LOCUS       NM_013278               1060 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens interleukin 17C (IL17C), mRNA.
ACCESSION   NM_013278
VERSION     NM_013278.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Garcia,E.M., Lenz,J.D., Schaub,R.E., Hackett,K.T., Salgado-Pabon,W.
            and Dillard,J.P.
  TITLE     IL-17C is a driver of damaging inflammation during Neisseria
            gonorrhoeae infection of human Fallopian tube
  JOURNAL   Nat Commun 15 (1), 3756 (2024)
   PUBMED   38704381
  REMARK    GeneRIF: IL-17C is a driver of damaging inflammation during
            Neisseria gonorrhoeae infection of human Fallopian tube.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Zhang,F., Yin,J., Liu,L., Liu,S., Zhang,G., Kong,Y., Wang,Y.,
            Wang,N., Chen,X. and Wang,F.
  TITLE     IL-17C neutralization protects the kidney against acute injury and
            chronic injury
  JOURNAL   EBioMedicine 92, 104607 (2023)
   PUBMED   37263138
  REMARK    GeneRIF: IL-17C neutralization protects the kidney against acute
            injury and chronic injury.
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Swedik,S.M., Madola,A., Cruz,M.A., Llorens-Bonilla,B.J. and
            Levine,A.D.
  TITLE     Th17-Derived Cytokines Synergistically Enhance IL-17C Production by
            the Colonic Epithelium
  JOURNAL   J Immunol 209 (9), 1768-1777 (2022)
   PUBMED   36130829
  REMARK    GeneRIF: Th17-Derived Cytokines Synergistically Enhance IL-17C
            Production by the Colonic Epithelium.
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Soares-Schanoski,A., Sauerwald,N., Goforth,C.W., Periasamy,S.,
            Weir,D.L., Lizewski,S., Lizewski,R., Ge,Y., Kuzmina,N.A.,
            Nair,V.D., Vangeti,S., Marjanovic,N., Cappuccio,A., Cheng,W.S.,
            Mofsowitz,S., Miller,C.M., Yu,X.B., George,M.C., Zaslavsky,E.,
            Bukreyev,A., Troyanskaya,O.G., Sealfon,S.C., Letizia,A.G. and
            Ramos,I.
  TITLE     Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels
            of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth
            Factors Than Mild Symptomatic COVID-19
  JOURNAL   Front Immunol 13, 821730 (2022)
   PUBMED   35479098
  REMARK    GeneRIF: Asymptomatic SARS-CoV-2 Infection Is Associated With
            Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and
            Fibroblast Growth Factors Than Mild Symptomatic COVID-19.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Vella,G., Ritzmann,F., Wolf,L., Kamyschnikov,A., Stodden,H.,
            Herr,C., Slevogt,H., Bals,R. and Beisswenger,C.
  TITLE     IL-17C contributes to NTHi-induced inflammation and lung damage in
            experimental COPD and is present in sputum during acute
            exacerbations
  JOURNAL   PLoS One 16 (1), e0243484 (2021)
   PUBMED   33411748
  REMARK    GeneRIF: IL-17C contributes to NTHi-induced inflammation and lung
            damage in experimental COPD and is present in sputum during acute
            exacerbations.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1060)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1060)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1060)
  AUTHORS   Lock,C., Hermans,G., Pedotti,R., Brendolan,A., Schadt,E.,
            Garren,H., Langer-Gould,A., Strober,S., Cannella,B., Allard,J.,
            Klonowski,P., Austin,A., Lad,N., Kaminski,N., Galli,S.J.,
            Oksenberg,J.R., Raine,C.S., Heller,R. and Steinman,L.
  TITLE     Gene-microarray analysis of multiple sclerosis lesions yields new
            targets validated in autoimmune encephalomyelitis
  JOURNAL   Nat Med 8 (5), 500-508 (2002)
   PUBMED   11984595
  REMARK    GeneRIF: expressed in multiple sclerosis brain lesions
REFERENCE   10 (bases 1 to 1060)
  AUTHORS   Li,H., Chen,J., Huang,A., Stinson,J., Heldens,S., Foster,J.,
            Dowd,P., Gurney,A.L. and Wood,W.I.
  TITLE     Cloning and characterization of IL-17B and IL-17C, two new members
            of the IL-17 cytokine family
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 773-778 (2000)
   PUBMED   10639155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116552.2.
            
            On May 17, 2019 this sequence version replaced NM_013278.3.
            
            Summary: The protein encoded by this gene is a T cell-derived
            cytokine that shares the sequence similarity with IL17. This
            cytokine was reported to stimulate the release of tumor necrosis
            factor alpha and interleukin 1 beta from a monocytic cell line. The
            expression of this cytokine was found to be restricted to activated
            T cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358471.1, AF152099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2163459
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244241.5/ ENSP00000244241.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC116552.2         27933-28008         c
            77-405              AC116552.2         27271-27599         c
            406-1060            AC116552.2         26112-26766         c
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..1060
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /note="interleukin 17C"
                     /db_xref="GeneID:27189"
                     /db_xref="HGNC:HGNC:5983"
                     /db_xref="MIM:604628"
     exon            1..76
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..664
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /note="cytokine CX2"
                     /codon_start=1
                     /product="interleukin-17C precursor"
                     /protein_id="NP_037410.1"
                     /db_xref="CCDS:CCDS42217.1"
                     /db_xref="GeneID:27189"
                     /db_xref="HGNC:HGNC:5983"
                     /db_xref="MIM:604628"
                     /translation="MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPL
                     GQAPPHLLARGAKWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTH
                     QRSISPWRYRVDTDEDRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRR
                     RPCSRDGSGLPTPGAFAFHTEFIHVPVGCTCVLPRSV"
     exon            77..405
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1060
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /note="hexamer: ATTAAA"
     polyA_site      1060
                     /gene="IL17C"
                     /gene_synonym="CX2; IL-17C"
                     /note="major polyA site"
ORIGIN      
        1 aggtgcacct gtgggattgc cgccaggtgt gcaggccgct ccaagcccag cctgccccgc
       61 tgccgccacc atgacgctcc tccccggcct cctgtttctg acctggctgc acacatgcct
      121 ggcccaccat gacccctccc tcagggggca cccccacagt cacggtaccc cacactgcta
      181 ctcggctgag gaactgcccc tcggccaggc ccccccacac ctgctggctc gaggtgccaa
      241 gtgggggcag gctttgcctg tagccctggt gtccagcctg gaggcagcaa gccacagggg
      301 gaggcacgag aggccctcag ctacgaccca gtgcccggtg ctgcggccgg aggaggtgtt
      361 ggaggcagac acccaccagc gctccatctc accctggaga taccgtgtgg acacggatga
      421 ggaccgctat ccacagaagc tggccttcgc cgagtgcctg tgcagaggct gtatcgatgc
      481 acggacgggc cgcgagacag ctgcgctcaa ctccgtgcgg ctgctccaga gcctgctggt
      541 gctgcgccgc cggccctgct cccgcgacgg ctcggggctc cccacacctg gggcctttgc
      601 cttccacacc gagttcatcc acgtccccgt cggctgcacc tgcgtgctgc cccgttcagt
      661 gtgaccgccg aggccgtggg gcccctagac tggacacgtg tgctccccag agggcacccc
      721 ctatttatgt gtatttattg ttatttatat gcctccccca acactaccct tggggtctgg
      781 gcattccccg tgtctggagg acagcccccc actgttctcc tcatctccag cctcagtagt
      841 tgggggtaga aggagctcag cacctcttcc agcccttaaa gctgcagaaa aggtgtcaca
      901 cggctgcctg taccttggct ccctgtcctg ctcccggctt cccttaccct atcactggcc
      961 tcaggccccc gcaggctgcc tcttcccaac ctccttggaa gtacccctgt ttcttaaaca
     1021 attatttaag tgtacgtgta ttattaaact gatgaacaca
//
