LOCUS       NM_001385224            2056 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens interleukin 17D (IL17D), transcript variant 5, mRNA.
ACCESSION   NM_001385224
VERSION     NM_001385224.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Dong,S., Liu,S., Gao,Q., Shi,J., Song,K., Wu,Y., Liu,H., Guo,C.,
            Huang,Y., Du,S., Li,X., Ge,L. and Yu,J.
  TITLE     Interleukin-17D produced by alveolar epithelial type II cells
            alleviates LPS-induced acute lung injury via the Nrf2 pathway
  JOURNAL   Clin Sci (Lond) 137 (18), 1499-1512 (2023)
   PUBMED   37708335
  REMARK    GeneRIF: Interleukin-17D produced by alveolar epithelial type II
            cells alleviates LPS-induced acute lung injury via the Nrf2
            pathway.
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Lin,Z., Huang,Q., Liu,J., Wang,H., Zhang,X., Zhu,Z., Zhang,W.,
            Wei,Y., Liu,Z. and Du,W.
  TITLE     Interleukin-17D promotes lung cancer progression by inducing
            tumor-associated macrophage infiltration via the p38 MAPK signaling
            pathway
  JOURNAL   Aging (Albany NY) 14 (15), 6149-6168 (2022)
   PUBMED   35939336
  REMARK    GeneRIF: Interleukin-17D promotes lung cancer progression by
            inducing tumor-associated macrophage infiltration via the p38 MAPK
            signaling pathway.
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Liu,X., Li,T., Liu,Y., Sun,S. and Liu,D.
  TITLE     Nuclear factor erythroid 2-related factor 2 potentiates the
            generation of inflammatory cytokines by intestinal epithelial cells
            during hyperoxia by inducing the expression of interleukin 17D
  JOURNAL   Toxicology 457, 152820 (2021)
   PUBMED   34023435
  REMARK    GeneRIF: Nuclear factor erythroid 2-related factor 2 potentiates
            the generation of inflammatory cytokines by intestinal epithelial
            cells during hyperoxia by inducing the expression of interleukin
            17D.
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Tang,Y.J., Dou,H.T., Zhang,Q.H., Liu,J.J. and Yang,X.S.
  TITLE     Expression of inflammatory cytokines in ovarian epithelial cancer
            and their correlation
  JOURNAL   J Biol Regul Homeost Agents 31 (2), 413-418 (2017)
   PUBMED   28685546
  REMARK    GeneRIF: Study of the expression of IL-17 provides theoretical
            support for the clinical treatment and prognosis prediction of
            ovarian epithelial tumor.
REFERENCE   6  (bases 1 to 2056)
  AUTHORS   Al Omar,S., Flanagan,B.F., Almehmadi,M. and Christmas,S.E.
  TITLE     The effects of IL-17 upon human natural killer cells
  JOURNAL   Cytokine 62 (1), 123-130 (2013)
   PUBMED   23490420
  REMARK    GeneRIF: These experiments were designed to investigate the effects
            of IL-17 upon the phenotype and function of human Natural Killer
            (NK) cells.
REFERENCE   7  (bases 1 to 2056)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   8  (bases 1 to 2056)
  AUTHORS   Guzzo,C., Ayer,A., Basta,S., Banfield,B.W. and Gee,K.
  TITLE     IL-27 enhances LPS-induced proinflammatory cytokine production via
            upregulation of TLR4 expression and signaling in human monocytes
  JOURNAL   J Immunol 188 (2), 864-873 (2012)
   PUBMED   22156348
  REMARK    GeneRIF: IL-27 priming results in enhanced
            lipopolysaccharide-induced IL-6, tumor necrosis factor (TNF)-alpha,
            macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta
            expression in human primary monocytes.
REFERENCE   9  (bases 1 to 2056)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2056)
  AUTHORS   Starnes,T., Broxmeyer,H.E., Robertson,M.J. and Hromas,R.
  TITLE     Cutting edge: IL-17D, a novel member of the IL-17 family,
            stimulates cytokine production and inhibits hemopoiesis
  JOURNAL   J Immunol 169 (2), 642-646 (2002)
   PUBMED   12097364
  REMARK    GeneRIF: IL-17D stimulates production of cytokines in endothelial
            cells in vitro and suppresses proliferation of myeloid progenitors
            in colony formation assays.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161772.17 and AL512652.18.
            
            Summary: The protein encoded by this gene is a cytokine that shares
            the sequence similarity with IL17. The treatment of endothelial
            cells with this cytokine has been shown to stimulate the production
            of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The
            increased expression of IL8 induced by this cytokine was found to
            be NF-kappa B-dependent. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5), as well as variants 3 and 4,
            encodes isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359113.1, SRR14038195.2760781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682841.1/ ENSP00000508385.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               AL161772.17        116222-116814
            594-2056            AL512652.18        10580-12042
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..2056
                     /gene="IL17D"
                     /gene_synonym="IL-17D"
                     /note="interleukin 17D"
                     /db_xref="GeneID:53342"
                     /db_xref="HGNC:HGNC:5984"
                     /db_xref="MIM:607587"
     exon            1..593
                     /gene="IL17D"
                     /gene_synonym="IL-17D"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..912
                     /gene="IL17D"
                     /gene_synonym="IL-17D"
                     /note="isoform c precursor is encoded by transcript
                     variant 5"
                     /codon_start=1
                     /product="interleukin-17D isoform c precursor"
                     /protein_id="NP_001372153.1"
                     /db_xref="CCDS:CCDS9292.1"
                     /db_xref="GeneID:53342"
                     /db_xref="HGNC:HGNC:5984"
                     /db_xref="MIM:607587"
                     /translation="MLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQLYG
                     RLAAGVLSAFHHTLQLGPREQARNASCPAGGRPADRRFRPPTNLRSVSPWAYRISYDP
                     ARYPRYLPEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEAY
                     VTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP"
     exon            594..2056
                     /gene="IL17D"
                     /gene_synonym="IL-17D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17D"
                     /gene_synonym="IL-17D"
                     /note="hexamer: ATTAAA"
     polyA_site      2056
                     /gene="IL17D"
                     /gene_synonym="IL-17D"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcgccc cgcacccgcc ccccgtgcgg cccccggctc ggggcggcgg cggcggcggg
       61 ggccgggggc gcgcgggccg gcgccgggct gggccccggg gaccccgcgg gcggcgggca
      121 ggcggggagg gcgctctggg gcccgcccgc gcggctccca tcctccgggc cggcctctgg
      181 ctccgcgggg cgaggggagg cgcccgccgg ctccgggcgc cgcgggcggg acacgggcgc
      241 ggggcgcagg cgggctcctc cggcgcgtgc ggacgctgag cgtggcctgt ccctcaggtc
      301 tggatgctgg tagccggctt cctgctggcg ctgccgccga gctgggccgc gggcgccccg
      361 agggcgggca ggcgccccgc gcggccgcgg ggctgcgcgg accggccgga ggagctactg
      421 gagcagctgt acgggcgcct ggcggccggc gtgctcagtg ccttccacca cacgctgcag
      481 ctggggccgc gtgagcaggc gcgcaacgcg agctgcccgg cagggggcag gcccgccgac
      541 cgccgcttcc ggccgcccac caacctgcgc agcgtgtcgc cctgggccta cagaatctcc
      601 tacgacccgg cgaggtaccc caggtacctg cctgaagcct actgcctgtg ccggggctgc
      661 ctgaccgggc tgttcggcga ggaggacgtg cgcttccgca gcgcccctgt ctacatgccc
      721 accgtcgtcc tgcgccgcac ccccgcctgc gccggcggcc gttccgtcta caccgaggcc
      781 tacgtcacca tccccgtggg ctgcacctgc gtccccgagc cggagaagga cgcagacagc
      841 atcaactcca gcatcgacaa acagggcgcc aagctcctgc tgggccccaa cgacgcgccc
      901 gctggcccct gaggccggtc ctgccccggg aggtctcccc ggcccgcatc ccgaggcgcc
      961 caagctggag ccgcctggag ggctcggtcg gcgacctctg aagagagtgc accgagcaaa
     1021 ccaagtgccg gagcaccagc gccgcctttc catggagact cgtaagcagc ttcatctgac
     1081 acgggcatcc ctggcttgct tttagctaca agcaagcagc gtggctggaa gctgatggga
     1141 aacgacccgg cacgggcatc ctgtgtgcgg cccgcatgga gggtttggaa aagttcacgg
     1201 aggctccctg aggagcctct cagatcggct gctgcgggtg cagggcgtga ctcaccgctg
     1261 ggtgcttgcc aaagagatag ggacgcatat gctttttaaa gcaatctaaa aataataata
     1321 agtatagcga ctatatacct acttttaaaa tcaactgttt tgaatagagg cagagctatt
     1381 ttatattatc aaatgagagc tactctgtta catttcttaa catataaaca tcgtttttta
     1441 cttcttctgg tagaattttt taaagcataa ttggaatcct tggataaatt ttgtagctgg
     1501 tacactctgg cctgggtctc tgaattcagc ctgtcaccga tggctgactg atgaaatgga
     1561 cacgtctcat ctgacccact cttccttcca ctgaaggtct tcacgggcct ccaggtggac
     1621 caaagggatg cacaggcggc tcgcatgccc cagggccagc taagagttcc aaagatctca
     1681 gatttggttt tagtcatgaa tacataaaca gtctcaaact cgcacaattt tttccccctt
     1741 ttgaaagcca ctggggccaa tttgtggtta agaggtggtg agataagaag tggaacgtga
     1801 catctttgcc agttgtcaga agaatccaag caggtattgg cttagttgta agggctttag
     1861 gatcaggctg aatatgagga caaagtgggc cacgttagca tctgcagaga tcaatctgga
     1921 ggcttctgtt tctgcattct gccacgagag ctaggtcctt gatcttttct ttagattgaa
     1981 agtctgtctc tgaacacaat tatttgtaaa agttagtagt tcttttttaa atcattaaaa
     2041 gaggcttgct gaagga
//
