LOCUS       NM_001371417            6507 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens interleukin 17 receptor E like (IL17REL), transcript
            variant 3, mRNA.
ACCESSION   NM_001371417
VERSION     NM_001371417.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6507)
  AUTHORS   Dong,Z., Li,Y., Zhou,J., Jiang,S., Wang,Y., Chen,Y., Zhao,D.,
            Yang,C., Qian,Q., Ma,Y., He,H., Ji,H., Yang,Y., Wang,X., Xu,X.,
            Pang,Y., Zou,H., Jin,L., Zhang,F. and Wang,J.
  TITLE     Copy number variants of ABCF1, IL17REL, and FCGR3A are associated
            with the risk of gout
  JOURNAL   Protein Cell 8 (6), 467-470 (2017)
   PUBMED   28405828
  REMARK    GeneRIF: The high copy number variant in the ABCF1 gene was the
            strongest risk factor for gout (OR = 5.70), while a low copy number
            variant in the IL17REL gene was the strongest protective factor
            against gout (OR = 0.15)
REFERENCE   2  (bases 1 to 6507)
  AUTHORS   Sasaki,M.M., Skol,A.D., Hungate,E.A., Bao,R., Huang,L., Kahn,S.A.,
            Allan,J.M., Brant,S.R., McGovern,D.P., Peter,I., Silverberg,M.S.,
            Cho,J.H., Kirschner,B.S. and Onel,K.
  TITLE     Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in
            Familial and Sporadic Inflammatory Bowel Disease
  JOURNAL   Inflamm Bowel Dis 22 (1), 20-27 (2016)
   PUBMED   26480299
  REMARK    GeneRIF: Rare Il17REL Variants are associated with Familial and
            Sporadic Inflammatory Bowel Disease.
REFERENCE   3  (bases 1 to 6507)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6507)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   5  (bases 1 to 6507)
  AUTHORS   Franke,A., Balschun,T., Sina,C., Ellinghaus,D., Hasler,R., Mayr,G.,
            Albrecht,M., Wittig,M., Buchert,E., Nikolaus,S., Gieger,C.,
            Wichmann,H.E., Sventoraityte,J., Kupcinskas,L., Onnie,C.M.,
            Gazouli,M., Anagnou,N.P., Strachan,D., McArdle,W.L., Mathew,C.G.,
            Rutgeerts,P., Vermeire,S., Vatn,M.H., Krawczak,M., Rosenstiel,P.,
            Karlsen,T.H. and Schreiber,S.
  CONSRTM   IBSEN study group
  TITLE     Genome-wide association study for ulcerative colitis identifies
            risk loci at 7q22 and 22q13 (IL17REL)
  JOURNAL   Nat Genet 42 (4), 292-294 (2010)
   PUBMED   20228798
  REMARK    GeneRIF: We performed a genome-wide association analysis of
            ulcerative colitis and discovered new associations in il17rel
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022327.17.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695950.1/ ENSP00000512282.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL022327.17        25254-25474         c
            222-249             AL022327.17        21346-21373         c
            250-399             AL022327.17        13791-13940         c
            400-509             AL022327.17        13463-13572         c
            510-624             AL022327.17        13187-13301         c
            625-669             AL022327.17        12905-12949         c
            670-809             AL022327.17        12537-12676         c
            810-881             AL022327.17        12140-12211         c
            882-936             AL022327.17        12000-12054         c
            937-1109            AL022327.17        10846-11018         c
            1110-1154           AL022327.17        10734-10778         c
            1155-1212           AL022327.17        10394-10451         c
            1213-1376           AL022327.17        10029-10192         c
            1377-1457           AL022327.17        9703-9783           c
            1458-6507           AL022327.17        4520-9569           c
FEATURES             Location/Qualifiers
     source          1..6507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..6507
                     /gene="IL17REL"
                     /note="interleukin 17 receptor E like"
                     /db_xref="GeneID:400935"
                     /db_xref="HGNC:HGNC:33808"
                     /db_xref="MIM:613414"
     exon            1..221
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1643
                     /gene="IL17REL"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; putative interleukin-17 receptor E-like;
                     IL-17RE-like; IL-17 receptor E-like; interleukin-17
                     receptor E-like protein"
                     /codon_start=1
                     /product="interleukin-17 receptor E-like protein isoform 3
                     precursor"
                     /protein_id="NP_001358346.1"
                     /db_xref="CCDS:CCDS93182.1"
                     /db_xref="GeneID:400935"
                     /db_xref="HGNC:HGNC:33808"
                     /db_xref="MIM:613414"
                     /translation="MLAGQALAFLGLTWGTFQSLAIPRITECGLSCSQGFACRSHRNR
                     NIFNSFCRPRPVSMSRSVLEALTSSTAMQCVPSDGCAMLLRVRASITLHERLRGLEAC
                     AMSLDTQETQCQSVWVARASHRQQGGQQLQVHFGCFAVSVAQHLYVTLRTIPHFCGVQ
                     LDQRHLVEDCGEEDVGRSVPDCLAGKLSYWVDRRRKAILVQVPRASGSPDYYLRLCLK
                     RFTCEDAGAPVRVTANSVSQAVFLPYSQELPCLCLEGWSATPDAVRIQICPFENDTEA
                     LEVLWDTVYYHPESQTLSWEPACPVSGHVSLCWRPGPGAGCRKLQQSSQLVHRRVQYP
                     LVDTQPQLCLKFSTSWGSWVRCPFEQRRFPTWKMTIQPSPTKGHLRVTFFSSSPAHFQ
                     VHLCHRRKSQLPACQRTLQASPLPSASGDLAAAPAFAFLDLPREEACAPGICIQGWRT
                     DVHFSVPQQLCNLRSSGCPSLRGRRRPRTRPRPPTAGWAWRALNRRLGGGNGETIRP"
     exon            222..249
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            250..399
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            400..509
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            510..624
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            625..669
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            670..809
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            810..881
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            882..936
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1109
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1154
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1212
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1376
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1457
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..6507
                     /gene="IL17REL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6485..6490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17REL"
                     /note="hexamer: AATAAA"
     polyA_site      6507
                     /gene="IL17REL"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttgtct ttggggctgg agctgcaggg tcagcctgga gccgctgcca cagggcatcc
       61 tgcaaacttg ccccactcac atccacgctt accagtggga gctctcactg cacagccaga
      121 tgctggctgg gcaagcactc gcgttcttgg gcctgacctg gggcactttc cagagcctgg
      181 ccatcccccg gattacagaa tgtggcctct cctgttctca gggctttgcc tgcaggagcc
      241 acaggaaccg gaacattttt aacagcttct gccggccacg ccccgtgtcc atgtccaggt
      301 cagtcctgga ggccctgacg tcctccactg ccatgcagtg tgtcccctct gacggctgcg
      361 cgatgctcct gcgtgtacgc gcctccatca ccctgcatga gcgcctgcgg ggcctggagg
      421 cctgtgccat gagcctggac acccaggaga cgcagtgtca gagcgtgtgg gtggccaggg
      481 cctcccaccg gcagcagggg gggcagcagc tccaagtgca ctttggctgc tttgcggtga
      541 gcgtggccca gcacctctat gtcaccctga ggaccatccc tcatttctgc ggggtccagc
      601 tggaccagag gcacctcgtg gaagactgcg gagaggagga cgtggggagg agcgtgcccg
      661 actgcctcgc ggggaagctc agctactggg tggaccggag gcgcaaggcg attctggtgc
      721 aagtgcccag ggcctccggg agccccgact actacctgcg gctctgcctc aagcggttca
      781 cctgcgagga cgccggcgcc cctgtgcgag tgaccgccaa cagcgtctcc caggccgtct
      841 tcctgcccta cagccaggag ctgccgtgcc tgtgcctgga gggctggtct gcgacccctg
      901 acgcggtgcg gatccagatc tgcccctttg aaaacgacac tgaggcactg gaggtgctgt
      961 gggacacggt ctactaccac ccggagagcc agacactgag ctgggagccc gcctgccctg
     1021 tgagtggcca tgtgagcctg tgctggcgcc cggggccggg ggccggctgc cgtaagctgc
     1081 agcaatccag ccagctggtg catcgcagag tgcagtaccc gctggtggac acccagcccc
     1141 agctctgcct gaagttctct accagttggg ggtcctgggt gcggtgccct ttcgaacagc
     1201 gtcgcttccc aacctggaaa atgaccatcc agccttcgcc cacaaagggc cacctccggg
     1261 tcaccttctt ctcgtccagc cccgcccact tccaggtgca cctgtgtcac aggaggaagt
     1321 cacagctccc tgcctgccaa cgcacactcc aggccagccc gctcccttca gcctcaggtg
     1381 acctggcagc cgcccctgct tttgccttcc tagaccttcc cagggaggag gcctgtgccc
     1441 caggcatctg catccagggc tggaggaccg atgtacactt ctccgtcccc cagcagctct
     1501 gcaacctccg ctccagtggg tgcccatctc tcaggggccg caggaggccg aggactagac
     1561 ctaggcctcc cacggcaggc tgggcgtggc gtgcactgaa caggagactg ggtgggggaa
     1621 acggggagac catccggccc tgagtcaggt caggcttctg cgccaaaccc aggtctgtgc
     1681 ccagcactgc cctccagcct tgcatttccc tccaccacac accgctgggc ctcccgcacg
     1741 cccaccctgg tctcactgtc actggccttg cctcctcctc cctgggggtc caccttccct
     1801 gatcagagct ctggttccaa ccgccagtga cttgggatgt ccctttgccc accagccact
     1861 gaggcccagg ctcccaggac ccagggtaca tcaggacagg actctgccca gtggacagaa
     1921 ctaagcacat gtggcctggg tgtggtcagg agcgtggctc tgccttggag tccaggaagg
     1981 gtcagagctg gcactcctac ctgcacccct ccctgtgagc aaaagagctt gcctagcttc
     2041 gggtggggtg aaccgcaaca gccacagagg tgggaggggt gggagggggt ggataggaca
     2101 gcctggcacc cagggcctct ggagaccctt tccagggagc accagtgggc caggcagggg
     2161 tctctggaat gtctcctcag ctcagctgag ccacagccat ttcagggcag cctgctgccc
     2221 acaggacatg cccagggccg tggcagtacc cgcagacctt cagctccccc ttctcccagc
     2281 aagacttttt ggccaagcct aggtccccct ccctagcaaa ggtcacctcc agcagatcac
     2341 agactaaagg ggcaatggcc acctgctggt caggtgtccc tggggctggc acctgccact
     2401 gtggagtgcc catgctatgc tgggcaagtc cacggcccca gggacaggcc tggaggcagc
     2461 aggaggaccg ggcctggctc aggtgggggg atctgggggt catacacact cctcttgggg
     2521 ccagggtggg ctcctccttc acttgtctgc tgagcctccc tgcagatgga aggctgctgt
     2581 ccacagccac tggcacccca ggactgggca gccccctccc cttccctcac atgtctcagc
     2641 ctcgcacagt gggggcaggg ctgggaggtg gtgtcccagc cagtaccacc cctacgtctc
     2701 tctccagctg cacccaccca catgggacgg cagcctgagg ccaggaatct cctcacgaac
     2761 aagtaggtgc cagggacaca ttgctggggg gcaggaggcc aaggcacagc ctcggacagc
     2821 tgagccaggc ccccctccga gagtgtgggg tgttctcacc tgactgtggg gcctaggcac
     2881 ctgctggctg tcctggggct acagctccat ggggccctca ggggctctgg gtcacataaa
     2941 agaccttcag ccctgtcctg agtcccctgg gaacagcagg agctgggtgg gctacccctt
     3001 ccccggatgg cccaggtgct ggaccccagc ctccctctca gacaattcat ggtcatggcc
     3061 actgtccctg gccctgaaga caaggccctg gcagctgcct ggagcttccc cagtgctctg
     3121 gggtgcaggg tgcaacccca cccttcctgt agctgatcag gcccgaggtg gtcaaggatc
     3181 accccagttt ctgcccaggg caccccacac tggctggagt ccacctctcc tgtctgtgca
     3241 tccttgggtg ctgagcttca ctggggcacc cgccccactc ggacccctcc agagggtctc
     3301 agcttcccca gatcccagcc ccactcaccc agcaacggtc agtcacttcc tgtggtctca
     3361 gaggccacct gcctgggggc cacctgctgg gatgtgcggt tctcagacat tccaagtggc
     3421 acatccaggt cccagccagg ggtgcccagc agtggcctgt gcagtgggcc atggggtcgg
     3481 cccttgaaga cttctcgtgt gggtcacgta ggctctccgg cttccccgct gagccaccct
     3541 ctggagcctg gacatcgtct cacctgagtg ctgtgcagga ccacatgccc agcctgtccc
     3601 agcggtggtc gcaccccatc tgcagatgca ctcccaccgc agtctgggcc caggctgccc
     3661 tcttccagct ggccgtgggc cgctgggcct tcttttccct cctgcaacag aggctgctat
     3721 gtcccataga ctggagaggg ggctgcagag cgagtaagtc cccgccactc agtaaacatt
     3781 ggtccagggg tagctgttaa aatggagctt gggcctggct ggatggtgac ggcaccaggg
     3841 acaagtctgg agtgcgggtg tcgtggagcc atccccacca ggctggaccc aagagcaccc
     3901 caaaggcgtg ggaggccgca cccccatggg catgtggggg gcagggagca ccttgggact
     3961 caggggaggt gccgggtctc tgggagtgga tttgaggtca gcgtcacatg gtgtgaccag
     4021 acatccccat ccaagtgtcc ccataaagga ccagtggtgg agacaccctg gggatgcgga
     4081 ggtcaggcca ggtgaggggc tttagaagct gggtttgagc accaggggca gggaggccag
     4141 tggggggcat ggacagggtg tccctcccta acctggagat caggggcatg gggggatgca
     4201 ggctgccact cgcccaggtg cccttcccta acctggagat caggggaatg gggggataca
     4261 ggctgccact cacccaggtg cccctcccta gcctggggga ggtcaggggc acagtggggg
     4321 tggggggcac agcacaagct gccactctgc tctctccatg tctcctctgg agaccccgtc
     4381 cgcccccagc cagaaaacaa gtgtcccggc tcagcagggc agtccccgcc ccaggttcct
     4441 gctcctgcct cctggaccag ccaggggtgc tccctgtggt gcacaaagac ccctgctctg
     4501 acccagggct actccgggaa tcctggccac cgtggaggtg gggctgggga ggattggcca
     4561 gaccagggtc acagagctga gctcctgcct gacgggtgtg ggctccctca agccttccac
     4621 agatggggga aactgagtct tttcttctgc agatggggga aactgagtct ttggggactg
     4681 ttaagaggct gtgttcagat ctcagctgtc ctactgtccc tcccagacaa gggaggaacc
     4741 tgctggagga cacacgcgtg ctgccaccag gcggcagtgg ctcttagtgc tggtgctgag
     4801 ccggatcagc cgccccagca cccaacacgg agcgcccaca gcccagtgca cccaccgcct
     4861 ccttggccag ggacgctgcc ctccctccac caccaccgcc ggaaacccac ccccacacct
     4921 gccaggagaa aagtgctgag gaccccgggc cccagaaagg ggggtgcggt aggggcgggc
     4981 aggagcacct gtactggggt gcacagccct gctcacatct gggccacagt ataacacggg
     5041 tgagccttgg acgcccgcct gcctcattca ctcatgacac acagctgagc aggccttggg
     5101 ccctgggccc cgacccagca ccgggaacaa acaacactgg caaagatccc gggccctgca
     5161 gctgggggac caagtctggg gctgcctggc actaaggagg gtcttgggtc agagtgtcag
     5221 tgctgacacc aggacagtcc caggcaaact gggatcatgg agctgacctt tgcatgagag
     5281 agacaaccag agccaagtga cataagtaag cgagggggcg tggctggtgc cagtgtgggg
     5341 tgaggaatga ggctgggagc acgatgggga gtgtggggag ctgcaatctg aaatagggtg
     5401 ggtctgggca cggtggctcc cgcctgtaat cccagcactt tgggagacca aggcgggtgg
     5461 attacttaag gtcaggagtt tgagaccacc tggccaacat ggggaaaccc cagctctact
     5521 aaaaatacaa aaattaacca ggcattgtgg tgggcacctg taatcccagc tactcaggag
     5581 gctgaggcag gagaatcgct tgaacccaga aggcagaggt tgcagtgagc tgagatcatg
     5641 ccactgcact ccatcctggg tgactgaatg agacaccatc ttaaaaataa taaactaaaa
     5701 attaaaatga aataaaatag ggtggggcca ggcatggtgt tgcacacctg taatcccagc
     5761 actttgggag gccaaggcag gaggattgtt tgagcctggg ggattgaggc tgcagtgagc
     5821 catgattgca ccactgcact ccagcctggg taacagagca agaccctatt tcaatagata
     5881 taaaatttca aaaatagggt ggtccctggg aggctcagac aaggtgatgt gtgaacagag
     5941 actgcagagg cagggccttt gcattgcccg gctctaacag ggtccctgac tgcctcacgg
     6001 aagagcagcg agagtcagct tgtggagggc aggcaggtgg ggagaagtgc agaaggtgag
     6061 gccttcgggg tgtcctggca cgcaagtgtg aataaaagtg accaacgttt tggcctcagc
     6121 tccttgtgga caaatttgtg tccacaaatt tgtggaaaaa ttctttgtgg acaaaggata
     6181 gacagaactc aaagtcatcc gtctgctcac tgagataaat gcatatctga tttcttcctt
     6241 tggaaaggct aatcagaaac tcaaaagaat gcaactgttt gtctcttatc tgtgacccag
     6301 aagccccctc tccaatttga attgtcccac ttttccagac agaaccaatg tacttcttac
     6361 atatattgac tgatgtctca tttctcctta taatgtataa aaccaagctg tgcccggacc
     6421 acctcaggca catgtcagga cctcctgagg ctgtgtcatg ggctcgtgtc ctcaaccttg
     6481 gccaaataaa cttcctgaat tgacgga
//
