LOCUS       NM_153480               2679 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens interleukin 17 receptor E (IL17RE), transcript variant
            1, mRNA.
ACCESSION   NM_153480
VERSION     NM_153480.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Wang,J., Wang,X., Wang,M., Wang,J., Wu,Y. and Qi,X.
  TITLE     Clinical significance of Interleukin 17 receptor E in diabetic
            nephropathy
  JOURNAL   Int Immunopharmacol 120, 110324 (2023)
   PUBMED   37235960
  REMARK    GeneRIF: Clinical significance of Interleukin 17 receptor E in
            diabetic nephropathy.
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Jiang,Y., Wang,L., Peng,Y., Qin,J., Tan,A. and Wang,S.
  TITLE     Interleukin 17 receptor E identifies heterogeneous T helper 17
            cells in peritoneal fluid of moderate and severe endometriosis
            patients
  JOURNAL   Clin Exp Immunol 207 (3), 360-369 (2022)
   PUBMED   35553626
  REMARK    GeneRIF: Interleukin 17 receptor E identifies heterogeneous T
            helper 17 cells in peritoneal fluid of moderate and severe
            endometriosis patients.
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Barati,M., Sinaeian,M., Shokrollahi Barough,M., Pak,F., Semnani,V.,
            Kokhaei,P. and Momtazi-Borojeni,A.A.
  TITLE     Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression
            in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and
            Normal Subjects
  JOURNAL   J Interferon Cytokine Res 40 (3), 139-144 (2020)
   PUBMED   31905037
  REMARK    GeneRIF: Evaluation of Interleukin 25 and Interleukin 25 Receptor
            Expression in Peripheral Blood Mononuclear Cells of Breast Cancer
            Patients and Normal Subjects.
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Nies,J.F. and Panzer,U.
  TITLE     IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology
  JOURNAL   Front Immunol 11, 341 (2020)
   PUBMED   32174926
  REMARK    GeneRIF: IL-17C/IL-17RE: Emergence of a Unique Axis in TH17
            Biology.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   Tang,W., Smith,S.G., Salter,B., Oliveria,J.P., Mitchell,P.,
            Nusca,G.M., Howie,K., Gauvreau,G.M., O'Byrne,P.M. and Sehmi,R.
  TITLE     Allergen-Induced Increases in Interleukin-25 and Interleukin-25
            Receptor Expression in Mature Eosinophils from Atopic Asthmatics
  JOURNAL   Int Arch Allergy Immunol 170 (4), 234-242 (2016)
   PUBMED   27685606
  REMARK    GeneRIF: Our findings suggest that the IL-25/IL-25R axis may play
            an important role in promoting the recruitment and proinflammatory
            function of eosinophils in allergic asthma.
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Wu,B., Jin,M., Zhang,Y., Wei,T. and Bai,Z.
  TITLE     Evolution of the IL17 receptor family in chordates: a new subfamily
            IL17REL
  JOURNAL   Immunogenetics 63 (12), 835-845 (2011)
   PUBMED   21732179
REFERENCE   7  (bases 1 to 2679)
  AUTHORS   Chang,S.H., Reynolds,J.M., Pappu,B.P., Chen,G., Martinez,G.J. and
            Dong,C.
  TITLE     Interleukin-17C promotes Th17 cell responses and autoimmune disease
            via interleukin-17 receptor E
  JOURNAL   Immunity 35 (4), 611-621 (2011)
   PUBMED   21982598
REFERENCE   8  (bases 1 to 2679)
  AUTHORS   Song,X., Zhu,S., Shi,P., Liu,Y., Shi,Y., Levin,S.D. and Qian,Y.
  TITLE     IL-17RE is the functional receptor for IL-17C and mediates mucosal
            immunity to infection with intestinal pathogens
  JOURNAL   Nat Immunol 12 (12), 1151-1158 (2011)
   PUBMED   21993849
  REMARK    GeneRIF: IL-17RE as a receptor of IL-17C that regulates early
            innate immunity to intestinal pathogens.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2679)
  AUTHORS   Ramirez-Carrozzi,V., Sambandam,A., Luis,E., Lin,Z., Jeet,S.,
            Lesch,J., Hackney,J., Kim,J., Zhou,M., Lai,J., Modrusan,Z., Sai,T.,
            Lee,W., Xu,M., Caplazi,P., Diehl,L., de Voss,J., Balazs,M.,
            Gonzalez,L. Jr., Singh,H., Ouyang,W. and Pappu,R.
  TITLE     IL-17C regulates the innate immune function of epithelial cells in
            an autocrine manner
  JOURNAL   Nat Immunol 12 (12), 1159-1166 (2011)
   PUBMED   21993848
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2679)
  AUTHORS   Li,T.S., Li,X.N., Chang,Z.J., Fu,X.Y. and Liu,L.
  TITLE     Identification and functional characterization of a novel
            interleukin 17 receptor: a possible mitogenic activation through
            ras/mitogen-activated protein kinase signaling pathway
  JOURNAL   Cell Signal 18 (8), 1287-1298 (2006)
   PUBMED   16310341
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF458069.1, BC137077.1 and
            AK074238.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153480.1.
            
            Summary: This gene encodes a transmembrane protein that functions
            as the receptor for interleukin-17C. The encoded protein signals to
            downstream components of the mitogen activated protein kinase
            (MAPK) pathway. Activity of this protein is important in the immune
            response to bacterial pathogens. Alternatively spliced transcript
            variants have been described for this gene. [provided by RefSeq,
            Sep 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF458069.1, AY358451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383814.8/ ENSP00000373325.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1044              AF458069.1         21-1064
            1045-2599           BC137077.1         1027-2581
            2600-2679           AK074238.1         2674-2753
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..2679
                     /gene="IL17RE"
                     /note="interleukin 17 receptor E"
                     /db_xref="GeneID:132014"
                     /db_xref="HGNC:HGNC:18439"
                     /db_xref="MIM:614995"
     exon            1..217
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2089
                     /gene="IL17RE"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-17 receptor E"
                     /codon_start=1
                     /product="interleukin-17 receptor E isoform 1 precursor"
                     /protein_id="NP_705613.1"
                     /db_xref="CCDS:CCDS2589.1"
                     /db_xref="GeneID:132014"
                     /db_xref="HGNC:HGNC:18439"
                     /db_xref="MIM:614995"
                     /translation="MGSSRLAALLLPLLLIVIDLSDSAGIGFRHLPHWNTRCPLASHT
                     DDSFTGSSAYIPCRTWWALFSTKPWCVRVWHCSRCLCQHLLSGGSGLQRGLFHLLVQK
                     SKKSSTFKFYRRHKMPAPAQRKLLPRRHLSEKSHHISIPSPDISHKGLRSKRTQPSDP
                     ETWESLPRLDSQRHGGPEFSFDLLPEARAIRVTISSGPEVSVRLCHQWALECEELSSP
                     YDVQKIVSGGHTVELPYEFLLPCLCIEASYLQEDTVRRKKCPFQSWPEAYGSDFWKSV
                     HFTDYSQHTQMVMALTLRCPLKLEAALCQRHDWHTLCKDLPNATARESDGWYVLEKVD
                     LHPQLCFKFSFGNSSHVECPHQTGSLTSWNVSMDTQAQQLILHFSSRMHATFSAAWSL
                     PGLGQDTLVPPVYTVSQARGSSPVSLDLIIPFLRPGCCVLVWRSDVQFAWKHLLCPDV
                     SYRHLGLLILALLALLTLLGVVLALTCRRPQSGPGPARPVLLLHAADSEAQRRLVGAL
                     AELLRAALGGGRDVIVDLWEGRHVARVGPLPWLWAARTRVAREQGTVLLLWSGADLRP
                     VSGPDPRAAPLLALLHAAPRPLLLLAYFSRLCAKGDIPPPLRALPRYRLLRDLPRLLR
                     ALDARPFAEATSWGRLGARQRRQSRLELCSRLEREAARLADLG"
     exon            218..233
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            234..353
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            354..451
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            452..611
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            612..751
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            752..820
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            821..887
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1063
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1111
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1157
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1312
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1381
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1433
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1532
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..2679
                     /gene="IL17RE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RE"
                     /note="hexamer: AATAAA"
     polyA_site      2679
                     /gene="IL17RE"
                     /note="major polyA site"
ORIGIN      
        1 gtgttcgctg ctgcacagca aggccctgcc acccaccttc aggccatgca gccatgttcc
       61 gggagcccta attgcacaga agcccatggg gagctccaga ctggcagccc tgctcctgcc
      121 tctcctcctc atagtcatcg acctctctga ctctgctggg attggctttc gccacctgcc
      181 ccactggaac acccgctgtc ctctggcctc ccacacggat gacagtttca ctggaagttc
      241 tgcctatatc ccttgccgca cctggtgggc cctcttctcc acaaagcctt ggtgtgtgcg
      301 agtctggcac tgttcccgct gtttgtgcca gcatctgctg tcaggtggct caggtcttca
      361 acggggcctc ttccacctcc tggtgcagaa atccaaaaag tcttccacat tcaagttcta
      421 taggagacac aagatgccag cacctgctca gaggaagctg ctgcctcgtc gtcacctgtc
      481 tgagaagagc catcacattt ccatcccctc cccagacatc tcccacaagg gacttcgctc
      541 taaaaggacc caaccttcgg atccagagac atgggaaagt cttcccagat tggactcaca
      601 aaggcatgga ggacccgagt tctcctttga tttgctgcct gaggcccggg ctattcgggt
      661 gaccatatct tcaggccctg aggtcagcgt gcgtctttgt caccagtggg cactggagtg
      721 tgaagagctg agcagtccct atgatgtcca gaaaattgtg tctgggggcc acactgtaga
      781 gctgccttat gaattccttc tgccctgtct gtgcatagag gcatcctacc tgcaagagga
      841 cactgtgagg cgcaaaaaat gtcccttcca gagctggcca gaagcctatg gctcggactt
      901 ctggaagtca gtgcacttca ctgactacag ccagcacact cagatggtca tggccctgac
      961 actccgctgc ccactgaagc tggaagctgc cctctgccag aggcacgact ggcataccct
     1021 ttgcaaagac ctcccgaatg ccacagctcg agagtcagat gggtggtatg ttttggagaa
     1081 ggtggacctg cacccccagc tctgcttcaa gttctctttt ggaaacagca gccatgttga
     1141 atgcccccac cagactgggt ctctcacatc ctggaatgta agcatggata cccaagccca
     1201 gcagctgatt cttcacttct cctcaagaat gcatgccacc ttcagtgctg cctggagcct
     1261 cccaggcttg gggcaggaca ctttggtgcc ccccgtgtac actgtcagcc aggcccgggg
     1321 ctcaagccca gtgtcactag acctcatcat tcccttcctg aggccagggt gctgtgtcct
     1381 ggtgtggcgg tcagatgtcc agtttgcctg gaagcacctc ttgtgtccgg atgtctctta
     1441 cagacacctg gggctcttga tcctggcact gctggccctc ctcaccctac tgggtgttgt
     1501 tctggccctc acctgccggc gcccacagtc aggcccgggc ccagcgcggc cagtgctcct
     1561 cctgcacgcg gcggactcgg aggcgcagcg gcgcctggtg ggagcgctgg ctgaactgct
     1621 acgggcagcg ctgggcggcg ggcgcgacgt gatcgtggac ctgtgggagg ggaggcacgt
     1681 ggcgcgcgtg ggcccgctgc cgtggctctg ggcggcgcgg acgcgcgtag cgcgggagca
     1741 gggcactgtg ctgctgctgt ggagcggcgc cgaccttcgc ccggtcagcg gccccgaccc
     1801 ccgcgccgcg cccctgctcg ccctgctcca cgctgccccg cgcccgctgc tgctgctcgc
     1861 ttacttcagt cgcctctgcg ccaagggcga catccccccg ccgctgcgcg ccctgccgcg
     1921 ctaccgcctg ctgcgcgacc tgccgcgtct gctgcgggcg ctggacgcgc ggcctttcgc
     1981 agaggccacc agctggggcc gccttggggc gcggcagcgc aggcagagcc gcctagagct
     2041 gtgcagccgg ctcgaacgag aggccgcccg acttgcagac ctaggttgag cagagctcca
     2101 ccgcagtccc gggtgtctgc ggccgcaacg caacggacac tggctggaac cccggaatga
     2161 gccttcgacc ctgaaatcct tggggtgcct cgaggacgac tggccgaaaa gccgcattcc
     2221 ctgcctcaca ggccggaagt cccagcccag tccccgcgcg cgtccctctt cctcctcata
     2281 ctttcccttg actgagagct cctctaaccc ctgttctgat gggggagggc ggtcttccca
     2341 cttcctctcc agaactccag aaagagcagt gtgcttatgc ttcagtccag gctggagagg
     2401 ttggggccgg ggtagggagg caggagccat gtcagttctg aaggagggtg aggcggtggg
     2461 ggattgcagg gggcggctga gagaaaacct ccttgggggc cagggattcc ctttcccact
     2521 ctgaggctct ggccagaggg agagaggact ctggacctag gaaaagaggc ttttggctcc
     2581 aggtggtcag gacagtgggg gttgggggtg gggtgggtgg gtgctggcgg tggggaccaa
     2641 gatccggaaa gatgaataaa gacaaacatg acaaactaa
//
