LOCUS       NM_153758               1347 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 19 (IL19), transcript variant 1, mRNA.
ACCESSION   NM_153758
VERSION     NM_153758.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Parhoudeh,S., Saadaty,A., Khashei Varnamkhasti,K., Khashei
            Varnamkhasti,S., Naeimi,L. and Naeimi,S.
  TITLE     Highlighting allelic variations at the interleukin-19 locus in term
            of preeclampsia predisposing factors and access to an accurate
            diagnostic/screening option
  JOURNAL   BMC Pregnancy Childbirth 23 (1), 839 (2023)
   PUBMED   38057745
  REMARK    GeneRIF: Highlighting allelic variations at the interleukin-19
            locus in term of preeclampsia predisposing factors and access to an
            accurate diagnostic/screening option.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Dumycz,K., Kunkiel,K., Stelmaszczyk-Emmel,A., Jozefczuk,P.,
            Adamiec,A., Kulus,M. and Feleszko,W.
  TITLE     Interleukin-19 is associated with severity and age-related
            phenotype of atopic dermatitis in children
  JOURNAL   Clin Exp Allergy 53 (1), 109-112 (2023)
   PUBMED   36161738
  REMARK    GeneRIF: Interleukin-19 is associated with severity and age-related
            phenotype of atopic dermatitis in children.
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Saheb Sharif-Askari,F., Saheb Sharif-Askari,N., Hafezi,S., Goel,S.,
            Ali Hussain Alsayed,H., Ansari,A.W., Mahboub,B., Al-Muhsen,S.,
            Temsah,M.H., Hamid,Q. and Halwani,R.
  TITLE     Upregulation of interleukin-19 in saliva of patients with COVID-19
  JOURNAL   Sci Rep 12 (1), 16019 (2022)
   PUBMED   36163397
  REMARK    GeneRIF: Upregulation of interleukin-19 in saliva of patients with
            COVID-19.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Mohammed,A.K.
  TITLE     Comparison of TNF-alpha and IL-19 concentrations at different
            stages of breast cancer
  JOURNAL   J Med Life 15 (6), 845-849 (2022)
   PUBMED   35928364
  REMARK    GeneRIF: Comparison of TNF-alpha and IL-19 concentrations at
            different stages of breast cancer.
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Sang,Z., Tan,W., Wu,H., Tian,T. and Li,L.
  TITLE     Association between interleukin-19 gene polymorphisms and maternal
            puerperal infection
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (4), 24-30 (2022)
   PUBMED   35988273
  REMARK    GeneRIF: Association between interleukin-19 gene polymorphisms and
            maternal puerperal infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1347)
  AUTHORS   Wolk,K., Kunz,S., Asadullah,K. and Sabat,R.
  TITLE     Cutting edge: immune cells as sources and targets of the IL-10
            family members?
  JOURNAL   J Immunol 168 (11), 5397-5402 (2002)
   PUBMED   12023331
REFERENCE   7  (bases 1 to 1347)
  AUTHORS   Fickenscher,H., Hor,S., Kupers,H., Knappe,A., Wittmann,S. and
            Sticht,H.
  TITLE     The interleukin-10 family of cytokines
  JOURNAL   Trends Immunol 23 (2), 89-96 (2002)
   PUBMED   11929132
REFERENCE   8  (bases 1 to 1347)
  AUTHORS   Dumoutier,L., Leemans,C., Lejeune,D., Kotenko,S.V. and Renauld,J.C.
  TITLE     Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through
            IL-20 receptor complexes of two types
  JOURNAL   J Immunol 167 (7), 3545-3549 (2001)
   PUBMED   11564763
REFERENCE   9  (bases 1 to 1347)
  AUTHORS   Blumberg,H., Conklin,D., Xu,W.F., Grossmann,A., Brender,T.,
            Carollo,S., Eagan,M., Foster,D., Haldeman,B.A., Hammond,A.,
            Haugen,H., Jelinek,L., Kelly,J.D., Madden,K., Maurer,M.F.,
            Parrish-Novak,J., Prunkard,D., Sexson,S., Sprecher,C., Waggie,K.,
            West,J., Whitmore,T.E., Yao,L., Kuechle,M.K., Dale,B.A. and
            Chandrasekher,Y.A.
  TITLE     Interleukin 20: discovery, receptor identification, and role in
            epidermal function
  JOURNAL   Cell 104 (1), 9-19 (2001)
   PUBMED   11163236
REFERENCE   10 (bases 1 to 1347)
  AUTHORS   Gallagher,G., Dickensheets,H., Eskdale,J., Izotova,L.S.,
            Mirochnitchenko,O.V., Peat,J.D., Vazquez,N., Pestka,S.,
            Donnelly,R.P. and Kotenko,S.V.
  TITLE     Cloning, expression and initial characterization of interleukin-19
            (IL-19), a novel homologue of human interleukin-10 (IL-10)
  JOURNAL   Genes Immun 1 (7), 442-450 (2000)
   PUBMED   11196675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513315.15.
            
            On Feb 13, 2021 this sequence version replaced NM_153758.4.
            
            Summary: The protein encoded by this gene is a cytokine that
            belongs to the IL10 cytokine subfamily. This cytokine is found to
            be preferentially expressed in monocytes. It can bind the IL20
            receptor complex and lead to the activation of the signal
            transducer and activator of transcription 3 (STAT3). A similar
            cytokine in mouse is reported to up-regulate the expression of IL6
            and TNF-alpha and induce apoptosis, which suggests a role of this
            cytokine in inflammatory responses. Alternatively spliced
            transcript variants encoding the distinct isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY040367.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000659997.3/
                                                ENSP00000499459.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AL513315.15        5249-5554
            307-452             AL513315.15        33337-33482
            453-598             AL513315.15        71137-71282
            599-664             AL513315.15        71434-71499
            665-817             AL513315.15        74326-74478
            818-892             AL513315.15        75480-75554
            893-1347            AL513315.15        77003-77457
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1347
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /note="interleukin 19"
                     /db_xref="GeneID:29949"
                     /db_xref="HGNC:HGNC:5990"
                     /db_xref="MIM:605687"
     exon            1..306
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..452
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..598
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..988
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /note="melanoma differentiation associated protein-like
                     protein"
                     /codon_start=1
                     /product="interleukin-19 precursor"
                     /protein_id="NP_715639.2"
                     /db_xref="CCDS:CCDS1469.1"
                     /db_xref="GeneID:29949"
                     /db_xref="HGNC:HGNC:5990"
                     /db_xref="MIM:605687"
                     /translation="MKLQCVSLWLLGTILILCSVDNHGLRRCLISTDMHHIEESFQEI
                     KRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILR
                     KISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGEL
                     DVFLAWINKNHEVMFSA"
     exon            599..664
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..817
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..892
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1347
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /note="hexamer: AATAAA"
     polyA_site      1347
                     /gene="IL19"
                     /gene_synonym="IL-10C; MDA1; NG.1; ZMDA1"
                     /note="major polyA site"
ORIGIN      
        1 agtctttcct catttacagc tagctctgcc agtctgtgtc tttgctgtgt ctgtggatgt
       61 gagtgtccct gctggtctgt aggagatggt attttggggg cagctgcaag ggaaaaaact
      121 gatctgctac ttacacagcg ccgtagcctc agcctgaggg tcttcaggtt ctcccccagg
      181 gagttcacat gcgccttgat gtctgggtct tggttctcag cttggggcat cacctcctcc
      241 aggtaaaact ggatcatctc agacaaggct tggcaaccca ggtaacccta agggcaggag
      301 ccaaagagcg gtgcttgcac acactgacag gagtccaaga atgtgcactg agggagcgtt
      361 tccgcacaga tctgcgtgtt ccttaccact cacacatgtg cacacacata tccatgtgtg
      421 tgtgccagtg ctttggggct ctgttccacg gggcatgaag ttacagtgtg tttccctttg
      481 gctcctgggt acaatactga tattgtgctc agtagacaac cacggtctca ggagatgtct
      541 gatttccaca gacatgcacc atatagaaga gagtttccaa gaaatcaaaa gagccatcca
      601 agctaaggac accttcccaa atgtcactat cctgtccaca ttggagactc tgcagatcat
      661 taagccctta gatgtgtgct gcgtgaccaa gaacctcctg gcgttctacg tggacagggt
      721 gttcaaggat catcaggagc caaaccccaa aatcttgaga aaaatcagca gcattgccaa
      781 ctctttcctc tacatgcaga aaactctgcg gcaatgtcag gaacagaggc agtgtcactg
      841 caggcaggaa gccaccaatg ccaccagagt catccatgac aactatgatc agctggaggt
      901 ccacgctgct gccattaaat ccctgggaga gctcgacgtc tttctagcct ggattaataa
      961 gaatcatgaa gtaatgttct cagcttgatg acaaggaacc tgtatagtga tccagggatg
     1021 aacaccccct gtgcggttta ctgtgggaga cagcccacct tgaaggggaa ggagatgggg
     1081 aaggcccctt gcagctgaaa gtcccactgg ctggcctcag gctgtcttat tccgcttgaa
     1141 aatagccaaa aagtctactg tggtatttgt aataaactct atctgctgaa agggcctgca
     1201 ggccatcctg ggagtaaagg gctgccttcc catctaattt attgtaaagt catatagtcc
     1261 atgtctgtga tgtgagccaa gtgatatcct gtagtacaca ttgtactgag tggtttttct
     1321 gaataaattc catattttac ctatgaa
//
