LOCUS       NM_153460               2409 bp    mRNA    linear   PRI 14-NOV-2023
DEFINITION  Homo sapiens interleukin 17 receptor C (IL17RC), transcript variant
            1, mRNA.
ACCESSION   NM_153460
VERSION     NM_153460.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Arikan S, Ozturk O, Duygulu S, Atalay EO and Atalay A.
  TITLE     Associations of IL-17 and IL-17 receptor polymorphisms with
            Behcet's disease in Denizli Province of Turkey
  JOURNAL   Immunol Res 71 (4), 600-608 (2023)
   PUBMED   36701075
  REMARK    GeneRIF: Associations of IL-17 and IL-17 receptor polymorphisms
            with Behcet's disease in Denizli Province of Turkey.
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Kang JH, Park S, Rho J, Hong EJ, Cho YE, Won YS and Kwon HJ.
  TITLE     IL-17A promotes Helicobacter pylori-induced gastric carcinogenesis
            via interactions with IL-17RC
  JOURNAL   Gastric Cancer 26 (1), 82-94 (2023)
   PUBMED   36125689
  REMARK    GeneRIF: IL-17A promotes Helicobacter pylori-induced gastric
            carcinogenesis via interactions with IL-17RC.
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N,
            Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A,
            Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE,
            Paust HJ, Krebs CF and Panzer U.
  TITLE     IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and
            Tissue Injury in Immune-Mediated Kidney Diseases
  JOURNAL   J Am Soc Nephrol 32 (12), 3081-3098 (2021)
   PUBMED   35167487
  REMARK    GeneRIF: IL-17 Receptor C Signaling Controls CD4(+) TH17 Immune
            Responses and Tissue Injury in Immune-Mediated Kidney Diseases.
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Goepfert A, Lehmann S, Blank J, Kolbinger F and Rondeau JM.
  TITLE     Structural Analysis Reveals that the Cytokine IL-17F Forms a
            Homodimeric Complex with Receptor IL-17RC to Drive
            IL-17RA-Independent Signaling
  JOURNAL   Immunity 52 (3), 499-512 (2020)
   PUBMED   32187518
  REMARK    GeneRIF: The crystal structure of the interleukin 17 receptor C
            (IL-17RC):interleukin 17F (IL-17F) complex provides a structural
            basis for IL-17F signaling through IL-17RC.
REFERENCE   5  (bases 1 to 2409)
  AUTHORS   Tian J, Bai Y, You A, Shen R, Yan J, Deng W, Wen L, Li M and Teng
            J.
  TITLE     Interleukin-17 receptor C gene polymorphism reduces treatment
            effect and promotes poor prognosis of ischemic stroke
  JOURNAL   Biosci Rep 39 (10) (2019)
   PUBMED   31481525
  REMARK    GeneRIF: Interleukin-17 receptor C gene polymorphism reduces
            treatment effect and promotes poor prognosis of ischemic stroke.
            Erratum:[Biosci Rep. 2020 Jan 31;40(1):. PMID: 31934726]
REFERENCE   6  (bases 1 to 2409)
  AUTHORS   Haudenschild DR, Curtiss SB, Moseley TA and Reddi AH.
  TITLE     Generation of interleukin-17 receptor-like protein (IL-17RL) in
            prostate by alternative splicing of RNA
  JOURNAL   Prostate 66 (12), 1268-1274 (2006)
   PUBMED   16688746
  REMARK    GeneRIF: IL-17RL exists as multiple isoforms due to extensive
            alternative splicing. Changes in RNA IL-17RL splicing occur in
            advanced cancers.
REFERENCE   7  (bases 1 to 2409)
  AUTHORS   Zhang Z and Henzel WJ.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 2409)
  AUTHORS   Gerritsen ME, Tomlinson JE, Zlot C, Ziman M and Hwang S.
  TITLE     Using gene expression profiling to identify the molecular basis of
            the synergistic actions of hepatocyte growth factor and vascular
            endothelial growth factor in human endothelial cells
  JOURNAL   Br J Pharmacol 140 (4), 595-610 (2003)
   PUBMED   14504135
  REMARK    Review article
REFERENCE   9  (bases 1 to 2409)
  AUTHORS   Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
            Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
            Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
            Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
            Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
            Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
            K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
            A, Wood WI, Godowski P and Gray A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2409)
  AUTHORS   Haudenschild D, Moseley T, Rose L and Reddi AH.
  TITLE     Soluble and transmembrane isoforms of novel interleukin-17
            receptor-like protein by RNA splicing and expression in prostate
            cancer
  JOURNAL   J Biol Chem 277 (6), 4309-4316 (2002)
   PUBMED   11706037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC381087.1, AK225650.1,
            AC018809.5, AF458065.1, AK096824.1 and AY358840.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 16, 2018 this sequence version replaced NM_153460.3.
            
            Summary: This gene encodes a single-pass type I membrane protein
            that shares similarity with the interleukin-17 receptor (IL-17RA).
            Unlike IL-17RA, which is predominantly expressed in hemopoietic
            cells, and binds with high affinity to only IL-17A, this protein is
            expressed in nonhemopoietic tissues, and binds both IL-17A and
            IL-17F with similar affinities. The proinflammatory cytokines,
            IL-17A and IL-17F, have been implicated in the progression of
            inflammatory and autoimmune diseases. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            detected for this gene, and it has been proposed that soluble,
            secreted proteins lacking transmembrane and intracellular domains
            may function as extracellular antagonists to cytokine signaling.
            [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript containing all the coding exons, and encodes isoform 1
            (also known as IL-17RCFL).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF458065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403601.8/ ENSP00000384969.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               DC381087.1         19-566
            549-1137            AK225650.1         518-1106
            1138-1138           AC018809.5         50742-50742         c
            1139-1277           AK225650.1         1108-1246
            1278-2350           AF458065.1         1257-2329
            2351-2408           AK096824.1         2293-2350
            2409-2409           AY358840.1         2350-2350
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..2409
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /note="interleukin 17 receptor C"
                     /db_xref="GeneID:84818"
                     /db_xref="HGNC:HGNC:18358"
                     /db_xref="MIM:610925"
     exon            1..323
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2381
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL17F receptor; IL-17RL; IL17Rhom; zcytoR14;
                     IL-17 receptor C; interleukin-17 receptor homolog;
                     interleukin-17 receptor-like protein"
                     /codon_start=1
                     /product="interleukin-17 receptor C isoform 1 precursor"
                     /protein_id="NP_703190.2"
                     /db_xref="CCDS:CCDS46746.1"
                     /db_xref="GeneID:84818"
                     /db_xref="HGNC:HGNC:18358"
                     /db_xref="MIM:610925"
                     /translation="MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPGLSCRLWDS
                     DILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDE
                     EKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVY
                     DCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADG
                     DNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVW
                     PLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPG
                     GDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLK
                     DDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDD
                     DLGALWACPMDKYIHKRWALVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGA
                     AARGRAALLLYSADDSGFERLVGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQ
                     RRQTLQEGGVVVLLFSPGAVALCSEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGR
                     APGSYVGACFDRLLHPDAVPALFRTVPVFTLPSQLPDFLGALQQPRAPRSGRLQERAE
                     QVSRALQPALDSYFHPPGTPAPGRGVGPGAGPGAGDGT"
     exon            324..345
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            346..498
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            499..573
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            574..683
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            684..795
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            796..840
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            841..980
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1040
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1095
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1277
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1328
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1374
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1496
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1556
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1605
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1701
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1740
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2409
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="IL17RC"
                     /gene_synonym="CANDF9; IL17-RL; IL17RL"
                     /note="major polyA site"
ORIGIN      
        1 aaaacgaaag cactccgtgc tggaagtagg aggagagtca ggactcccag gacagagagt
       61 gcacaaacta cccagcacag ccccctccgc cccctctgga ggctgaagag ggattccagc
      121 ccctgccacc cacagacacg ggctgactgg ggtgtctgcc ccccttgggg gggggcagca
      181 cagggcctca ggcctgggtg ccacctggca cctagaagat gcctgtgccc tggttcttgc
      241 tgtccttggc actgggccga agcccagtgg tcctttctct ggagaggctt gtggggcctc
      301 aggacgctac ccactgctct ccgggcctct cctgccgcct ctgggacagt gacatactct
      361 gcctgcctgg ggacatcgtg cctgctccgg gccccgtgct ggcgcctacg cacctgcaga
      421 cagagctggt gctgaggtgc cagaaggaga ccgactgtga cctctgtctg cgtgtggctg
      481 tccacttggc cgtgcatggg cactgggaag agcctgaaga tgaggaaaag tttggaggag
      541 cagctgactc aggggtggag gagcctagga atgcctctct ccaggcccaa gtcgtgctct
      601 ccttccaggc ctaccctact gcccgctgcg tcctgctgga ggtgcaagtg cctgctgccc
      661 ttgtgcagtt tggtcagtct gtgggctctg tggtatatga ctgcttcgag gctgccctag
      721 ggagtgaggt acgaatctgg tcctatactc agcccaggta cgagaaggaa ctcaaccaca
      781 cacagcagct gcctgactgc agggggctcg aagtctggaa cagcatcccg agctgctggg
      841 ccctgccctg gctcaacgtg tcagcagatg gtgacaacgt gcatctggtt ctgaatgtct
      901 ctgaggagca gcacttcggc ctctccctgt actggaatca ggtccagggc cccccaaaac
      961 cccggtggca caaaaacctg actggaccgc agatcattac cttgaaccac acagacctgg
     1021 ttccctgcct ctgtattcag gtgtggcctc tggaacctga ctccgttagg acgaacatct
     1081 gccccttcag ggaggacccc cgcgcacacc agaacctctg gcaagccgcc cgactgcaac
     1141 tgctgaccct gcagagctgg ctgctggacg caccgtgctc gctgcccgca gaagcggcac
     1201 tgtgctggcg ggctccgggt ggggacccct gccagccact ggtcccaccg ctttcctggg
     1261 agaacgtcac tgtggacaag gttctcgagt tcccattgct gaaaggccac cctaacctct
     1321 gtgttcaggt gaacagctcg gagaagctgc agctgcagga gtgcttgtgg gctgactccc
     1381 tggggcctct caaagacgat gtgctactgt tggagacacg aggcccccag gacaacagat
     1441 ccctctgtgc cttggaaccc agtggctgta cttcactacc cagcaaagcc tccacgaggg
     1501 cagctcgcct tggagagtac ttactacaag acctgcagtc aggccagtgt ctgcagctat
     1561 gggacgatga cttgggagcg ctatgggcct gccccatgga caaatacatc cacaagcgct
     1621 gggccctcgt gtggctggcc tgcctactct ttgccgctgc gctttccctc atcctccttc
     1681 tcaaaaagga tcacgcgaaa gggtggctga ggctcttgaa acaggacgtc cgctcggggg
     1741 cggccgccag gggccgcgcg gctctgctcc tctactcagc cgatgactcg ggtttcgagc
     1801 gcctggtggg cgccctggcg tcggccctgt gccagctgcc gctgcgcgtg gccgtagacc
     1861 tgtggagccg tcgtgaactg agcgcgcagg ggcccgtggc ttggtttcac gcgcagcggc
     1921 gccagaccct gcaggagggc ggcgtggtgg tcttgctctt ctctcccggt gcggtggcgc
     1981 tgtgcagcga gtggctacag gatggggtgt ccgggcccgg ggcgcacggc ccgcacgacg
     2041 ccttccgcgc ctcgctcagc tgcgtgctgc ccgacttctt gcagggccgg gcgcccggca
     2101 gctacgtggg ggcctgcttc gacaggctgc tccacccgga cgccgtaccc gcccttttcc
     2161 gcaccgtgcc cgtcttcaca ctgccctccc aactgccaga cttcctgggg gccctgcagc
     2221 agcctcgcgc cccgcgttcc gggcggctcc aagagagagc ggagcaagtg tcccgggccc
     2281 ttcagccagc cctggatagc tacttccatc ccccggggac tcccgcgccg ggacgcgggg
     2341 tgggaccagg cgcgggacct ggggcggggg acgggactta aataaaggca gacgctgttt
     2401 ttctaccca
//
