LOCUS       NM_000576               1507 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens interleukin 1 beta (IL1B), mRNA.
ACCESSION   NM_000576
VERSION     NM_000576.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Huang,Y., Xu,L., Yang,Q., Xiao,X., Ye,Z., Li,R., Guan,Y. and Wu,X.
  TITLE     NLRP12 c.1382dup promotes the development of Crohn's disease
            through the ERK/NLRP3/ IL-1beta pathway
  JOURNAL   Gene 931, 148855 (2024)
   PUBMED   39181275
  REMARK    GeneRIF: NLRP12 c.1382dup promotes the development of Crohn's
            disease through the ERK/NLRP3/ IL-1beta pathway.
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Di,T., Chen,Y., Zhou,Z., Liu,J., Du,Y., Feng,C., Zhu,B. and Wang,L.
  TITLE     Effect of alpha7 nAChR-autophagy axis of deciduous tooth pulp stem
            cells in regulating IL-1beta in the process of physiological root
            resorption of deciduous teeth
  JOURNAL   J Mol Med (Berl) 102 (9), 1135-1149 (2024)
   PUBMED   39002004
  REMARK    GeneRIF: Effect of alpha7 nAChR-autophagy axis of deciduous tooth
            pulp stem cells in regulating IL-1beta in the process of
            physiological root resorption of deciduous teeth.
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Lang,J.C., Brutscher,A., Ehrstrom,M. and Melican,K.
  TITLE     Tissue resident cells differentiate S. aureus from S. epidermidis
            via IL-1beta following barrier disruption in healthy human skin
  JOURNAL   PLoS Pathog 20 (8), e1012056 (2024)
   PUBMED   39208402
  REMARK    GeneRIF: Tissue resident cells differentiate S. aureus from S.
            epidermidis via IL-1beta following barrier disruption in healthy
            human skin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Subramani,M., Lambrecht,B. and Ahmad,I.
  TITLE     Human microglia-derived proinflammatory cytokines facilitate human
            retinal ganglion cell development and regeneration
  JOURNAL   Stem Cell Reports 19 (8), 1092-1106 (2024)
   PUBMED   39059376
  REMARK    GeneRIF: Human microglia-derived proinflammatory cytokines
            facilitate human retinal ganglion cell development and
            regeneration.
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Inoue,T., Emoto,T., Yamanaka,K., Chomei,S., Miyahara,S.,
            Takahashi,H., Shinohara,R., Kondo,T., Taniguchi,M., Furuyashiki,T.,
            Yamashita,T., Hirata,K.I. and Okada,K.
  TITLE     Intense impact of IL-1beta expressing inflammatory macrophages in
            acute aortic dissection
  JOURNAL   Sci Rep 14 (1), 14893 (2024)
   PUBMED   38937528
  REMARK    GeneRIF: Intense impact of IL-1beta expressing inflammatory
            macrophages in acute aortic dissection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Nanduri,V.B., Hulmes,J.D., Pan,Y.C., Kilian,P.L. and Stern,A.S.
  TITLE     The role of arginine residues in interleukin 1 receptor binding
  JOURNAL   Biochim Biophys Acta 1118 (1), 25-35 (1991)
   PUBMED   1837236
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Grenfell,S., Smithers,N., Witham,S., Shaw,A., Graber,P. and
            Solari,R.
  TITLE     Analysis of mutations in the putative nuclear localization sequence
            of interleukin-1 beta
  JOURNAL   Biochem J 280 (Pt 1) (Pt 1), 111-116 (1991)
   PUBMED   1835838
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Howard,A.D., Kostura,M.J., Thornberry,N., Ding,G.J., Limjuco,G.,
            Weidner,J., Salley,J.P., Hogquist,K.A., Chaplin,D.D., Mumford,R.A.
            et al.
  TITLE     IL-1-converting enzyme requires aspartic acid residues for
            processing of the IL-1 beta precursor at two distinct sites and
            does not cleave 31-kDa IL-1 alpha
  JOURNAL   J Immunol 147 (9), 2964-2969 (1991)
   PUBMED   1919001
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Chistiakov,D.A., Arsenian,S.G., Braga,E.A., Lapidus,A.D.,
            Kozlov,Iu.I., Mashko,S.V., Nosikov,V.V., Sverdlov,E.D. and
            Debabov,V.G.
  TITLE     [Elimination of introns from the interleukin 1 beta genome by DNA
            amplification and expression of interleukin 1 beta in Escherichia
            coli]
  JOURNAL   Mol Biol (Mosk) 25 (5), 1273-1284 (1991)
   PUBMED   1753956
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Merrill,J.E.
  TITLE     Effects of interleukin-1 and tumor necrosis factor-alpha on
            astrocytes, microglia, oligodendrocytes, and glial precursors in
            vitro
  JOURNAL   Dev Neurosci 13 (3), 130-137 (1991)
   PUBMED   1752215
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079753.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000576.2.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 cytokine family. This cytokine is produced by
            activated macrophages as a proprotein, which is proteolytically
            processed to its active form by caspase 1 (CASP1/ICE). This
            cytokine is an important mediator of the inflammatory response, and
            is involved in a variety of cellular activities, including cell
            proliferation, differentiation, and apoptosis. The induction of
            cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central
            nervous system (CNS) is found to contribute to inflammatory pain
            hypersensitivity. Similarly, IL-1B has been implicated in human
            osteoarthritis pathogenesis. Patients with severe Coronavirus
            Disease 2019 (COVID-19) present elevated levels of pro-inflammatory
            cytokines such as IL-1B in bronchial alveolar lavage fluid samples.
            The lung damage induced by the Severe acute respiratory syndrome
            coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the
            inflammatory response promoted by cytokines such as IL-1B. This
            gene and eight other interleukin 1 family genes form a cytokine
            gene cluster on chromosome 2. [provided by RefSeq, Jul 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.109183.1,
                                           SRR5189652.136888.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000263341.7/ ENSP00000263341.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC079753.7         52118-52189         c
            73-134              AC079753.7         51593-51654         c
            135-186             AC079753.7         50976-51027         c
            187-388             AC079753.7         48784-48985         c
            389-553             AC079753.7         48072-48236         c
            554-684             AC079753.7         46702-46832         c
            685-1507            AC079753.7         45161-45983         c
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..1507
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /note="interleukin 1 beta"
                     /db_xref="GeneID:3553"
                     /db_xref="HGNC:HGNC:5992"
                     /db_xref="MIM:147720"
     exon            1..72
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            73..134
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..897
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /note="preinterleukin 1 beta; interleukin 1beta;
                     catabolin; pro-interleukin-1-beta; IL-1 beta"
                     /codon_start=1
                     /product="interleukin-1 beta proprotein"
                     /protein_id="NP_000567.1"
                     /db_xref="CCDS:CCDS2102.1"
                     /db_xref="GeneID:3553"
                     /db_xref="HGNC:HGNC:5992"
                     /db_xref="MIM:147720"
                     /translation="MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPL
                     DGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEP
                     IFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSM
                     SFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFN
                     KIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS"
     exon            135..186
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            187..388
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..553
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..684
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1507
                     /gene="IL1B"
                     /gene_synonym="IL-1; IL1-BETA; IL1beta; IL1F2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc
       61 ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg
      121 atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag
      181 atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga
      241 atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg
      301 gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc
      361 accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag
      421 gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa
      481 aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat
      541 atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa
      601 atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat
      661 gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg
      721 gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc
      781 cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga
      841 gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga
      901 gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag
      961 ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg
     1021 cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc
     1081 agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc
     1141 tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc
     1201 tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt
     1261 ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt
     1321 aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt
     1381 taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat
     1441 atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaagaa
     1501 aaaaaaa
//
