (2), 382-384 (1994)
   PUBMED   8188271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY029413.1 and AY358846.1.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. This gene and eight other
            interleukin 1 family genes form a cytokine gene cluster on
            chromosome 2. This cytokine is thought to participate in a network
            of interleukin 1 family members to regulate adapted and innate
            immune responses. Two alternatively spliced transcript variants
            encoding the same protein have been reported. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029413.1, AY358846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341010.6/ ENSP00000341794.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     Protein         1..152
                     /product="interleukin-1 family member 10"
                     /note="interleukin-1 HY2; interleukin-1 receptor
                     antagonist FKSG75; interleukin-1 receptor antagonist-like
                     FIL1 theta; IL-1F10 (canonical form IL-1F10a); IL-1 theta;
                     interleukin-38; family of interleukin 1-theta; interleukin
                     1 family member 10 (theta)"
                     /calculated_mol_wt=16812
     Region          3..151
                     /region_name="beta-trefoil_IL38"
                     /note="beta-trefoil domain found in interleukin-38 (IL-38)
                     and similar proteins; cd23302"
                     /db_xref="CDD:466784"
     CDS             1..152
                     /gene="IL1F10"
                     /gene_synonym="FIL1-theta; FKSG75; IL-1HY2; IL-38;
                     IL1-theta; IL1HY2"
                     /coded_by="NM_173161.3:76..534"
                     /db_xref="CCDS:CCDS2112.1"
                     /db_xref="GeneID:84639"
                     /db_xref="HGNC:HGNC:15552"
                     /db_xref="MIM:615296"
ORIGIN      
        1 mcslpmaryy iikyadqkal ytrdgqllvg dpvadnccae kicilpnrgl artkvpiflg
       61 iqggsrclac veteegpslq ledvnieely kggeeatrft ffqsssgsaf rleaaawpgw
      121 flcgpaepqq pvqltkesep sartkfyfeq sw
//
