LOCUS       NM_017563               8698 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens interleukin 17 receptor D (IL17RD), transcript variant
            2, mRNA.
ACCESSION   NM_017563 NM_001080973
VERSION     NM_017563.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8698)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   2  (bases 1 to 8698)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8698)
  AUTHORS   Men,M., Wang,X., Wu,J., Zeng,W., Jiang,F., Zheng,R. and Li,J.D.
  TITLE     Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4
            variants in a large Chinese cohort with isolated hypogonadotropic
            hypogonadism
  JOURNAL   J Med Genet 58 (1), 66-72 (2021)
   PUBMED   32389901
  REMARK    GeneRIF: Prevalence and associated phenotypes of DUSP6, IL17RD and
            SPRY4 variants in a large Chinese cohort with isolated
            hypogonadotropic hypogonadism.
REFERENCE   4  (bases 1 to 8698)
  AUTHORS   Su,Y., Huang,J., Zhao,X., Lu,H., Wang,W., Yang,X.O., Shi,Y.,
            Wang,X., Lai,Y. and Dong,C.
  TITLE     Interleukin-17 receptor D constitutes an alternative receptor for
            interleukin-17A important in psoriasis-like skin inflammation
  JOURNAL   Sci Immunol 4 (36) (2019)
   PUBMED   31175175
  REMARK    GeneRIF: IL-17RD is a functional receptor for IL-17A in vitro and
            in vivo and mediates the proinflammatory gene expression downstream
            of IL-17A..
REFERENCE   5  (bases 1 to 8698)
  AUTHORS   Preger,E., Ziv,I., Shabtay,A., Sher,I., Tsang,M., Dawid,I.B.,
            Altuvia,Y. and Ron,D.
  TITLE     Alternative splicing generates an isoform of the human Sef gene
            with altered subcellular localization and specificity
  JOURNAL   Proc Natl Acad Sci U S A 101 (5), 1229-1234 (2004)
   PUBMED   14742870
  REMARK    GeneRIF: CUG codon functions as a major translation initiation site
            in the alternatively spliced transcript variant hSef-b.
REFERENCE   6  (bases 1 to 8698)
  AUTHORS   Yang,R.B., Ng,C.K., Wasserman,S.M., Komuves,L.G., Gerritsen,M.E.
            and Topper,J.N.
  TITLE     A novel interleukin-17 receptor-like protein identified in human
            umbilical vein endothelial cells antagonizes basic fibroblast
            growth factor-induced signaling
  JOURNAL   J Biol Chem 278 (35), 33232-33238 (2003)
   PUBMED   12807873
  REMARK    GeneRIF: human SEF is likely to play critical roles in endothelial
            or epithelial functions such as proliferation, migration, and
            angiogenesis
REFERENCE   7  (bases 1 to 8698)
  AUTHORS   Kovalenko,D., Yang,X., Nadeau,R.J., Harkins,L.K. and Friesel,R.
  TITLE     Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1
            tyrosine phosphorylation and subsequent ERK activation
  JOURNAL   J Biol Chem 278 (16), 14087-14091 (2003)
   PUBMED   12604616
  REMARK    GeneRIF: Sef exerts its inhibitory effects at the level of FGFR and
            upstream of Ras providing an additional level of negative
            regulation of FGF signaling
REFERENCE   8  (bases 1 to 8698)
  AUTHORS   Furthauer,M., Lin,W., Ang,S.L., Thisse,B. and Thisse,C.
  TITLE     Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF
            signalling
  JOURNAL   Nat Cell Biol 4 (2), 170-174 (2002)
   PUBMED   11802165
REFERENCE   9  (bases 1 to 8698)
  AUTHORS   Tsang,M., Friesel,R., Kudoh,T. and Dawid,I.B.
  TITLE     Identification of Sef, a novel modulator of FGF signalling
  JOURNAL   Nat Cell Biol 4 (2), 165-169 (2002)
   PUBMED   11802164
REFERENCE   10 (bases 1 to 8698)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY024286.1, AF458067.1,
            AK302045.1, AC097358.2 and BQ017683.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017563.4.
            
            Summary: This gene encodes a membrane protein belonging to the
            interleukin-17 receptor (IL-17R) protein family. The encoded
            protein is a component of the interleukin-17 receptor signaling
            complex, and the interaction between this protein and IL-17R does
            not require the interleukin. The gene product also affects
            fibroblast growth factor signaling, inhibiting or stimulating
            growth through MAPK/ERK signaling. Alternate splicing generates
            multiple transcript variants encoding distinct isoforms. [provided
            by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) represents the shorter
            transcript and encodes the longer isoform a (also known as hSef-a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494208.1, SRR1803615.154012.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296318.12/ ENSP00000296318.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                HY024286.1         47-113
            68-726              AF458067.1         1-659
            727-1598            AK302045.1         599-1470
            1599-2733           AF458067.1         1532-2666
            2734-8072           AC097358.2         51467-56805         c
            8073-8698           BQ017683.1         17-642              c
FEATURES             Location/Qualifiers
     source          1..8698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..8698
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /note="interleukin 17 receptor D"
                     /db_xref="GeneID:54756"
                     /db_xref="HGNC:HGNC:17616"
                     /db_xref="MIM:606807"
     exon            1..193
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2287
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; IL17Rhom; sef homolog; IL-17 receptor D;
                     interleukin-17 receptor-like protein; similar expression
                     to fgf genes"
                     /codon_start=1
                     /product="interleukin-17 receptor D isoform a precursor"
                     /protein_id="NP_060033.3"
                     /db_xref="CCDS:CCDS2880.2"
                     /db_xref="GeneID:54756"
                     /db_xref="HGNC:HGNC:17616"
                     /db_xref="MIM:606807"
                     /translation="MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGV
                     GPASRNSGLYNITFKYDNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGA
                     LGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYF
                     VKVVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSF
                     DHAPHNFGFRFFYLHYKLKHEGPFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDT
                     NTTRKVMHYALKPVHSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLD
                     EESSESSTYTAALPRERLRPRPKVFLCYSSKDGQNHMNVVQCFAYFLQDFCGCEVALD
                     LWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNYKHKGGGRGSGKGELF
                     LVAVSAIAEKLRQAKQSSSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLC
                     SHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFVP
                     FHPPPLRYREPVLEKFDSGLVLNDVMCKPGPESDFCLKVEAAVLGATGPADSQHESQH
                     GGLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPRDSGIYDSSVPSSELSLPLMEGL
                     STDQTETSSLTESVSSSSGLGEEEPPALPSKLLSSGSCKADLGCRSYTDELHAVAPL"
     exon            194..251
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            252..377
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            378..496
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            497..617
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            618..662
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            663..814
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            815..880
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            881..935
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1046
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1231
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..2174
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..8698
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8679..8684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /note="hexamer: AATAAA"
     polyA_site      8698
                     /gene="IL17RD"
                     /gene_synonym="HH18; IL-17RD; IL17RLM; SEF"
                     /note="major polyA site"
ORIGIN      
        1 actcggggct ggccagcggc gggcggccgg ggcgcagaga acggcctggc tgggcgagcg
       61 cacggccatg gccccgtggc tgcagctctg ctccgtcttc tttacggtca acgcctgcct
      121 caacggctcg cagctggctg tggccgctgg cgggtccggc cgcgcgcggg gcgccgacac
      181 ctgtggctgg aggggagtgg ggccagccag cagaaacagt gggctgtaca acatcacctt
      241 caaatatgac aattgtacca cctacttgaa tccagtgggg aagcatgtga ttgctgacgc
      301 ccagaatatc accatcagcc agtatgcttg ccatgaccaa gtggcagtca ccattctttg
      361 gtccccaggg gccctcggca tcgaattcct gaaaggattt cgggtaatac tggaggagct
      421 gaagtcggag ggaagacagt gccaacaact gattctaaag gatccgaagc agctcaacag
      481 tagcttcaaa agaactggaa tggaatctca acctttcctg aatatgaaat ttgaaacgga
      541 ttatttcgta aaggttgtcc cttttccttc cattaaaaac gaaagcaatt accacccttt
      601 cttctttaga acccgagcct gtgacctgtt gttacagccg gacaatctag cttgtaaacc
      661 cttctggaag cctcggaacc tgaacatcag ccagcatggc tcggacatgc aggtgtcctt
      721 cgaccatgca ccgcacaact tcggcttccg tttcttctat cttcactaca agctcaagca
      781 cgaaggacct ttcaagcgaa agacctgtaa gcaggagcaa actacagaga cgaccagctg
      841 cctccttcaa aatgtttctc caggggatta tataattgag ctggtggatg acactaacac
      901 aacaagaaaa gtgatgcatt atgccttaaa gccagtgcac tccccgtggg ccgggcccat
      961 cagagccgtg gccatcacag tgccactggt agtcatatcg gcattcgcga cgctcttcac
     1021 tgtgatgtgc cgcaagaagc aacaagaaaa tatatattca catttagatg aagagagctc
     1081 tgagtcttcc acatacactg cagcactccc aagagagagg ctccggccgc ggccgaaggt
     1141 ctttctctgc tattccagta aagatggcca gaatcacatg aatgtcgtcc agtgtttcgc
     1201 ctacttcctc caggacttct gtggctgtga ggtggctctg gacctgtggg aagacttcag
     1261 cctctgtaga gaagggcaga gagaatgggt catccagaag atccacgagt cccagttcat
     1321 cattgtggtt tgttccaaag gtatgaagta ctttgtggac aagaagaact acaaacacaa
     1381 aggaggtggc cgaggctcgg ggaaaggaga gctcttcctg gtggcggtgt cagccattgc
     1441 cgaaaagctc cgccaggcca agcagagttc gtccgcggcg ctcagcaagt ttatcgccgt
     1501 ctactttgat tattcctgcg agggagacgt ccccggtatc ctagacctga gtaccaagta
     1561 cagactcatg gacaatcttc ctcagctctg ttcccacttg cactcccgag accacggcct
     1621 ccaggagccg gggcagcaca cgcgacaggg cagcagaagg aactacttcc ggagcaagtc
     1681 aggccggtcc ctatacgtcg ccatttgcaa catgcaccag tttattgacg aggagcccga
     1741 ctggttcgaa aagcagttcg ttcccttcca tcctcctcca ctgcgctacc gggagccagt
     1801 cttggagaaa tttgattcgg gcttggtttt aaatgatgtc atgtgcaaac cagggcctga
     1861 gagtgacttc tgcctaaagg tagaggcggc tgttcttggg gcaaccggac cagccgactc
     1921 ccagcacgag agtcagcatg ggggcctgga ccaagacggg gaggcccggc ctgcccttga
     1981 cggtagcgcc gccctgcaac ccctgctgca cacggtgaaa gccggcagcc cctcggacat
     2041 gccgcgggac tcaggcatct atgactcgtc tgtgccctca tccgagctgt ctctgccact
     2101 gatggaagga ctctcgacgg accagacaga aacgtcttcc ctgacggaga gcgtgtcctc
     2161 ctcttcaggc ctgggtgagg aggaacctcc tgcccttcct tccaagctcc tctcttctgg
     2221 gtcatgcaaa gcagatcttg gttgccgcag ctacactgat gaactccacg cggtcgcccc
     2281 tttgtaacaa aacgaaagag tctaagcatt gccactttag ctgctgcctc cctctgattc
     2341 cccagctcat ctccctggtt gcatggccca cttggagctg aggtctcata caaggatatt
     2401 tggagtgaaa tgctggccag tacttgttct cccttgcccc aaccctttac cggatatctt
     2461 gacaaactct ccaattttct aaaatgatat ggagctctga aaggcatgtc cataaggtct
     2521 gacaacagct tgccaaattt ggttagtcct tggatcagag cctgttgtgg gaggtaggga
     2581 ggaaatatgt aaagaaaaac aggaagatac ctgcactaat cattcagact tcattgagct
     2641 ctgcaaactt tgcctgtttg ctattggcta ccttgatttg aaatgctttg tgaaaaaagg
     2701 cacttttaac atcatagcca cagaaatcaa gtgccagtct atctggaatc catgttgtat
     2761 tgcagataat gttctcattt atttttgatg tagaatttac attgccatgg gtgttaaata
     2821 agctttgagt caaaagtcaa gaaagtgact gaatatacag tcacctttta tgaaatgagt
     2881 ctctgtgtta ctgggtggca tgactgattg aggtgaagct cacggggcca ggctgaccgt
     2941 cttgaccgtt ccacttgaga taggttggtc atcgtgcaga aggccccagg acctcagcac
     3001 acacagcctc ctcttggtct gagtaggcat catgtggggg ccagatctgc ctgctgtttc
     3061 catgggttac atttactgtg ctgtatctca gatgttggtg tctggaagtt tattcttaag
     3121 agactgctac ccagctggtc tgtattattg gaagttgcag ttcgtgcttt ggttggcctt
     3181 ctggtctaaa gctgtgtcct gaatattagg gatcacaatt cactgaaata cagcagtgtg
     3241 tggaggtgat ggccagttaa tctgctgaac tggttttgac taatgacaaa cctcttttta
     3301 agatggtaga atggaggtga tagtcacaaa agtaaatgtt ccatttttat gaatgacttt
     3361 ctacagagtt tctatttcta aagaaaaaac aattgttcac atcccatctg atgattagca
     3421 tgtgtgtaat gaatgctgtc ttggtctccc ctgtggaaac ccttctccct gtgccttaga
     3481 gcaggtgtgt acatctctca ctacctttct catgggtgct gttagatttt ggcacccgtt
     3541 ttctcagcat tcagcccagg gaatgtggtt ttcacttctt cgtcagataa gaccaacatg
     3601 aaggggtatg ttgagaaaca tcctgaggca aggtgggagg tgggatgggg caggactttc
     3661 ccttccaagc acatgcatgg caggtgggga aaggggggct tgcacccctg ctggaaagaa
     3721 aaggtttgtg tatatttctg atgcaaatgt catactcact gctctgtaaa ggcagctggc
     3781 agctttttgg gaaaagaacg tgctcgtctg ttctctggca tcaagtttct tgcagctgct
     3841 ctgagggaga gacagtgagc tgcaagactg cctccccata acaacaggca actcagagaa
     3901 gagtcatttt atgttgttcc tatggaatct ggaatgagtg cagagctcct acccacacat
     3961 gactgccccg ccatttcatc ctaggcattc tgtgaaggag attggttagt ccaaacttgc
     4021 taacatacga aaattcactt ggaacatgat gagagatttc ttattgaggc caagagatgt
     4081 ttcctgtccc agaggaacca ttaggagtcg cttttagggt attcagcttt gttcatgaaa
     4141 taaggcatct ctgagaaagt ggccccaggg agagaatgga ggactgggag gagaagcatt
     4201 aactgagctc caagggtgtg tgggcagaga gcttgctatg tgaactcact ccttaagaaa
     4261 atggaagaga aaaagagagt gctagttaaa aaatcgggat gttttagttt ggatttaggg
     4321 ttttgatact tatgttgaaa tactaatgtt tctgatcaat aaaatcaaac tcttaatata
     4381 ccgagtaatg aaaccatagt gtgattgcct cagaataaat tgagaagtcc aacttcctag
     4441 ttttgtttaa ttagtttcac tttttctact ctccccagta tgctagaaat gggaatcgtt
     4501 gccctgcaga ttacggcaaa acatctgttt taagcaaagc tgcatttttt gactcagaaa
     4561 ttgtcccaga cggtggatat aagatgaaat tcagaaaaac gttctgccaa gtcacaggct
     4621 tttagatatt atggaaacaa gaaatggaaa acaggatgat ctccatgaga ggccttgatc
     4681 ctgagagtaa aaggcttgtg tagataggtt agacaacgtc ctctagaaaa gagaccaggg
     4741 ataagtccag gtttccagga aaaccaagaa gcctgcgggt agctgaaggt agagtgctag
     4801 ttgttcatct taacttacca atgagctaca gaaaggactt agcatctgat gtcatcagct
     4861 ttgccaggag agtgatcaag gaggttaaag ctcaggtaaa ggtgtgcctt ctcagagatt
     4921 ggctacaagc aacagagacc acctcaacag agaccacctc aacagactca gcccagccat
     4981 acaaggtgcc aaagctcctc cagagggctg tcttgggcct ttgaggcaat tgatctccag
     5041 aaagagtcag aagtcattcc agtccaggcc caggtattca gatggtgacc cagccagata
     5101 atagtatctt gagcaaataa tagtatcttg agtgcaaata agcaggaaga ctgtccttca
     5161 aaaaatgtgg ggttacatga ttttcagagc ctttttttca gagttgagca tcttttcttt
     5221 taaaagaaat aaggggcaag aggaccaatt ttattccttg aggaaaaatg acacaccctt
     5281 ctcccaaaag aaagaaaact ctctggcccc ccaacttcaa cactaatttg gctccctgaa
     5341 gaagagagaa aatattattt ctgtctttat tgaagagaaa tgggcaatgc caatgtgaag
     5401 gttactagtc ttttttattt tctattggtg aagactacta ctgctcttat ttagcagatc
     5461 ttataccttc agtggtcacc agtatagcag gtgaggtata aggaaaacag cagtgtgatg
     5521 ataaatggta attaatatac tttgtctgtg tcagcaatag ggaatggtgg ggactgtggc
     5581 aaactgaagc gcccctgttc cacccacagt gggtaatttt ccagtcgact gtggccatga
     5641 agtacttcct gatcttccca tttttcaaga aaagctgaca atctggattt ttatatgaaa
     5701 aattctgatt ttaaaaaata ttggcaacta agttaaaatt caagtgaatt tagacccagc
     5761 agaagacatg gatggacctg atttggtcca ctgactacca gtttgttaac ctgtgcttta
     5821 taagatttga aggaaaggca ttcatggtaa ttacagacgg tgccaccaga aaatgctctt
     5881 gctaaatgca gccagtagtt agattgcttc tttctccagt ctcccccgca aagaaatttg
     5941 acgtgattct gaatgcactg gacatgtctt gattgcgtct ttacatttca cagtgtctta
     6001 aaagaaaggc aagccagttg ttaatttcag aatcagattt atgctctctc aatttaaaaa
     6061 atgctgggaa caatttcatt tttttttttt tgagatggag tcttgctctg ttgcccaggc
     6121 tggagtgcag tggcgtgatc tcggctcact gcaagctcca cctcccgggt tcacgccatt
     6181 ctcctgcctc agcctcctga gtagctggga ctacaggcgc ccaccaccac gcctggctaa
     6241 tttttttgta tttttagtag agacggggtt tcactgtgtt agccaggatg atctcgatct
     6301 cctgacctgg tgatccgctt gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc
     6361 actgcgcccg gcctaacaat ttcatttaaa ctccacaacc taaagggctt tgtttatagt
     6421 tttagctctt ggcataattt ttttcaggtg gtgtgcaatt ctgagcatag gccaagacat
     6481 gattaggaaa gcaggcagtt gtagagagta aggcaaggaa cctcctagcg tccattagag
     6541 ccaggtattt gcattatctt ccgttttaag tggtctgtga attgactgtg ttttggaggt
     6601 gtgaaacagt atacagagaa aagcttttcc tgatactgag atatcagtta ggagtccaaa
     6661 tggggtgttg ggtcatcctt gccatatcac ctcctttcca ggctcagagt gaaaatagac
     6721 aaaaggaaat ctgactgcaa gccagtggct ttgattccag tttcagagtt tagggactag
     6781 gagagagttt agattatcta gcatattctc cccctggtgt cagacagggc tgtgcctgaa
     6841 ttattccaga catatggctg tagatggtat tctttatttt ataagaagga gattctgtaa
     6901 cctaccctgc tgatcagata gttctttgta tgtcttagag aaattcaagc cagcttcctt
     6961 ttgttcggct tgtagtggag aaagaacagc tggtcacctt ccatgtattc aaaaaccaca
     7021 gtgaagtcat ccccctggtg tttttatttc agtgataaat aattccaccc acttaaacca
     7081 ttcttcatgg ctcttgtttt ccaggggcct aataattttc actgctgtaa tgtttctcag
     7141 cttcacactt agtttagttg cccaaacaat gttggtgcct tactcacatt ggtgccttgt
     7201 gaagacgagg ctcaggatgg ggattatggg gaaattcttg cacacccagc tcctcttacc
     7261 acttaaaaat ataatggcac tttcacaaaa tgatatgtca cctatattca ttgagaatta
     7321 tttgactgcc acatttttcc cctgatgata gtcatctatc ataacttgtg tttgttttcc
     7381 tcctgagatc aaacacttgg tgcttattcc tgatgtatac tctgagacca gctcttacct
     7441 tctgagtggc agctacccct ccctcccaat tttagatcct atttttacac atctctatag
     7501 atatcacctt tatttcatga ctcacaatat taaatggtac agacttcagt ttaaccactg
     7561 gtgtggtaac agcagtagtt gctaagtacc accttcccat tgctgtttga gggctaattt
     7621 gcaaagacat ttgaatctcc cagtgaagat gtctggggaa ttttggccag ttgtcttccc
     7681 tcttgccctt ttgttcttta aaattcagct tggaccatag acacctccag gatcttgttt
     7741 atgttctgct ctcaattgac caagcactgc gttttgcaca atcagaagtc tcacaaaagc
     7801 aaacagttat gactgcatat ctgatgttta tatcctataa aatttcagga agattcagag
     7861 tcaatcttct atttgtacat gatgtagaca aaattagctg ctccaattgt tagacaaaaa
     7921 attgccattg gattacacta atgtgctcat ctgttgtttt aaaagtttgg tatcaggcgg
     7981 ggcacggtgg ctcacgcctg taatcccagc attttgggag gccaaggtgg gcggatcacc
     8041 tgaggtccag agttcaagac cagcctgacc aacatggtga aaccctgtct ctactaaaaa
     8101 tacaaaatta atcaggcgtg gttgtgtgtg cctgtaatcc cagctactcg agaggctgag
     8161 gcaggagaat cgcttgaatc cgggaggcag aggttgcagt gagctgagat cacgccattg
     8221 cactctagcc tgggcaacaa gagcgaaact ccgtctcaac aacaacaaca aaaagtttgg
     8281 tatgtttctc tcaagaaaaa agcatggtga gtccagacag cagcaaaagc ttttgtgaaa
     8341 accaattgtg ttcatctaga tagtaagtaa ctcctatttt tactgttaat tttttaaaag
     8401 agaatttttc cctgtggaaa ctccctgtta gtacgtccta ggggagaaag cctgtggaat
     8461 atggtggtta ttgatggcgt tgcctttgtt tcatctttga gtttgccctt tgtgggatct
     8521 agtgggataa tgagcactga cagaactctt aacagcgtgc tgtatttttg acattgaaaa
     8581 tgttaatgac ttgatttgta cataactctg taactaggtg aaagtagatc acagctgaca
     8641 tttacaaaat gtttttgtac cttagaattt ctgcattaaa taaaatgttt tgttttaa
//
