LOCUS       NM_002190               1871 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens interleukin 17A (IL17A), mRNA.
ACCESSION   NM_002190
VERSION     NM_002190.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Nakanishi,T., Mieda,K., Kuramoto,H. and Takegawa,D.
  TITLE     Effect of interleukin-17A on inflammatory mediator production in
            interleukin-1beta-stimulated human dental pulp fibroblasts
  JOURNAL   Eur J Oral Sci 132 (5), e13019 (2024)
   PUBMED   39302740
  REMARK    GeneRIF: Effect of interleukin-17A on inflammatory mediator
            production in interleukin-1beta-stimulated human dental pulp
            fibroblasts.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Orlov,M., Wander,P.L., Morrell,E.D., Mikacenic,C. and Wurfel,M.M.
  TITLE     A Case for Targeting Th17 Cells and IL-17A in SARS-CoV-2 Infections
  JOURNAL   J Immunol 205 (4), 892-898 (2020)
   PUBMED   32651218
  REMARK    Review article
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Raucci,F., Mansour,A.A., Casillo,G.M., Saviano,A., Caso,F.,
            Scarpa,R., Mascolo,N., Iqbal,A.J. and Maione,F.
  TITLE     Interleukin-17A (IL-17A), a key molecule of innate and adaptive
            immunity, and its potential involvement in COVID-19-related
            thrombotic and vascular mechanisms
  JOURNAL   Autoimmun Rev 19 (7), 102572 (2020)
   PUBMED   32376393
  REMARK    Review article
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Liu,S.
  TITLE     Structural Insights into the Interleukin-17 Family Cytokines and
            Their Receptors
  JOURNAL   Adv Exp Med Biol 1172, 97-117 (2019)
   PUBMED   31628653
  REMARK    Review article
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Shaikh,S.B., Prabhu,A. and Bhandary,Y.P.
  TITLE     Interleukin-17A: A Potential Therapeutic Target in Chronic Lung
            Diseases
  JOURNAL   Endocr Metab Immune Disord Drug Targets 19 (7), 921-928 (2019)
   PUBMED   30652654
  REMARK    Review article
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Krstic,J., Obradovic,H., Kukolj,T., Mojsilovic,S.,
            Okic-Dordevic,I., Bugarski,D. and Santibanez,J.F.
  TITLE     An Overview of Interleukin-17A and Interleukin-17 Receptor A
            Structure, Interaction and Signaling
  JOURNAL   Protein Pept Lett 22 (7), 570-578 (2015)
   PUBMED   25990083
  REMARK    Review article
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Yao,Z., Spriggs,M.K., Derry,J.M., Strockbine,L., Park,L.S.,
            VandenBos,T., Zappone,J.D., Painter,S.L. and Armitage,R.J.
  TITLE     Molecular characterization of the human interleukin (IL)-17
            receptor
  JOURNAL   Cytokine 9 (11), 794-800 (1997)
   PUBMED   9367539
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Fossiez,F., Djossou,O., Chomarat,P., Flores-Romo,L., Ait-Yahia,S.,
            Maat,C., Pin,J.J., Garrone,P., Garcia,E., Saeland,S., Blanchard,D.,
            Gaillard,C., Das Mahapatra,B., Rouvier,E., Golstein,P.,
            Banchereau,J. and Lebecque,S.
  TITLE     T cell interleukin-17 induces stromal cells to produce
            proinflammatory and hematopoietic cytokines
  JOURNAL   J Exp Med 183 (6), 2593-2603 (1996)
   PUBMED   8676080
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Yao,Z., Painter,S.L., Fanslow,W.C., Ulrich,D., Macduff,B.M.,
            Spriggs,M.K. and Armitage,R.J.
  TITLE     Human IL-17: a novel cytokine derived from T cells
  JOURNAL   J Immunol 155 (12), 5483-5486 (1995)
   PUBMED   7499828
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Rouvier,E., Luciani,M.F., Mattei,M.G., Denizot,F. and Golstein,P.
  TITLE     CTLA-8, cloned from an activated T cell, bearing AU-rich messenger
            RNA instability sequences, and homologous to a herpesvirus saimiri
            gene
  JOURNAL   J Immunol 150 (12), 5445-5456 (1993)
   PUBMED   8390535
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391221.15 and U32659.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 29, 2018 this sequence version replaced NM_002190.2.
            
            Summary: This gene is a member of the IL-17 receptor family which
            includes five members (IL-17RA-E) and the encoded protein is a
            proinflammatory cytokine produced by activated T cells.
            IL-17A-mediated downstream pathways induce the production of
            inflammatory molecules, chemokines, antimicrobial peptides, and
            remodeling proteins. The encoded protein elicits crucial impacts on
            host defense, cell trafficking, immune modulation, and tissue
            repair, with a key role in the induction of innate immune defenses.
            This cytokine stimulates non-hematopoietic cells and promotes
            chemokine production thereby attracting myeloid cells to
            inflammatory sites. This cytokine also regulates the activities of
            NF-kappaB and mitogen-activated protein kinases and can stimulate
            the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well
            as enhance the production of nitric oxide (NO). IL-17A plays a
            pivotal role in various infectious diseases, inflammatory and
            autoimmune disorders, and cancer. High levels of this cytokine are
            associated with several chronic inflammatory diseases including
            rheumatoid arthritis, psoriasis and multiple sclerosis. The lung
            damage induced by the severe acute respiratory syndrome coronavirus
            2 (SARS-CoV-2) is to a large extent, a result of the inflammatory
            response promoted by cytokines such as IL17A. [provided by RefSeq,
            Sep 2020].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U32659.1, Z58820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000648244.1/ ENSP00000497968.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL391221.15        121508-121519
            13-1769             U32659.1           9-1765
            1770-1871           AL391221.15        125670-125771
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.2"
     gene            1..1871
                     /gene="IL17A"
                     /gene_synonym="CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17"
                     /note="interleukin 17A"
                     /db_xref="GeneID:3605"
                     /db_xref="HGNC:HGNC:5981"
                     /db_xref="MIM:603149"
     exon            1..84
                     /gene="IL17A"
                     /gene_synonym="CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..525
                     /gene="IL17A"
                     /gene_synonym="CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17"
                     /note="interleukin 17 (cytotoxic T-lymphocyte-associated
                     serine esterase 8); cytotoxic T-lymphocyte-associated
                     protein 8; cytotoxic T-lymphocyte-associated antigen 8;
                     interleukin-17"
                     /codon_start=1
                     /product="interleukin-17A precursor"
                     /protein_id="NP_002181.1"
                     /db_xref="CCDS:CCDS4937.1"
                     /db_xref="GeneID:3605"
                     /db_xref="HGNC:HGNC:5981"
                     /db_xref="MIM:603149"
                     /translation="MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRT
                     VMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINA
                     DGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA"
     exon            85..287
                     /gene="IL17A"
                     /gene_synonym="CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17"
                     /inference="alignment:Splign:2.1.0"
     exon            288..1871
                     /gene="IL17A"
                     /gene_synonym="CTLA-8; CTLA8; IL-17; IL-17A; IL17; ILA17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccatctca tagcaggcac aaactcatcc atccccagtt gattggaaga aacaacgatg
       61 actcctggga agacctcatt ggtgtcactg ctactgctgc tgagcctgga ggccatagtg
      121 aaggcaggaa tcacaatccc acgaaatcca ggatgcccaa attctgagga caagaacttc
      181 ccccggactg tgatggtcaa cctgaacatc cataaccgga ataccaatac caatcccaaa
      241 aggtcctcag attactacaa ccgatccacc tcaccttgga atctccaccg caatgaggac
      301 cctgagagat atccctctgt gatctgggag gcaaagtgcc gccacttggg ctgcatcaac
      361 gctgatggga acgtggacta ccacatgaac tctgtcccca tccagcaaga gatcctggtc
      421 ctgcgcaggg agcctccaca ctgccccaac tccttccggc tggagaagat actggtgtcc
      481 gtgggctgca cctgtgtcac cccgattgtc caccatgtgg cctaagagct ctggggagcc
      541 cacactcccc aaagcagtta gactatggag agccgaccca gcccctcagg aaccctcatc
      601 cttcaaagac agcctcattt cggactaaac tcattagagt tcttaaggca gtttgtccaa
      661 ttaaagcttc agaggtaaca cttggccaag atatgagatc tgaattacct ttccctcttt
      721 ccaagaagga aggtttgact gagtaccaat ttgcttcttg tttacttttt taagggcttt
      781 aagttattta tgtatttaat atgccctgag ataactttgg ggtataagat tccattttaa
      841 tgaattacct actttatttt gtttgtcttt ttaaagaaga taagattctg ggcttgggaa
      901 ttttattatt taaaaggtaa aacctgtatt tatttgagct atttaaggat ctatttatgt
      961 ttaagtattt agaaaaaggt gaaaaagcac tattatcagt tctgcctagg taaatgtaag
     1021 atagaattaa atggcagtgc aaaatttctg agtctttaca acatacggat atagtatttc
     1081 ctcctctttg tttttaaaag ttataacatg gctgaaaaga aagattaaac ctactttcat
     1141 atgtattaat ttaaattttg caatttgttg aggttttaca agagatacag caagtctaac
     1201 tctctgttcc attaaaccct tataataaaa tccttctgta ataataaagt ttcaaaagaa
     1261 aatgtttatt tgttctcatt aaatgtattt tagcaaactc agctcttccc tattgggaag
     1321 agttatgcaa attctcctat aagcaaaaca aagcatgtct ttgagtaaca atgacctgga
     1381 aatacccaaa attccaagtt ctcgatttca catgccttca agactgaaca ccgactaagg
     1441 ttttcatact attagccaat gctgtagaca gaagcatttt gataggaata gagcaaataa
     1501 gataatggcc ctgaggaatg gcatgtcatt attaaagatc atatggggaa aatgaaaccc
     1561 tccccaaaat acaagaagtt ctgggaggag acattgtctt cagactacaa tgtccagttt
     1621 ctcccctaga ctcaggcttc ctttggagat taaggcccct cagagatcaa cagaccaaca
     1681 tttttctctt cctcaagcaa cactcctagg gcctggcttc tgtctgatca aggcaccaca
     1741 caacccagaa aggagctgat ggggcagaac gaactttaag tatgagaaaa gttcagccca
     1801 agtaaaataa aaactcaatc acattcaatt ccagagtagt ttcaagtttc acatcgtaac
     1861 cattttcgcc c
//
