LOCUS       NM_001039660            1697 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens interleukin 18 binding protein (IL18BP), transcript
            variant F, mRNA.
ACCESSION   NM_001039660
VERSION     NM_001039660.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Min,H.K., Kim,S.H., Lee,J.Y., Lee,S.H. and Kim,H.R.
  TITLE     Interleukin-18 binding protein regulates the apoptosis and
            necroptosis of fibroblast-like synoviocytes and chondrocytes in
            rheumatoid arthritis
  JOURNAL   Clin Exp Rheumatol 41 (11), 2207-2215 (2023)
   PUBMED   37083154
  REMARK    GeneRIF: Interleukin-18 binding protein regulates the apoptosis and
            necroptosis of fibroblast-like synoviocytes and chondrocytes in
            rheumatoid arthritis.
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Wang,X., Wang,L., Wen,X., Zhang,L., Jiang,X. and He,G.
  TITLE     Interleukin-18 and IL-18BP in inflammatory dermatological diseases
  JOURNAL   Front Immunol 14, 955369 (2023)
   PUBMED   36742296
  REMARK    GeneRIF: Interleukin-18 and IL-18BP in inflammatory dermatological
            diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Sismanlar Eyuboglu,T., Aslan,A.T., Ramasli Gursoy,T., Pekcan,S.,
            Kose,M., Hangul,M., Aral,L.A. and Bulut,V.
  TITLE     Caspase-1 and interleukin-18 in children with post infectious
            bronchiolitis obliterans: a case-control study
  JOURNAL   Eur J Pediatr 181 (8), 3093-3101 (2022)
   PUBMED   35705877
  REMARK    GeneRIF: Caspase-1 and interleukin-18 in children with post
            infectious bronchiolitis obliterans: a case-control study.
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Detry,S., Andries,J., Bloch,Y., Gabay,C., Clancy,D.M. and
            Savvides,S.N.
  TITLE     Structural basis of human IL-18 sequestration by the decoy receptor
            IL-18 binding protein in inflammation and tumor immunity
  JOURNAL   J Biol Chem 298 (5), 101908 (2022)
   PUBMED   35398099
  REMARK    GeneRIF: Structural basis of human IL-18 sequestration by the decoy
            receptor IL-18 binding protein in inflammation and tumor immunity.
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Corbaz,A., ten Hove,T., Herren,S., Graber,P., Schwartsburd,B.,
            Belzer,I., Harrison,J., Plitz,T., Kosco-Vilbois,M.H., Kim,S.H.,
            Dinarello,C.A., Novick,D., van Deventer,S. and Chvatchko,Y.
  TITLE     IL-18-binding protein expression by endothelial cells and
            macrophages is up-regulated during active Crohn's disease
  JOURNAL   J Immunol 168 (7), 3608-3616 (2002)
   PUBMED   11907126
  REMARK    GeneRIF: IL-18BP messenger transcript and protein are significantly
            increased in surgically resected specimens from active Crohn's
            disease compared with control patients, correlating with an
            up-regulation of IL-18.
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Paulukat,J., Bosmann,M., Nold,M., Garkisch,S., Kampfer,H.,
            Frank,S., Raedle,J., Zeuzem,S., Pfeilschifter,J. and Muhl,H.
  TITLE     Expression and release of IL-18 binding protein in response to
            IFN-gamma
  JOURNAL   J Immunol 167 (12), 7038-7043 (2001)
   PUBMED   11739524
  REMARK    GeneRIF: trancriptional activation and release of IL-18 binding
            protein in response to IFN-gamma
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Kim,S.H., Eisenstein,M., Reznikov,L., Fantuzzi,G., Novick,D.,
            Rubinstein,M. and Dinarello,C.A.
  TITLE     Structural requirements of six naturally occurring isoforms of the
            IL-18 binding protein to inhibit IL-18
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1190-1195 (2000)
   PUBMED   10655506
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Xiang,Y. and Moss,B.
  TITLE     Identification of human and mouse homologs of the MC51L-53L-54L
            family of secreted glycoproteins encoded by the Molluscum
            contagiosum poxvirus
  JOURNAL   Virology 257 (2), 297-302 (1999)
   PUBMED   10329540
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Aizawa,Y., Akita,K., Taniai,M., Torigoe,K., Mori,T., Nishida,Y.,
            Ushio,S., Nukada,Y., Tanimoto,T., Ikegami,H., Ikeda,M. and
            Kurimoto,M.
  TITLE     Cloning and expression of interleukin-18 binding protein
  JOURNAL   FEBS Lett 445 (2-3), 338-342 (1999)
   PUBMED   10094485
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
            Rubinstein,M.
  TITLE     Interleukin-18 binding protein: a novel modulator of the Th1
            cytokine response
  JOURNAL   Immunity 10 (1), 127-136 (1999)
   PUBMED   10023777
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002490.4, BX357194.2,
            CB154498.1, AF110799.1 and AW295729.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001039660.1.
            
            Summary: The protein encoded by this gene functions as an inhibitor
            of the proinflammatory cytokine, IL18. It binds IL18, prevents the
            binding of IL18 to its receptor, and thus inhibits IL18-induced
            IFN-gamma production, resulting in reduced T-helper type 1 immune
            responses. This protein is constitutively expressed and secreted in
            mononuclear cells. Elevated level of this protein is detected in
            the intestinal tissues of patients with Crohn's disease.
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Feb 2011].
            
            Transcript Variant: This variant (F) differs in the 5' UTR compared
            to variant A. Variants A, E, F and G encode the same isoform (a,
            also known as IL-18BPa).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.377351.1,
                                           SRR5189655.25064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393703.9/ ENSP00000377306.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AP002490.4         88133-88135
            4-111               BX357194.2         21-128
            112-562             CB154498.1         112-562
            563-1349            AF110799.1         453-1239
            1350-1421           AW295729.1         16-87               c
            1422-1697           AP002490.4         91753-92028
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1697
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /note="interleukin 18 binding protein"
                     /db_xref="GeneID:10068"
                     /db_xref="HGNC:HGNC:5987"
                     /db_xref="MIM:604113"
     exon            1..111
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /inference="alignment:Splign:2.1.0"
     exon            112..197
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..754
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /note="isoform a precursor is encoded by transcript
                     variant F; MC51L-53L-54L homolog gene product;
                     tadekinig-alfa"
                     /codon_start=1
                     /product="interleukin-18-binding protein isoform a
                     precursor"
                     /protein_id="NP_001034749.1"
                     /db_xref="CCDS:CCDS8206.2"
                     /db_xref="GeneID:10068"
                     /db_xref="HGNC:HGNC:5987"
                     /db_xref="MIM:604113"
                     /translation="MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASV
                     RSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLG
                     NGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQ
                     RHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG"
     exon            198..404
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /inference="alignment:Splign:2.1.0"
     exon            405..528
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /inference="alignment:Splign:2.1.0"
     exon            529..676
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1697
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /note="hexamer: CATAAA"
     polyA_site      1420
                     /gene="IL18BP"
                     /gene_synonym="FVH; IL18BPa"
                     /note="major polyA site"
ORIGIN      
        1 gtatttcctg tggtgggttc acacgcagct agacacagct aacttgagtc ttggagctcc
       61 tagagggaag cttctggaaa ggaaggctct tcaggacctc ttaggagcca gagaagagga
      121 cgttgtcaca gataaagagc caggctcacc agctcctgac gcatgcatca tgaccatgag
      181 acacaactgg acaccagacc tcagcccttt gtgggtcctg ctcctgtgtg cccacgtcgt
      241 cactctcctg gtcagagcca cacctgtctc gcagaccacc acagctgcca ctgcctcagt
      301 tagaagcaca aaggacccct gcccctccca gcccccagtg ttcccagcag ctaagcagtg
      361 tccagcattg gaagtgacct ggccagaggt ggaagtgcca ctgaatggaa cgctgagctt
      421 atcctgtgtg gcctgcagcc gcttccccaa cttcagcatc ctctactggc tgggcaatgg
      481 ttccttcatt gagcacctcc caggccgact gtgggagggg agcaccagcc gggaacgtgg
      541 gagcacaggt acgcagctgt gcaaggcctt ggtgctggag cagctgaccc ctgccctgca
      601 cagcaccaac ttctcctgtg tgctcgtgga ccctgaacag gttgtccagc gtcacgtcgt
      661 cctggcccag ctctgggctg ggctgagggc aaccttgccc cccacccaag aagccctgcc
      721 ctccagccac agcagtccac agcagcaggg ttaagactca gcacagggcc agcagcagca
      781 caaccttgac cagagcttgg gtcctacctg tctacctgga gtgaacagtc cctgactgcc
      841 tgtaggctgc gtggatgcgc aacacacccc ctccttctct gctttgggtc ccttctctca
      901 ccaaattcaa actccattcc cacctaccta gaaaatcaca gcctccttat aatgcctcct
      961 cctcctgcca ttctctctcc acctatccat tagccttcct aacgtcctac tcctcacact
     1021 gctctactgc tcagaaacca ccaagactgt tgatgcctta gccttgcact ccagggccct
     1081 acctgcattt cccacatgac tttctggaag cctcccaact attcttgctt ttcccagaca
     1141 gctcccactc ccatgtctct gctcatttag tcccgtcttc ctcaccgccc cagcagggga
     1201 acgctcaagc ctggttgaaa tgctgcctct tcagtgaagt catcctcttt cagctctggc
     1261 cgcattctgc agacttccta tcttcgtgct gtatgttttt tttttccccc ttcactctaa
     1321 tggactgttc cagggaaggg atgggggcag cagctgcttc ggatccacac tgtatctgtg
     1381 tcatccccac atgggtcctc ataaaggatt attcaatgga ggcatcctga catctgttca
     1441 tttaggcttc agttccactc ccaggaactt tgcctgtccc acgagggagt atgggagaga
     1501 gggactgcca cacagaagct gaagacaaca cctgcttcag gggaacacag gcgcttgaaa
     1561 aagaaaagag agaacagccc ataatgctcc ccgggagcag aggccactaa tggagagtgg
     1621 gaagagcctg gaaagatgtg gcctcaggaa aagggatgag agaaaggagg tggtatggaa
     1681 gactcagcag gaacaag
//
