LOCUS       NM_003855               4149 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens interleukin 18 receptor 1 (IL18R1), transcript variant
            1, mRNA.
ACCESSION   NM_003855
VERSION     NM_003855.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4149)
  AUTHORS   Di,Y., Wang,Z., Xiao,J., Zhang,X., Ye,L., Wen,X., Qin,J., Lu,L.,
            Wang,X. and He,W.
  TITLE     ACSL6-activated IL-18R1-NF-kappaB promotes IL-18-mediated tumor
            immune evasion and tumor progression
  JOURNAL   Sci Adv 10 (38), eadp0719 (2024)
   PUBMED   39292786
  REMARK    GeneRIF: ACSL6-activated IL-18R1-NF-kappaB promotes IL-18-mediated
            tumor immune evasion and tumor progression.
REFERENCE   2  (bases 1 to 4149)
  AUTHORS   Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and
            Shao,F.
  TITLE     Recognition and maturation of IL-18 by caspase-4 noncanonical
            inflammasome
  JOURNAL   Nature 624 (7991), 442-450 (2023)
   PUBMED   37993714
REFERENCE   3  (bases 1 to 4149)
  AUTHORS   Abhilasha,A., Mitra,P., Suri,S., Saxena,I., Shukla,R., Shukla,K.K.
            and Sharma,P.
  TITLE     Increased expression of serum IL-18 and IL-18R in newly diagnosed
            type 2 diabetes mellitus
  JOURNAL   Minerva Endocrinol (Torino) 48 (1), 35-41 (2023)
   PUBMED   33103874
  REMARK    GeneRIF: Increased expression of serum IL-18 and IL-18R in newly
            diagnosed type 2 diabetes mellitus.
REFERENCE   4  (bases 1 to 4149)
  AUTHORS   Guo,Q., Wu,C.Y., Jiang,N., Tong,S., Wan,J.H., Xiao,X.Y., Mei,P.Y.,
            Liu,H.S. and Wang,S.H.
  TITLE     Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer
            proliferation and migration and is associated with dismal prognosis
            and immunity in lung squamous cell carcinoma
  JOURNAL   Front Immunol 13, 986447 (2022)
   PUBMED   36544782
  REMARK    GeneRIF: Downregulation of T-cell cytotoxic marker IL18R1 promotes
            cancer proliferation and migration and is associated with dismal
            prognosis and immunity in lung squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4149)
  AUTHORS   Ponasenko,A.V., Tsepokina,A.V., Khutornaya,M.V., Sinitsky,M.Y. and
            Barbarash,O.L.
  TITLE     IL18-family Genes Polymorphism Is Associated with the Risk of
            Myocardial Infarction and IL18 Concentration in Patients with
            Coronary Artery Disease
  JOURNAL   Immunol Invest 51 (4), 802-816 (2022)
   PUBMED   33522333
  REMARK    GeneRIF: IL18-family Genes Polymorphism Is Associated with the Risk
            of Myocardial Infarction and IL18 Concentration in Patients with
            Coronary Artery Disease.
REFERENCE   6  (bases 1 to 4149)
  AUTHORS   Hoshino,K., Tsutsui,H., Kawai,T., Takeda,K., Nakanishi,K.,
            Takeda,Y. and Akira,S.
  TITLE     Cutting edge: generation of IL-18 receptor-deficient mice: evidence
            for IL-1 receptor-related protein as an essential IL-18 binding
            receptor
  JOURNAL   J Immunol 162 (9), 5041-5044 (1999)
   PUBMED   10227969
REFERENCE   7  (bases 1 to 4149)
  AUTHORS   Dale,M. and Nicklin,M.J.
  TITLE     Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1,
            IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human
            chromosome 2q
  JOURNAL   Genomics 57 (1), 177-179 (1999)
   PUBMED   10191101
REFERENCE   8  (bases 1 to 4149)
  AUTHORS   Torigoe,K., Ushio,S., Okura,T., Kobayashi,S., Taniai,M.,
            Kunikata,T., Murakami,T., Sanou,O., Kojima,H., Fujii,M., Ohta,T.,
            Ikeda,M., Ikegami,H. and Kurimoto,M.
  TITLE     Purification and characterization of the human interleukin-18
            receptor
  JOURNAL   J Biol Chem 272 (41), 25737-25742 (1997)
   PUBMED   9325300
REFERENCE   9  (bases 1 to 4149)
  AUTHORS   Lovenberg,T.W., Crowe,P.D., Liu,C., Chalmers,D.T., Liu,X.J.,
            Liaw,C., Clevenger,W., Oltersdorf,T., De Souza,E.B. and Maki,R.A.
  TITLE     Cloning of a cDNA encoding a novel interleukin-1 receptor related
            protein (IL 1R-rp2)
  JOURNAL   J Neuroimmunol 70 (2), 113-122 (1996)
   PUBMED   8898719
REFERENCE   10 (bases 1 to 4149)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007248.4.
            
            On Aug 29, 2019 this sequence version replaced NM_003855.4.
            
            Summary: The protein encoded by this gene is a cytokine receptor
            that belongs to the interleukin 1 receptor family. This receptor
            specifically binds interleukin 18 (IL18), and is essential for IL18
            mediated signal transduction. IFN-alpha and IL12 are reported to
            induce the expression of this receptor in NK and T cells. This gene
            along with four other members of the interleukin 1 receptor family,
            including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form
            a gene cluster on chromosome 2q. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1105771.1,
                                           SRR11853560.16320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233957.7/ ENSP00000233957.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-605               AC007248.4         128556-129160
            606-691             AC007248.4         135393-135478
            692-935             AC007248.4         140585-140828
            936-1101            AC007248.4         144713-144878
            1102-1258           AC007248.4         148667-148823
            1259-1321           AC007248.4         154380-154442
            1322-1442           AC007248.4         157638-157758
            1443-1582           AC007248.4         159621-159760
            1583-1744           AC007248.4         162816-162977
            1745-1903           AC007248.4         167229-167387
            1904-4149           AC007248.4         169291-171536
FEATURES             Location/Qualifiers
     source          1..4149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..4149
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /note="interleukin 18 receptor 1"
                     /db_xref="GeneID:8809"
                     /db_xref="HGNC:HGNC:5988"
                     /db_xref="MIM:604494"
     exon            1..605
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            606..691
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..2259
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /EC_number="3.2.2.6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL1 receptor-related protein; cytokine
                     receptor; CD218 antigen-like family member A;
                     interleukin-18 receptor alpha"
                     /codon_start=1
                     /product="interleukin-18 receptor 1 isoform 1 precursor"
                     /protein_id="NP_003846.1"
                     /db_xref="CCDS:CCDS2060.1"
                     /db_xref="GeneID:8809"
                     /db_xref="HGNC:HGNC:5988"
                     /db_xref="MIM:604494"
                     /translation="MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCS
                     LAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKN
                     YTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKK
                     LLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLL
                     GPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKW
                     HASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIA
                     VLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEE
                     HTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSN
                     EVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSY
                     NSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES"
     exon            692..935
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1101
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1258
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1321
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1442
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1582
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1744
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1903
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..4149
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /note="hexamer: AATACA"
     polyA_site      4149
                     /gene="IL18R1"
                     /gene_synonym="CD218a; CDw218a; IL-18R-alpha; IL-18Ralpha;
                     IL-1Rrp; IL18RA; IL18Ralpha2; IL1RRP"
                     /note="major polyA site"
ORIGIN      
        1 gggacccgcg ccgcgcggct gggcaggaag cgccagacgc ctggggccca cgccgtccgc
       61 gggaaaaggg caaggcgctg ggttttccag cagcaacctt tggaccccgc gatccagtag
      121 ctccggtaac tccacgcggg gcgtctgggt ggaggagccg gtcctggagc acggctgcga
      181 ggagcacccg gaccggaggg tccccagacc gggacctccg agtcagggag gattctacgc
      241 cagggagcgc cccagactga gagcgcccca gaccgctaca ctcccggacc cggagcttcg
      301 cccgaccgcg ggcagtgccc acctgcagcc tccaccggcc ggggttagca gccaggagct
      361 gccagacgcc tgacattctt ctttctgttc ctactttttt tccttcttct tctttttttt
      421 tttttttgta gccctctctg ggtgccttat ctctttaatc acacctctct ttcactttcc
      481 acggtagtca ggaggcggag atcgctgctt ctcacctact ttctgaactt ggcctccgca
      541 gtcgcgacct ggcgtgaagg aggagctgcc gcccccgccc cagcctcggg gacgcctctc
      601 tgaagagaag ccatttgaag cagaatccaa accatgaatt gtagagaatt acccttgacc
      661 ctttgggtgc ttatatctgt aagcactgca gaatcttgta cttcacgtcc ccacattact
      721 gtggttgaag gggaaccttt ctatctgaaa cattgctcgt gttcacttgc acatgagatt
      781 gaaacaacca ccaaaagctg gtacaaaagc agtggatcac aggaacatgt ggagctgaac
      841 ccaaggagtt cctcgagaat tgctttgcat gattgtgttt tggagttttg gccagttgag
      901 ttgaatgaca caggatctta ctttttccaa atgaaaaatt atactcagaa atggaaatta
      961 aatgtcatca gaagaaataa acacagctgt ttcactgaaa gacaagtaac tagtaaaatt
     1021 gtggaagtta aaaaattttt tcagataacc tgtgaaaaca gttactatca aacactggtc
     1081 aacagcacat cattgtataa gaactgtaaa aagctactac tggagaacaa taaaaaccca
     1141 acgataaaga agaacgccga gtttgaagat caggggtatt actcctgcgt gcatttcctt
     1201 catcataatg gaaaactatt taatatcacc aaaaccttca atataacaat agtggaagat
     1261 cgcagtaata tagttccggt tcttcttgga ccaaagctta accatgttgc agtggaatta
     1321 ggaaaaaacg taaggctcaa ctgctctgct ttgctgaatg aagaggatgt aatttattgg
     1381 atgttcgggg aagaaaatgg atcggatcct aatatacatg aagagaaaga aatgagaatt
     1441 atgactccag aaggcaaatg gcatgcttca aaagtattga gaattgaaaa tattggtgaa
     1501 agcaatctaa atgttttata taattgcact gtggccagca cgggaggcac agacaccaaa
     1561 agcttcatct tggtgagaaa agcagacatg gctgatatcc caggccacgt cttcacaaga
     1621 ggaatgatca tagctgtttt gatcttggtg gcagtagtgt gcctagtgac tgtgtgtgtc
     1681 atttatagag ttgacttggt tctattttat agacatttaa cgagaagaga tgaaacatta
     1741 acagatggaa aaacatatga tgcttttgtg tcttacctaa aagaatgccg acctgaaaat
     1801 ggagaggagc acacctttgc tgtggagatt ttgcccaggg tgttggagaa acattttggg
     1861 tataagttat gcatatttga aagggatgta gtgcctggag gagctgttgt tgatgaaatc
     1921 cactcactga tagagaaaag ccgaagacta atcattgtcc taagtaaaag ttatatgtct
     1981 aatgaggtca ggtatgaact tgaaagtgga ctccatgaag cattggtgga aagaaaaatt
     2041 aaaataatct taattgaatt tacacctgtt actgacttca cattcttgcc ccaatcacta
     2101 aagcttttga aatctcacag agttctgaag tggaaggccg ataaatctct ttcttataac
     2161 tcaaggttct ggaagaacct tctttactta atgcctgcaa aaacagtcaa gccaggtaga
     2221 gacgaaccgg aagtcttgcc tgttctttcc gagtcttaat cttcagaaac agtgaacgcc
     2281 aaaaagaact caagatattc tggggactga gcatatgaac ctgttcataa caaaggctgt
     2341 gactcgaaat aattaacttt gtcaaaatcc tgctcacaat ttgaagatga aacttgtcat
     2401 taggttggcg ggaatgagac taaagattgc gctgtgggct gtggtcacgt gctcccagaa
     2461 gacctggaat tcaaaagaaa tggagctatt ctttttctcc ctctttcata actggatgca
     2521 gctgctcata ctcaatccca tattcagcaa gtgtgaagct ggacgtgatg caaaataacc
     2581 gatgccctac aaaaagggcg catctttaag agttttaatg ccagtgctta attcgaatga
     2641 ggggatttta agtgtctgaa gaggcatttt ctagggacca gtgggtgact gagtaactga
     2701 aatgctgctt tcactcccta acaccatgga tctggttgtg cataggatgt gggaggaggg
     2761 gctggcaggg ccgccttcag aggctgcagg gcctcagcct caggatgcat ttaatgtatc
     2821 ctggccacag ttgcagccaa cggttcttga aagctcggta aggccctgca acgcagagcc
     2881 tgcttatgtg gatctattta tgggaacttc ttaaaaggac cccagaatag ctctttatct
     2941 ttcacaagag acacaaattc taattgagtt aattatctgg gcctttcact ttggatgctc
     3001 tgaaacattt gttgattttg tgtgaatgtt tatatcaaaa tgtttgccag gttgtattag
     3061 ccattgaata gcaaaaaact gatagttact tgcttgtttt ttaaaaatta catattaaaa
     3121 atgcccttgg cataaggcag catggtgtgg cagttaagag atgggctgtg cagcccatcc
     3181 tgagctccag tcctgagttt gctacttact tctgtggcct ctggaacctt atccaacctc
     3241 ttggtgcttc agtttcctca tctgtgaaat tagaatttat aataattgca cctacctccc
     3301 aggggtaact aaatgaataa atataataaa gtacttacag tggttcctga cacagactca
     3361 gcactccgtc agtgttgcca tgactatttt tattatcatt attaatgatt acttagatca
     3421 attatttagc agtggactaa tggaagctac agagcaggga agggaagcag atctagggag
     3481 gaaggcagtt ttgatttgag gaggtttgca catgtagaga agcatactgg agaagcatat
     3541 ccagagggcg aaagatatct ctccattgtg catctgcctc ttttgacgtt ggaagacaca
     3601 tgtcttaccc cccaaaggga gcccagcact gggagccttc ttgatgatct caaaaataat
     3661 agctattcaa gaaaatcacc aagtgactgt gaaaccgtca gttcggaagg ctggttagaa
     3721 catgtgggag caacatgaat gttctacaaa agtttaaagc agagattgtt tcaaatgggt
     3781 gtagtagata ttactgaaaa ccaaaaaaga gtgagattgt cagtgtaaga atgtgattta
     3841 atgtttgtag tgcttacaat tttgtgtacc aactggatga ctaaaaagag taaaataatt
     3901 taattaatag ctcatatttt atgtgtgaaa acatgttagt gaacatatat aatcaaaata
     3961 gatttcattg ctattgcata gtctctaata catagaatga ttttgctttt ctcttttatt
     4021 atacttgctt taaaatactt gaaatatatt ttgcattaaa tgcatttcaa gttaaatgtc
     4081 ttaaatgtat acattagatg tgtgttttaa aatgcataaa acacgttgaa atacattaat
     4141 gaaccatta
//
