LOCUS       NM_001393487            2302 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens interleukin 18 receptor accessory protein (IL18RAP),
            transcript variant 3, mRNA.
ACCESSION   NM_001393487
VERSION     NM_001393487.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Chen,W., Song,T., Zou,F., Xia,Y., Xing,J., Yu,W., Rao,T., Zhou,X.,
            Li,C., Ning,J., Zhao,S., Ruan,Y. and Cheng,F.
  TITLE     Prognostic and immunological roles of IL18RAP in human cancers
  JOURNAL   Aging (Albany NY) 15 (17), 9059-9085 (2023)
   PUBMED   37698530
  REMARK    GeneRIF: Prognostic and immunological roles of IL18RAP in human
            cancers.
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Eitan,C., Siany,A., Barkan,E., Olender,T., van Eijk,K.R.,
            Moisse,M., Farhan,S.M.K., Danino,Y.M., Yanowski,E.,
            Marmor-Kollet,H., Rivkin,N., Yacovzada,N.S., Hung,S.T.,
            Cooper-Knock,J., Yu,C.H., Louis,C., Masters,S.L., Kenna,K.P., van
            der Spek,R.A.A., Sproviero,W., Al Khleifat,A., Iacoangeli,A.,
            Shatunov,A., Jones,A.R., Elbaz-Alon,Y., Cohen,Y., Chapnik,E.,
            Rothschild,D., Weissbrod,O., Beck,G., Ainbinder,E., Ben-Dor,S.,
            Werneburg,S., Schafer,D.P., Brown,R.H. Jr., Shaw,P.J., Van
            Damme,P., van den Berg,L.H., Phatnani,H., Segal,E., Ichida,J.K.,
            Al-Chalabi,A., Veldink,J.H. and Hornstein,E.
  CONSRTM   Project MinE ALS Sequencing Consortium; NYGC ALS Consortium
  TITLE     Whole-genome sequencing reveals that variants in the Interleukin 18
            Receptor Accessory Protein 3'UTR protect against ALS
  JOURNAL   Nat Neurosci 25 (4), 433-445 (2022)
   PUBMED   35361972
  REMARK    GeneRIF: Whole-genome sequencing reveals that variants in the
            Interleukin 18 Receptor Accessory Protein 3'UTR protect against
            ALS.
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Ouellette,T.W., Wright,G.E., Drogemoller,B.I., Ross,C.J. and
            Carleton,B.C.
  TITLE     Integrating disease and drug-related phenotypes for improved
            identification of pharmacogenomic variants
  JOURNAL   Pharmacogenomics 22 (5), 251-261 (2021)
   PUBMED   33769074
  REMARK    GeneRIF: Integrating disease and drug-related phenotypes for
            improved identification of pharmacogenomic variants.
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Li,S., Jiang,L., Beckmann,K., Hojen,J.F., Pessara,U., Powers,N.E.,
            de Graaf,D.M., Azam,T., Lindenberger,J., Eisenmesser,E.Z.,
            Fischer,S. and Dinarello,C.A.
  TITLE     A novel anti-human IL-1R7 antibody reduces IL-18-mediated
            inflammatory signaling
  JOURNAL   J Biol Chem 296, 100630 (2021)
   PUBMED   33823154
  REMARK    GeneRIF: A novel anti-human IL-1R7 antibody reduces IL-18-mediated
            inflammatory signaling.
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Fiszer,D., Rozwadowska,N., Rychlewski,L., Kosicki,W. and Kurpisz,M.
  TITLE     Identification of IL-18RAP mRNA truncated splice variants in human
            testis and the other human tissues
  JOURNAL   Cytokine 39 (3), 178-183 (2007)
   PUBMED   17897836
  REMARK    GeneRIF: Truncated forms of IL-18RAP may be involved in the complex
            mechanism of IL-18 activity regulation.
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Salvati,V.M., MacDonald,T.T., Bajaj-Elliott,M., Borrelli,M.,
            Staiano,A., Auricchio,S., Troncone,R. and Monteleone,G.
  TITLE     Interleukin 18 and associated markers of T helper cell type 1
            activity in coeliac disease
  JOURNAL   Gut 50 (2), 186-190 (2002)
   PUBMED   11788557
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Debets,R., Timans,J.C., Churakowa,T., Zurawski,S., de Waal
            Malefyt,R., Moore,K.W., Abrams,J.S., O'Garra,A., Bazan,J.F. and
            Kastelein,R.A.
  TITLE     IL-18 receptors, their role in ligand binding and function:
            anti-IL-1RAcPL antibody, a potent antagonist of IL-18
  JOURNAL   J Immunol 165 (9), 4950-4956 (2000)
   PUBMED   11046021
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Sareneva,T., Julkunen,I. and Matikainen,S.
  TITLE     IFN-alpha and IL-12 induce IL-18 receptor gene expression in human
            NK and T cells
  JOURNAL   J Immunol 165 (4), 1933-1938 (2000)
   PUBMED   10925275
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Mee,J.B., Alam,Y. and Groves,R.W.
  TITLE     Human keratinocytes constitutively produce but do not process
            interleukin-18
  JOURNAL   Br J Dermatol 143 (2), 330-336 (2000)
   PUBMED   10951141
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Born,T.L., Thomassen,E., Bird,T.A. and Sims,J.E.
  TITLE     Cloning of a novel receptor subunit, AcPL, required for
            interleukin-18 signaling
  JOURNAL   J Biol Chem 273 (45), 29445-29450 (1998)
   PUBMED   9792649
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007248.4 and AC007278.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is an accessory subunit
            of the heterodimeric receptor for interleukin 18 (IL18), a
            proinflammatory cytokine involved in inducing cell-mediated
            immunity. This protein enhances the IL18-binding activity of the
            IL18 receptor and plays a role in signaling by IL18. Mutations in
            this gene are associated with Crohn's disease and inflammatory
            bowel disease, and susceptibility to celiac disease and leprosy.
            Alternatively spliced transcript variants of this gene have been
            described, but their full-length nature is not known. [provided by
            RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069630.1, DRR138524.110584.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000687160.1/ ENSP00000510345.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC007248.4         195920-196107
            189-513             AC007248.4         196571-196895
            514-697             AC007248.4         196991-197174
            698-848             AC007278.4         8637-8787
            849-914             AC007278.4         12737-12802
            915-1038            AC007278.4         14625-14748
            1039-1190           AC007278.4         16614-16765
            1191-1328           AC007278.4         18495-18632
            1329-1502           AC007278.4         22273-22446
            1503-2302           AC007278.4         23191-23990
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..2302
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /note="interleukin 18 receptor accessory protein"
                     /db_xref="GeneID:8807"
                     /db_xref="HGNC:HGNC:5989"
                     /db_xref="MIM:604509"
     exon            1..188
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            189..513
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            514..697
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            698..848
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            849..914
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1038
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1190
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1328
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1502
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..2302
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /note="hexamer: AATAAA"
     polyA_site      2302
                     /gene="IL18RAP"
                     /gene_synonym="ACPL; CD218b; CDw218b; IL-18R-beta;
                     IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB"
                     /note="major polyA site"
ORIGIN      
        1 ccatttcttg atttacagaa atgaagggga tactcagggc agagttctga atctcaaaac
       61 actctactct ggcaaaggaa tgaagttatt ggagtgatga caggaacacg ggagaacaat
      121 gctctgtttg ggctggatat ttctttggct tgttgcagga gagcgaatta aaggatttaa
      181 tatttcaggt tgttccacaa aaaaactcct ttggacatat tctacaagga gtgaagagga
      241 atttgtctta ttttgtgatt taccagagcc acagaaatca catttctgcc acagaaatcg
      301 actctcacca aaacaagtcc ctgagcacct gcccttcatg ggtagtaacg acctatctga
      361 tgtccaatgg taccaacaac cttcgaatgg agatccatta gaggacatta ggaaaagcta
      421 tcctcacatc attcaggaca aatgtaccct tcactttttg accccagggg tgaataattc
      481 tgggtcatat atttgtagac ccaagatgat taagagcccc tatgatgtag cctgttgtgt
      541 caagatgatt ttagaagtta agccccagac aaatgcatcc tgtgagtatt ccgcatcaca
      601 taagcaagac ctacttcttg ggagcactgg ctctatttct tgccccagtc tcagctgcca
      661 aagtgatgca caaagtccag cggtaacctg gtacaagaat ggaaaactcc tctctgtgga
      721 aaggagcaac cgaatcgtag tggatgaagt ttatgactat caccagggca catatgtatg
      781 tgattacact cagtcggata ctgtgagttc gtggacagtc agagctgttg ttcaagtgag
      841 aaccattgtg ggagacacta aactcaaacc agatattctg gatcctgtcg aggacacact
      901 ggaagtagaa cttggaaagc ctttaactat tagctgcaaa gcacgatttg gctttgaaag
      961 ggtctttaac cctgtcataa aatggtacat caaagattct gacctagagt gggaagtctc
     1021 agtacctgag gcgaaaagta ttaaatccac tttaaaggat gaaatcattg agcgtaatat
     1081 catcttggaa aaagtcactc agcgtgatct tcgcaggaag tttgtttgct ttgtccagaa
     1141 ctccattgga aacacaaccc agtccgtcca actgaaagaa aagagaggag tggtgctcct
     1201 gtacatcctg cttggcacca tcgggaccct ggtggccgtg ctggcggcga gtgccctcct
     1261 ctacaggcac tggattgaaa tagtgctgct gtaccggacc taccagagca aggatcagac
     1321 gcttggggat aaaaaggatt ttgatgcttt cgtatcctat gcaaaatgga gctcttttcc
     1381 aagtgaggcc acttcatctc tgagtgaaga acacttggcc ctgagcctat ttcctgatgt
     1441 tttagaaaac aaatatggat atagcctgtg tttgcttgaa agagatgtgg ctccaggagg
     1501 agtgtatgca gaagacattg tgagcattat taagagaagc agaagaggaa tatttatctt
     1561 gagccccaac tatgtcaatg gacccagtat ctttgaacta caagcagcag tgaatcttgc
     1621 cttggatgat caaacactga aactcatttt aattaagttc tgttacttcc aagagccaga
     1681 gtctctacct catctcgtga aaaaagctct cagggttttg cccacagtta cttggagagg
     1741 cttaaaatca gttcctccca attctaggtt ctgggccaaa atgcgctacc acatgcctgt
     1801 gaaaaactct cagggattca cgtggaacca gctcagaatt acctctagga tttttcagtg
     1861 gaaaggactc agtagaacag aaaccactgg gaggagctcc cagcctaagg aatggtgaaa
     1921 tgagccctgg agccccctcc agtccagtcc ctgggataga gatgttgctg gacagaactc
     1981 acagctctgt gtgtgtgtgt tcaggctgat aggaaattca aagagtctcc tgccagcacc
     2041 aagcaagctt gatggacaat ggagtgggat tgagactgtg gtttagagcc tttgatttcc
     2101 tggactggac tgacggcgag tgaattctct agaccttggg tactttcagt acacaacacc
     2161 cctaagattt cccagtggtc cgagcagaat cagaaaatac agctacttct gccttatggc
     2221 tagggaactg tcatgtctac catgtattgt acatatgact ttatgtatac ttgcaatcaa
     2281 ataaatatta ttttattaga aa
//
