LOCUS       NM_018725               2016 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens interleukin 17 receptor B (IL17RB), mRNA.
ACCESSION   NM_018725
VERSION     NM_018725.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Kawamura,K., Matsumura,Y., Kawamura,T., Araki,H., Hamada,N.,
            Kuramoto,K., Yagi,H., Onoyama,I., Asanoma,K. and Kato,K.
  TITLE     Endometrial senescence is mediated by interleukin 17 receptor B
            signaling
  JOURNAL   Cell Commun Signal 22 (1), 363 (2024)
   PUBMED   39010112
  REMARK    GeneRIF: Endometrial senescence is mediated by interleukin 17
            receptor B signaling.
            Erratum:[Cell Commun Signal. 2024 Jul 22;22(1):370. doi:
            10.1186/s12964-024-01754-z.. PMID: 39039545]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   van Sluis,M., Yu,Q., van der Woude,M., Gonzalo-Hansen,C.,
            Dealy,S.C., Janssens,R.C., Somsen,H.B., Ramadhin,A.R.,
            Dekkers,D.H.W., Wienecke,H.L., Demmers,J.J.P.G., Raams,A.,
            Davo-Martinez,C., Llerena Schiffmacher,D.A., van Toorn,M.,
            Hackes,D., Thijssen,K.L., Zhou,D., Lammers,J.G., Pines,A.,
            Vermeulen,W., Pothof,J., Demmers,J.A.A., van den Berg,D.L.C.,
            Lans,H. and Marteijn,J.A.
  TITLE     Transcription-coupled DNA-protein crosslink repair by CSB and
            CRL4CSA-mediated degradation
  JOURNAL   Nat Cell Biol 26 (5), 770-783 (2024)
   PUBMED   38600236
  REMARK    GeneRIF: Transcription-coupled DNA-protein crosslink repair by CSB
            and CRL4[CSA]-mediated degradation.
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Yuan,S.F., Su,C.W., Chan,L.P., Nguyen,H.D.H., Chen,Y.K., Du,J.K.,
            Cheng,K.H. and Wang,Y.Y.
  TITLE     IL17RB expression is associated with malignant cancer behaviors and
            poor prognosis in oral cancer
  JOURNAL   Oral Dis 30 (4), 2027-2038 (2024)
   PUBMED   37448179
  REMARK    GeneRIF: IL17RB expression is associated with malignant cancer
            behaviors and poor prognosis in oral cancer.
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Deng,J., Zhang,T., Liu,F., Han,Q., Li,Q., Guo,X., Ma,Y., Li,L. and
            Shao,G.
  TITLE     CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of
            BARD1
  JOURNAL   Biochem Biophys Res Commun 611, 107-113 (2022)
   PUBMED   35487060
  REMARK    GeneRIF: CRL4-DCAF8L2 E3 ligase promotes ubiquitination and
            degradation of BARD1.
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Liu,S., Sun,Y., Tang,Y., Hu,R., Zhou,Q. and Li,X.
  TITLE     IL-25 promotes trophoblast proliferation and invasion via binding
            with IL-17RB and associated with PE
  JOURNAL   Hypertens Pregnancy 40 (3), 209-217 (2021)
   PUBMED   34264790
  REMARK    GeneRIF: IL-25 promotes trophoblast proliferation and invasion via
            binding with IL-17RB and associated with PE.
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Lee,J., Ho,W.H., Maruoka,M., Corpuz,R.T., Baldwin,D.T.,
            Foster,J.S., Goddard,A.D., Yansura,D.G., Vandlen,R.L., Wood,W.I.
            and Gurney,A.L.
  TITLE     IL-17E, a novel proinflammatory ligand for the IL-17 receptor
            homolog IL-17Rh1
  JOURNAL   J Biol Chem 276 (2), 1660-1664 (2001)
   PUBMED   11058597
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Shi,Y., Ullrich,S.J., Zhang,J., Connolly,K., Grzegorzewski,K.J.,
            Barber,M.C., Wang,W., Wathen,K., Hodge,V., Fisher,C.L., Olsen,H.,
            Ruben,S.M., Knyazev,I., Cho,Y.H., Kao,V., Wilkinson,K.A.,
            Carrell,J.A. and Ebner,R.
  TITLE     A novel cytokine receptor-ligand pair. Identification, molecular
            characterization, and in vivo immunomodulatory activity
  JOURNAL   J Biol Chem 275 (25), 19167-19176 (2000)
   PUBMED   10749887
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Tian,E., Sawyer,J.R., Largaespada,D.A., Jenkins,N.A., Copeland,N.G.
            and Shaughnessy,J.D. Jr.
  TITLE     Evi27 encodes a novel membrane protein with homology to the IL17
            receptor
  JOURNAL   Oncogene 19 (17), 2098-2109 (2000)
   PUBMED   10815801
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Schwandner,R., Yamaguchi,K. and Cao,Z.
  TITLE     Requirement of tumor necrosis factor receptor-associated factor
            (TRAF)6 in interleukin 17 signal transduction
  JOURNAL   J Exp Med 191 (7), 1233-1240 (2000)
   PUBMED   10748240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA093617.1 and BC000980.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018725.3.
            
            Summary: The protein encoded by this gene is a cytokine receptor.
            This receptor specifically binds to IL17B and IL17E, but does not
            bind to IL17 and IL17C. This receptor has been shown to mediate the
            activation of NF-kappaB and the production of IL8 induced by IL17E.
            The expression of the rat counterpart of this gene was found to be
            significantly up-regulated during intestinal inflammation, which
            suggested the immunoregulatory activity of this receptor. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.254406.1,
                                           SRR1803615.62904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288167.8/ ENSP00000288167.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               DA093617.1         19-462
            445-2016            BC000980.1         433-2004
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..2016
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /note="interleukin 17 receptor B"
                     /db_xref="GeneID:55540"
                     /db_xref="HGNC:HGNC:18015"
                     /db_xref="MIM:605458"
     exon            1..81
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1530
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /note="IL-17B receptor; interleukin 17 receptor homolog 1;
                     cytokine receptor CRL4; IL-17RB; IL-17Rh1; IL-17 receptor
                     B; IL-17 receptor homolog 1; cytokine receptor-like 4;
                     interleukin-17B receptor"
                     /codon_start=1
                     /product="interleukin-17 receptor B precursor"
                     /protein_id="NP_061195.2"
                     /db_xref="CCDS:CCDS2874.1"
                     /db_xref="GeneID:55540"
                     /db_xref="HGNC:HGNC:18015"
                     /db_xref="MIM:605458"
                     /translation="MSLVLLSLAALCRSAVPREPTVQCGSETGPSPEWMLQHDLIPGD
                     LRDLRVEPVTTSVATGDYSILMNVSWVLRADASIRLLKATKICVTGKSNFQSYSCVRC
                     NYTEAFQTQTRPSGGKWTFSYIGFPVELNTVYFIGAHNIPNANMNEDGPSMSVNFTSP
                     GCLDHIMKYKKKCVKAGSLWDPNITACKKNEETVEVNFTTTPLGNRYMALIQHSTIIG
                     FSQVFEPHQKKQTRASVVIPVTGDSEGATVQLTPYFPTCGSDCIRHKGTVVLCPQTGV
                     PFPLDNNKSKPGGWLPLLLLSLLVATWVLVAGIYLMWRHERIKKTSFSTTTLLPPIKV
                     LVVYPSEICFHHTICYFTEFLQNHCRSEVILEKWQKKKIAEMGPVQWLATQKKAADKV
                     VFLLSNDVNSVCDGTCGKSEGSPSENSQDLFPLAFNLFCSDLRSQIHLHKYVVVYFRE
                     IDTKDDYNALSVCPKYHLMKDATAFCAELLHVKQQVSAGKRSQACHDGCCSL"
     exon            82..106
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..247
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..375
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..502
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..550
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..693
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..768
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..868
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..967
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..2016
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /note="major polyA site"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="IL17RB"
                     /gene_synonym="CRL4; EVI27; IL17BR; IL17RH1"
ORIGIN      
        1 atcccgcgca gtggcccggc gatgtcgctc gtgctgctaa gcctggccgc gctgtgcagg
       61 agcgccgtac cccgagagcc gaccgttcaa tgtggctctg aaactgggcc atctccagag
      121 tggatgctac aacatgatct aatccccgga gacttgaggg acctccgagt agaacctgtt
      181 acaactagtg ttgcaacagg ggactattca attttgatga atgtaagctg ggtactccgg
      241 gcagatgcca gcatccgctt gttgaaggcc accaagattt gtgtgacggg caaaagcaac
      301 ttccagtcct acagctgtgt gaggtgcaat tacacagagg ccttccagac tcagaccaga
      361 ccctctggtg gtaaatggac attttcctac atcggcttcc ctgtagagct gaacacagtc
      421 tatttcattg gggcccataa tattcctaat gcaaatatga atgaagatgg cccttccatg
      481 tctgtgaatt tcacctcacc aggctgccta gaccacataa tgaaatataa aaaaaagtgt
      541 gtcaaggccg gaagcctgtg ggatccgaac atcactgctt gtaagaagaa tgaggagaca
      601 gtagaagtga acttcacaac cactcccctg ggaaacagat acatggctct tatccaacac
      661 agcactatca tcgggttttc tcaggtgttt gagccacacc agaagaaaca aacgcgagct
      721 tcagtggtga ttccagtgac tggggatagt gaaggtgcta cggtgcagct gactccatat
      781 tttcctactt gtggcagcga ctgcatccga cataaaggaa cagttgtgct ctgcccacaa
      841 acaggcgtcc ctttccctct ggataacaac aaaagcaagc cgggaggctg gctgcctctc
      901 ctcctgctgt ctctgctggt ggccacatgg gtgctggtgg cagggatcta tctaatgtgg
      961 aggcacgaaa ggatcaagaa gacttccttt tctaccacca cactactgcc ccccattaag
     1021 gttcttgtgg tttacccatc tgaaatatgt ttccatcaca caatttgtta cttcactgaa
     1081 tttcttcaaa accattgcag aagtgaggtc atccttgaaa agtggcagaa aaagaaaata
     1141 gcagagatgg gtccagtgca gtggcttgcc actcaaaaga aggcagcaga caaagtcgtc
     1201 ttccttcttt ccaatgacgt caacagtgtg tgcgatggta cctgtggcaa gagcgagggc
     1261 agtcccagtg agaactctca agacctcttc ccccttgcct ttaacctttt ctgcagtgat
     1321 ctaagaagcc agattcatct gcacaaatac gtggtggtct actttagaga gattgataca
     1381 aaagacgatt acaatgctct cagtgtctgc cccaagtacc acctcatgaa ggatgccact
     1441 gctttctgtg cagaacttct ccatgtcaag cagcaggtgt cagcaggaaa aagatcacaa
     1501 gcctgccacg atggctgctg ctccttgtag cccacccatg agaagcaaga gaccttaaag
     1561 gcttcctatc ccaccaatta cagggaaaaa acgtgtgatg atcctgaagc ttactatgca
     1621 gcctacaaac agccttagta attaaaacat tttataccaa taaaattttc aaatattgct
     1681 aactaatgta gcattaacta acgattggaa actacattta caacttcaaa gctgttttat
     1741 acatagaaat caattacagt tttaattgaa aactataacc attttgataa tgcaacaata
     1801 aagcatcttc agccaaacat ctagtcttcc atagaccatg cattgcagtg tacccagaac
     1861 tgtttagcta atattctatg tttaattaat gaatactaac tctaagaacc cctcactgat
     1921 tcactcaata gcatcttaag tgaaaaacct tctattacat gcaaaaaatc attgttttta
     1981 agataacaaa agtagggaat aaacaagctg aaccca
//
