LOCUS       NM_014339               8566 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens interleukin 17 receptor A (IL17RA), transcript variant
            1, mRNA.
ACCESSION   NM_014339 XR_109693 XR_112219 XR_115439
VERSION     NM_014339.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8566)
  AUTHORS   Jiang,J.K., Lin,C.H., Chang,T.A., Lo,L.C., Lin,C.P., Lu,R.H. and
            Yang,C.Y.
  TITLE     Decreased interleukin-17RA expression is associated with good
            prognosis in patients with colorectal cancer and inhibits tumor
            growth and vascularity in mice
  JOURNAL   Cancer Med 13 (5), e7059 (2024)
   PUBMED   38491831
  REMARK    GeneRIF: Decreased interleukin-17RA expression is associated with
            good prognosis in patients with colorectal cancer and inhibits
            tumor growth and vascularity in mice.
REFERENCE   2  (bases 1 to 8566)
  AUTHORS   Zhao,R., Zhang,Y.W., Yao,J.Y., Qiao,J., Song,S., Zhang,S.X.,
            Wang,C.H. and Li,X.F.
  TITLE     Genetic association between interleukin-17 and susceptibility to
            rheumatoid arthritis
  JOURNAL   BMC Med Genomics 16 (1), 277 (2023)
   PUBMED   37926850
  REMARK    GeneRIF: Genetic association between interleukin-17 and
            susceptibility to rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8566)
  AUTHORS   Chen,Z., Qiao,S., Yang,L., Sun,M., Li,B., Lu,A. and Li,F.
  TITLE     Mechanistic Insights into the Roles of the IL-17/IL-17R Families in
            Pancreatic Cancer
  JOURNAL   Int J Mol Sci 24 (17), 13539 (2023)
   PUBMED   37686343
  REMARK    GeneRIF: Mechanistic Insights into the Roles of the IL-17/IL-17R
            Families in Pancreatic Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8566)
  AUTHORS   Puscas,A.D., Morar,I.I., Vesa,S.C., Catana,A., Puscas,C.,
            Ilies,R.F. and Orasan,R.I.
  TITLE     Association between IL-17F, IL-17RA Gene Polymorphisms and Response
            to Biological Drugs in Psoriasis and Beyond
  JOURNAL   Genes (Basel) 14 (5), 1123 (2023)
   PUBMED   37239484
  REMARK    GeneRIF: Association between IL-17F, IL-17RA Gene Polymorphisms and
            Response to Biological Drugs in Psoriasis and Beyond.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8566)
  AUTHORS   Zhang,W., Liu,X., Wang,J., Wang,X. and Zhang,Y.
  TITLE     Immunogenic Cell Death Associated Molecular Patterns and the Dual
            Role of IL17RA in Interstitial Cystitis/Bladder Pain Syndrome
  JOURNAL   Biomolecules 13 (3), 421 (2023)
   PUBMED   36979355
  REMARK    GeneRIF: Immunogenic Cell Death Associated Molecular Patterns and
            the Dual Role of IL17RA in Interstitial Cystitis/Bladder Pain
            Syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8566)
  AUTHORS   Kehlen,A., Thiele,K., Riemann,D. and Langner,J.
  TITLE     Expression, modulation and signalling of IL-17 receptor in
            fibroblast-like synoviocytes of patients with rheumatoid arthritis
  JOURNAL   Clin Exp Immunol 127 (3), 539-546 (2002)
   PUBMED   11966773
  REMARK    GeneRIF: Expression, modulation and signalling of IL-17 receptor in
            fibroblast-like synoviocytes of patients with rheumatoid arthritis
REFERENCE   7  (bases 1 to 8566)
  AUTHORS   Haudenschild,D., Moseley,T., Rose,L. and Reddi,A.H.
  TITLE     Soluble and transmembrane isoforms of novel interleukin-17
            receptor-like protein by RNA splicing and expression in prostate
            cancer
  JOURNAL   J Biol Chem 277 (6), 4309-4316 (2002)
   PUBMED   11706037
REFERENCE   8  (bases 1 to 8566)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
REFERENCE   9  (bases 1 to 8566)
  AUTHORS   Honorati,M.C., Meliconi,R., Pulsatelli,L., Cane,S., Frizziero,L.
            and Facchini,A.
  TITLE     High in vivo expression of interleukin-17 receptor in synovial
            endothelial cells and chondrocytes from arthritis patients
  JOURNAL   Rheumatology (Oxford) 40 (5), 522-527 (2001)
   PUBMED   11371660
REFERENCE   10 (bases 1 to 8566)
  AUTHORS   Yao,Z., Spriggs,M.K., Derry,J.M., Strockbine,L., Park,L.S.,
            VandenBos,T., Zappone,J.D., Painter,S.L. and Armitage,R.J.
  TITLE     Molecular characterization of the human interleukin (IL)-17
            receptor
  JOURNAL   Cytokine 9 (11), 794-800 (1997)
   PUBMED   9367539
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB044543.1, U58917.1,
            AC006946.20 and BU585070.1.
            
            On Aug 31, 2019 this sequence version replaced NM_014339.6.
            
            Summary: Interleukin 17A (IL17A) is a proinflammatory cytokine
            secreted by activated T-lymphocytes. It is a potent inducer of the
            maturation of CD34-positive hematopoietic precursors into
            neutrophils. The transmembrane protein encoded by this gene
            (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane
            glycoprotein that binds with low affinity to interleukin 17A.
            Interleukin 17A and its receptor play a pathogenic role in many
            inflammatory and autoimmune diseases such as rheumatoid arthritis.
            Like other cytokine receptors, this receptor likely has a
            multimeric structure. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011624.2, U58917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319363.11/ ENSP00000320936.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                CB044543.1         50-134
            86-3180             U58917.1           26-3120
            3181-8404           AC006946.20        129821-135044
            8405-8566           BU585070.1         260-421
FEATURES             Location/Qualifiers
     source          1..8566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.1"
     gene            1..8566
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="interleukin 17 receptor A"
                     /db_xref="GeneID:23765"
                     /db_xref="HGNC:HGNC:5985"
                     /db_xref="MIM:605461"
     exon            1..230
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2693
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-17 receptor A"
                     /codon_start=1
                     /product="interleukin-17 receptor A isoform 1 precursor"
                     /protein_id="NP_055154.3"
                     /db_xref="CCDS:CCDS13739.1"
                     /db_xref="GeneID:23765"
                     /db_xref="HGNC:HGNC:5985"
                     /db_xref="MIM:605461"
                     /translation="MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCS
                     QPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQT
                     DASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVT
                     VHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLR
                     VSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGC
                     CRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVG
                     SVILLIVCMTWRLAGPGSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYV
                     DVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRG
                     TRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVS
                     CDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQ
                     LRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLV
                     REPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVE
                     PGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLL
                     PEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYIS
                     RSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDT
                     MGSESEGPSA"
     exon            231..255
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            256..402
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            403..515
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            516..642
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            643..690
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            691..854
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            855..938
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1023
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1035
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1137
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1179
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..8566
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2853
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="major polyA site"
     regulatory      5629..5634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="hexamer: AATAAA"
     polyA_site      5650
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="major polyA site"
     regulatory      8545..8550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="hexamer: AATAAA"
     polyA_site      8566
                     /gene="IL17RA"
                     /gene_synonym="CANDF5; CD217; CDw217; hIL-17R; IL-17RA;
                     IL17R; IMD51"
                     /note="major polyA site"
ORIGIN      
        1 gactcgaact ccaccgcgga aaagaaagcc tcagaacgtt cgttcgctgc gtccccagcc
       61 ggggccgagc cctccgcgac gccagccggg ccatgggggc cgcacgcagc ccgccgtccg
      121 ctgtcccggg gcccctgctg gggctgctcc tgctgctcct gggcgtgctg gccccgggtg
      181 gcgcctccct gcgactcctg gaccaccggg cgctggtctg ctcccagccg gggctaaact
      241 gcacggtcaa gaatagtacc tgcctggatg acagctggat tcaccctcga aacctgaccc
      301 cctcctcccc aaaggacctg cagatccagc tgcactttgc ccacacccaa caaggagacc
      361 tgttccccgt ggctcacatc gaatggacac tgcagacaga cgccagcatc ctgtacctcg
      421 agggtgcaga gttatctgtc ctgcagctga acaccaatga acgtttgtgc gtcaggtttg
      481 agtttctgtc caaactgagg catcaccaca ggcggtggcg ttttaccttc agccactttg
      541 tggttgaccc tgaccaggaa tatgaggtga ccgttcacca cctgcccaag cccatccctg
      601 atggggaccc aaaccaccag tccaagaatt tccttgtgcc tgactgtgag cacgccagga
      661 tgaaggtaac cacgccatgc atgagctcag gcagcctgtg ggaccccaac atcaccgtgg
      721 agaccctgga ggcccaccag ctgcgtgtga gcttcaccct gtggaacgaa tctacccatt
      781 accagatcct gctgaccagt tttccgcaca tggagaacca cagttgcttt gagcacatgc
      841 accacatacc tgcgcccaga ccagaagagt tccaccagcg atccaacgtc acactcactc
      901 tacgcaacct taaagggtgc tgtcgccacc aagtgcagat ccagcccttc ttcagcagct
      961 gcctcaatga ctgcctcaga cactccgcga ctgtttcctg cccagaaatg ccagacactc
     1021 cagaaccaat tccggactac atgcccctgt gggtgtactg gttcatcacg ggcatctcca
     1081 tcctgctggt gggctccgtc atcctgctca tcgtctgcat gacctggagg ctagctgggc
     1141 ctggaagtga aaaatacagt gatgacacca aatacaccga tggcctgcct gcggctgacc
     1201 tgatcccccc accgctgaag cccaggaagg tctggatcat ctactcagcc gaccaccccc
     1261 tctacgtgga cgtggtcctg aaattcgccc agttcctgct caccgcctgc ggcacggaag
     1321 tggccctgga cctgctggaa gagcaggcca tctcggaggc aggagtcatg acctgggtgg
     1381 gccgtcagaa gcaggagatg gtggagagca actctaagat catcgtcctg tgctcccgcg
     1441 gcacgcgcgc caagtggcag gcgctcctgg gccggggggc gcctgtgcgg ctgcgctgcg
     1501 accacggaaa gcccgtgggg gacctgttca ctgcagccat gaacatgatc ctcccggact
     1561 tcaagaggcc agcctgcttc ggcacctacg tagtctgcta cttcagcgag gtcagctgtg
     1621 acggcgacgt ccccgacctg ttcggcgcgg cgccgcggta cccgctcatg gacaggttcg
     1681 aggaggtgta cttccgcatc caggacctgg agatgttcca gccgggccgc atgcaccgcg
     1741 taggggagct gtcgggggac aactacctgc ggagcccggg cggcaggcag ctccgcgccg
     1801 ccctggacag gttccgggac tggcaggtcc gctgtcccga ctggttcgaa tgtgagaacc
     1861 tctactcagc agatgaccag gatgccccgt ccctggacga agaggtgttt gaggagccac
     1921 tgctgcctcc gggaaccggc atcgtgaagc gggcgcccct ggtgcgcgag cctggctccc
     1981 aggcctgcct ggccatagac ccgctggtcg gggaggaagg aggagcagca gtggcaaagc
     2041 tggaacctca cctgcagccc cggggtcagc cagcgccgca gcccctccac accctggtgc
     2101 tcgccgcaga ggagggggcc ctggtggccg cggtggagcc tgggcccctg gctgacggtg
     2161 ccgcagtccg gctggcactg gcgggggagg gcgaggcctg cccgctgctg ggcagcccgg
     2221 gcgctgggcg aaatagcgtc ctcttcctcc ccgtggaccc cgaggactcg ccccttggca
     2281 gcagcacccc catggcgtct cctgacctcc ttccagagga cgtgagggag cacctcgaag
     2341 gcttgatgct ctcgctcttc gagcagagtc tgagctgcca ggcccagggg ggctgcagta
     2401 gacccgccat ggtcctcaca gacccacaca cgccctacga ggaggagcag cggcagtcag
     2461 tgcagtctga ccagggctac atctccagga gctccccgca gccccccgag ggactcacgg
     2521 aaatggagga agaggaggaa gaggagcagg acccagggaa gccggccctg ccactctctc
     2581 ccgaggacct ggagagcctg aggagcctcc agcggcagct gcttttccgc cagctgcaga
     2641 agaactcggg ctgggacacg atggggtcag agtcagaggg gcccagtgca tgagggcggc
     2701 tccccaggga ccgcccagat cccagctttg agagaggagt gtgtgtgcac gtattcatct
     2761 gtgtgtacat gtctgcatgt gtatatgttc gtgtgtgaaa tgtaggcttt aaaatgtaaa
     2821 tgtctggatt ttaatcccag gcatccctcc taacttttct ttgtgcagcg gtctggttat
     2881 cgtctatccc caggggaatc cacacagccc gctcccagga gctaatggta gagcgtcctt
     2941 gaggctccat tattcgttca ttcagcattt attgtgcacc tactatgtgg cgggcatttg
     3001 ggataccaag ataaattgca tgcggcatgg ccccagccat gaaggaactt aaccgctagt
     3061 gccgaggaca cgttaaacga acaggatggg ccgggcacgg tggctcacgc ctgtaatccc
     3121 agcacactgg gaggccgagg caggtggatc actctgaggt caggagtttg agccagcctg
     3181 gccaacatgg tgaaacccca tctccactaa aaatagaaaa attagccggg catggtgaca
     3241 catgcctgta gtcctagcta cttgggaggc tgaggcagga gaattgcttg aatctgggag
     3301 gcagaggttg cagtgagccg agattgtgcc attgcactgc agcctggatg acagagcgag
     3361 actctatctc aaaaaaaaaa aaaaaaaaag atggtcacgc gggatgtaaa cgctgaatgg
     3421 gccaggtgca gtggctcatg cttgtaatcc cagcactttg ggaaggcgag gcaggtggat
     3481 tgcttgagct caggagttca agaccagcct gggcgacata gtgagacctc atctctacct
     3541 aaattttttt ttagtcagtc atggtggcac atgcctgtag tcccagctac tcgggaggct
     3601 gatgccagat gatcacttga gcccaggagg tagaggctgc agtgagctat aatggtacca
     3661 ttgcaatcca gcctgggcag cagagtgaga ccctgtctca aaaaaaataa aaaagtagaa
     3721 agatggagtg gaagcctgcc cagggttgtg agcatgcacg ggaaaggcac ccaggtcagg
     3781 ggggatcccc gaggagatgc ctgagctgaa ggattgtggt tggggaaagc gtagtcccag
     3841 caaggaagca gtttgtgggt aagtgctggg aggtgagtgg agtgagcttg tcagggagct
     3901 gctggtggag cctggagggg aaggagggag gcagtgagag agatcggggt ggggggtggg
     3961 gggatgtcgc cagagctcag gggtggggac agccttgtgc gcatcagtcc tgaggcctgg
     4021 ggcacctttc gtctgatgag cctctgcatg gagagaggct gagggctaaa cacagctgga
     4081 tgtcacctga gttcatttat aggaagagag aaatgtcgag gtgaaacgta aaagcatctg
     4141 gcaggaaggt gagtctgaag ccctgcaccc gcgttccgac tatcagtggg gagctgttag
     4201 cacgtaggat tcttcagagc agctgggctg gagctcccct gagctcagga agccccaggg
     4261 tgcaagggca aggaaatgag gggtggtggg tcagtgaaga tctgggcaga ccttgtgtgg
     4321 ggaaggggtg ctgctgtgac ttcagggtct gaggtccaaa gacagcattt gaaaagaggc
     4381 tctgaagcca gtgtttgaag aatttgttcc tgaagtacct cctgggggta ggctagaggc
     4441 ttctggcttc agggtcctga agaacacatt gaggtgccgt ctgacactgg aatagggtgc
     4501 ccttcattcc tatgcctgag tccttaacta tatttccaac ctccagtgag gaggagaaga
     4561 ttcggaaatg tgacaggaga gcaaacagga cagtttgcat gtgtgtgtgc gcacacatac
     4621 atgtgcgtga aagattatca ataaaagtgc ataaatttgt tgatctggta agagtttcta
     4681 gcaggaaggt cgagccactt actgtaggtc aagaagttgc tagttgcgga gttttttctt
     4741 gcagttagac tttacctagt ggtagcaggg ccaccaaagc tctgtgtccc agatggtgta
     4801 tggcccataa tccacccaac agcagcaaag gaccaggcaa aggagaacag gagcagaagc
     4861 ctcccagcca ctagcctttt gggctcagtc tctccaataa tcctggagag gggcttcgtt
     4921 gggtctggac acctaccatg cattctgtga cctttcccta gcttccaata aataactgtt
     4981 tgacgcccag agtacaggat accacaatgc actcttcctg cgtagagcac atgttcccat
     5041 ctgctcccat tcctcaggaa ccttgaattc tagctctgct ggcctttgag cccatgccag
     5101 taaatgtcct gatgggcatt gcctactatc tccagggcag ctgcctttgt cctcctaaca
     5161 gctttattgg agtacagttc acttaccata caatccacaa ttgaccctgc acaatttgat
     5221 gccggtttag tatagtcaca gttcagcagc catcagcaca gtcagtctta gagtttacta
     5281 cccccaaaag aaatccagcc ccccttagtc accaccccaa cctccccatc cctaggcacc
     5341 cctaggctac tttgatctct gtagacttgc ctcttctgga catgacatag agaaaggagt
     5401 cataaattct ccaaggtgtc tgtttcttct ttaatgtcat tccctgtttc tcctcacatt
     5461 ccctccccat ttcctgggcc cagtctcaca ctggtccttg cttaccctaa atgctattaa
     5521 ttccatcact ctgagtatgg tgtttgctgt ccgctgaatg ccaagagctt caagagtgtg
     5581 tgtaaataaa gccacacctt tatttttgta ttattctgaa ccatggctaa taaattgttt
     5641 caccaagaaa tgtctctcta agaacaggtg ccctccacgc tgtgcccctc ccacctcttc
     5701 agctcgtctc ctgagtgtgc agaggtggtt ccggttggga aagaagcagc ggagcatcta
     5761 accatgcctg tgtccaggcc gattatgcac gcagccacca acaagctccc aactcccgcg
     5821 tagagtttca tgactttttc ctgcctacta tcttgatcct agtttttttt ttgttttttt
     5881 tttttttaag gaataattac tttgattcaa aaccagtttc tcttttctgc ataggaaggt
     5941 ccttgaaggt gtttagggtc taaaaagggt ggtgttcggt ctctgaaaca tccattcagc
     6001 agtttgagct gggatctctg aatgcaaggg tatgatggat atacttcttt cttgcttttg
     6061 ttgtgttttg gttttttgtt tgtttttaag tcagggtctc tctgtcacca ggctgtatta
     6121 cagtggtgca atcatggctc actgcagcct cgacctccca ggctcaagcc atctttccac
     6181 ctcagcctgc cagtggctag aactacaggc gtgcaccact gtgcccggct aatttgtgtg
     6241 tatatatttt gtagaaatgg ggtttcacca tgttgtccag gctggtcacg aactcctggg
     6301 ctcaagccat ctgcccgcct catcctccca aagtgctggg attataggcc tgagcccacc
     6361 gtgcctggcc tttcctgttt atctttgaaa attaaatagg gcataagaga gaagaagatg
     6421 tacttacaat gcagtgggtg gttttaactc tatagccttt gggctctgtg gttggtgctc
     6481 cccttcctaa ataaatgagg tgtatgcagg gccctcttct gccttagcgc cctgccagct
     6541 gggactccag caaggcccgg ggcacctgag gacagagtga gatggagggc cgctgctcca
     6601 gcagccgggc ctgcatccca caagtcaact gtgtcggaca gaggatcctt acaaagaaga
     6661 ggcagcaggg ttgggggctg gccagctgct cgtccgccct aggtagcttg ctcatctgta
     6721 aagtgggtgg ggcaggagtt cccacctcat ggggtcctgg caagcctgca gtatccccga
     6781 gtggcaccag cctgcttctg gggcagagca gtttgtgccc cctgaggtac cactgatcct
     6841 ctttccctgc tattaggtat tgctctcttc ctccggtgtt tgccttttca gattatagaa
     6901 gtaatatgtg ttcccatatt tggcgtctct caggagctca ggaagtactt ggctgagtga
     6961 acatgtccat tgtggaaaaa tggcaacaat atggattcca tgggtatatt ttatagaaga
     7021 atatgaagaa aagcagctac ccctaaaccc attgcacaag ctgttcatgt taattctgta
     7081 cccgacgctt tccccacggg gcctcccctc actctgaaat ggcatccagg tccatcttgc
     7141 cctccacctc tgcatggctc tccatgcccc atcgcctctc ccagatccta gcactgggtc
     7201 cacactctcg ccctgtccat ttaggttgat gaaagcaggc agtcacccgg gtgggccagt
     7261 cttgcctgtg ggaggaacat gcagtctcct gtctcatggt ttgaagtgtg ccaggaagcc
     7321 tggcccagcc cacctccccc tggagtcctt cccaggagga ataacccctt aggtcattga
     7381 ctataagatg agttcgctca ctggatcctt cctctctgat gagacaggaa gaaggtacac
     7441 agtgaccagg taggaggagg agagggagta gaaaggaggg atgcgggtgg ctggtccctg
     7501 catttgcctg cttccctgca cgggtgtccc actggccgcc tctgctcacc agtgtcatgg
     7561 gattctctca gaagatgaaa acagcccctg cttttttgct agaatggctg agctttcatg
     7621 gaaaggaagc tggacccaag caacagccga ctaccgaagg ttgcctggag cagtgcagat
     7681 gtgggaggaa gaagggcctt ggtgcacact ggcttttctt cctgactgca atgtggcatt
     7741 gtgccagcta cctcctcttt ctcggcctca ggaaaatgga gagaaagcag ccctgaaggt
     7801 ggctgtgacg agggaagggg cagagggcct gacagtcaac cacgcgctat attttcctgt
     7861 tcttccttag ggcaagaact gcatggccag actcaggcaa ggcctaggtg tgggctgggc
     7921 attgcctaca cgtgaagaga tcactccgcg tccctactgc acctgtcaca aagtgccttc
     7981 tgatatgcct ggcaaaccaa aatcggtgag cgccagcttg cttccctaga agacatttct
     8041 aaatattcat aacatgcttg ctcaaatcaa tcaccttatt ttacatccgc tccagggaga
     8101 aatgaagaca tggtcctacg ttgttctgta attattttct atgtaaattt tgttccttgt
     8161 tacaattata tatgtcttag gggaaaggac catttcacat gtgtcacctc atgtgattct
     8221 caccacagcc ctgtgattgc tcctgtttta taaataatga catagttcca gttgatggcc
     8281 aaagccacag ctaacgagag gcagagagag ctcaggctcc caggagcttc cactctcaga
     8341 ccttgcctcc cgggctgccc tgagtgaaac gcctgcttag catttggcac agccagaagc
     8401 agcaagctag ggtcacaaca cagagagggg ctgtgtaata ctggctgcct ctgtgctaag
     8461 aaaaaaaaaa aatcactgtg tgtttgttta ttttggtgca ggcccagtgt tcttgcttag
     8521 acttaatact acccttcatg ttaaaataaa accaaacaaa aaccca
//
