LOCUS       NM_172217               9634 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens interleukin 16 (IL16), transcript variant 2, mRNA.
ACCESSION   NM_172217 XM_011521520
VERSION     NM_172217.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9634)
  AUTHORS   Zhu,X., Li,X., Liu,S., Zhao,Y.H., Liu,X.R., Liu,X.Y., Yao,R.,
            Tian,L., Liu,X.Q., Meng,F. and Liang,L.
  TITLE     Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates
            neuropathic pain via activating astrocytes in female mice
  JOURNAL   Neuropharmacology 259, 110115 (2024)
   PUBMED   39137872
  REMARK    GeneRIF: Enhanced interleukin-16-CD4 signaling in CD3 T cell
            mediates neuropathic pain via activating astrocytes in female mice.
REFERENCE   2  (bases 1 to 9634)
  AUTHORS   Watrowski,R., Schuster,E., Van Gorp,T., Hofstetter,G.,
            Fischer,M.B., Mahner,S., Polterauer,S., Zeillinger,R. and
            Obermayr,E.
  TITLE     Association of the Single Nucleotide Polymorphisms rs11556218,
            rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with
            Ovarian Cancer
  JOURNAL   Int J Mol Sci 25 (19), 10272 (2024)
   PUBMED   39408600
  REMARK    GeneRIF: Association of the Single Nucleotide Polymorphisms
            rs11556218, rs4778889, rs4072111, and rs1131445 of the
            Interleukin-16 Gene with Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9634)
  AUTHORS   Ali,Y.B.M., Saed,M.M., Abdel-Hakem,N.E., Hussein,M.A.E.A. and
            El-Shahat,M.
  TITLE     Genetic Association of Interleukin 16 Gene Polymorphisms
            (rs11556218 & rs4778889) with Type 1 Diabetes in Egyptian Children:
            A Case-Control Study
  JOURNAL   Immunol Invest 53 (5), 830-842 (2024)
   PUBMED   38771670
  REMARK    GeneRIF: Genetic Association of Interleukin 16 Gene Polymorphisms
            (rs11556218 & rs4778889) with Type 1 Diabetes in Egyptian Children:
            A Case-Control Study.
REFERENCE   4  (bases 1 to 9634)
  AUTHORS   Brosecke,F., Pfau,A., Ermer,T., Dein Terra Mota Ribeiro,A.B.,
            Rubenbauer,L., Rao,V.S., Burlein,S., Genser,B., Reichel,M.,
            Aronson,P.S., Coca,S. and Knauf,F.
  TITLE     Interleukin-16 is increased in dialysis patients but is not a
            cardiovascular risk factor
  JOURNAL   Sci Rep 14 (1), 11323 (2024)
   PUBMED   38760468
  REMARK    GeneRIF: Interleukin-16 is increased in dialysis patients but is
            not a cardiovascular risk factor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9634)
  AUTHORS   Reyes-Farias,M., Fernandez-Garcia,P., Corrales,P., Gonzalez,L.,
            Soria-Gondek,A., Martinez,E., Pellitero,S., Tarasco,J., Moreno,P.,
            Sumoy,L., Medina-Gomez,G., Sanchez-Infantes,D. and Herrero,L.
  TITLE     Interleukin-16 is increased in obesity and alters adipogenesis and
            inflammation in vitro
  JOURNAL   Front Endocrinol (Lausanne) 15, 1346317 (2024)
   PUBMED   38544694
  REMARK    GeneRIF: Interleukin-16 is increased in obesity and alters
            adipogenesis and inflammation in vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9634)
  AUTHORS   Bannert,N., Baier,M., Werner,A. and Kurth,R.
  TITLE     Interleukin-16 or not?
  JOURNAL   Nature 381 (6577), 30 (1996)
   PUBMED   8609984
REFERENCE   7  (bases 1 to 9634)
  AUTHORS   Ryan,T.C., Cruikshank,W.W., Kornfeld,H., Collins,T.L. and
            Center,D.M.
  TITLE     The CD4-associated tyrosine kinase p56lck is required for
            lymphocyte chemoattractant factor-induced T lymphocyte migration
  JOURNAL   J Biol Chem 270 (29), 17081-17086 (1995)
   PUBMED   7615501
REFERENCE   8  (bases 1 to 9634)
  AUTHORS   Cruikshank,W.W., Center,D.M., Nisar,N., Wu,M., Natke,B.,
            Theodore,A.C. and Kornfeld,H.
  TITLE     Molecular and functional analysis of a lymphocyte chemoattractant
            factor: association of biologic function with CD4 expression
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 5109-5113 (1994)
   PUBMED   7910967
REFERENCE   9  (bases 1 to 9634)
  AUTHORS   Rand,T.H., Cruikshank,W.W., Center,D.M. and Weller,P.F.
  TITLE     CD4-mediated stimulation of human eosinophils: lymphocyte
            chemoattractant factor and other CD4-binding ligands elicit
            eosinophil migration
  JOURNAL   J Exp Med 173 (6), 1521-1528 (1991)
   PUBMED   1851800
REFERENCE   10 (bases 1 to 9634)
  AUTHORS   Kobatake,K., Sako,K., Izawa,M., Yamamoto,Y.L. and Hakim,A.M.
  TITLE     Autoradiographic determination of brain pH following middle
            cerebral artery occlusion in the rat
  JOURNAL   Stroke 15 (3), 540-547 (1984)
   PUBMED   6729885
  REMARK    GeneRIF: Correlations between increased levels of secreted IL-16,
            CD4+ Th1 cell inflammation, and phosphorylation of axonal
            cytoskeleton in Multiple sclerosis (MS) lesions. Possible role for
            IL-16 in regulation of inflammation and axonal cytoskeleton in MS.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC036196.10 and AC103858.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_172217.4.
            
            Summary: The protein encoded by this gene is a pleiotropic cytokine
            that functions as a chemoattractant, a modulator of T cell
            activation, and an inhibitor of HIV replication. The signaling
            process of this cytokine is mediated by CD4. The product of this
            gene undergoes proteolytic processing, which is found to yield two
            functional proteins. The cytokine function is exclusively
            attributed to the secreted C-terminal peptide, while the N-terminal
            product may play a role in cell cycle control. Caspase 3 is
            reported to be involved in the proteolytic processing of this
            protein. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and and
            5' coding region and initiates translation at an alternate start
            codon, compared to variant 1. The encoded isoform (2) is longer at
            the N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.138443.1,
                                           SRR1803613.159215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683961.1/ ENSP00000508085.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AC036196.10        144279-144552
            275-687             AC036196.10        172699-173111
            688-796             AC103858.2         75441-75549
            797-939             AC103858.2         81328-81470
            940-1050            AC103858.2         85207-85317
            1051-1165           AC103858.2         88759-88873
            1166-1239           AC103858.2         94486-94559
            1240-1456           AC103858.2         95227-95443
            1457-1574           AC103858.2         98308-98425
            1575-1707           AC103858.2         101367-101499
            1708-1795           AC103858.2         106122-106209
            1796-2277           AC103858.2         108225-108706
            2278-2428           AC103858.2         112597-112747
            2429-3524           AC103858.2         115049-116144
            3525-3693           AC103858.2         117013-117181
            3694-3795           AC103858.2         119218-119319
            3796-4054           AC103858.2         121577-121835
            4055-4180           AC103858.2         122089-122214
            4181-9634           AC103858.2         124274-129727
FEATURES             Location/Qualifiers
     source          1..9634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..9634
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="interleukin 16"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
     exon            1..274
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            275..687
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..4374
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lymphocyte chemoattractant factor; prointerleukin 16;
                     neuronal interleukin 16"
                     /codon_start=1
                     /product="pro-interleukin-16 isoform 2"
                     /protein_id="NP_757366.2"
                     /db_xref="CCDS:CCDS42069.1"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
                     /translation="MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDP
                     FEISLAQGKEGIFHSSVQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFF
                     MKESSTASSREKPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAA
                     PTDRQPYSLCSNRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIV
                     LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA
                     GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF
                     ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSV
                     AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQL
                     KEAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMI
                     RSSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQES
                     PPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPPPRKYFKSDSDPQKSLEERENSSCS
                     SGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRA
                     SPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQP
                     NASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKG
                     LRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPD
                     KGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEA
                     RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRARSFPLTRS
                     QSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNE
                     DSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSE
                     ELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP
                     NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMP
                     DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLT
                     INRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS
                     LQSKETTAAGDS"
     exon            688..796
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            797..939
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1050
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1165
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1239
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1456
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1574
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1707
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1795
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2277
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2428
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..3524
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3693
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3795
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..4054
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4180
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..9634
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4642..4647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="hexamer: AATAAA"
     polyA_site      4667
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="major polyA site"
     regulatory      5155..5160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="hexamer: AATACA"
     polyA_site      5175
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
     regulatory      8309..8314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="hexamer: AATAAA"
     polyA_site      8337
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
     regulatory      9612..9617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /note="hexamer: AATAAA"
     polyA_site      9634
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
ORIGIN      
        1 acatttgtcc tgagtcacct gtccagagca ggtggtgaat attgtgtcct actcacggca
       61 tctcaactat cggagcctgg gatctgactc aaaggccggc ctccgtctga gaactgagcg
      121 tccatttctc aatccttgcc ggctctgacc caggcctggg ccacaggctg tccgggaata
      181 agtggtgctg caatccctgc tgggcagatg gagagaggag caagggagat ggcagccccg
      241 ggggactgtg catagggagg taggtgggca ccagggactc atgaagtggc agctaagccc
      301 tgtccagtgg ccacccgtca gccaagggcc agagaccagg aaaggaagaa aggcagcttc
      361 acttcctctt tgaggatgga gtcgcacagc cgcgctggaa agagcagaaa atctgcaaaa
      421 tttcggtcca tctccaggtc cctgatgctc tgtaatgcta agaccagtga tgatggctct
      481 agccctgatg agaaatatcc tgatcccttt gagatttcct tggcccaggg caaggaggga
      541 attttccact catctgtgca gctggcagac acatcggagg ctgggcccag cagtgttcct
      601 gatctagcac tggcctcgga ggctgctcaa ctccaagcag ctgggaatga tcgaggcaag
      661 acctgtagga ggatattctt catgaaggaa tcttccacag cttcctctcg agaaaagcct
      721 ggaaaactag aagcacaaag tagtaacttc ctgtttccta aagcctgcca ccaaagggca
      781 cgcagcaact caaccagtgt taatccctat tgcacaagag aaattgattt tccaatgacc
      841 aagaaatctg cagcgcccac ggacaggcag ccttactctc tctgcagtaa caggaagtcc
      901 ctctctcaac aattggactg tccagcagga aaggctgcgg gaacttcgag accaacacgg
      961 tccctgagca cagctcagct cgtgcagcca tctgggggcc tccaggcttc agtcatctcc
     1021 aacatcgtgc tgatgaaggg ccaggctaag ggtctgggct tcagcatcgt tgggggaaaa
     1081 gacagcattt atggccccat tgggatttac gtcaaaacca tttttgcagg gggagcagca
     1141 gcagccgatg gaaggctaca ggaaggtgat gaaattctgg agctcaatgg tgaatcaatg
     1201 gctggactaa cacatcagga tgctttgcag aagttcaagc aagccaaaaa ggggctcctc
     1261 accctcaccg tgagaacccg cctgacggcg cctccttccc tgtgcagcca cctgtctccc
     1321 ccactgtgcc gctccctgag ctccagcact tgtatcacca aggacagcag ctccttcgcc
     1381 ttggaaagcc cctcggctcc catcagcacc gccaagccca attacagaat catggtggag
     1441 gtttctctgc agaaagaggc cggcgtgggc ctgggcatcg gcctgtgcag cgttccctac
     1501 ttccaatgca tctctggcat tttcgtccac acgctgtcac caggatccgt ggcgcacctg
     1561 gacggacgtc tccggtgtgg ggacgagatt gtggaaatca gtgattcccc tgtgcactgc
     1621 ctgacgctca atgaagtcta cacgatcctg agtcactgtg atcccggtcc agtccccatc
     1681 attgttagcc gacatccaga cccacaggtc tctgaacagc aactcaaaga agctgtggcc
     1741 caggctgtgg aaaacaccaa gtttggaaag gagaggcatc agtggagtct ggaaggtgtc
     1801 aaaaggctgg aaagcagttg gcacgggcgg cccaccttgg agaaggaacg agagaagaac
     1861 tcagcacccc cgcatcgcag ggctcagaag gtcatgatcc gctccagcag tgacagcagc
     1921 tacatgtctg ggtccccagg gggaagtcct gggagtggca gtgctgagaa gccgtcctct
     1981 gacgtggaca tcagcacaca cagccccagc ttgcctctgg cacgggagcc agtggtgctt
     2041 tctatagcat cctccaggct gccccaggag agcccacccc tcccagagag ccgggacagc
     2101 cacccgccgc tgagactgaa gaaatccttt gagattttgg tgagaaagcc tatgtcctcc
     2161 aagcccaagc ctccacccag aaaatacttt aaaagtgaca gtgaccctca gaagagtctg
     2221 gaagagagag agaactcctc atgctcttct gggcacaccc cacccacctg tggccaggaa
     2281 gcgagagagc tgctgccact gctgctacca caggaagaca cagcagggag aagccctagt
     2341 gcctctgccg gctgcccagg acctggtatc ggcccacaga ccaagtcctc cacagagggc
     2401 gagccagggt ggagaagagc cagcccagtg acccaaacat ccccgataaa acacccactg
     2461 cttaagaggc aggctcggat ggactatagc tttgatacca cagccgaaga cccttgggtt
     2521 aggatttctg actgcatcaa aaacttattt agccccatca tgagtgagaa ccatggccac
     2581 atgcctctac agcccaatgc cagcctgaat gaagaagaag ggacacaggg ccacccagat
     2641 gggaccccac caaagctgga caccgccaat ggcactccca aagtttacaa gtcagcagac
     2701 agcagcactg tgaagaaagg tcctcctgtg gctcccaagc cagcctggtt tcgccaaagc
     2761 ttgaaaggtt tgaggaatcg tgcttcagac ccaagagggc tccctgatcc tgccttgtcc
     2821 acccagccag cacctgcttc cagggagcac ctaggatcac acatccgggc ctcctcctcc
     2881 tcctcctcca tcaggcagag aatcagctcc tttgaaacct ttggctcctc tcaactgcct
     2941 gacaaaggag cccagagact gagcctccag ccctcctctg gggaggcagc aaaacctctt
     3001 gggaagcatg aggaaggacg gttttctgga ctcttggggc gaggggctgc acccactctt
     3061 gtgccccagc agcctgagca agtactgtcc tcggggtccc ctgcagcctc cgaggccaga
     3121 gacccaggtg tgtctgagtc ccctccccca gggcggcagc ccaatcagaa aactctcccc
     3181 cctggcccgg acccgctcct aaggctgctg tcaacacagg ctgaggaatc tcaaggccca
     3241 gtgctcaaga tgcctagcca gcgagcacgg agcttccccc tgaccaggtc ccagtcctgt
     3301 gagacgaagc tacttgacga aaagaccagc aaactctatt ctatcagcag ccaagtgtca
     3361 tcggctgtca tgaaatcctt gctgtgcctt ccatcttcta tctcctgtgc ccagactccc
     3421 tgcatcccca aggaaggggc atctccaaca tcatcatcca acgaagactc agctgcaaat
     3481 ggttctgctg aaacatctgc cttggacaca gggttctcgc tcaacctttc agagctgaga
     3541 gaatatacag agggtctcac ggaagccaag gaagacgatg atggggacca cagttccctt
     3601 cagtctggtc agtccgttat ctccctgctg agctcagaag aattaaaaaa actcatcgag
     3661 gaggtgaagg ttctggatga agcaacatta aagcaattag acggcatcca tgtcaccatc
     3721 ttacacaagg aggaaggtgc tggtcttggg ttcagcttgg caggaggagc agatctagaa
     3781 aacaaggtga ttacggttca cagagtgttt ccaaatgggc tggcctccca ggaagggact
     3841 attcagaagg gcaatgaggt tctttccatc aacggcaagt ctctcaaggg gaccacgcac
     3901 catgatgcct tggccatcct ccgccaagct cgagagccca ggcaagctgt gattgtcaca
     3961 aggaagctga ctccagaggc catgcccgac ctcaactcct ccactgactc tgcagcctca
     4021 gcctctgcag ccagtgatgt ttctgtagaa tctacagcag aggccacagt ctgcacggtg
     4081 acactggaga agatgtcggc agggctgggc ttcagcctgg aaggagggaa gggctcccta
     4141 cacggagaca agcctctcac cattaacagg attttcaaag gagcagcctc agaacaaagt
     4201 gagacagtcc agcctggaga tgaaatctta cagctgggtg gcactgccat gcagggcctc
     4261 acacggtttg aagcctggaa catcatcaag gcactgcctg atggacctgt cacgattgtc
     4321 atcaggagaa aaagcctcca gtccaaggaa accacagctg ctggagactc ctaggcagga
     4381 catgctgaag ccaaagccaa taacacacag ctaacacaca gctcccataa ccgctgattc
     4441 tcagggtctc tgctgccgcc ccacccagat gggggaaagc acaggtgggc ttcccagtgg
     4501 ctgctgccca ggcccagacc ttctaggacg ccacccagca aaaggttgtt cctaaaataa
     4561 gggcagagtc acacgggggc agctgataca aattgcagac tgtgtaaaaa gagagcttaa
     4621 tgataatatt gtggtgccac aaataaaatg gatttattag aatttcatat gacattcatg
     4681 cctggcttcg caaaatgttt caagtactgt aactgtgtca tgattcaccc ccaaacagtg
     4741 acatttattt ttctcatgaa tctgcaatgt gggcagagat tggaatgggc agctcatctc
     4801 tgtcccactt ggcatcagct ggcgtcatgc aaagtcatgc aaaggctggg accacgtgag
     4861 atcattcact catacatctg gccgttgatg ttggctggga actcacctgg ggctgctggc
     4921 ctgaatgctt ataggtggcc tctccttgtg gcctgggcct cctcacaaca tggtgtctgg
     4981 attcccagga tgagcatccc aggatcgcaa gagccatgta gaagctgcat cttgtttata
     5041 cctttgcctt ggaagttgca tggcatcacc tccaccatac tccatcagtt agagctgaca
     5101 caaacctgcc tgggtttaag gggagaggaa atattgctgg ggtcatttat gaaaaataca
     5161 gtttgtcaca tgaaacattt gcaaaattgt ttttggttgg attggagaag taatcctagg
     5221 gaagggtggt ggagccagta aacagaggag tacaggtgaa gcaccaagct caaagcgtgg
     5281 acaggtgtgc cgacagaagg aaccagcgtg tatatgaggg tatcaaataa aattgctact
     5341 acttacctac cacatgccaa gcactgtgct cagggctaaa cgggcattgc ctttagtgat
     5401 cacagcagct tctacggtgt atggttctgt gccaatgtat tgataagagg gcacacactg
     5461 tgtacagtaa atggcttatc cagctggtga gtgatgcggc agattgagtt ttcttctgtg
     5521 attcggtgga gactatcagc ccaagatgct ttaagtgcac aacattacag ggaatgcctg
     5581 agtgcctggc caaagggata tttggtttgg ccatctctgg atgcctgatt gccaagctca
     5641 ggaccaggca atgtgacttt gcatcagcaa caaccagcat cccttgacca ggcctgggcc
     5701 agagtattgg tctcctctca gcccctgatc ctgtgaagta aggatgtggg ggaagacctg
     5761 gcaaggacac agatgaaaca caaacaatag taattctcag gccatcatca gtggagccat
     5821 gttaatgtaa tctgatggct tctccagggt ccacaggaag tgaagaatct gtttcccagc
     5881 agtggactca aaacccatct gggctcctaa ccttcctgta aaccccttta gtggcttcat
     5941 tagagcaggc gttcagctca ctgttctatt catctcaagg aataatgggc ttagagcagt
     6001 ttctgtcctg ctggttaact tgtttggcct attccattct ggattttgtc aagcagtaga
     6061 caagcaatta gacaagaact tggaggcacc atttgtatcc actttttaga cttaatagaa
     6121 acattgaaga tgaacataat ctaccaacga aagacgtgat tcaattcaac actcccttcc
     6181 catgacccag gctgggcaag gaggccacgt gatgtggagg gcacattcct tgcctgcaca
     6241 aactcaccat ctgtgcacgc agtggccttc cctaaaatca gggaattgtt ttaagtctta
     6301 tcaagcagcc aagggatgaa agagaaggtg ggttttcatc aagactggaa ggtggggaca
     6361 gggatgagca tggagctggc cgtgggcctg gggtaccaag agactccttg agagaccagg
     6421 caaagcaagt gattgggaca gaggttatct gtcccaggtt atctgggcat agatgcaggt
     6481 gagcccatgg ccctcccagt acctcctgtc tctggcctgt tttagaaggt tctctcctcc
     6541 ccaaggagac acaacaactc ctagggccac tgaagatata actattgccc aggtttctgg
     6601 tctctaggct ggggaagtcc tctgggtagg aatcagcaag aagatcctaa aacaaaagct
     6661 catccatttg cgttccatga tgctgggatt tacacttgag gcttagcttt gctctgccaa
     6721 cttcttcaga gctgacacag gatgaaggca atgccatcct caaacactgc aggcatcaca
     6781 gctaacaatt gtgaagtcgt cttaactcac cataaaaagg aatccactcc caggcagccc
     6841 tacttctttg ctttgcccag cattttactg attcatacat tatctcactt gtgccaacac
     6901 tcaagaagca ggctacactg acactggtat tcctgcctcc atattttctt taaaagacaa
     6961 atcaaagcag atatattaag tgactgttca agagcacact tggcccaagt ggcagagctt
     7021 ggactggatg catgttttcc agctcctcat ccagggctct gaccagttta acctgatgca
     7081 gtcacgtgga ggagcagtgc aggcacagta tgtcccatag gcccagtgag atgcattctt
     7141 ggttggctgg ccttccactt ggctacacag ggatgtacaa ggcgatccca tcttgataag
     7201 accaccacct cagagtatgg agctcagaga gggcaggcat gaagtttcct tggctggtgc
     7261 acctagaatt ggctgaactc atgagaagtt gatatagaac agtgcttgcc acagagcggg
     7321 gactcggtaa gcacttaatg aatgaatgaa ttctaagtca atccaagagt ctgatgattt
     7381 cttgaaaagg gtgttagcta aaggatctta ggcatgactg tagaatttgt agttgcaata
     7441 gaacagagaa agaggaagct ttctgtctcc ttaacactga gctgtcatgt tttaaagctt
     7501 gctcacatct tggcacattt aagagacagt caccccagga ctcaaaaata gggaagtaac
     7561 agtaacgcag gggaaacgtt ttctgtttgg aggagcaaag gctgagaaca ctgtgaaaac
     7621 attttgcgcg cacaatagta acctgggtaa atgcagcgtg aagggatttt agtcacacgt
     7681 ggtctttctt acaaggaagg tggtgggggt gcagatgagg ttgctagaga atgttagagg
     7741 atccctctct ggattggaga tagggaaaga aagttgcacg gctgctgagg ccccttctag
     7801 gtggcaaggc tgtgctccct ggttctgatg atgtgcctgg gtggacatgg cccctgtgag
     7861 tttgtacagt cttgcagcag gatctagagg ggggatttcc agccagggct gctagacgga
     7921 ggcctactct tccatctttc ctgatggcag gatggcctgg ccagggcctg gaagacagag
     7981 acctcctgcc tccgcctcag taagacgaca aggaaaggca aatgcccaag ggaaagaaaa
     8041 ggaaggctct tctccccaga gttccccatg cagacatgag tgcgtgctca gttcagaatc
     8101 acttctgaga actcatccct aatgctgcag atttgggctg gaacagattc acactgtctg
     8161 gtttcaccga ggacatgaaa ctccaccttg cggggataaa gagagaaaaa caaattcatc
     8221 aaatggaaga cacattgaaa gtgtttttcc ttaatgctta tcctgttttt aaaccattat
     8281 ttccaagttg acaccttttt taaggaaaaa taaatatttt gcggcattaa agccatatac
     8341 aaggtctata tcagaaaaat atatttgggg ggctgcagca caggactgag ggagcggtac
     8401 atgcttaaaa ggcaacaggg cctggttttc agtggcgatg atgattctct atgacagtca
     8461 gggaaacgtg gtctctgaga gtgatgggca cataaagcct tggtgccaga gtgcatcgca
     8521 tggtgtccag gccgagtctc tgtcagatgg ttagaggcct gggtctaccc tgccaggaga
     8581 ggcgtgtttg ggtaacaggc agatggagtt tggaacacat gaatggctca tcacacgcca
     8641 accctgagtg gggcaggagg caggaagggt gggctgccgc ctctggttgg cattctcaga
     8701 gatgcgcagt ccatcagctt gttccaaaga gtgaacacag gcctctgcgt gctcccaggc
     8761 tccttggtgt cccaacagct ggagctcctc gatgagtcac gggagttctt tgccaagaag
     8821 taacgatagc attactcatg gaattgcttc actgctttct gaaggttggc ataaaaccgg
     8881 gtcatgctgc gggggaagaa ggagtccacc acgttctgtg ggaggtaacc gctgaggtcg
     8941 gtatggaaga atgtgaccag gttggtcttg gtgggttccc tgtgaaggca acagcagagc
     9001 tgtgttatga tctgcagcag aggtgctggg gacgagcgcc aggcaggtga gcagagccca
     9061 gcccagtgga aatggccatg atacagtgat cgcgtctcat cccttgctgt gccctccacc
     9121 caggagtcct ctctggacct gctgattttc aggatggaaa cccatcctgt cggggatgca
     9181 ttccacagcc tctcccggcc tccagggagg aagaagtccc tactcccagc ccaaaaaccc
     9241 agtaccctgc tgcccgattc actcagcaaa tgctttcaga gaactcactt tgtgccaggc
     9301 cctgagagga acgaagagat gctgcccttc actatttagg gtctgcaacc tcctgggggc
     9361 tcctgggacc ctttcaaggg gtctacaaag ttaacactat ttttataaca acacgaacat
     9421 gtgattcgcc ttctctcaca tgcatacagt ggggttttcc ggaggttaca tgatatgtga
     9481 tattgcaaca gactacacgc acaagcaggt atgagtttct gttaagcctg gcatgaaaga
     9541 gatgggcaaa aatataaaaa caatgccact cttttcacag tattttttgt tttaaaaaaa
     9601 tagtttttta aaataaaaat gttatctatg ttaa
//
