LOCUS       NM_052872                813 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens interleukin 17F (IL17F), mRNA.
ACCESSION   NM_052872
VERSION     NM_052872.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 813)
  AUTHORS   Salah,S., Sadeq,Y.I., Mosaad,Y.M., Elmenshawi,I.E.H. and
            Tawhid,Z.M.E.
  TITLE     Association of interleukin-17F (rs763780) single nucleotide
            polymorphism with multiple sclerosis and optic neuritis
  JOURNAL   Sci Rep 14 (1), 13643 (2024)
   PUBMED   38871733
  REMARK    GeneRIF: Association of interleukin-17F (rs763780) single
            nucleotide polymorphism with multiple sclerosis and optic neuritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 813)
  AUTHORS   Matsuda,K.M., Kotani,H., Hisamoto,T., Kuzumi,A., Fukasawa,T.,
            Yoshizaki-Ogawa,A., Sato,S. and Yoshizaki,A.
  TITLE     Dual blockade of interleukin-17A and interleukin-17F as a
            therapeutic strategy for liver fibrosis: Investigating the
            potential effect and mechanism of brodalumab
  JOURNAL   Cytokine 178, 156587 (2024)
   PUBMED   38531177
  REMARK    GeneRIF: Dual blockade of interleukin-17A and interleukin-17F as a
            therapeutic strategy for liver fibrosis: Investigating the
            potential effect and mechanism of brodalumab.
REFERENCE   3  (bases 1 to 813)
  AUTHORS   da Silva,D.D., Frederico,F.B., Previato,M., Siqueira,R.C.,
            Bonini-Domingos,C.R., de Souza,V.H., Castiglioni,L., Brandao,C.C.,
            de Mattos,L.C. and Ayo,C.M.
  TITLE     Interleukin 17F Gene Polymorphism as a Potential Protective Factor
            in the Immunopathology of Ocular Toxoplasmosis
  JOURNAL   Parasite Immunol 46 (5), e13038 (2024)
   PUBMED   38767154
  REMARK    GeneRIF: Interleukin 17F Gene Polymorphism as a Potential
            Protective Factor in the Immunopathology of Ocular Toxoplasmosis.
REFERENCE   4  (bases 1 to 813)
  AUTHORS   Akadam-Teker,A.B. and Aksan,B.
  TITLE     Association of IL-17F rs763780 polymorphism and risk of psoriasis
            in Turkish population: a case-control study
  JOURNAL   An Bras Dermatol 99 (3), 357-361 (2024)
   PUBMED   38331704
  REMARK    GeneRIF: Association of IL-17F rs763780 polymorphism and risk of
            psoriasis in Turkish population: a case-control study.
REFERENCE   5  (bases 1 to 813)
  AUTHORS   Shen,C., Li,Y., Huang,J., Li,J., Qi,G., Zhu,Z. and Zheng,H.
  TITLE     Association of Interleukin-17A and Interleukin-17F Gene
            Polymorphisms with Atopic Dermatitis in Chinese Children
  JOURNAL   Genet Test Mol Biomarkers 28 (2), 43-49 (2024)
   PUBMED   38416662
  REMARK    GeneRIF: Association of Interleukin-17A and Interleukin-17F Gene
            Polymorphisms with Atopic Dermatitis in Chinese Children.
REFERENCE   6  (bases 1 to 813)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 813)
  AUTHORS   Kawaguchi,M., Onuchic,L.F. and Huang,S.K.
  TITLE     Activation of extracellular signal-regulated kinase (ERK)1/2, but
            not p38 and c-Jun N-terminal kinase, is involved in signaling of a
            novel cytokine, ML-1
  JOURNAL   J Biol Chem 277 (18), 15229-15232 (2002)
   PUBMED   11891214
  REMARK    GeneRIF: a cytokine involved in the activaion of MAP kinases
REFERENCE   8  (bases 1 to 813)
  AUTHORS   Kawaguchi,M., Onuchic,L.F., Li,X.D., Essayan,D.M., Schroeder,J.,
            Xiao,H.Q., Liu,M.C., Krishnaswamy,G., Germino,G. and Huang,S.K.
  TITLE     Identification of a novel cytokine, ML-1, and its expression in
            subjects with asthma
  JOURNAL   J Immunol 167 (8), 4430-4435 (2001)
   PUBMED   11591768
REFERENCE   9  (bases 1 to 813)
  AUTHORS   Starnes,T., Robertson,M.J., Sledge,G., Kelich,S., Nakshatri,H.,
            Broxmeyer,H.E. and Hromas,R.
  TITLE     Cutting edge: IL-17F, a novel cytokine selectively expressed in
            activated T cells and monocytes, regulates angiogenesis and
            endothelial cell cytokine production
  JOURNAL   J Immunol 167 (8), 4137-4140 (2001)
   PUBMED   11591732
REFERENCE   10 (bases 1 to 813)
  AUTHORS   Hymowitz,S.G., Filvaroff,E.H., Yin,J.P., Lee,J., Cai,L., Risser,P.,
            Maruoka,M., Mao,W., Foster,J., Kelley,R.F., Pan,G., Gurney,A.L., de
            Vos,A.M. and Starovasnik,M.A.
  TITLE     IL-17s adopt a cystine knot fold: structure and activity of a novel
            cytokine, IL-17F, and implications for receptor binding
  JOURNAL   EMBO J 20 (19), 5332-5341 (2001)
   PUBMED   11574464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070124.1 and AF332389.1.
            
            On Aug 2, 2019 this sequence version replaced NM_052872.3.
            
            Summary: The protein encoded by this gene is a cytokine that shares
            sequence similarity with IL17. This cytokine is expressed by
            activated T cells, and has been shown to stimulate the production
            of several other cytokines, including IL6, IL8, and CSF2/GM_CSF.
            This cytokine is also found to inhibit the angiogenesis of
            endothelial cells and induce endothelial cells to produce IL2,
            TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070124.1, CD639406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336123.5/ ENSP00000337432.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               BC070124.1         1-552
            553-697             AF332389.1         666-810
            698-813             BC070124.1         698-813
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.2"
     gene            1..813
                     /gene="IL17F"
                     /gene_synonym="CANDF6; IL-17F; IL17A; ML-1; ML1"
                     /note="interleukin 17F"
                     /db_xref="GeneID:112744"
                     /db_xref="HGNC:HGNC:16404"
                     /db_xref="MIM:606496"
     exon            1..104
                     /gene="IL17F"
                     /gene_synonym="CANDF6; IL-17F; IL17A; ML-1; ML1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..563
                     /gene="IL17F"
                     /gene_synonym="CANDF6; IL-17F; IL17A; ML-1; ML1"
                     /note="cytokine ML-1"
                     /codon_start=1
                     /product="interleukin-17F precursor"
                     /protein_id="NP_443104.1"
                     /db_xref="CCDS:CCDS4938.1"
                     /db_xref="GeneID:112744"
                     /db_xref="HGNC:HGNC:16404"
                     /db_xref="MIM:606496"
                     /translation="MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKP
                     ESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQC
                     RNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIH
                     HVQ"
     exon            105..325
                     /gene="IL17F"
                     /gene_synonym="CANDF6; IL-17F; IL17A; ML-1; ML1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..813
                     /gene="IL17F"
                     /gene_synonym="CANDF6; IL-17F; IL17A; ML-1; ML1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacacaggc atacacagga agatacattc acagaaagag cttcctgcac aaagtaagcc
       61 accagcgcaa catgacagtg aagaccctgc atggcccagc catggtcaag tacttgctgc
      121 tgtcgatatt ggggcttgcc tttctgagtg aggcggcagc tcggaaaatc cccaaagtag
      181 gacatacttt tttccaaaag cctgagagtt gcccgcctgt gccaggaggt agtatgaagc
      241 ttgacattgg catcatcaat gaaaaccagc gcgtttccat gtcacgtaac atcgagagcc
      301 gctccacctc cccctggaat tacactgtca cttgggaccc caaccggtac ccctcggaag
      361 ttgtacaggc ccagtgtagg aacttgggct gcatcaatgc tcaaggaaag gaagacatct
      421 ccatgaattc cgttcccatc cagcaagaga ccctggtcgt ccggaggaag caccaaggct
      481 gctctgtttc tttccagttg gagaaggtgc tggtgactgt tggctgcacc tgcgtcaccc
      541 ctgtcatcca ccatgtgcag taagaggtgc atatccactc agctgaagaa gctgtagaaa
      601 tgccactcct tacccagtgc tctgcaacaa gtcctgtctg acccccaatt ccctccactt
      661 cacaggactc ttaataagac ctgcacggat ggaaacagaa aatattcaca atgtatgtgt
      721 gtatgtacta cactttatat ttgatatcta aaatgttagg agaaaaatta atatattcag
      781 tgctaatata ataaagtatt aataatttaa aaa
//
