LOCUS       NM_014443                712 bp    mRNA    linear   PRI 25-DEC-2023
DEFINITION  Homo sapiens interleukin 17B (IL17B), transcript variant 1, mRNA.
ACCESSION   NM_014443
VERSION     NM_014443.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 712)
  AUTHORS   Nyangiri OA, Mulindwa J, Namulondo J, Kitibwa A, Nassuuna J,
            Elliott A, Kimuda MP, Boobo A, Nerima B, Adriko M, Dunton NJ,
            Madhan GK, Kristiansen M, Casacuberta-Partal M, Noyes H and Matovu
            E.
  CONSRTM   TrypanoGEN+ Research group of the H3Africa consortium
  TITLE     Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are
            associated with Schistosoma mansoni worm burden in the Albert Nile
            region of Uganda
  JOURNAL   PLoS Negl Trop Dis 17 (11), e0011796 (2023)
   PUBMED   38033168
  REMARK    GeneRIF: Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci
            are associated with Schistosoma mansoni worm burden in the Albert
            Nile region of Uganda.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 712)
  AUTHORS   Husein-ElAhmed H and Steinhoff M.
  TITLE     Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen
            planus: a systematic review with META-analysis
  JOURNAL   J Eur Acad Dermatol Venereol 36 (10), 1735-1744 (2022)
   PUBMED   35570406
  REMARK    GeneRIF: Potential role of INTERLEUKIN-17 in the pathogenesis of
            oral lichen planus: a systematic review with META-analysis.
            Review article
REFERENCE   3  (bases 1 to 712)
  AUTHORS   Ramirez-Carrozzi V, Ota N, Sambandam A, Wong K, Hackney J,
            Martinez-Martin N, Ouyang W and Pappu R.
  TITLE     Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2
            Inflammation from Human Lymphocytes
  JOURNAL   J Immunol 202 (7), 1935-1941 (2019)
   PUBMED   30770417
  REMARK    GeneRIF: Our data reveal that analogous to other IL-17 family
            members, IL-17B has an inflammatory role in the human system.
REFERENCE   4  (bases 1 to 712)
  AUTHORS   Yang YF, Lee YC, Lo S, Chung YN, Hsieh YC, Chiu WC and Yuan SF.
  TITLE     A positive feedback loop of IL-17B-IL-17RB activates
            ERK/beta-catenin to promote lung cancer metastasis
  JOURNAL   Cancer Lett 422, 44-55 (2018)
   PUBMED   29496538
  REMARK    GeneRIF: Gene expression microarray analysis followed by
            Kaplan-Meier survival curve showed that high expression level of
            IL-17B was associated with poor survival of patients with lung
            neoplasm.
REFERENCE   5  (bases 1 to 712)
  AUTHORS   Alinejad V, Dolati S, Motallebnezhad M and Yousefi M.
  TITLE     The role of IL17B-IL17RB signaling pathway in breast cancer
  JOURNAL   Biomed Pharmacother 88, 795-803 (2017)
   PUBMED   28160754
  REMARK    GeneRIF: This comprehensive review details the recognition of
            activity, signaling, and the roles of IL17B-IL17RB in breast cancer
            have caused to determination of new therapeutic
            mechanisms--{REVIEW}
            Review article
REFERENCE   6  (bases 1 to 712)
  AUTHORS   Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS,
            Noh SM, Kim S, Yoo HS, Kim YS and Kim NS.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 712)
  AUTHORS   Ryan AW, Thornton JM, Brophy K, Daly JS, McLoughlin RM, O'Morain C,
            Abuzakouk M, Kennedy NP, Stevens FM, Feighery C, Kelleher D and
            McManus R.
  TITLE     Chromosome 5q candidate genes in coeliac disease: genetic variation
            at IL4, IL5, IL9, IL13, IL17B and NR3C1
  JOURNAL   Tissue Antigens 65 (2), 150-155 (2005)
   PUBMED   15713213
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 712)
  AUTHORS   Moore EE, Presnell S, Garrigues U, Guilbot A, LeGuern E, Smith D,
            Yao L, Whitmore TE, Gilbert T, Palmer TD, Horner PJ and Kuestner
            RE.
  TITLE     Expression of IL-17B in neurons and evaluation of its possible role
            in the chromosome 5q-linked form of Charcot-Marie-Tooth disease
  JOURNAL   Neuromuscul Disord 12 (2), 141-150 (2002)
   PUBMED   11738356
REFERENCE   9  (bases 1 to 712)
  AUTHORS   Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber
            MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM,
            Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA and Ebner R.
  TITLE     A novel cytokine receptor-ligand pair. Identification, molecular
            characterization, and in vivo immunomodulatory activity
  JOURNAL   J Biol Chem 275 (25), 19167-19176 (2000)
   PUBMED   10749887
REFERENCE   10 (bases 1 to 712)
  AUTHORS   Li H, Chen J, Huang A, Stinson J, Heldens S, Foster J, Dowd P,
            Gurney AL and Wood WI.
  TITLE     Cloning and characterization of IL-17B and IL-17C, two new members
            of the IL-17 cytokine family
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 773-778 (2000)
   PUBMED   10639155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131025.1.
            
            On Nov 25, 2018 this sequence version replaced NM_014443.2.
            
            Summary: The protein encoded by this gene is a T cell-derived
            cytokine that shares sequence similarity with IL17. This cytokine
            was reported to stimulate the release of TNF alpha (TNF) and IL1
            beta (IL1B) from a monocytic cell line. Immunohistochemical
            analysis of several nerve tissues indicated that this cytokine is
            primarily localized to neuronal cell bodies. Alternative splicing
            results in multiple splice variants. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF212311.1, AF152098.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2149178,
                                           SAMEA2158188 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261796.4/ ENSP00000261796.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC131025.1         82810-82897
            89-378              AC131025.1         85077-85366
            379-712             AC131025.1         87502-87835
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..712
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /note="interleukin 17B"
                     /db_xref="GeneID:27190"
                     /db_xref="HGNC:HGNC:5982"
                     /db_xref="MIM:604627"
     exon            1..88
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..610
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin 20; cytokine-like protein ZCYTO7;
                     neuronal interleukin-17 related factor; interleukin-17
                     beta"
                     /codon_start=1
                     /product="interleukin-17B isoform 1 precursor"
                     /protein_id="NP_055258.1"
                     /db_xref="CCDS:CCDS4297.1"
                     /db_xref="GeneID:27190"
                     /db_xref="HGNC:HGNC:5982"
                     /db_xref="MIM:604627"
                     /translation="MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQ
                     VPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWG
                     YSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRT
                     GPCRQRAVMETIAVGCTCIF"
     exon            89..378
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /inference="alignment:Splign:2.1.0"
     exon            379..712
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /note="hexamer: AGTAAA"
     polyA_site      712
                     /gene="IL17B"
                     /gene_synonym="IL-17B; IL-20; NIRF; ZCYTO7"
                     /note="major polyA site"
ORIGIN      
        1 attctctcgg cggcatctgg ggttccaggc gggcagcagc tgcaggctga ccttgcagct
       61 tggcggaatg gactggcctc acaacctgct gtttcttctt accatttcca tcttcctggg
      121 gctgggccag cccaggagcc ccaaaagcaa gaggaagggg caagggcggc ctgggcccct
      181 ggcccctggc cctcaccagg tgccactgga cctggtgtca cggatgaaac cgtatgcccg
      241 catggaggag tatgagagga acatcgagga gatggtggcc cagctgagga acagctcaga
      301 gctggcccag agaaagtgtg aggtcaactt gcagctgtgg atgtccaaca agaggagcct
      361 gtctccctgg ggctacagca tcaaccacga ccccagccgt atccccgtgg acctgccgga
      421 ggcacggtgc ctgtgtctgg gctgtgtgaa ccccttcacc atgcaggagg accgcagcat
      481 ggtgagcgtg ccggtgttca gccaggttcc tgtgcgccgc cgcctctgcc cgccaccgcc
      541 ccgcacaggg ccttgccgcc agcgcgcagt catggagacc atcgctgtgg gctgcacctg
      601 catcttctga atcacctggc ccagaagcca ggccagcagc ccgagaccat cctccttgca
      661 cctttgtgcc aagaaaggcc tatgaaaagt aaacactgac ttttgaaagc aa
//
